Abstracts Archive - Page 1971 of 2425 - ACR Meeting Abstracts

Abstract Number: 1207 • 2014 ACR/ARHP Annual Meeting
Novel Role of Liver X Receptor Alpha (LXRα) in the Attenuation of TLR Signalling: Implications in Congenital Heart Block
Susmita Bagchi¹, Mark Halushka², Robert M. Clancy¹ and Jill P. Buyon¹, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD
Background/Purpose: Anti-SSA/Ro associated congenital heart block provides a unique opportunity to examine the effector arm of immunity and define the molecular mechanisms that link maternal…
Abstract Number: 1206 • 2014 ACR/ARHP Annual Meeting
Low Dose Colchicine Anti-Inflammatory Effects Are Transduced By AMP-Activated Protein Kinase (AMPK)
Ru Bryan¹, Robert Terkeltaub² and Yun Wang³, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA
Background/Purpose AMPK is a master metabolic energy regulator, whose tissue activity drops in response to nutritional excesses, alcohol consumption, and in obesity, metabolic syndrome and…
Abstract Number: 1205 • 2014 ACR/ARHP Annual Meeting
Expression of Lectin-like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis
Paulina Chalan¹, Johan Bijzet², Minke G. Huitema³, Bart-Jan Kroesen⁴, Elisabeth Brouwer¹ and Annemieke M.H. Boots¹, ¹Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Dept. of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose Precursor Th17 lineage cells expressing CD161 are implicated in rheumatoid arthritis (RA) pathogenesis. CD4+CD161+ T cells were found to accumulate in RA synovial fluid…
Abstract Number: 1204 • 2014 ACR/ARHP Annual Meeting
Oral Administration of Nano-Emulsion Curcumin in Mice Suppresses Inflammatory-Induced NFkB Signaling and Macrophage Migration
Nicholas A. Young¹, Michael Bruss², Mark Gardner³, William Willis³, Xiaokui Mo³, Giancarlo Valiente³, Yu Cao⁴, Zhongfa Liu⁴, Lai-Chu Wu¹ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Rheumatology and Immunology, The Ohio State University Wexner Medical Center, columbus, OH, ⁵Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The major obstacles to successful use of curcumin as an anti-inflammatory agent are its low solubility in water and rapid metabolism, which both translate…
Abstract Number: 1203 • 2014 ACR/ARHP Annual Meeting
NK/NKT Cells from Early and Definite Systemic Sclerosis Patients Show Different Immunological Responses after IL-2 Stimulation
Marta Cossu¹, Lenny van Bon¹, Stefan Nierkens², Alessandro Santaniello³, Lorenzo Beretta⁴ and Timothy Radstake⁵, ¹Department of Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²U-DAIR- Laboratory of Translational Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ³Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁴Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁵Rheumatology, Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: The innate immune system may be implicated in the fibrotic processes of systemic sclerosis (SSc); to date little has been done to unravel the…
Abstract Number: 1202 • 2014 ACR/ARHP Annual Meeting
Type I Interferon Promotes Inflammatory Cytokine Production By Inhibiting Mir-146a Maturation in SLE
Bo Qu¹, Jianchang Cao², Feifei Zhang² and Nan Shen^1,2,3, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China, Shanghai, China, ³The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose Systemic lupus erythematosus (SLE) is characterized by the uncontrolled inflammation along with over produced inflammatory cytokines, among which type I interferon (IFN) is recognized…
Abstract Number: 1201 • 2014 ACR/ARHP Annual Meeting
Hypoxia Modulates Peptidyl Arginine Deiminase 4 Activity and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous¹, Luke W. Thomas³, Margaret Ashcroft³, Joanna C. Porter² and Ian Giles¹, ¹Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ³Centre for Cell Signalling and Molecular Genetics, Centre for Cell Signalling and Molecular Genetics, University College London, London, United Kingdom
Background/Purpose RA is an autoimmune rheumatic disease characterised by ACPA, endothelial dysfunction, platelet activation, synovial hyperplasia and hypoxia in affected joints. ACPA recognise citrullinated proteins,…
Abstract Number: 1220 • 2014 ACR/ARHP Annual Meeting
Higher Inflammatory Response in Elderly Patients during Gout Attack
Ji Ae Yang¹, Jae Hyun Lee¹, Eun Young Lee², Eun Bong Lee¹, Yeong Wook Song³ and Jin Kyun Park¹, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ²Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Higher inflammatory response in elderly patients during gout attack Background/Purpose Clinical experiences suggest that gout attacks in elderly patients are accompanied by stronger systemic inflammatory…
Abstract Number: 1219 • 2014 ACR/ARHP Annual Meeting
Lack of Gene-Diuretic Interactions on Risk of Incident Gout: The Nurses’ Health Study and Health Professionals Follow-up Study
Ying Bao¹, Tony R. Merriman², Gary Curhan³, Eli A. Stahl⁴, David B. Mount⁵, Robert M. Plenge⁶, Peter Kraft⁷ and Hyon K. Choi⁸, ¹Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, ²Department of Biochemistry, University of Otago, Dunedin, New Zealand, ³German Research Center for Environmental Health, Harvard Medical School, Boston, MA, ⁴Mt Sinai School of Medicine, New York City, NY, ⁵Renal Division, Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy and Division of Genetics, Brigham and Women's Hospital, Boston, MA, ⁷Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, ⁸Boston University School of Medicine, Boston, MA
Background/Purpose: Diuretics, particularly thiazide and loop diuretics, increase the risk of gout, likely through urate transporters (e.g., OAT4) and volume depletion promoting urate reabsorption. As…
Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting
The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice
Yoshitaka Kimura^1,2, Tamiko Yanagida³, Akiko Onda⁴, Hajime Kono², Maki Takayama², Kurumi Asako², Akiko Okamoto², Hirotoshi Kikuchi² and Toshihiro Nanki⁵, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan
Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
Abstract Number: 1217 • 2014 ACR/ARHP Annual Meeting
The Random Urine Uric Acid to Creatinine Ratio As a Predictor of 24-Hour Urine Uric Acid Excretion in Gout Patients
Sang Tae Choi¹, Jung-Soo Song² and Eun-Hye Park², ¹Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea, ²Chung-Ang University College of Medicine, Seoul, South Korea
Background/Purpose: Gout is an inflammatory disease resulted from an increased body pool of uric acid. The measurement of 24-hour uric acid excretion is important to…
Abstract Number: 1216 • 2014 ACR/ARHP Annual Meeting
The Relationship Between Serum Homocysteine, Uric Acid and Renal Function in Chronic Gouty Patients: 2 Year Follow-up Results
Eun-Hye Park¹, Sang Tae Choi² and Jung-Soo Song¹, ¹Chung-Ang University College of Medicine, Seoul, South Korea, ²Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea
Background/Purpose: Hyperhomocysteinemia is one of the important factors for the endothelial cell damage and also a risk factor for cardiovascular events. Gout is known to…
Abstract Number: 1215 • 2014 ACR/ARHP Annual Meeting
Circulating Mediators of Bone Remodeling in Patients with Tophaceous Gout
Ashika Chhana¹, Opetaia Aati², Gregory Gamble², Karen E. Callon¹, Anthony Doyle³, Mark Roger⁴, Fiona M. McQueen⁵, Anne Horne², Ian R. Reid², Jillian Cornish¹ and Nicola Dalbeth², ¹Medicine, University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³University of Auckland, Auckland, New Zealand, ⁴Department of Radiology, Auckland District Health Board, Auckland, New Zealand, ⁵Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Disordered bone remodeling has been implicated in the development of bone erosion in tophaceous gout. The function of bone cells in the skeleton is…
Abstract Number: 1197 • 2014 ACR/ARHP Annual Meeting
Febuxostat Inhibits Monosodium Urate Crystal-Induced IL-1beta Secretion and Cell Death Via ROS- and Intracellular ATP-Dependent Pathways
Johji Nomura¹, Nathalie Busso², Mizuho Tamura¹, Tsunefumi Kobayashi¹ and Alexander So³, ¹Pharmaceutical Development Research Laboratories, Teijin Institute for Bio-Medical Research, Teijin Pharma Limited, Tokyo, Japan, ²Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland, ³Rheumatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland
Background/Purpose: In gout, monosodium urate (MSU) crystals trigger acute inflammation. MSU has been reported to activate NLRP3 inflammasome via ROS-dependent pathways, which result in IL-1beta…
Abstract Number: 1196 • 2014 ACR/ARHP Annual Meeting
Inflammation Develops in a Toll-like Receptor 9-Independent Manner in Experimental Arthritis and Rheumatoid Arthritis
Julie Mussard¹, Matthieu Ribon¹, Gaelle Clavel², Marie-Christophe Boissier³ and Patrice Decker¹, ¹INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité and Rheumatology Department, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France, ²Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, ³INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France
Background/Purpose Rheumatoid arthritis (RA) is an inflammatory disease of unknown etiology. Toll-like receptor (TLR) 9 recognizes pathogen-derived DNA and even self DNA under certain circumstances.…

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