Abstracts Archive - Page 1962 of 2607 - ACR Meeting Abstracts

Abstract Number: 1367 • 2015 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes Shape and Perpetuate the Inflammatory Immune Responses Associated with Antibiotic-Refractory Lyme Arthritis.
Klemen Strle¹, Robert Locchead², Annalisa Pianta³, Jameson T. Crowley³, Sheila Arvikar¹ and John Aversa⁴, ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Allery and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, ³Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Yale Medical Group, Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT
Background/Purpose: Antibiotic-refractory Lyme arthritis is defined as persistent synovitis for months to years after antibiotic therapy for Borrelia burgdorferi, the causative agent of Lyme disease.…
Abstract Number: 1368 • 2015 ACR/ARHP Annual Meeting
PMN Reactivity Contribute to Acute Onset Joint Inflammation By Increasing CXCL8 Production in Joints of RA Patients with Anti-Collagen II Antibodies
Vivek Anand Manivel¹, Azita Sohrabian² and Johan Rönnelid^3,4, ¹Immunology, Genetics and Pathology, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden, ²Department of Immunology Genetics and Pathology,Uppsala University, Uppsala, Sweden, ³Department of Immunology, Genetics and Pathology,Uppsala University, Uppsala, Sweden, ⁴4Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: RA patients with antibodies against collagen type II (CII) have a distinct acute onset RA phenotype, associated with cytokine induction by surface-bound anti-CII IC…
Abstract Number: 1369 • 2015 ACR/ARHP Annual Meeting
Enhanced Myelopoiesis Downstream of Toll-like Receptor 9 Activation Drives a Feed-Forward Inflammatory Response
Lehn K. Weaver¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Pediatric Rheumatology, Childrens Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Monocytes are myeloid cells important for the initiation of inflammation and have been implicated in the pathogenesis of autoimmunity. Monocytes interact with their environment…
Abstract Number: 1370 • 2015 ACR/ARHP Annual Meeting
CD40/CD40L Pathway Is Associated with Increased Oxidative Burst and Neutrophil Extracellular Traps Release in Behcet´s Disease
Sandro F. Perazzio^1,2, Paulo Vitor Soeiro Pereira³, Alexandre W.S. Souza⁴, Antonio Condino-Neto³ and Luis Eduardo C. Andrade⁵, ¹Rheumatology Division, Universidade Federal de São Paulo, Sao Paulo, Brazil, ²Fleury Medicine and Health, Sao Paulo, Brazil, ³Immunology, ICB IV - Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ⁵Immunology Division, Fleury Medicine and Health, São Paulo, Brazil
Background/Purpose: Previous studies suggested that unknown plasma factors increase oxidative burst in Behçet’s disease (BD), but little is known about neutrophil extracellular traps (NET) formation.…
Abstract Number: 1371 • 2015 ACR/ARHP Annual Meeting
Complement-Mediated Neutrophil Lysis-a Mechanism Promoting Hypercitrullination in Rheumatoid Arthritis?
Tal Gazitt¹, Christian Lood², Jeffrey Ledbetter³ and Keith B. Elkon³, ¹Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Lund, Sweden, ³Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Protein citrullination, the post-translational conversion of arginine to citrulline, mediated by peptidylarginine deiminase (PAD) enzymes, is considered a likely mechanism for the stimulation of…
Abstract Number: 1372 • 2015 ACR/ARHP Annual Meeting
Characterization of Synovial Mast Cells in Knee Osteoarthritis: Association with Clinical Parameters
Badelog J.E. de Lange-Brokaar¹, Margreet Kloppenburg¹, Stefan Andersen¹, Annemarie Dorjee¹, Erlangga Yusuf¹, Linda van Toorn¹, Herman Kroon², Anne-Marie Zuurmond³, Vedrana Stojanovic-Susulic⁴, Johan Bloem², Rob Nelissen⁵, René E. M. Toes⁶ and Andreea Ioan-Facsinay¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³TNO, Leiden, Netherlands, ⁴Janssen, Pharmaceutical Companies Johnson & Johnson, Springhouse, PA, ⁵Orthopaedics, Leiden University Medical Center, Leiden, Netherlands, ⁶Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Synovial inflammation is a common feature of osteoarthritis (OA) and rheumatoid arthritis (RA) patients. Comparative studies indicated that synovitis, measured by histology or imaging,…
Abstract Number: 1373 • 2015 ACR/ARHP Annual Meeting
Epigenetic Mechanisms Contribute to the Lack of LPS-Induced Tolerance in Rheumatoid Arthritis Synovial Fibroblasts
Kerstin Klein¹, Renate E. Gay¹, Christoph Kolling², Adrian Ciurea¹, Diego Kyburz¹, Beat A. Michel¹, Lih-Ling Lin³, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ³Inflammation and Immunology Research Unit, Pfizer, Cambridge, MA
Background/Purpose: In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to a tolerant state of the cell which protects inflamed tissues from damage. We…
Abstract Number: 1374 • 2015 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T- Cells Are Decreased and Functionally Immature in Peripheral Blood of Patients with Primary Sjögren Syndrome
Tatjana Banovic^1,2,3, Jing Jing Wang⁴, Dimitra Beroukas⁵, Pravin Hissaria⁶ and Tom Gordon^2,6, ¹Immunology, Level 3, SA Pathology, Adelaide, Australia, ²Flinders University, Adelaide, Australia, ³Pediatrics, University of Adelaide, Adelaide, Australia, ⁴Immunology, Flinders University, Adelaide, Australia, ⁵SA Pathology, Adelaide, Australia, ⁶Immunology, SA Pathology, Adelaide, Australia
Background/Purpose: Primary Sjögren Syndrome (pSS) is characterized by organ-specific autoimmune destruction of salivary and lacrimal glands. Patients typically experience debilitating symptoms of dry mouth and…
Abstract Number: 1375 • 2015 ACR/ARHP Annual Meeting
S100A8/A9, a Serum and Imaging Biomarker for Assessing Joint Inflammation and Destruction in Experimental Seronegative Arthritis
Edwin J. W. Geven¹, Shahla Abdolahi-Roodsaz¹, Annet Sloetjes¹, Marije I. Koenders¹, Dirk Föll², Johannes Roth³, Thomas Vogl³ and Peter L. E. M. van Lent¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Pediatric Rheumatology and Immunology, University of Münster, Münster, Germany, ³Institute of Immunology, University of Münster, Münster, Germany
Background/Purpose: Seronegative joint diseases such as psoriatic arthritis and juvenile idiopathic arthritis are characterized by the lack of autoantibodies, potent biomarkers used for predicting disease…
Abstract Number: 1376 • 2015 ACR/ARHP Annual Meeting
Presence of the Interferon Signature in Anti-Nuclear Antibody Positive Individuals Prior to the Onset of Systemic Autoimmune Rheumatic Disease
Joan Wither¹, Tony Liu¹, Babak Noamani², Dennisse Bonilla¹, Sindhu R. Johnson³, Earl Silverman⁴, Arthur Bookman¹, Larissa Lisnevskaia⁵ and Carolina Landolt-Marticorena¹, ¹University Health Network, Toronto, ON, Canada, ²Genetics and developmental biology, University Health Network, Toronto, ON, Canada, ³Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada, ⁴The Hospital for Sick Children, Toronto, ON, Canada, ⁵Lakeridge Health Services, Oshawa, ON, Canada
Background/Purpose: Patients with systemic autoimmune rheumatic diseases (SARD) often have a prolonged pre-clinical phase during which they are anti-nuclear antibody (ANA)+ but lack clinical symptoms. …
Abstract Number: 1377 • 2015 ACR/ARHP Annual Meeting
IL-22 Drives the Proliferation and Differentiation of Human Bone Marrow Mesenchymal Stem Cells (MSCs); A Novel Pathway That May Contribute to Aberrant New Bone Formation in Human Spa and Beyond
Yasser El-Sherbiny¹, Ahmed Elzayadi², Evangelos M. Fragkakis¹, Richard Cuthbert¹, Thomas Baboolal³, Elena Jones¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Obstetrics and Gynaecology, Mansoura University, Egypt, MD, MSc., Mansoura, Egypt, ³PhD, Leeds, United Kingdom
Background/Purpose: The human spondyloarthropathies (SpA) are associated with single nucleotide polymorphisms (SNPs) in the IL-23 pathway and IL-23/17 axis therapy is effective in SpA. The…
Abstract Number: 1378 • 2015 ACR/ARHP Annual Meeting
AMP-Activated Protein Kinase As an Anti-Inflammatory Target for Methotrexate
Cornelia Cudrici¹, Amma Agyemang¹, Martin Pelletier¹, Gregory Steinberg² and Richard M. Siegel¹, ¹NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ²Department of Medicine, Division of Endocrinology,McMaster University, Hamilton, ON, Canada
Background/Purpose: Methotrexate (MTX) is a first-line medication effective in multiple forms of inflammatory arthritis. The anti-inflammatory effects of MTX are more prolonged than its plasma…
Abstract Number: 1379 • 2015 ACR/ARHP Annual Meeting
High Serum IgG4 Concentration Is a Risk Factor for Relapse in IgG4-Related Disease
Sho Sendo¹, Jun Saegusa¹, Akira Onishi², Ikuko Naka¹, Kosaku Tsuda¹, Takaichi Okano¹, Kengo Akashi¹, Soshi Takahashi¹, Miwa Nishida¹, Keisuke Nishimura¹, Yo Ueda¹, Yoshinori Kogata³, Goichi Kageyama¹, Goh Tsuji⁴, Shunichi Kumagai⁵ and Akio Morinobu¹, ¹Department of Rheumatology, Kobe University Hospital, Kobe, Japan, ²Department for Rheumatology, Kobe University Hospital, Kobe, Japan, ³Department of Clinical Pathology and Immunology, Kobe University Hospital, Kobe, Japan, ⁴Center for Rheumatic disease, Shinko Hospital, Kobe, Japan, ⁵Center for Rheumatic Disease, Shinko Hospital, Kobe, Japan
Background/Purpose: IgG4-related disease (IgG4-RD) is a recently recognized systemic fibro-inflammatory disease of unknown etiology with multi-organ involvement. Although the organ involvement in IgG4-RD usually improve…
Abstract Number: 1380 • 2015 ACR/ARHP Annual Meeting
Characterization of Lymphocytes Subsets in Peripheral Blood of Untreated IgG4-Related Disease Patients
Aurélie Grados¹, Mikael Ebbo¹, Christelle Piperoglou², Matthieu Groh³, Alexis Regent⁴, Maxime Samson⁵, Benjamin Terrier⁶, Nathalie Morel⁷, Sylvain Audia⁵, Francois Maurier⁸, Julie Graveleau⁹, Mohamed Hamidou¹⁰, Amandine Forestier¹¹, Sylvain Palat¹², Emanuelle Bernit¹, Gilles Kaplanski¹³, Frederique Retornaz¹⁴, Bernard Bonotte⁵, Catherine Farnarier¹⁵, Jean-Robert Harle¹⁶, Nathalie Costedoat-Chalumeau⁷, Frederic Vely¹⁷ and Nicolas Schleinitz¹, ¹Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, ²Immunology, CIML, AP-HM, Marseille, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁴Service de médecine interne, Hôpital Cochin, Paris, France, ⁵Department of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France, ⁶Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ⁷Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁸HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁹Medecine Interne Hotel Dieu Nantes, Nantes, France, ¹⁰Internal Medicine Department, Nantes University Hospital, Nantes, France, ¹¹Internal Medicine, Groupe Hospitalier Mutualiste de Grenoble, Grenoble, France, ¹²Service de Medecine Interne, CHU limoges, Limoges, France, ¹³Internal Medicine hopital conception, Aix-Marseille Université, Marseille, France, ¹⁴Conseil General 13 cellule recherche, Marseille, France, ¹⁵Laboratoire d'immunologie, Hopital de la Conception, Marseille, France, ¹⁶Internal Medicine, Aix-Marseille Université, APHM, Marseille, France, ¹⁷CIML, Laboratoire d'Immunologie Conception AP-HM, Aix-Marseille université, Marseille, France
Background/Purpose: IgG4-related disease (IgG4-RD) is associated with characteristic pathological changes including lymphoplasmocytic infiltration with abundant IgG4 positive plasma cells, storiform fibrosis and obliterative phlebitis. The…
Abstract Number: 1381 • 2015 ACR/ARHP Annual Meeting
The Relationship Between Serum Cholinesterase, Number of Organ Involvement and Fibrotic Markers in Japanese Patients with IgG4-Related Disease
Hirofumi Nishikawa¹, Yoshinori Taniguchi¹, Yoshiko Shimamura¹, Kosuke Inoue¹, Taro Horino¹, Susumu Nishiyama², Yasuhiko Yoshinaga² and Yoshio Terada¹, ¹Kochi University, Nankoku, Japan, ²Kurashiki Medical Center, Kurashiki, Japan
Background/Purpose: To evaluate the relationship between cholinesterase, number of organ involvement and serum fibrotic markers in Japanese patients with IgG4-related disease (IgG4-RD). Methods: The clinical…

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