Abstracts Archive - Page 1965 of 2425 - ACR Meeting Abstracts

Abstract Number: 1317 • 2014 ACR/ARHP Annual Meeting
Anti-p155/140 Autoantibodies and Selected Features at Illness Onset Are Associated with a Chronic Course of Illness in the Juvenile Idiopathic Inflammatory Myopathies
G. Esther A. Habers¹, Adam M. Huber², Gulnara Mamyrova³, Ira Targoff⁴, Chantal Boonacker⁵, Marco van Brussel¹, Frederick W. Miller⁶, Lisa G. Rider⁶ and Annet van Royen-Kerkhof⁷, ¹Child Development and Exercise Center, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, Netherlands, ²IWK Health Centre, Halifax, NS, Canada, ³Rheumatology, George Washington University, Washington, DC, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands, ⁶Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ⁷Paediatric Immunology and Rheumatology, University Medical Centre Utrecht - Wilhelmina Children's Hospital, Utrecht, Netherlands
Background/Purpose : Three types of disease courses can be distinguished in patients with juvenile idiopathic inflammatory myopathies (JIIM), namely monocyclic (M), polycyclic (P), and chronic…
Abstract Number: 1316 • 2014 ACR/ARHP Annual Meeting
A Hybrid Conjoint Analysis Model Is Proposed As the Definition of Minimal, Moderate and Major Clinical Improvement in Juvenile Dermatomyositis Clinical Trials
Lisa G. Rider¹, Rohit Aggarwal², Nastaran Bayat¹, Brian Erman³, Brian M. Feldman⁴, Adam M. Huber⁵, Rolando Cimaz⁶, Rubén J. Cuttica⁷, Sheila K. Feitosa de Oliveira⁸, Carol B. Lindsley⁹, Clarissa A Pilkington¹⁰, Marilynn G. Punaro¹¹, Angelo Ravelli¹², Ann M. Reed¹³, Kelly A. Rouster-Stevens¹⁴, Annet van Royen-Kerkhof¹⁵, Luca Villa¹⁶, Mariangela Rinaldi¹⁶, Angela Pistorio¹⁷, Howard Rockette¹⁸, Peter A. Lachenbruch¹, Frederick W. Miller¹, Jiri Vencovsky¹⁹ and Nicolino Ruperto²⁰, ¹Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ²Medicine, University of Pittsburgh, Pittsburgh, PA, ³Social and Scientific Systems, Inc., Durham, NC, ⁴Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵IWK Health Centre, Halifax, NS, Canada, ⁶Pediatrics, University of Firenze, Firenze, Italy, ⁷Hospital de Niños Pedro de Elizalde - University of Buenos Aires, Buenes Aires, Argentina, ⁸Pediatric Rheumatology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil, ⁹Dept of Pediatrics/ PTD, Univ Kansas City Med Ctr, Kansas City, KS, ¹⁰Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ¹¹Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, ¹²University of Genova, Genova, Italy, ¹³Rheumatology, Mayo Clinic, Rochester, MN, ¹⁴Pediatrics, Emory University School of Medicine, Atlanta, GA, ¹⁵Paediatric Immunology and Rheumatology, University Medical Centre Utrecht - Wilhelmina Children's Hospital, Utrecht, Netherlands, ¹⁶Pediatria II, Reumatologia, PRINTO, IRCCS Istituto G. Gaslini, Genova, Italy, ¹⁷Istituto Giannina Gaslini, Genova, Italy, ¹⁸University of Pittsburgh, Pittsburgh, PA, ¹⁹Institute of Rheumatology, Charles University, Prague, Czech Republic, ²⁰Pediatria II,, Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: Preliminary definitions of improvement (DOIs) for juvenile dermatomyositis (JDM) combining IMACS or PRINTO core set activity measures (CSMs) have been used as a…
Abstract Number: 1315 • 2014 ACR/ARHP Annual Meeting
Cross-Sectional Evaluation of Hydroxychloroquine (HCQ) Therapy in Children with Juvenile Dermatomyositis (JDM) Enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry
Yonit Sterba¹, Dawn Wahezi² and For the CARRA investigators³, ¹Pediatric Rheumatology, Montefiore Medical Center, Bronx, NY, ²Pediatric Rheumatology, Children's Hospital at Montefiore, Bronx, NY, ³Duke Children's Hospital, Durham, NC
Background/Purpose: Hydroxychloroquine is an antimalarial agent commonly used in the treatment of rheumatologic diseases. Data on the use of HCQ in JDM is limited, primarily…
Abstract Number: 1301 • 2014 ACR/ARHP Annual Meeting
Trabecular Bone Impairment Assessed By HR-pQCT in Juvenile-Onset Systemic Lupus Erythematous with Vertebral Fractures
Juliane Paupitz, Glauce Lima, Valéria Caparbo, Henrique Fuller, Eloisa Bonfa and Rosa M R Pereira, Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose The three-dimensional evaluation of bone by HR-pQCT has the advantage to provide assessment to not only bone density, but also to a noninvasive evaluation…
Abstract Number: 1300 • 2014 ACR/ARHP Annual Meeting
Subclinical Right Ventricle Systolic Dysfunction By Two-Dimensional Speckle-Tracking Echocardiography in Childhood-Onset Systemic Lupus Erythematosus Patients
Gabriela N Leal¹, Kellen F Silva¹, Camila M. P. França², Alessandro C. Lianza³, José L. Andrade¹, Lucia M. A. Campos², Eloisa Bonfa⁴ and Clovis A Silva⁵, ¹Radiology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Radiology, University of São Paulo, Sao Paulo, Brazil, ⁴Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁵Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Evaluation of right ventricle (RV) systolic function by standard echocardiogram remains a challenge because of the complex geometry of this chamber. Recently, two-dimensional Speckle-tracking…
Abstract Number: 1299 • 2014 ACR/ARHP Annual Meeting
A Cross-Sectional Study of Mental Health Symptoms and Mental Health Care in Pediatric SLE/MCTD Patients and Their Peers
Andrea Knight^1,2, Michelle Vickery¹, Pamela Weiss^1,2,3, Knashawn Morales³ and Ron Keren^3,4, ¹Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ²Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, ⁴Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Mental health problems are prevalent in pediatric systemic lupus erythematosus (SLE). We aimed to compare the rates of mental health problems and mental health…
Abstract Number: 1298 • 2014 ACR/ARHP Annual Meeting
Macrophage Activation Macrophage Activation Syndrome: A Severe and Frequent Manifestation of Acute Pancreatitis in Childhood-Onset Compared to Adult Systemic Lupus Erythematosus Patients
Natali W. Spelling¹, Carini I. Otsuzi¹, Diego L. Barros¹, Mariana A. da Silva¹, Rosa M. R. Pereira¹, Lucia M. A. Campos¹, Eduardo F. Borba¹, Eloisa Bonfá¹ and Clovis A Silva², ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Acute pancreatitis (AP) is a rare and severe manifestation of childhood-onset systemic lupus erythematosus (cSLE) and adult SLE (aSLE) patients. Macrophage activation syndrome (MAS)…
Abstract Number: 1297 • 2014 ACR/ARHP Annual Meeting
Safety and Efficacy of Rituximab in Pediatric Lupus and Other Rheumatic Diseases
Ajay Tambralli¹, Timothy Beukelman², Randy Q. Cron² and Matthew L. Stoll², ¹Medicine, University of Rochester, Rochester, NY, ²Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rituximab (RTX) is a chimeric monoclonal antibody that specifically targets CD20 positive B cells and is used successfully for a variety of pediatric rheumatologic…
Abstract Number: 1296 • 2014 ACR/ARHP Annual Meeting
Pulse- Pediatric Update on Lupus in South Africa: Epidemiology and Management
Laura Lewandowski¹, Laura Schanberg¹, Nathan Thielman² and Christiaan Scott³, ¹Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ²Duke Hubert Yeargan Center for Global Health, Durham, NC, ³Rheumatology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa
Background/Purpose: In developed nations, SLE is more common and severe in people of African extraction than in Caucasians; however, the epidemiology of SLE in Africa…
Abstract Number: 1295 • 2014 ACR/ARHP Annual Meeting
Childhood-Onset Systemic Lupus Erythematosus: Short-Term Treatment Response Rates in Proliferative Lupus Nephritis
Andrea Human¹, Simon Yu Tian², Earl D. Silverman³ and Deborah M. Levy¹, ¹Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ²Rheumatology and Program of Child Health Evaluative Sciences, The Hospital for Sick Children, Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Proliferative Lupus Nephritis (PLN) occurs in up to 50% of patients with childhood-onset systemic lupus erythematosus (cSLE). PLN is a significant source of morbidity and…
Abstract Number: 1294 • 2014 ACR/ARHP Annual Meeting
Gender Differences in the Lupus Nephritis Biomarkers in Children
Khalid Abulaban¹, Hermine Brunner², Michael Bennett³, Shannen L. Nelson⁴, Jun Ying⁵ and Prasad Devarajan³, ¹Pediatric Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁴Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁵University of Cincinnati, Cincinnati, OH
Background/Purpose: Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. The non-invasive traditional measures of LN (LN-TM) currently used to monitor LN have…
Abstract Number: 1293 • 2014 ACR/ARHP Annual Meeting
Identification of an Inflammation-Driven Phenotype of Osteoarthritis By Quantification of Synovial Inflammation Ex Vivo and in Serum from Patients
Cecilie F. Kjelgaard-Petersen¹, Anne Sofie Siebuhr², Kristian Kjaer Petersen³, Lars Arendt-Nielsen⁴, Thomas Eskehave⁵, Hans Christian Hoeck⁵, Ole Simonsen⁶, Thorbjørn Christiansen⁷, Line Lindhardt Egsgaard⁸, Morten A. Karsdal⁹ and Anne C. Bay-Jensen¹, ¹Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ²Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, ³Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Denmark, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁴Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁵Center for Clinical and Basic Research (CCBR), Aalborg, Denmark, ⁶Frederikshavn Hospital, Frederikshavn, Denmark, ⁷Orthopaedic Surgery Unit, Gentofte University Hospital, Gentofte, Denmark, ⁸Center for Sensory-Motor Interaction (SMI), Aalborg University, Aalborg, Denmark, ⁹Research & Development, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark
Background/Purpose Osteoarthritis (OA) is a multifaceted degenerative joint disease, where inflammation of the synovial membrane leads to accelerated joint destruction, resulting in elevated release of…
Abstract Number: 1292 • 2014 ACR/ARHP Annual Meeting
Synovitis Characteristics and Associated Intra-Articular Pathology in a Cohort of Patients Undergoing Meniscectomy for Meniscal Tear
Marta Favero¹, Giovanni Trisolino², Antonello Lazzaro³, Mary B. Goldring⁴, Steven R. Goldring⁵, Elisa Assirelli⁶, Claudio Iacobellis⁷, Augusto Cigolotti⁸, Assunta Pozzuoli³, Ambrogio Fassina⁸, Ermanno Martucci², Leonardo Punzi⁹, Andrea Facchini⁶ and Eleonora Olivotto⁶, ¹University Hospital of Padova, Italy, Rheumatology Unit, Padova, Italy, ²Rizzoli Orthopaedic Institute, Reconstructive Hip and Knee Joint Surgery, Bologna, Italy, ³University of Padova, Orthopaedic Clinic, Padova, Italy, ⁴Tissue Engineering Repair and Regeneration Program, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY, ⁵Hospital for Special Surgery, New York, NY, ⁶Rizzoli Orthopaedic Institute, Laboratory of Immunorheumatology and Tissue Regeneration/RAMSES, Bologna, Italy, ⁷Hospital of Padova, UOC of Orthopaedic and Traumatology, Padova, Italy, ⁸University of Padova, Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, Italy, Padova, Italy, ⁹Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose: Previous epidemiologic studies have established that there is a strong relationship between meniscal tear and the risk for subsequent development of osteoarthritis (OA). Though…
Abstract Number: 1291 • 2014 ACR/ARHP Annual Meeting
Relationships Between Inflammation, Disease Severity and Synovial Fluid Calcium Crystals Detected By Scanning Electronic Microscopy in Early Osteoarthritis
Paola Frallonardo¹, Francesca Oliviero¹, Luca Peruzzo², Leonardo Tauro³, Anna Scanu¹, Mariagrazia Lorenzin¹, Augusta Ortolan¹, Leonardo Punzi⁴ and Roberta Ramonda¹, ¹Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italy, ²Institute for Geosciences and Earth Resources IGG-CNR, Padova, Italy, ³Department of Geosciences, University of Padova, Padova, Italy, ⁴Department of Medicine - DIMED, University of Padova, Padova, Italy
Background/Purpose The presence of calcium crystals (CC) in synovial fluid (SF) of osteoarthritis (OA) is a well known and frequent feature (1). However, their role…
Abstract Number: 1289 • 2014 ACR/ARHP Annual Meeting
Classification of Osteoarthritis Phenotypes By Metabolomics Analysis
Weidong Zhang¹, Sergei Likhodii², Yuhua Zhang¹, Erfan Aref-Eshghi¹, Patricia E. Harper¹, Edward Randell², Roger Green¹, Glynn Martin³, Andrew Furey³, Guang Sun⁴, Proton Rahman^5,6 and Guangju Zhai¹, ¹Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ²Department of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ³Department of Surgery, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁴Discipline of Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁵Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁶Rheumatology, St. Claires Mercy Hospital, St. Johns, NF, Canada
Background/Purpose: Osteoarthritis (OA) is a group of heterogeneous conditions consisting of different subgroups or phenotypes that continuously evolve, eventually leading to common clinical manifestations. Identifying…

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