Abstracts Archive - Page 1982 of 2425 - ACR Meeting Abstracts

Abstract Number: 1043 • 2014 ACR/ARHP Annual Meeting
Identification of Putative Biomarkers and Molecular Mechanisms Associated with Adverse Tissue Reactions to Metal-on-Metal and Modular Neck Hip Implants
Ed Purdue¹, Gabrielle Wilner², Kritti Kolatat², Geoffrey H. Westrich³, Friedrich Boettner⁴, Seth Jerabek⁴ and Steven R. Goldring⁵, ¹535 East 70th Street, Hospital for Special Surgery, New York, NY, ²Research, Hospital for Special Surgery, New York, NY, ³Orthopedics, Hospital for Special Surgery, New York, NY, ⁴Orthopaedics, Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, New York, NY
Background/Purpose Total hip replacement (THR) is a highly successful treatment for degenerative arthritis, alleviating pain and restoring joint function in the vast majority of patients.…
Abstract Number: 1042 • 2014 ACR/ARHP Annual Meeting
IL-1β and TNF-α Promote Monocyte Viability through the Induction of GM-CSF Expression By Rheumatoid Arthritis Synovial Fibroblasts
Christelle Darrieutort-Laffite^1,2, Marie Astrid Boutet¹, Mathias Chatelais¹, Regis Brion³, Frederic Blanchard¹, Dominique Heymann³ and Benoit Le Goff^1,2, ¹Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, INSERM, UMR 957, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France, ³Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, INSERM, UMR 957, Nantes, France
Background/Purpose Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). They can interact in the synovial micro-environment…
Abstract Number: 1041 • 2014 ACR/ARHP Annual Meeting
Imaging the Role of Chemoattractants in Inflammatory Arthritis
Yoshishige Miyabe¹, Thomas T. Murooka¹, Chie Miyabe¹, Nancy Kim², Thorsten R. Mempel¹ and Andrew D. Luster¹, ¹Massachusetts General Hospital, Charlestown, MA, ²Div of Rheumatology, Massachusetts General Hospital, Charlestown, MA
Background/Purpose: Inflammatory arthritis, including rheumatoid arthritis, is characterized by neutrophil recruitment into the diseased joint. Our previous studies and the work of others have demonstrated…
Abstract Number: 1060 • 2014 ACR/ARHP Annual Meeting
Musculoskeletal Surgeries and Procedures in Patients with RA: Results from a UK Retrospective Study
H Cawston¹, F Bourhis¹, T Le² and E Alemao³, ¹OptumInsight, Nanterre, France, ²Bristol-Myers Squibb, Hopewell, NJ, ³Bristol-Myers Squibb, Princeton, NJ
Background/Purpose: Musculoskeletal surgeries and procedures substantially improve the quality of life of patients with RA, but represent an important burden in terms of medical costs.…
Abstract Number: 1059 • 2014 ACR/ARHP Annual Meeting
Patients with RA from Wealthier Countries Perform Better on Clinical Disease Activity Measures, but Tend to Show Worse Person Reported Outcomes
Polina Putrik¹, Sofia Ramiro², Andras Keszei³, Ihsane Hmamouchi⁴, Maxime Dougados⁵, Monika Hifinger⁶, Laure Gossec⁷ and Annelies Boonen⁸, ¹Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ²Rheumatology, Amsterdam Rheumatology Center, University of Amsterdam & Hospital Garcia de Orta, Almada, Portugal, Amsterdam, Netherlands, ³Medical Informatics, Uniklinik RWTH Aachen University, Aachen, Germany, ⁴Biostatistics, Epidemiology LBRCE, Mohamed V Souissi University, Rabat, Morocco, ⁵Cochin Hospital, Paris Descartes University, Paris, France, ⁶Rheumatology, MUMC, University Hospital Maastricht, Maastricht, Netherlands, ⁷Rheumatology, Pierre et Marie Curie University, Paris, France, ⁸Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose Inequalities in health between low and high income countries are often reported, but it is not known whether clinical disease activity measures (“objective”) and…
Abstract Number: 1058 • 2014 ACR/ARHP Annual Meeting
Levels of Fatigue Are Dependent on Country of Residence in Rheumatoid Arthritis: An Analysis Among 3920 Patients from 17 Countries
Monika Hifinger^1,2, Polina Putrik^3,4, Sofia Ramiro^5,6, Maxime Dougados⁷, Laure Gossec⁸, Andras Keszei⁹, Ihsane Hmamouchi¹⁰ and Annelies Boonen¹¹, ¹Rheumatology, University of Maastricht, Maastricht, Netherlands, ²Rheumatology, MUMC, University Hospital Maastricht, Maastricht, Netherlands, ³Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Health Promotion, Maastricht University, Maastricht, Netherlands, ⁵Clinical Immunology and Rheumatology, Amsterdam Rheumatology Center/University of Amsterdam, Amsterdam, Netherlands, ⁶Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ⁷Cochin Hospital, Paris Descartes University, Paris, France, ⁸Rheumatology, Pierre et Marie Curie University, Paris, France, ⁹Medical Informatics, Uniklinik RWTH Aachen University, Aachen, Germany, ¹⁰Biostatistics, Epidemiology LBRCE, Mohamed V Souissi University, Rabat, Morocco, ¹¹Internal Medicine-Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: For patients with rheumatoid arthritis (RA), fatigue is an important aspect of disease which impacts quality of life. However the complex relationship between fatigue…
Abstract Number: 1057 • 2014 ACR/ARHP Annual Meeting
Work-Related Behavior and Experiences in Patients with Rheumatoid Arthritis
Jutta G. Richter¹, Thomas Muth², Ralph Brinks³, Tobias Koch¹, Peter Angerer² and Matthias Schneider⁴, ¹Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ²Institute for Occupational and Social Medicine, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ³Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany, ⁴Department of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany
Background/Purpose: Work-related behavior and experiences are discussed to be either risk factors or resources for individual‘s health. Diseases and related changing working conditions and/or experiences…
Abstract Number: 1056 • 2014 ACR/ARHP Annual Meeting
Factors Associated with Impairment on Quality of Life in Early or Established RA Patients
Dam Kim¹, Yoon-Kyoung Sung^2,3, Soo-Kyung Cho^1,3, Soyoung Won¹, Minkyung Han¹, So-Young Bang⁴, Hoon-Suk Cha⁵, Chan-Bum Choi^2,3, Jung-Yoon Choe⁶, Won Tae Chung⁷, Seung-Jae Hong⁸, Jae-Bum Jun³, Young Ok Jung⁹, Jinseok Kim¹⁰, Seong-Kyu Kim¹¹, Tae-Hwan Kim¹², Tae-Jong Kim¹³, Eunmi Koh¹⁴, Choong Ki Lee¹⁵, Hye-Soon Lee¹⁶, Joo-Hyun Lee¹⁷, Jaejoon Lee¹⁸, Jisoo Lee¹⁹, Sang-Heon Lee²⁰, Shin-Seok Lee²¹, Sung Won Lee²², Seung-Cheol Shim²³, Dae-Hyun Yoo², Wan-Hee Yoo²⁴, Bo Young Yoon²⁵ and Sang-Cheol Bae^1,2, ¹Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, ²Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁴Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, ⁵Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁶Division of Rheumatology, Catholic University of Daegu School of Medicine, Daegu, South Korea, ⁷Dong-A University Hospital, Busan, South Korea, ⁸Division of Rheumatology, Department of Internal Medicine, Kyung Hee University, Seoul, South Korea, ⁹Rheumatology dept, Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea, ¹⁰Jeju National University Hospital, Jeju, South Korea, ¹¹Catholic University of Daegu School of Medicine, Daegu, South Korea, ¹²Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ¹³Chonnam Nat`l University Medical School&Hospital, Gwangju, South Korea, ¹⁴Dept of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ¹⁵Internal medicine, school of medicine, Yeungnam University, Daegu, South Korea, ¹⁶Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ¹⁷Department of Rheumatology, Ilsan Paik Hospital, Inje University, Goyang, South Korea, ¹⁸Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ¹⁹Ewha Womans University School of Medicine, Seoul, South Korea, ²⁰Dept of Internal Medicine, Konkuk University Hospital, Seoul, South Korea, ²¹Division of, Chonnam National University Med School, Gwangju, South Korea, ²²Dong-A university,Busan, South Korea, Pusan, South Korea, ²³Chungnam National University Hospital, Daejeon, South Korea, ²⁴Division of Rheumatology, Department of Internal Medicine, Chonbuk National University School of Medicine, Jeonju, South Korea, ²⁵Inje University Ilsan Paik Hospital, Goyang, South Korea
Background/Purpose Rheumatoid arthritis (RA) is a chronic inflammatory disabling disease with significant impact on the quality of life (QOL) of patients. Since clinical features are…
Abstract Number: 1034 • 2014 ACR/ARHP Annual Meeting
Therapeutic Potential of Targeting Sialic Acid Modified Receptors in Osteoarthritis
Maria Dolores Mayan^1,2, Paula Carpintero-Fernández¹, Raquel Gago-Fuentes¹, Marta Varela-Eirin¹, Gary S. Goldberg³ and Francisco Javier Blanco^1,4,5, ¹Cartilage Biology Research Group, Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Email: [email protected], A Coruña, Spain, ³Rowan University, Department of Molecular Biology, School of Osteopathic Medicine, Stratford, NJ, ⁴Rheumatology Division, CIBER-BBN/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁵Rheumatology Division, ProteoRed/ISCIII, Proteomics Group, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain
Background/Purpose: Glycosylated proteins are essential components of the extracellular matrix (ECM) of cartilage and contribute to the maintenance of its function. A shift from a-2,6-…
Abstract Number: 1033 • 2014 ACR/ARHP Annual Meeting
Stat3 Promotes IL-10 Expression in SLE T Cells through Trans-activation and Chromatin Remodeling
Christian Hedrich¹, Thomas Rauen², Sokratis Apostolidis³, Alexandros P. Grammatikos⁴, Noe Rodriguez Rodriguez⁴, Christina Ioannidis³, Vasileios C. Kyttaris⁴, José C. Crispin⁴ and George C. Tsokos⁵, ¹Children's Hospital, Dresden, Germany, ²Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ³Medicine, Rheumatology, BIDMC, Boston, MA, ⁴Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-10 is an immune-regulatory cytokine that is expressed by a wide range of cells and tissues. It plays a central role in the regulation…
Abstract Number: 1032 • 2014 ACR/ARHP Annual Meeting
Neutralization of IL-17 Ameliorated Kidney Pathology Associated with Immune-Complex Mediated Autoimmune Glomerulonephritis
Partha Biswas¹, Kritika Ramani², Kelly Maers³, Anna Huppler⁴ and Sarah L. Gaffen⁵, ¹Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Dept of Medicine, University of Pittsburgh, Pittsburgh, PA, ³Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴Medicine, University of Pittsburgh, Pittsurgh, PA, ⁵Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Immune complex mediated autoimmune glomerulonephritis (AGN) is an often-fatal clinical manifestation of systemic lupus erythematosus. In recent years, pro-inflammatory cytokines in the nephritic kidney…
Abstract Number: 1031 • 2014 ACR/ARHP Annual Meeting
Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a
Salahuddin Ahmed¹, Laura Walsh², Anil Singh¹, Maria Beamer³, Kuladeep Sudini⁴ and Douglas Leaman⁴, ¹Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ²Department of Pharmacology, University of Toledo, Toledo, OH, ³Department of Pharmacology, Department of Pharmacology, University of Toledo, Toledo, OH, ⁴Department of Biological Sciences, University of Toledo, Toledo, OH
Background/Purpose: In rheumatoid arthritis (RA), the paucity of pro-apoptotic protein expression may significantly contribute to the resistance of synovial fibroblasts (FLS) to apoptosis. In the…
Abstract Number: 1030 • 2014 ACR/ARHP Annual Meeting
ABT-122, a Novel Dual Variable Domain (DVD)-Ig^TM, Targeting TNF and IL-17, Inhibits Peripheral Blood Mononuclear Cell Production of GM-CSF and Decreases Lymphocyte Expression of CXCR4 in Healthy Subjects
Melanie Ruzek¹, Donna Conlon¹, Heikki Mansikka², Robert Padley² and Carolyn Cuff³, ¹AbbVie, Inc, Worcester, MA, ²AbbVie, Inc, North Chicago, IL, ³Immunology, AbbVie, Inc, Worcester, MA
Background/Purpose: TNF and IL-17 contribute to the pathogenesis of several inflammatory disorders and are known to synergistically induce chemokines and cytokines, including chemokine (C-X-C motif)…
Abstract Number: 1029 • 2014 ACR/ARHP Annual Meeting
Anandamide and Related Eicosanoids Decrease the Production of Pro-Inflammatory Cytokines in Synovial Fibroblasts By a COX-2 Dependent Mechanism: Involvement of Calcium and TRP Channels
Torsten Lowin¹, Tanja Späth², Angelika Graeber¹ and Rainer Straub³, ¹Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, ²Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, Regensburg, Germany, ³Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: Endocannabinoids are immunomodulatory lipid compounds that act on cannabinoid receptors type 1 and 2 but also on transient receptor potential (TRP) channels. Their action…
Abstract Number: 1028 • 2014 ACR/ARHP Annual Meeting
ADAM-10 Plays Monocyte Migration and Adhesion in Rheumatoid Arthritis Synovial Fibroblasts
Takeo Isozaki^1,2, Sho Ishii², Shinichiro Nishimi², Airi Maeoka², Mayu Saito², Nao Oguro², Shinya Seki², Yoko Miura², Yusuke Miwa², Koei Oh³, Yoichi Toyoshima³, Masanori Nakamura³, Katsunori Inagaki³ and Tsuyoshi Kasama², ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, ³Department of Orthopedics, Showa University School of Med, Tokyo, Japan
Background/Purpose :A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We previously reported that ADAM-10…

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