ACR Meeting Abstracts

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  • Abstract Number: 1276 • 2014 ACR/ARHP Annual Meeting

    Hyperglycemia and Risk of Osteoarthritis

    Mona Walimbe1, Ann V. Schwartz2, Irina Tolstykh2, Charles E. McCulloch2, David T. Felson3, Cora E. Lewis4, Neil A. Segal5, Michael C. Nevitt2 and Nancy E. Lane6, 1Medicine, UCSF (University of California, San Francisco), San Francisco, CA, 2Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, 3Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 4Preventive Medicine, The University of Alabama at Birmingham, Birmingham, AL, 5Orthopaedics and Rehabilitation, University of Iowa, Iowa City, IA, 6Internal Medicine, Center for Musculoskeletal Health, UC Davis School of Medicine, Sacramento, CA

    Background/Purpose Osteoarthritis (OA) is reported to be more prevalent in individuals with diabetes mellitus (DM).  Potential etiologies include advanced glycation endproducts, which reduce cartilage integrity,…
  • Abstract Number: 1275 • 2014 ACR/ARHP Annual Meeting

    Association Between Cardiometabolic Disorders and Hand Osteoarthritis Severity: A Cross-Sectional and Longitudinal Study

    Alice Courties1, Jérémie Sellam1, Francis Berenbaum1, Emmanuel Maheu1, Yoann Barthe2, Fabrice Carrat2 and Christian Cadet3, 1AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, 2Public Health, Saint-Antoine Hospital, Inserm UMRS_1136, UPMC Univ Paris 06, AP-HP, Paris, France, 3Rheumatology, Private office, Paris, France

    Background/Purpose Obesity and metabolic disorders increase the risk of hand osteoarthritis (HOA).  This study aimed to determine i) clinical and radiographic features associated with HOA…
  • Abstract Number: 1274 • 2014 ACR/ARHP Annual Meeting

    Patients with Osteoarthritis Do NOT Have Increased Risk of Cardiovascular Disease in Ullensaker Community in Norway

    Silvia Rollefstad1, Ingvild Eeg2, Ida K. Haugen2, Inge C. Olsen3, Nina Østerås4, Barbara Christensen2, Hilde Berner Hammer5, Lars Nordsletten6, Bård Natvig7, Tore K. Kvien8 and Anne Grete Semb1, 1Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Department of rheumatology, National Advisory Unit for rehabilitation in rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, 6Dept of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway, 7General Practice, Oslo University, Oslo, Norway, 8Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose Controversies exist regarding whether patients with osteoarthritis (OA) have an increased risk of cardiovascular (CV) disease. Our aim was to evaluate the CV risk…
  • Abstract Number: 1273 • 2014 ACR/ARHP Annual Meeting

    Assessment of the Effect of Rituximab in the Treatment of Interstitial Lung Disease  associated with the Antisynthetase Syndrome

    Tracy Doyle1, Juan Osorio2, Eduarda Nilo DeMagaldi3, Rachna Madan4, Fernanda Cabral5, Ivan Rosas2 and Paul Dellaripa6, 1Division of pulmonary medicine, Brigham and Women's Hospital, Boston, MA, 2Division of pulmonary medicine, Brigham and Women's Hospital, Boston, MA, 3medicine, Harvard Medical School, Boston, MA, 4Radiology, Brigham and women's Hospital, Boston, MA, 5Radiiology, Brigham and women's Hospital, boston, MA, 6Division of Rheumatology, Brigham and Women's Hospital, Boston, MA

    Background/purpose: To assess clinical outcomes including pulmonary function and radiographic imaging in patients with ILD and the antisynthetase syndrome who were treated with Rituxan (RTX)Methods:…
  • Abstract Number: 1272 • 2014 ACR/ARHP Annual Meeting

    Myositis-Specific and Myositis Associated Autoantibodies in Indian Patients with Inflammatory Myositis

    Puja Srivastava, Ramnath Misra, Able Lawrence, Amita Aggarwal and Vikas Agarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose Recently, idiopathic inflammatory myositis (IIM) has been categorised into distinct subsets based on myositis specific autoantibodies (MSA) and myositis associated autoantibodies (MAA). However, there is…
  • Abstract Number: 1271 • 2014 ACR/ARHP Annual Meeting

    Myocarditis in Antisynthetase Syndrome

    Céline Dieval1, Olivier Benveniste2, Christophe Deligny3, Alain Meyer4, Guillaume Lefevre5, Yoland Schoindre6, Aude Rigolet7 and Baptiste Hervier8, 1Internal Medicine, Rochefort Hospital, Rochefort, France, 2UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, 3Internal Medicine, CHU Fort de France, Fort de France, France, 4Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, 5Internal Medicine, CHRU Lille, Lille, France, 6DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, PARIS, France, 7Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, 8Internal Medicine & Clinical Immunology Dpt, Pitié-Salpêtrière Hospital, APHP, Paris, France

    Background/Purpose Antisynthetase syndrome (aSS) corresponds to an overlapping inflammatory myopathy identified by different myositis specific autoantibodies (directed against tRNA-synthetases). Myocardial involvement in this condition is poorly…
  • Abstract Number: 1270 • 2014 ACR/ARHP Annual Meeting

    Distinctive Muscle Histopathological Features of Anti-Synthetase Syndrome

    Baptiste Hervier1, Yves Allenbach2, Lenaig Mescam-Mancini3, Thierry Maisonobe4, Werner Stenzel5, Aude Rigolet6 and Olivier Benveniste2, 1Internal Medicine & Clinical Immunology Dpt, Pitié-Salpêtrière Hospital, APHP, Paris, France, 2UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, 3Pathology Dpt, University hospital, Grenoble, France, 4Neuropathology, Pitie-Salpetriere Hospital, Paris, France, 5Department of Neuropathology, Charite Hospital, Berlin, Germany, 6Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France

    Background/Purpose As supported by recent studies, anti-histidyl tRNA synthetase (anti-Jo1) antibodies are specific for clinico-biological features and outcomes. Though, anti-Jo1 synthetase syndrome is a clinical…
  • Abstract Number: 1269 • 2014 ACR/ARHP Annual Meeting

    Epidemiology and Characteristics of Antisynthetase Syndrome in the African Descent Population of Martinique

    Christophe Deligny1, Maryvonne Dueymes2, Serge Arfi1, José Zécler3, Maia Forgues4, Véronique Dehlinger5, Michel DeBandt6, Lauren Brunier-Agot6, Remi Bellance7, Isabelle Lamaury8, Nadege Cordel8, Nicolas Baillet9, Gilbert. Cadelis10, Georges Jean Baptiste11 and Katlyne Polomat12, 1Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique, 2Immunology, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, 3Respiratory, Centre Hospitalier Universitaire de Fort de France, Fort de France, Martinique, 4Internal medicine, Centre Hospitalier Andre Rosemon, Cayenne, French Guiana, 5Rheumatology, Centre Hospitalier universitaire de Fort de France, Fort De France - Martinique, Martinique, 6Rheumatology, Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique, 7National center for rare neuromuscular disorders, Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique, 8Infectious diseases, dermatology and internal medicine, Centre Hospitalier universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, 9internal medicine, Centre Hospitalier de la Basse Terre, Basse Terre, Guadeloupe, 10Respiratory, Cnetre Hospitalier Universitaire de Guadeloupe, Pointe à Pitre, Guadeloupe, 11Rheumatology, Centre Hospitalier Universitaire de Fort de France, Fort de France, Guadeloupe, 12Centre Hospitalier universitaire de Fort de France, Fort de France, Martinique

    Background/Purpose : There is no population based epidemiologic studies of antisynthetase syndrome (ASS). We described characteristics and epidemiology of this disease in Martinique, populated by…
  • Abstract Number: 1268 • 2014 ACR/ARHP Annual Meeting

    Study of Autoantibodies in a cohort of Mexican patients with idiopathic inflammatory myopathies

    Yelitza Gonzalez-Bello1, Miguel Angel Ortiz-Villalvazo2, Ignacio Garcia-Valladares1, Gabriel Medrano-Ramírez3, José E. Navarro-Zarza4, Lilia Andrade-Ortega5, Arnulfo Nava-Zavala6, Gerardo Orozco-Barocio1, Marco Maradiaga-Ceceña7, Marvin Fritzler8 and Ignacio Garcia-De La Torre9, 1Immunology and Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, 2Internal Medicine, Hospital Civil de Guadalajara, Guadalajara, Jal., Mexico, 3Rheumatology, Hospital General de Mexico de la Secretaría de Salud, Mexico City, Mexico, 4Rheumatology, Hospital General de Chilpancingo, Chilpancingo, Gro., Mexico, 5Rheumatology, CMN 20 Noviembre ISSSTE, Mexico City, Mexico, 6Rheumatology, Hospital General de Occidente, Zapopan, Jal., Mexico, 7Rheumatology, Hospital General de Culiacan de la Secretaría de Salud, Culiacan, Sin., Mexico, 8Medicine, University of Calgary, Calgary, AB, Canada, 9Immunology and Rheumatology, Universidad de Guadalajara, Guadalajara, Jal., Mexico

    Background/Purpose Idiopathic inflammatory myopathies (IIM) are a group of autoimmune disorders characterized by muscle inflammation, progressive weakness with a combination of clinical, electromyography and laboratory…
  • Abstract Number: 1267 • 2014 ACR/ARHP Annual Meeting

    Are Anti-SRP Auto-Antibodies Specific for Myositis?

    Samantha Rodriguez-Muguruza1, Ines Lozano2, Jaume Coll3, Maria Lourdes Mateo1, Susana Holgado1, Eva Martínez-Cácerez2 and Alejandro Olivé Marqués1, 1Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, 2Immunology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, 3Neurology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain

    Background/Purpose . Myositis-specific auto-antibodies (Ab) include those directed against aminoacyl-tRNA synthetases (ARS), signal recognition particle (SRP) and nuclear helicase Mi-2. Anti-SRP Ab are among the…
  • Abstract Number: 1266 • 2014 ACR/ARHP Annual Meeting

    Anti-MDA5 Is Associated with Rapidly-Progressive Interstitial Lung Disease and Poor Survival in U.S. Patients with Amyopathic and Myopathic Dermatomyositis

    Siamak Moghadam-Kia1, Chester V. Oddis2, Shinji Sato3, Masataka Kuwana4 and Rohit Aggarwal1, 1Medicine, University of Pittsburgh, Pittsburgh, PA, 2Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 3Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, 4Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose : Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) presenting with the characteristic rash(es) of DM without objective muscle weakness. Asian studies…
  • Abstract Number: 1265 • 2014 ACR/ARHP Annual Meeting

    Diabetes and Atorvastatin Are Potential Risk Factors for Statin-Associated Myopathy with Autoantibodies Against 3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase

    Pari Basharat1, Arash Lahouti H.1, Andrew L. Mammen2, Iago Pinal-Fernandez1, Tanmayee Bichile3, Thomas E. Lloyd4, Sonye K. Danoff5, Livia Casciola-Rosen6 and Lisa Christopher-Stine7, 1Medicine, Johns Hopkins University, Baltimore, MD, 2Neurology and Medicine, Johns Hopkins University, Baltimore, MD, 3Rehumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Neurology, Johns Hopkins, Baltimore, MD, 5Medicine/Pulmonary, Johns Hopkins University, Baltimore, MD, 6Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD, 7Medicine and Neurology, Johns Hopkins University, Baltimore, MD

    Background/Purpose The idiopathic inflammatory myopathies (IIM) comprise a group of autoimmune disorders that target skeletal muscle. Some IIM cases may be associated with an autoantibody…
  • Abstract Number: 1264 • 2014 ACR/ARHP Annual Meeting

    Analysis of Clinical Manifestations and Myositis-Specific Autoantibodies Associated with Severity of Physical Dysfunction after Treatment for Polymyositis and Dermatomyositis

    Hidenaga Kawasumi1, Takahisa Gono1, Yasushi Kawaguchi1, Yasuhiro Katsumata1, Hisae Ichida1, Akiko Tochimoto1, Masanori Hanaoka1, Yuko Okamoto1, Sayuri Kataoka1 and Hisashi Yamanaka2, 1Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 2Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan

    Background/Purpose: Half of all polymyositis (PM)/dermatomyositis (DM) patients suffer from muscle weakness after initial treatment. Therefore, many patients with PM/DM have trouble with daily living…
  • Abstract Number: 1246 • 2014 ACR/ARHP Annual Meeting

    Assessment of Protective Factors of Bone Mineral Density in a New Orleans Sarcoidosis Population

    McCall Walker1, Harmanjot K. Grewal2, Adam Janot3, Mary Yu4, Sophia Cenac5, Matthew R. Lammi6,7 and Lesley Ann Saketkoo8, 1LSUHSC School of Medicine, New Orleans, LA, 2Rheumatology, Lousiana State University Health Sciences Center, New Orleans, LA, 3Department of Ophthalmology, Virginia Commonwealth University –Medical College of Virginia, Charlottesville, VA, 4Internal Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, 5Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University Health Science Center, New Orleans, LA, 6Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, 7Section of Pulmonary and Critical Care Medicine, LSU Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, 8Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA

    Background/Purpose: Sarcoidosis often involves pathological dysregulation of dependent factors of bone metabolism, e.g. calcitriol /calcium, and administration of high dose glucocorticoids (GCs) leading to low…
  • Abstract Number: 1245 • 2014 ACR/ARHP Annual Meeting

    Long Term Outcome of Infliximab in Severe and Refractory Systemic Sarcoidosis: Report of 16 Cases

    Catherine Chapelon1, David Saadoun1, Lucie Biard2, Matthieu Resche-Rigon3, Baptiste Hervier4, Nathalie Costedoat-Chalumeau5, Aurélie Drier6, Jean-Marc Léger7 and Patrice Cacoub8, 1DHU 2iB Internal Medicine Referal Center for Autoimmune diseases Pitie Hospital, Paris, France, 2Hôpital St Louis, Biostatistics, Paris, France, 3Biostatistics, Hopital Saint-Louis, Paris, France, 4Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, PARIS, France, 5Internal Medicine, Assistance Publique-Hôpitaux de Paris, Hopital Pitié-Salpétrière, Paris, France, 6Hôpital Pitié-Salpêtrière, Neuroradiology, Paris, France, 7Neurology, Hôpital Pitié-Salpêtrière, Neurology, Paris, France, 8Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France

    Background/Purpose: Infliximab (IFX) appears to be effective in refractory sarcoidosis. However, data are lacking regarding its efficacy in severe sarcoidosis (i.e. with cardiac and/or neurological…
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