ACR Meeting Abstracts

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  • Abstract Number: 1244 • 2014 ACR/ARHP Annual Meeting

    The Prevalence of Malignancy in Adult-Onset Still’s Disease

    Rupal Chavda1, Melissa R. Bussey2, Rodney Tehrani3 and Rochella A. Ostrowski1, 1Rheumatology, Loyola University Medical Center, Maywood, IL, 2Rheumatology, Division of Rheumatology, Loyola University Medical Center, Maywood, IL, 3Division of Rheumatology, Loyola University Medical Center, Maywood, IL

     Background/Purpose: Adult-onset Still's disease (AOSD) is a systemic inflammatory disease of unknown etiology.  It is characterized by high fever, evanescent salmon-colored rash, sore throat, liver…
  • Abstract Number: 1243 • 2014 ACR/ARHP Annual Meeting

    Macrophage Activation Syndrome Complicating Adult Onset Still’s Disease – Single Center Experience and Literature Review

    Aleksander Lenert1 and Qingping Yao2, 1Orthopaedic and Rheumatologic Institute, Dept. of Rheumatic & Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 2Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Hemophagocytic lymphohistiocytosis (HLH) is a life threatening complication typically associated with hematologic malignancies and infections. HLH, also referred to as macrophage activation syndrome (MAS),…
  • Abstract Number: 1242 • 2014 ACR/ARHP Annual Meeting

    Switching Biologic Agents in Refractory Adult-Onset Still’s Disease: Efficacy and Safety in a Cohort of 20 Patients at a Single Referral Center

    Giulio Cavalli1, Stefano Franchini1, Corrado Campochiaro1, Elena Baldissera2, Lorenzo Dagna3 and Maria Grazia Sabbadini3, 1Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milan, Italy, 2Clinical immunopathology and advanced medical therapeutics, San Raffaele Scientific Institute, Milan, Italy, 3Internal Medicine and Clinical Immunology, Vita-Salute San Raffaele University, Milano, Italy

    Background/Purpose No data is available on the long-term clinical outcome of Adult-Onset Still's Disease (AOSD) patients treated with biological drugs, nor on the efficacy and…
  • Abstract Number: 1241 • 2014 ACR/ARHP Annual Meeting

    Efficacy of Tocilizumab Therapy in Korean Patients with Adults Onset Still’s Disease: Multicenter Retrospective Study of 20 Cases

    Jin Ju Kim1, Joo Hyun Lee2, Chang-Nam Son3, Hyoun-Ah Kim4, Kwang-Hoon Lee5, Sang Tae Choi6, Eun Young Lee7, Ki Chul Shin8, Hoon-Suk Cha9 and Dae-Hyun Yoo1, 1Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 2Department of Rheumatology, Ilsan Paik Hospital, Inje University, Goyang, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, South Korea, 4Department of Rheumatology, Ajou University School of Medicine, Suwan, South Korea, 5Dongguk University Ilsan Hospital, Goyang, South Korea, 6Rheumatology, Chung-Ang University College of Medicine, Seoul, South Korea, 7Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 8Rheumatology, Seoul National University College of Medicine, Seoul, South Korea, 9Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Background/Purpose Adult onset Still’s disease (AOSD) is a rare inflammatory disorder of unknown etiology. Refractory cases to conventional therapy require biologic agents. Although IL-1 targeting…
  • Abstract Number: 1260 • 2014 ACR/ARHP Annual Meeting

    The Early Use of Cyclosporine Is Beneficial for Long-Term Prognosis in Patients of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease with Anti- Synthetase Antibodies

    Yuji Hosono1, Ran Nakashima2, Yoshitaka Imura3, Naoichiro Yukawa2, Hajime Yoshifuji2, Takaki Nojima4, Koichiro Ohmura2 and Tsuneyo Mimori2, 1Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, 4Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose: Interstitial lung disesases (ILD) is the most common cause of mortality in polymyosotis (PM) and dermatomyositis (DM). Cyclosporine had been reported to improve clinical…
  • Abstract Number: 1259 • 2014 ACR/ARHP Annual Meeting

    A Multi-Center Study for Validation of a New Assay for Anti-Melanoma Differentiation-Associated Gene 5 (MDA5) Autoantibody

    Shinji Sato1, Akihiro Murakami2, Akiko Kuwajima3, Kazuhiko Takehara4, Tsuneyo Mimori5, Atsushi Kawakami6, Michiaki Mishima7, Takafumi Suda8, Mariko Seishima9, Manabu Fujimoto10 and Masataka Kuwana11, 1Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, 2Medical & Biological Laboratories Co., Ltd, Nagaya, Japan, 3Medical & Biological Laboratories Co.,Ltd., Nagoya, Japan, 4Dermatology, Kanazawa University, Kanazawa, Japan, 5Dept of Rheum & Clinical Immunology, Kyoto Univ Grad Schl of Med, Kyoto, Japan, 6Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 7Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Kyoto, Japan, 8Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan, 9Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, 10Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 11Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose Anti-Melanoma Differentiation-Associated Gene 5 (MDA5) antibody is found specifically in patients with dermatomyositis (DM). This autoantibody is associated with clinically amyopathic DM (CADM) and…
  • Abstract Number: 1258 • 2014 ACR/ARHP Annual Meeting

    Enzyme-Linked Immunosorbent Assays for Detection of Anti-Transcriptional Intermediary Factor-1 Gamma and Anti-Mi-2 Autoantibodies in Dermatomyositis: Utility and Crossreactivity

    Manabu Fujimoto1, Akihiro Murakami2, Shunsuke Kurei2, Akiko Kuwajima3, Yasuhiro Fujisawa1, Atsushi Kawakami4, Michiaki Mishima5, Shinji Sato6, Mariko Seishima7, Takafumi Suda8, Tsuneyo Mimori9, Kazuhiko Takehara10 and Masataka Kuwana11, 1Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Medical & Biological Laboratories Co., Ltd, Nagaya, Japan, 3Medical & Biological Laboratories Co.,Ltd., Nagoya, Japan, 4Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 5Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Kyoto, Japan, 6Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, 7Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan, 8Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan, 9Dept of Rheum & Clinical Immunology, Kyoto Univ Grad Schl of Med, Kyoto, Japan, 10Dermatology, Kanazawa University, Kanazawa, Japan, 11Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose Anti-transcriptional intermediary factor 1 (TIF-1) and anti-Mi-2 antibodies (Abs) are myositis-specific autoantibodies (MSA) selectively detected in dernatomyositis (DM) patients. Anti-TIF-1 Ab is frequently found…
  • Abstract Number: 1256 • 2014 ACR/ARHP Annual Meeting

    Clinical and Temporal Characterization of Anti-Jo-1 Positive Anti-Synthetase Syndrome: Preliminary Results of an International Multicentre Study

    Lorenzo Cavagna1, Miguel A González-Gay2, Santos Castañeda-Sanz3, Franco Franceschini4, Paolo Airo5, Ilaria Cavazzana6, Laura Nuno7, Trinitario Pina Murcia2, Francisco Javier Lopez Longo8, Norberto Ortego-Centeno9, Rossella Neri10, Simone Barsotti10, Enrico Fusaro11, Simone Parisi12, Giuseppe Paolazzi13, Giovanni Barausse13, Luca Quartuccio14, Elena Bartoloni-Bocci15, Carlo Selmi16, Carlo Alberto Scirè17, Elena Bravi18, Javier Bachiller Corral19, Lesley Ann Saketkoo20, Gianluigi Bajocchi21, Raffaele Pellerito22, Marcello Govoni23, Andreas Schwarting24, Christof Specker25, Carlomaurizio Montecucco1 and Roberto Caporali26, 1Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, 2Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 3Rheumatology, Hospital Universitario de La Princesa. Madrid. Spain, Madrid, Spain, 4AO Spedali Civili, Rheumatology and Clinical Immunology Unit, Brescia, Italy, 5Rheumatology and Clinical Immunology, Spedali Civili, AO Spedali Civili, Brescia, Italy, 6Rheumatology and Clinical Immunology Unit, AO Spedali Civili, Brescia, Italy, 7Rheumatology, Hospital Universitario La Paz, Madrid, Spain, 8Rheumatology, Hospital Gregorio Marañón. Madrid, Madrid, Spain, 9Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain, 10Rheumatology Unit, University of Pisa, Pisa, Italy, 11Department of Rheumatology, Azienda Ospedaliera Universitaria Città della Salute e della Scienza di Torino, Turin, Italy, 12Rheumatology, Azienda Ospedaliera Città Della Salute e della Scienza, Turin, Italy, 13Rheumatology, Santa Chiara Hospital, Trento, Italy, 14Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, 15Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 16Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Italy, 17Italian Society for Rheumatology, Milan, Italy, 18Internal Medicine, Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy, 19Rheumatology, Hospital Ramon y Cajal, Madrid, Spain, 20Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, 21Department of Internal Medicine, Rheumatology Unit, Arcispedale S Maria Nuova. IRCCS, Reggio Emilia, Italy, 22Rheumatology, Ospedale Mauriziano, Turin, Italy, 23Clinical and Experimental Medicine, Section of Rheumatology, University of Ferrara, Ferrara, Italy, 24Rheumatology, University Hospital Johannes-Gutenberg, Mainz, Germany, 25Rheumazentrum Rhein-Ruhr e.V., St. Josef Krankenhaus (Kliniken Essen Süd), Universitätsklinikum Essen, Esssen, Germany, 26Rheumatology, Division of Rheumatology, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy

    Background/Purpose: anti Jo-1 antibodies are the main marker of the antisynthetase syndrome (As), a connective tissue disease chiefly characterized by arthritis (A), myositis (M) and…
  • Abstract Number: 1257 • 2014 ACR/ARHP Annual Meeting

    A New Multianalyte Assay for Detection of Dermatomyositis-Specific Autoantibodies Undetectable By Commercially Available Immunoassays

    Masataka Kuwana1, Yuka Okazaki2 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: The disease expression of dermatomyositis (DM) is highly variable among patients, ranging form those with severe muscle weakness in the absence of internal organ…
  • Abstract Number: 1255 • 2014 ACR/ARHP Annual Meeting

    Pathogenic Role of Tyrosyl–Transfer RNA Synthetase in Anti-Synthetase Syndrome

    Yuko Okamoto1, Yasuhiro Katsumata1, Yasushi Kawaguchi1, Manabu Kawamoto1, Ken Iwaki2, Miki Miyanokoshi2, Keisuke Wakasugi2, Koji Tahara3, Kaori Ito3, Hiroaki Hattori3, Takahisa Gono1, Masanori Hanaoka1, Tomoaki Higuchi1, Hidenaga Kawasumi1 and Hisashi Yamanaka4, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan, 3Advanced Medical Technology and Development, BML, Saitama, Japan, 4Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose : Autoantibodies directed against the aminoacyl transfer RNA (tRNA) synthetases are associated with myositis, arthritis, Raynaud’s phenomenon, mechanic’s hands, fever, and interstitial lung disease,…
  • Abstract Number: 1254 • 2014 ACR/ARHP Annual Meeting

    Anakinra for the Management of Resistant Idiopathic Recurrent Pericarditis in Adults

    Dimitrios Vassilopoulos1, Panagiotis Vasileiou2, Christos Koutsianas1, Katerina Antonatou3, Christina Tsalapaki1, Dimitrios Pectasides4 and George Lazaros5, 12nd Department of Medicine and Laboratory of Clinical Immunology-Rheumatology, Hippokration General Hospital, University of Athens Medical School, Athens, Greece, 2Department of Cardiology, University of Athens Medical School, Athens, Greece, 32nd Department of Medicine and Laboratory, Hippokration General Hospital, Hippokration General Hospital, Athens, Greece, 42nd Department of Medicine and Laboratory, Hippokration General Hospital, University of Athens Medical School, Athens, Greece, 5Department of Cardiology, Hippokration General Hospital, Athens, Greece

    Background/Purpose Recurrent idiopathic pericarditis is currently considered as an auto-inflammatory disorder which is frequently either resistant to standard therapy (with NSAIDs, colchicine or corticosteroids-CS) or…
  • Abstract Number: 1253 • 2014 ACR/ARHP Annual Meeting

    Anakinra – a Promising New Therapy for Idiopathic Recurrent Pericarditis

    Sonia Jain1, Charat Thongprayoon2, Raul Espinosa1, Sharonne Hayes1, Kyle Klarich1, Kevin Moder3, Nandan Anavekar1, Jae Oh1 and Eric L. Matteson4, 1Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, 2Department of Medicine, Mayo clinic, Rochester, MN, 3Division of Rheumatology, Mayo Clinic, Rochester, MN, 4Rheumatology, Mayo Clinic, Rochester, MN

    Background/Purpose Idiopathic recurrent pericarditis (IRP) is a debilitating condition that can be recalcitrant to conventional therapy. Some patients develop steroid dependency with the attendant risks…
  • Abstract Number: 1252 • 2014 ACR/ARHP Annual Meeting

    Intravenous Methylprednisolone Pulse Therapy in Severe Inflammatory Eye Disease. a Multicenter Study

    Montserrat Santos-Gómez1, Emma Beltrán2, Vanesa Calvo-Río1, Ricardo Blanco1, Norberto Ortego3, Jose L. García Serrano4, Lucía Martínez Costa4, Alejandro Fonollosa5, Marisa Hernández6, Elia Valls7, Félix Francisco8, Miguel A. Reyes9, Ignacio Torre Salaberri10, Olga Maíz11, Ana Blanco12, Santiago Muñoz-Fernández13, M. Mar Esteban14, Esperanza Pato15, Manuel Díaz-Llopis16, Roberto Gallego16, Miguel Cordero17, Francisco Ortiz-Sanjuán1, Joaquín Cañal Villanueva18, Leyre Riancho-Zarrabeitia1 and Miguel A González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 2Rheumatology, Hospital General Universitario de Valencia. Spain, Valencia, Spain, 3Autoimmune Disease Unit, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, 4Ophthalmology, Hospital Universitario San Cecilio. Granada. Spain, Granada, Spain, 5Ophthalmology, Hospital de Cruces. Bilbao. Spain, Bilbao, Spain, 6Ophthalmology, Hospital General Universitario de Valencia. Spain, Valencia, Spain, 7Rheumatology, Hospital Dr. Peset. Valencia. Spain, Valencia, Spain, 8Rheumatology, Hospital Doctor Negrín. Las Palmas de Gran Canaria. Spain, Las Palmas de Gran Canaria, Spain, 9Ophthalmology, Hospital Doctor Negrín. Las Palmas de Gran Canaria. Spain, Las Palmas de Gran Canaria, Spain, 10Rheumatology, Hospital Universitario de Basurto. Bilbao. Spain, Bilbao, Spain, 11Rheumatology, Hospital Universitario de Donostia. San Sebastián. Spain, San Sebastián, Spain, 12Ophthalmology, Hospital Universitario de Donostia. San Sebastián. Spain, San Sebastián, Spain, 13Rheumatology, Hospital Infanta Sofía. San Sebastián de los Reyes. Spain, Madrid, Spain, 14Ophthalmology, Hospital Infanta Sofía. San Sebastián de los Reyes. Spain, Madrid, Spain, 15Rheumatology, Hospital Clínico San Carlos. Madrid. Spain, Madrid, Spain, 16Ophthalmology, Hospital Universitario La Fe. Valencia. Spain, Valencia, Spain, 17Ophthalmology, Hospital de León. Spain, León, Spain, 18Ophthalmology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain

    Intravenous methylprednisolone pulse therapy in severe inflammatory eye disease. A Multicenter Study.Background/Purpose Treatment with high-dose intravenous methylprednisolone (IVMP) pulse therapy has proved to be effective…
  • Abstract Number: 1251 • 2014 ACR/ARHP Annual Meeting

    Efficacy of Certolizumab in Patients with Refractory Uveitis to Other Biologic Therapy. Study of 7 Cases

    Montserrat Santos-Gómez1, Victor Llorens2, Marina Mesquida2, Ricardo Blanco1, Vanesa Calvo-Río1, Olga Maíz3, Ana Blanco4, Maite Sainz de la Maza2, Alfredo Adan2, Leyre Riancho-Zarrabeitia1 and Miguel A. González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 2Ophthalmology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 3Rheumatology, Hospital Universitario de Donostia. San Sebastián. Spain, San Sebastián, Spain, 4Ophthalmology, Hospital Universitario de Donostia. San Sebastián. Spain, San Sebastián, Spain

    Background/Purpose Anti-TNF-α therapy may be useful in cases of uveitis refractory to standard synthetic immunosuppressive drugs. Infliximab (IFX) and adalimumab (ADA) are the biologic agents…
  • Abstract Number: 1250 • 2014 ACR/ARHP Annual Meeting

    Golimumab As an Alternative Therapy in Patients with Uveitis Refractory to Other Anti-TNFα Drugs. Multicenter Study of 29 Cases

    Montserrat Santos-Gómez1, Francisco Ortiz-Sanjuán1, Ricardo Blanco1, Joaquín Cañal Villanueva2, Alfredo Adan3, Marina Mesquida3, M. Victoria Hernández4, Esteban Rubio Romero5, Angel M. Garcia-Aparicio6, Antonio Atanes7, Ignacio Torre Salaberri8, Félix Francisco9, Cruz Fernández- Espartero10, Natalia Palmou11, Vanesa Calvo-Río1, Javier Loricera1, Juan Ventosa12, Trinitario Pina Murcia13, Leyre Riancho-Zarrabeitia1 and Miguel A. González-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 2Ophthalmology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 3Ophthalmology, Hospital Clinic. Barcelona. Spain, Barcelona, Spain, 4Arthritis Unit, Department of Rheumatology, Hospital Clinic, Barcelona, Barcelona, Spain, 5Rheumatology, Hospital Universitario Virgen del Rocío. Sevilla. Spain, Sevilla, Spain, 6Rheumatology, Virgen de la Salud Hospital, Toledo, Spain, 7HUCA. La coruña. Spain, La Coruña, Spain, 8Rheumatology, Hospital Universitario de Basurto. Bilbao. Spain, Bilbao, Spain, 9Rheumatology, Hospital Doctor Negrín. Las Palmas de Gran Canaria. Spain, Las Palmas de Gran Canaria, Spain, 10Rheumatology, Hospital Universitario de Móstoles. Madrid. Spain, Madrid, Spain, 11Complejo Hospitalario Universitario de Albacete. Spain, Albacete, Spain, 12Ophtalmology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 13Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain

    Background/Purpose To evaluate the clinical response and safety of golimumab (GLM) in a series of patients with non-infectious uveitis refractory to other anti-TNFα drugs.Methods Multicenter study of…
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