Abstracts Archive - Page 1966 of 2425 - ACR Meeting Abstracts

Abstract Number: 1290 • 2014 ACR/ARHP Annual Meeting
Knee Osteoarthritis Progression Is Predictable By Genetic Polymorphisms. Results from a Multicenter Association Study
Francisco J Blanco¹, Ingrid Möller², Nerea Bartolome³, Marta Artieda³, Diego Tejedor³, Antonio Martínez⁴, Eulàlia Montell⁵, Helena Martínez⁵, Marta Herrero⁵ and Josep Vergés⁵, ¹INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Instituto Poal de Reumatología., Barcelona, Spain, ³Progenika Biopharma, a Grifols Company, Derio, Bizkaia, Spain, ⁴Progenika, a Grifols Company, Derio, Bizkaia, Spain, ⁵Pharmascience Division, Bioiberica S.A., Barcelona, Spain
Background/Purpose: Single Nucleotide Polymorphisms (SNPs) are inherited genetic variations that can predispose or protect individuals against clinical events. Osteoarthritis (OA) has a multifactorial etiology with…
Abstract Number: 1288 • 2014 ACR/ARHP Annual Meeting
Older Adults with Osteoarthritis Do Not Have an Increased Risk of Cognitive Impairment
Bansari Gujar¹, Ann Gruber-Baldini², Mona Baumgarten³, William Hawkes², Michael C. Nevitt⁴, Kristine Yaffe⁵, Tamara Harris⁶ and Marc C. Hochberg⁷, ¹Division of Rheumatology, University of Maryland School of Medicine, Baltimore, MD, ²Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ³University of Maryland School of Medicine, Baltimore, MD, ⁴Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁵UCSF (University of California, San Francisco), San Francisco, CA, ⁶National Institute on Aging, National Institutes of Health, Bethesda, MD, ⁷Medicine, University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: A prior study showed an association between osteoarthritis (OA) and increased mortality from dementia. Recent preclinical studies suggest a possible association between OA and…
Abstract Number: 1287 • 2014 ACR/ARHP Annual Meeting
Patient Perspective of the Main Health Concerns and Needs of Living with Hand Osteoarthritis
Mariko L. Ishimori¹, Geraldine Racaza¹, Mellissa Withers² and Michael Weisman¹, ¹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Anthropology, UCLA, Los Angeles, CA
Background/Purpose: Hand OA (HOA) is associated with substantial pain, joint stiffness, functional impairment and disability, and cosmetic concerns. Data regarding patients’ perspective on living with…
Abstract Number: 1286 • 2014 ACR/ARHP Annual Meeting
The Natural Course of Physical Function in People with Symptomatic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Britt Elin Øiestad¹, Daniel White², Ross Booton³, Jingbo Niu³, Yuqing Zhang⁴, James C. Torner⁵, Cora E. Lewis⁶, Michael C. Nevitt⁷, Michael P. Lavalley⁸ and David T. Felson⁹, ¹Department of Orthopedics, Oslo University Hospital, 0407 Oslo, Norway, ²Clinical Epidemiology Training, Boston Univ School of Med, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵Epidemiology, University of Iowa, Iowa City, Iowa City, IA, ⁶Preventive Medicine, The University of Alabama at Birmingham, Birmingham, AL, ⁷Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁸Biostatistics, Boston University, Boston, MA, ⁹Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Longitudinal studies of people with knee osteoarthritis (OA) have reported stable or improved physical function, contrary to the progressive degenerative nature of OA. The…
Abstract Number: 1281 • 2014 ACR/ARHP Annual Meeting
Knee Pain and a Prior Injury Are Associated with Increased Risk of a New Knee Injury: Data from the Osteoarthritis Initiative
Jeffrey B. Driban¹, Grace H. Lo², Lori Lyn Price³, Charles Eaton⁴, Bing Lu⁵ and Timothy E. McAlindon⁶, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁴Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁵Rheumatology, Brigham and Women's Hospital, Foxboro, MA, ⁶Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: A knee injury increases the risk for early-onset osteoarthritis (OA) and accelerated knee OA progression but little is known about risk factors for injuries…
Abstract Number: 1282 • 2014 ACR/ARHP Annual Meeting
Systemic Pain Modulation Is Related to Body Perception in People with Knee Osteoarthritis
Jennifer Stevens-Lapsley¹ and Andrew Kittelson², ¹Physical Therapy Program, UCD Physical Therapy Program, Aurora, CO, ²Rehabilitation Science PhD Program, University of Colorado Denver, Aurora, CO
Background/Purpose Cortically mediated changes in body perception have been linked to a variety of chronic pain conditions, including knee osteoarthritis (OA). However, associations between body…
Abstract Number: 1284 • 2014 ACR/ARHP Annual Meeting
Sensitivity to Change of Patient Preference Outcome Measures for Pain in Trials of Patients with Knee Osteoarthritis
Matthew J. Parkes¹, Michael J. Callaghan¹, Terence W. O'Neill¹ and David T. Felson^1,2, ¹Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ²Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA
Background/Purpose A variety of pain and function instruments are often measured in osteoarthritis (OA) clinical trials. Instruments with maximal sensitivity to change are preferred as the…
Abstract Number: 1285 • 2014 ACR/ARHP Annual Meeting
Prevalence of Risk Factors for Gastrointestinal Side Effects of Drugs for the Treatment of Pain in Rheumatic Diseases and the Provision of Gastroprotective Treatment – Results of a Large Non-Intervention Study
Gustavo Citera¹, Edgardo Smecuol², Alberto Millán³, Manuel Robles⁴ and Ruben Mantilla⁵, ¹Universidad de Buenos Aires, Buenos Aires, Argentina, ²Hospital Municipal de Gastroenterología, Buenos Aires, Argentina, ³Hospital Universitario de Caracas, Caracas, Venezuela, ⁴Centro Médico Toluca, Toluca, Mexico, ⁵Clínica de Artritis y Rehabilitación (CAYRE), Bogota, Colombia
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are the long established first-line treatment for the management of pain associated with rheumatic diseases but carry a risk of…
Abstract Number: 1263 • 2014 ACR/ARHP Annual Meeting
Evidence for the Involvement of NK Cells in Antisynthetase Syndrome
Baptiste Hervier¹, Yves Allenbach², Mikael Perez³, Hervé Devilliers⁴, Fleur Cohen-Aubart⁵, Zahir Amoura⁶, Werner Stenzel⁷, Isabelle Cremer⁸, Olivier Benveniste² and Vincent Vieillard¹, ¹INSERM UMR-S 1135, UPMC, Paris, France, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³UMR-S 1138, INSERM & UPMC, Paris, France, ⁴CHU de Dijon, Dijon, France, ⁵Internal Medicine Dpt 2, Pitié-Salpêtrière Hospital, APHP, Paris, France, ⁶Internal medicine 2, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ⁷Department of Neuropathology, Charite Hospital, Berlin, Germany, ⁸INSERM UMR-S 1138, INSERM & UPMC, Paris, France
Background/Purpose Antisynthetase syndrome (aSS) is characterized by the association of interstitial lung disease and myositis with anti-tRNA-synthetase autoantibodies. Its pathogenesis remains unknown, especially regarding the…
Abstract Number: 1262 • 2014 ACR/ARHP Annual Meeting
Mechanisms of Muscular Necrosis in Auto-Immune Myopathies Associated with Anti-Signal Recognition Particle and Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Antibodies: Pathogenic Role of Auto-Antibodies
Yves Allenbach^1,2,3, Aude Rigolet³, Bruno Eymard⁴, Tanya Stojkovic⁴, Anthony. Behin⁴, Pascal Laforet⁴, Peter Hufnagl⁵, Norman Zerbe⁶, Thierry Maisonobe⁷, Kuberaka Mariampillai⁸, Serge Herson⁸, Olivier Benveniste^2,3 and Werner Stenzel⁹, ¹Neuropathology, Charite Hospital, Berlin, Germany, ²UMR 974, Sorbonne Universités, University Pierre et Marie-Curie-Paris 6, INSERM, Paris, France, ³Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Paris, France, ⁴Department of Neurology, Myology Institute, Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁵Pathology departmen, Charite Hospital, Berlin, Germany, ⁶Department of Pathology, Charite Hospital, Berlin, Germany, ⁷Neuropathology, Pitie-Salpetriere Hospital, Paris, France, ⁸Department: inflammation, immunopathology and biotherapy (DHU i2B), Assistance Publique - Hôpitaux de Paris, Pitié-Salpêtrière University, Paris, France, ⁹Department of Neuropathology, Charite Hospital, Berlin, Germany
Background/Purpose: Necrotizing auto-immune myopathies (NAM) are a group of acquired idiopathic inflammatory myopathies characterized by severe muscle weakness and no or mild extra-muscular involvement. Definition of…
Abstract Number: 1261 • 2014 ACR/ARHP Annual Meeting
Pulmonary Arterial Hypertension in Patients with Anti-PM-Scl Antibody
Hiromichi Tamaki¹, Colin O'Rourke² and Soumya Chatterjee³, ¹Rheumatology, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Rheumatic and Immunologic Ds, Cleveland Clinic, Cleveland, OH
Background/Purpose: Patients with anti-PM-Scl antibody (PM-Scl) can present with several different phenotypes: polymyositis (PM), dermatomyositis (DM), systemic sclerosis (SSc), scleromyositis, or sclero-dermatomyositis. Pulmonary arterial hypertension…
Abstract Number: 1280 • 2014 ACR/ARHP Annual Meeting
Relationship of Buckling and Knee Injury to Pain Exacerbation in Knee Osteoarthritis: A Web-Based Case-Crossover Stud
Isabelle Zobel^1,2, Tahereh Erfani³, Kim Bennell⁴, Joanna Makovey³, Ben Metcalf⁴, Jian Sheng Chen⁵, Lyn March³, Yuqing Zhang⁶, Felix Eckstein⁷ and David J. Hunter³, ¹Institute of Anatomy, Paracelsus Medical University Salzburg, Salzburg, Austria, ²Institute of Bone and Joint Research, Kolling Institute, University of Sydney, St Leonards, Australia, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴University of Melbourne, Melbourne, Australia, ⁵Rheumatology Royal North Shore Hospital, University of Sydney Institute of Bone and Joint Research, St Leonards, Australia, ⁶Boston University School of Medicine, Boston, MA, ⁷Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
Background/Purpose Knee osteoarthritis (OA) pain is neither constant nor stable and exacerbations of pain are disabling. We examined whether knee injury and buckling (giving way)…
Abstract Number: 1279 • 2014 ACR/ARHP Annual Meeting
Pre-Operative Musculoskeletal Comorbidities Limit Improvement in Functional Outcomes and Hip Pain in Total Hip Arthroplasty Patients
Scott Pascal¹, David Ayers², Wenjun Li², Leslie Harrold³, Jeroan Allison⁴ and Patricia D. Franklin², ¹University of Massachusetts Medical School, Worcester, MA, ²Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School, Worcester, MA, ³Department of Orthopedics and Medicine, University of Massachusetts Medical School, Worcester, MA, ⁴Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA
Pre-Operative Musculoskeletal Comorbidities Limit Improvement In Functional Outcomes And Hip Pain In Total Hip Arthroplasty PatientsBackground/Purpose: Identifying clinical factors predictive of total hip arthroplasty…
Abstract Number: 1278 • 2014 ACR/ARHP Annual Meeting
Association of Low Birth Weight and Preterm Birth with the Incidence of Knee and Hip Arthroplasty for Osteoarthritis
Sultana Monira Hussain¹, Yuanyuan Wang², Anita Wluka², Jonathan E Shaw³, Dianna J Magliano³, Stephen Graves⁴ and Flavia Cicuttini², ¹Department of Epidemiology and Preventive Medicine,, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ²Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ³Baker IDI Heart and Diabetes Institute, Melbourne, Australia, ⁴Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, Australia
Background/Purpose: Low birth weight and preterm birth have been associated with adverse adult outcomes including hypertension, insulin resistance, cardiovascular disease and reduced bone mass. It…
Abstract Number: 1277 • 2014 ACR/ARHP Annual Meeting
Retinal Arteriolar Narrowing and Incidence of Knee Replacement for Osteoarthritis: A Prospective Cohort Study
Sultana Monira Hussain¹, Yuanyuan Wang², Jonathan E Shaw³, Dianna J Magliano³, Tien Yin Wong⁴, Anita Wluka², Stephen Graves⁵, Robyn J Tapp⁶ and Flavia Cicuttini², ¹Department of Epidemiology and Preventive Medicine,, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ²Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia, ³Baker IDI Heart and Diabetes Institute, Melbourne, Australia, ⁴Singapore Eye Research Institute, Singapore, Singapore, ⁵Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, Australia, ⁶The University of Melbourne, Melbourne, Australia
Background/Purpose: Epidemiological studies suggest that macrovascular disease is involved in the pathogenesis of osteoarthritis (OA) possibly through reduced nutrition to the joint. However, the role…

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