Abstracts Archive - Page 1966 of 2607 - ACR Meeting Abstracts

Abstract Number: 1427 • 2015 ACR/ARHP Annual Meeting
Analgesic Effects of the Novel Alpha-2-Delta Ligand Mirogabalin (DS-5565) in Experimental Animal Models of Fibromyalgia
Yuki Domon¹, Naohisa Arakawa¹, Shun-ichi Yasuda², Kensuke Saeki², Mayumi Kano², Masami Kato² and Yutaka Kitano¹, ¹Biological Research Laboratories, Daiichi Sankyo Co., Ltd., Tokyo, Japan, ²Hashima Laboratory, Nihon Bioresearch Inc., Gifu, Japan
Background/Purpose: Mirogabalin (DS-5565) is a novel ligand of the α2δ subunit of voltage-gated calcium channels. Mirogabalin possesses unique binding characteristics to α2δ subunits, and potent…
Abstract Number: 1428 • 2015 ACR/ARHP Annual Meeting
Subchondral Bone Structure and Pain Behaviors in Complete Freund’s Adjuvant (CFA) Monoarthritis in Mice Treated with Intra-Articular (IA) Neurotoxin
Hollis E. Krug^1,2, Joseph Bert³, Fakhar Abbass⁴, Christopher W. Dorman⁵, Sandra Frizelle⁵ and Maren L. Mahowald^1,2, ¹Medicine, Minneapolis VA Health Care System, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³Internal Medicine, Division of Rheumatology, University of Minnesota, Minneapolis, MN, ⁴Minneapolis VA Health Care System, Minneapolis, MN, ⁵Research, Minneapolis VA Health Care System, Minneapolis, MN
Background/Purpose: Bone histomorphometry can define OA changes in rodents and in Antigen-Induced arthritis (AIA) in rats. We produced painful inflammatory monoarthritis in mouse knees with IA…
Abstract Number: 1429 • 2015 ACR/ARHP Annual Meeting
The Effect of Gabapentin and Cyclooxygenase Inhibitors on Evoked and Ongoing Pain-like Behavior in Two Arthritis Models in Mice
Katalin Sandor¹, HueJung Park², Johanna McQueen³, Sarah Woller³, Maripat Corr⁴, Camilla Svensson¹ and Tony Yaksh³, ¹Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, ²College of Medicine, Department of Anesthesiology and Pain Medicine, The Catholic University of Korea, Seoul, South Korea, ³Anesthesiology, UCSD, La Jolla, CA, ⁴Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA
Background/Purpose: Induction of K/BxN serum transfer arthritis and collagen antibody-induced arthritis (CAIA) leads to transient joint inflammation but persistent mechanical hypersensitivity lasting at least 2…
Abstract Number: 1430 • 2015 ACR/ARHP Annual Meeting
Peripheral HMGB1 Regulates Arthrtis-Associated Pain-like Behaviour
Nilesh Agalave¹, Teresa Fernandez Zafra², Peter Lundback³, Ulf Andersson⁴, Helena E. Harris³ and Camilla Svensson⁵, ¹Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, ²Physiology and pharmacology, Karolinska Institutet, Stockholm, Sweden, ³Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Center for Molecular medicine, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: HMGB1 has received attention for its emerging roles in the extracellular environment acting as damage associated molecular pattern molecule. The redox state of HMGB1…
Abstract Number: 1431 • 2015 ACR/ARHP Annual Meeting
Age and Sex Impacts the Development of Hypersensitivity in the Murine Partial Medial Menisectomy Model of Osteoarthritis
Ada Delaney¹, Azar Barharpoor¹, Tianle Gao¹, Jie Su¹, NIlesh Agalave¹ and Camilla Svensson², ¹Dept. of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden, ²Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic pain in European adults (37%; painineurope.com). Pain is the foremost symptom of OA, with both episodes…
Abstract Number: 1432 • 2015 ACR/ARHP Annual Meeting
Relationship Between Patient Reported Outcome Measures and Evoked Pain Measures in Knee Osteoarthritis
J. Ryan Scott¹, Steven E. Harte¹, David A. Williams^2,3, Daniel J. Clauw⁴ and Kristine Phillips⁵, ¹Department of Anesthesiology, University of Michigan, Ann Arbor, MI, ²Chronic Pain & Fatigue Rsch Ctr, Univ of MI Hlth System-Lobby M, Ann Arbor, MI, ³Anesthseiology, University of Michigan, Ann Arbor, MI, ⁴Anesthesiology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, University of Michigan, Ann Arbor, MI
Background/Purpose: Quantitative sensory testing (QST) can be used to assess pain processing mechanisms, and theoretically identify a subset of chronic pain patients that has central…
Abstract Number: 1433 • 2015 ACR/ARHP Annual Meeting
Predicting Response to Osteoarthritis Treatment Based on Patient Reported Outcome Measures and Quantitative Sensory Testing
Kristine Phillips¹, David A. Williams², Arnold Gammaitoni³, J. Ryan Scott⁴, Steven E. Harte⁴, Susan L. Murphy⁵ and Daniel J. Clauw⁶, ¹Internal Medicine, University of Michigan, Ann Arbor, MI, ²Anesthseiology, University of Michigan, Ann Arbor, MI, ³Zogenix, Inc, San Diego, CA, ⁴Department of Anesthesiology, University of Michigan, Ann Arbor, MI, ⁵Phyiscal Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI, ⁶Anesthesiology, University of Michigan, Ann Arbor, MI
Background/Purpose: Recent studies have suggested that a subset of individuals with arthritis have a component of sensitization to their pain. This subset of patients with…
Abstract Number: 1434 • 2015 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Rheumatoid Arthritis: Relation with Clinical Variables
Ferda Kaygisiz¹, Pinar Borman² and Aynur Karagoz³, ¹Dept of Physical Medicine and Rehabilitation, Ankara Training and Research Hospital, Ankara, Turkey, ²Department of Physical Medicine and Rehabilitation, University of Hacettepe Faculty of Medicine, Ankara, Turkey, ³Dept of Physical Medicine and Rehabilitation, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey
Background/Purpose: There are few studies in the literature indicating that neuropathic pain occurs in rheumatoid arthritis (RA). The aim of this cross sectional study was…
Abstract Number: 1435 • 2015 ACR/ARHP Annual Meeting
Central Pain Sensitization in Rheumatoid Arthritis – Role of ACPA?
Katarzyna Rogoz¹, Teresa Fernandez Zafra¹, Catia Cerqueira², Per Johan Jakobsson³, Katalin Sandor⁴, Erwan Le Maître⁵, Magnus LA. Andersson⁶, K. Lundberg⁷, Camilla Svensson⁴ and Jon Lampa⁸, ¹Physiology and pharmacology, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Department of Medicine, Unit of Rheumatology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden, ⁵Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁶Dep of Neurology, Karolinska Institute, Stockholm, Sweden, ⁷Karolinska Institute, Stockholm, Sweden, ⁸Dep of Medicine, Rheumatology unit, Karolinska Institute, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Chronic pain continues to be a significant problem for patients with rheumatoid arthritis (RA), even when the disease is medically controlled or in remission.…
Abstract Number: 1436 • 2015 ACR/ARHP Annual Meeting
Characterization of Patient Reported Pain Medication in Early Vs. Established Rheumatoid Arthritis
Apoorva Kelkar, Angela Cesta, Xiuying Li and Claire Bombardier, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Pain control in rheumatic diseases is complex and various pharmacotherapy approaches can be utilized for management of rheumatic pain. Currently, systematic clinical practice guidelines…
Abstract Number: 1437 • 2015 ACR/ARHP Annual Meeting
Prevalence of Pain, Its Impact and Management in a Population-Based Cohort of Patients with Rheumatoid Arthritis: Data from the Australian Rheumatology Association Database
Bethan Richards^1,2, Rachelle Buchbinder³, Marissa N. Lassere⁴ and Lyn March⁵, ¹Sydney Medical School, University of Sydney, Sydney, Australia, ²Royal Prince Alfred Hospital, Mulgrave, Vic, Australia, ³Monash Department of Clinical Epidemiology, Cabrini Institute and Monash University, Melbourne, Australia, ⁴Dept of Rheumatology, St George Hospital, Kogarah, Australia, ⁵Department of Rheumatology, Northern Clinical School, Institute of Bone and Joint Research, Kolling Institute, University of Sydney & Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, Australia
Background/Purpose: Despite advances in the treatments available for rheumatoid arthritis (RA), many patients continue to experience musculoskeletal pain. Untreated and under-treated pain are well known to increase…
Abstract Number: 1438 • 2015 ACR/ARHP Annual Meeting
Oral Potassium (K+) Reduces Pain in RA: A Randomized Active Control Study of Diet Based K+ Intervention
Toktam Kainifard¹, Manjit Saluja², Anuradha Venugopalan³, Raju Rane⁴ and Arvind Chopra⁵, ¹Rheumatology, PhD fellow, Pune, India, ²Clinical care, Center for Rheumatic Diseases, Pune, India, ³Rheumatology, R & D, Lab, Center for Rheumatic Diseases, Pune, India, ⁴Pathology, Pathologist, Pune, India, ⁵Rheumatology, Centre for Rheumatic Diseases, Pune 411001, India
Background/Purpose: National Health and Nutrition Survey III (1988-94,USA) data showed a low K+ body status in RA. Further information is scanty. K+ is critical to…
Abstract Number: 1439 • 2015 ACR/ARHP Annual Meeting
Reducing Gastric Ulcers in Patients with a History of Gastrointestinal (GI) Ulcers Who Require Long-Term High-Dose Non-Steroidal Anti-Inflammatory Drug (NSAID) Therapy
John Fort¹, Robert J. Holt², Jeffrey D. Kent³ and Alfonso Bello⁴, ¹POZEN Inc., Chapel Hill, NC, ²College of Pharmacy, University of Illinois-Chicago, Vernon Hill, IL, ³Horizon Pharma USA, Inc., Deerfield, IL, ⁴Illinois Bone & Joint Inst, Glenview, IL
Background/Purpose: Patients ≥65 taking naproxen with previous GI symptoms have a 29% annual incidence of significant upper gastrointestinal events.(1) Those patients who are older, with…
Abstract Number: 1440 • 2015 ACR/ARHP Annual Meeting
Outcomes and Cost-Effectiveness of Shoulder Injections with Sonographic Needle Guidance
Timothy Moore¹, Wilmer Sibbitt Jr.¹, Cole Paffett², Dan Tandberg³, Arthur Bankhurst⁴, Roderick Fields⁵ and Suzanne Emil¹, ¹Rheumatology, University of New Mexico, Albuquerque, NM, ²School of Medicine, Univeristy of New Mexico, Albuquerque, NM, ³University of New Mexico, Albuquerque, NM, ⁴Rheum/ MSC 105550, University of NM Med Ctr, Albuquerque, NM, ⁵Rheumatology, University of New Mexico, Albquerque, NM
Background/Purpose: Sonographic needle guidance (USG) of musculoskeletal injections has improved outcomes of intraarticular (IA) injections, but is associated with increased procedural costs. This practical randomized…
Abstract Number: 1441 • 2015 ACR/ARHP Annual Meeting
Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials
Ninna Karsbæk Senftleber^1,2, Sabrina Mai Nielsen^3,4, Jens Rikardt Andersen⁴, Henning Bliddal⁵, Simon Tarp³, Lotte Lauritzen⁴, Daniel E. Furst⁶, Maria E. Suarez-Almazor⁷, Anne Lyddiatt⁸ and Robin Christensen⁵, ¹Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg and Bispebjerg, Denmark, ²Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark, ³Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ⁴Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark, ⁵The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ⁶Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁷General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁸Musculoskeletal Group, Cochrane Collaboration, Ottawa, ON, Canada
Background/Purpose: Marine oil supplements (MOS) are suggested to have anti-inflammatory properties, but there is no consensus regarding the efficacy of MOS in the management of…

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