Abstracts Archive - Page 1970 of 2425 - ACR Meeting Abstracts

Abstract Number: 1237 • 2014 ACR/ARHP Annual Meeting
Retroperitoneal Fibrosis and IgG4 Disease: Response to Immunosuppressive Therapy – a Single Centre Retrospective Study
Shirish Sangle¹, Pamela Lutalo², Louise Nel³, James Pattison⁴, Tim OBrien⁵ and David P. D'Cruz⁶, ¹Rheumatology, Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom, ²Peter Gorer Department of Immunobiology, King's College London School of Medicine, London, United Kingdom, ³Rheumatology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom, ⁴Nephrology, Guy's and St Thomas' Hospital NHS Foundation Trust, London, United Kingdom, ⁵Urology, Guy's and St Thomas' Hospital NHS Trust, London, United Kingdom, ⁶Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom
Background/Purpose: A retrospective observational study of patients with IgG4 related disease and retroperitoneal fibrosis Methods: Retroperitoneal fibrosis (RPF) is a rare chronic inflammatory condition which…
Abstract Number: 1236 • 2014 ACR/ARHP Annual Meeting
IgG4 Immunostaining Is Common but Not Specific in Orbitbal Inflammatory Diseases
James T. Rosenbaum^1,2, Amanda Wong³, Patrick Stauffer³, Megan Troxell⁴, Donald Houghton⁵, Dongseok Choi⁶, Christine Harrington⁷, David Wilson⁸, Hans Grossniklaus⁹, Roger Dailey³, John Ng³, Eric Steele³, Patrick Yeatts¹⁰, Peter Dolman¹¹, Valerie White¹¹, Craig Czyz¹², Jill Foster¹², Deepak Edward¹³, Hind Alkatan¹³, Don Kikkawa¹⁴, Bobby Korn¹⁵, Dinesh Selva¹⁶, Gerald Harris¹⁷, Michael Kazim¹⁸, Payal Patel¹⁸ and Stephen R. Planck¹⁹, ¹OHSU, Portland, OR, ²Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR, ³Oregon Health & Science University, Portland, OR, ⁴Pathology, Oregon Health and Science University, Portland, OR, ⁵Pathology, Oregon Health & Science University, Portland, OR, ⁶Casey Eye Institute, Oregon Health and Science University, Portland, OR, ⁷Integrated Genomics, Oregon Health & Science University, Portland, OR, ⁸Casey Eye Institute/Ophthalmology, Oregon Health & Science University, Portland, OR, ⁹Ophthalmology, Emory University, Atlanta, GA, ¹⁰Ophthalmology, Wake Forest University, Winston-Salem, NC, ¹¹University of British Columbia, Vancouver, BC, Canada, ¹²Ohio State Univeristy, Columbus, OH, ¹³King Khaled Eye Hospital, Riyadh, Saudi Arabia, ¹⁴Ophthalmology, University of California, San Diego, San Diego, CA, ¹⁵University of California, San Diego, San Diego, CA, ¹⁶Royal Adelaide Hospital, Adelaide, Australia, ¹⁷Medical College of Wisconsin, Milwaukee, WI, ¹⁸Columbia University, New York City, NY, ¹⁹Casey Eye Inst/Ophthalmology, Oregon Health & Science University, Portland, OR
Background/Purpose: IgG4-related disease is an emerging clinical entity which frequently involves tissue within the orbit. In order to appreciate the implications of IgG4 immunostaining, we…
Abstract Number: 1235 • 2014 ACR/ARHP Annual Meeting
Recovery of Renal Function after Corticosteroid Therapy for IgG4-Related Kidney Disease
Takako Saeki¹, Mitsuhiro Kawano², Ichiro Mizushima², Motohisa Yamamoto³, Yoshifumi Ubara⁴, Hitoshi Nakashima⁵, Yoko Wada⁶, Tomoyuki Ito⁷, Hajime Yamazaki⁷, Ichiei Narita⁶ and Takao Saito^5,8, ¹Department of Internal Medicine, Nagaoka Red Cross Hospital, Nagaoka, Japan, ²Kanazawa University Hospital, Kanazawa, Japan, ³Sapporo Medical University School of Medicine, Sapporo, Japan, ⁴Toranomon Hospital, Tokyo, Japan, ⁵Div of Nephrol & Rheumatol, Dept of Int Med, Faculty of Medicine, Fukuoka University, Fukuoka, Japan, ⁶Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, ⁷Nagaoka Red Cross Hospital, Nagaoka, Japan, ⁸General Medical Research Center, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
Background/Purpose: In our earlier study of IgG4-related kidney disease (IgG4-RKD), we found that renal dysfunction, which was mostly attributable to IgG4-related tubulointerstitial nephritis, was significantly…
Abstract Number: 1234 • 2014 ACR/ARHP Annual Meeting
Periodic Fever Syndromes in an Academic Medical Center
Mark Cervinski¹ and Daniel Albert², ¹Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, ²Medicine, The Dartmouth Institute for Health Policy and Clinical Practice, lebanon, NH
Background/Purpose: Most published clinical data on this rapidly evolving group of diseases are from highly specialized centers and do not reflect what is commonly seen…
Abstract Number: 1233 • 2014 ACR/ARHP Annual Meeting
Tocilizumab (TCZ) in the Treatment of AA Amyloidosis in Patients with Familial Mediterranean Fever
Huri Ozdogan, Serdal Ugurlu, Aysa Hacioglu, Yasaman Adibnia and Vedat Hamuryudan, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: AA amyloidosis is the major long-term complication of various chronic inflammatory diseases like rheumatoid arthritis, ankylosing spondylitis, FMF and other autoinflammatory syndromes. Treatment of…
Abstract Number: 1232 • 2014 ACR/ARHP Annual Meeting
Canakinumab Therapy in Patients with Familial Mediterranean Fever
Serdal Ugurlu, Emire Seyahi, Gulen Hatemi, Aysa Hacioglu, Fatma Nihan Akkoc and Huri Ozdogan, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: According to a recent pilot study Canakinumab reduced the frequency of attacks in 9 patients with Familial Mediterranean Fever (FMF) resistant to colchicine with no…
Abstract Number: 1231 • 2014 ACR/ARHP Annual Meeting
Evidence Based Recommendations for Genetic Diagnosis of Familial Mediterranean Fever
Gabriella Giancane¹, Nienke ter Haar², Nico Wulffraat³, Bas Vastert⁴, Karyl Barron⁵, Veronique Hentgen⁶, Tilmann Kallinich⁷, Huri Ozdogan⁸, Jordi Anton⁹, Paul Brogan¹⁰, Luca Cantarini¹¹, Joost Frenkel⁴, Caroline Galeotti¹², Marco Gattorno¹³, Gilles Grateau¹⁴, Michael Hofer¹⁵, Isabelle Kone-Paut¹⁶, J B. Kuemmerle-Deschner¹⁷, Helen Lachmann¹⁸, Anna Simon¹⁹, Brian Feldman²⁰, Yosef Uziel²¹ and Seza Ozen²², ¹Pediatric Immunology, UMC, Utrecht, Netherlands, Utrecht, Netherlands, ²Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Pediatric rheumatology, Wilhelmina Children's Hospital/ UMC Utrecht, Utrecht, Netherlands, ⁴University Medical Center Utrecht, Utrecht, Netherlands, ⁵NIH, Bethesda, MD, ⁶Versailles Hospital, Le Chesnay Cedex, France, ⁷Charite, University Medicine Berlin, Berlin, Germany, ⁸Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ⁹Pediatric Rheumatology Unit. Hospital Sant Joan de Déu. Universitat de Barcelona, Barcelona, Spain, ¹⁰Rheumatology Unit, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹¹University of Siena, Siena, Italy, ¹²Bicêtre Hospital, University of Paris SUD, Paris, France, ¹³Istituto Giannina Gaslini, Genova, Italy, ¹⁴Service De Médecine Interne, Hopital Tenon, Paris, France, ¹⁵Centre Multisite Romand de Rhumatologie Pediatrique, Lausanne, Switzerland, ¹⁶Department of Pediatric Rheumatology, Reference Centre for Autoinflammatory Disorders CEREMAI, Bicêtre Hospital, University of Paris SUD, Paris, France, ¹⁷Division of Pediatric Rheumatology, Department of Pediatrics, University Hospital Tuebingen, Tuebingen, Germany, ¹⁸UK National Amyloidosis Centre, University College London Medical School, London, United Kingdom, ¹⁹Radboudumc, Nijmegen, Netherlands, ²⁰Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²¹Tel-Aviv University, Sackler School of Medicine, Tel-Aviv, Israel, ²²Deptartment. of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey
Background/Purpose: Familial Mediterranean Fever (FMF) is a disease that starts in childhood and can lead to significant morbidity. In 2013, an initiative called SHARE (Single…
Abstract Number: 1230 • 2014 ACR/ARHP Annual Meeting
Efficacy of Interleukin-1 Targeting Drugs in Familial Mediterranean Fever Patients
Pinar Cetin¹, Ismail Sari¹, Betul Sozeri², Ozlem Cam², Merih Birlik¹, Fatos Onen¹, Nurullah Akkoc¹ and Servet Akar¹, ¹Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, ²Pediatrics, Ege University School of Medicine, Izmir, Turkey
Background/Purpose Familial Mediterranean fever (FMF) is an autosomal-recessive autoinflammatory disorder characterized by recurrent episodes of fever accompanied by sterile peritonitis. The most devastating complication of…
Abstract Number: 1214 • 2014 ACR/ARHP Annual Meeting
Oxidative Stress from Use of Allopurinol – Is There a Reason for Patients with Gout to Take Vitamin C?
Lisa K. Stamp¹, Peter T. Chapman², John L. O'Donnell³, Irada Khalilova⁴, Rufus Turner⁴ and Anthony Kettle⁴, ¹Department of Medicine, University of Otago, Christchurch, Christchurch, New Zealand, ²Rheumatology, Immunology & Allergy, Christchurch Hospital, Christchurch, New Zealand, ³Rheumatology Immunology & Allergy, Canterbury Health Laboratories, Christchurch, New Zealand, ⁴Pathology, University of Otago, Christchurch, Christchurch, New Zealand
Background/Purpose During acute gout attacks neutrophils are activated and release a number of pro-inflammatory cytokines and enzymes. One of these enzymes is myeloperoxidase (MPO), which…
Abstract Number: 1212 • 2014 ACR/ARHP Annual Meeting
Behcets Disease in Females Due to Mutation in NEMO, the NF-Kb Essential Modulator
Alex Wessel¹, Spiros Vonortas², Jevgenia Zilberman-Rudenko³, Richard Siegel⁴ and Eric Hanson⁵, ¹5814 Beech Ave, NIH, Bethseda, MD, ²NIH, NIAMS, Bethesda, MD, ³Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴NIAMS, NIH, Bethesda, MD, ⁵National Institute of Health, Bethesda, MD
Background/Purpose: Behçet's disease (BD) is a chronic multi-system inflammatory disorder associated clinically with oral and genital ulceration, uveitis, erythema nodosum, and other inflammatory disease. The…
Abstract Number: 1213 • 2014 ACR/ARHP Annual Meeting
Absence of Hormone Responsive Estrogen Receptor Alpha Reduces the Activation of Plasmacytoid Dendritic Cells in Lupus Prone Mice
Jennifer L. Scott¹, Melissa A. Cunningham², Osama S. Naga³, Jackie G. Eudaly³, Jena R. Wirth⁴ and Gary S. Gilkeson⁵, ¹Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, ²Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, ³Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Med/Rheumatology, MUSC, Charleston, SC, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects women at a 9 to 1 ratio compared to men. To further understand…
Abstract Number: 1211 • 2014 ACR/ARHP Annual Meeting
Gene Expression Profile in Muscle Tissue before and after Immunosuppressive Treatment in Patients with Myositis
Joan Raouf¹, Ingela M. Loell², Yi-Wen Chen³, Rongye Shi⁴, Inger Nennesmo⁵, Helene Alexanderson⁶, Maryam Dastmalchi², Marina Korotkova⁷, Kanneboyina Nagaraju^8,9 and Ingrid E. Lundberg^10,11, ¹Department of Medicine, Rheumatology Unit, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, ³Research Center for Genetic Medicine, Children’s National Medical Center, Washington DC, USA., Washington DC, DC, ⁴Research Center for Genetic Medicine, Childrens National Medical Center, Research Center for Genetic Medicine, Washington DC, USA, Washington DC, WA, ⁵Institution for Laboratory Medicine (LABMED), Karolinska Universitetssjukhuset Huddinge, Stockholm, Sweden, Stockholm, Sweden, ⁶Karolinska Institutet, Department of medicine, Rheumatology Unit, Karolinska Universitetssjukhuset Solna, Stockholm, Sweden, Stockholm, Sweden, ⁷Department of Medicine, Rheumatology Unit, Department of Medicine, Karolinska University Hospital in Solna, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ⁸Genetic Medicine, Children's National Medical Center, Washinton D C, DC, ⁹Research Center for Genetic Medicine, Children’s National Medical Center, Washington DC, DC, ¹⁰Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ¹¹Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose Autoimmune muscle diseases such as polymyositis (PM) and dermatomyositis (DM) are characterized by infiltration of inflammatory cells, production of cytokines and chemokines, as well…
Abstract Number: 1210 • 2014 ACR/ARHP Annual Meeting
The Role of the Transcription Factor cAMP Responsive Element Binding Protein 1 in Lipopolysaccharide-Induced Tolerance
Kerstin Klein¹, Renate E. Gay², Christoph Kolling³, Lih-Ling Lin⁴, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ³Schulthess Clinic, Zurich, Switzerland, ⁴Inflammation and Remodeling Research Unit, Pfizer, Cambridge, MA
Background/Purpose In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to adaptation of signaling pathways and epigenetic modifications resulting in a tolerant state of…
Abstract Number: 1209 • 2014 ACR/ARHP Annual Meeting
Anti-Scavenger Receptor Autoantibodies Disrupted Marginal Zone Macrophage Integrity Via Bruton’s Tyrosine Kinase
Hao Li^1,2, Qi Wu¹, PingAr Yang¹, Zheng Wang³, Jun Li¹, Bao Luo¹, Jeffrey C. Edberg¹, Hui-Chen Hsu¹, John D. Mountz^1,4 and Robert P. Kimberly on behalf of PROFILE investigators⁵, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Med - Pulmonary/Allergy/Critical Care, University of Alabama at Birmingham, Birmingham, AL, ⁴Birmingham VA Medical Center, Birmingham, AL, ⁵Clinical Immun & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose Ibrutinib, a Btk kinase activity inhibitor, is a novel inhibitor under development for autoimmune disease therapy. We have shown that Btk was significantly upregulated…
Abstract Number: 1208 • 2014 ACR/ARHP Annual Meeting
Cholesterol Loading Induces Neutrophil Extracellular Traps, and Atorvastatin Attenuates This Effect
Ming-Lin Liu^1,2, Muhammad Bashir^1,3, Kevin Williams⁴ and Victoria Werth^5,6, ¹Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ²Department of Dermatology,, Philadelphia V.A. Hospital, Philadelphia, PA, ³Department of Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA, ⁴Department of Medicine, Temple University School of Medicine, Philadelphia, PA, ⁵Dermatology, University of Pennsylvania, Philadelphia, PA, ⁶Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA
Background/Purpose Neutrophils are the most common white blood cell, but their role in autoimmune and cardiovascular diseases has been underestimated. As part of host defense,…

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