Abstracts Archive - Page 1955 of 2425 - ACR Meeting Abstracts

Abstract Number: 1445 • 2014 ACR/ARHP Annual Meeting
Improving Osteoarthritis Outcomes Utilizing a Multidisciplinary Model of Care; Experience in a Diverse Multicultural Urban Teaching Hospital
Caroline Jones¹, Laurence A. Rubin², Angelo Papachristos³, Elaine Harniman³ and Jann Patrick Ong⁴, ¹Mobility Program, St. Michael's Hospital, Aurora, ON, Canada, ²Rheumatology, St. Michael Hospital, Toronto, ON, Canada, ³Physiotherapy, St Michael's Hospital, Toronto, ON, Canada, ⁴University of Toronto, Toronto, ON, Canada
Background/Purpose In 2008, a multidisciplinary osteoarthritis (MOA) clinic was established at St. Michael’s Hospital (SMH), a tertiary care academic teaching facility, serving a diverse social,…
Abstract Number: 1444 • 2014 ACR/ARHP Annual Meeting
The Vocational Experiences of Young People with Juvenile Idiopathic Arthritis and the Role of the Multidisciplinary Team Supporting Positive Employment Outcomes
Helen Hanson¹, Ruth Hart², Alison Jordan³, Rachel Tattersall⁴, Ben Thompson¹ and Helen E. Foster⁵, ¹Rheumatology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, ²Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom, ³Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁴Rheumatology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ⁵Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
Background/Purpose: Recent decades have seen marked changes in the management of juvenile idiopathic arthritis (JIA), with improved clinical outcomes for many patients. However, unemployment rates…
Abstract Number: 1443 • 2014 ACR/ARHP Annual Meeting
Increased Occurence of Carotid and Femoral Plaques, but Not Increased Arterial Stiffness of Hypertrophy, in Classical Risk Factor-Free Patients with Rheumatoid Arthritis
Aikaterini I. Arida¹, Evaggelia Zampeli¹, George Konstantonis¹, Kalliopi Fragkiadaki¹, George D. Kitas², Athanasios D. Protogerou¹ and Petros P. Sfikakis¹, ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²The Dudley Group of Hospitals NHS Foundation Trust, Dudley, and Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose Several lines of evidence indicate that classical cardiovascular disease (CVD) risk factors, such as arterial hypertension, diabetes mellitus, smoking and dyslipidemia, are significantly increased…
Abstract Number: 1442 • 2014 ACR/ARHP Annual Meeting
The 2013 ACC/AHA Cardiovascular Risk Prediction Model and Coronary Atherosclerosis in Patients with Rheumatoid Arthritis
Vivian K. Kawai¹, Cecilia P. Chung², Joseph F. Solus¹, Annette Oeser¹, Paolo Raggi³ and C. Michael Stein¹, ¹Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³University of Alberta, Edmonton, AB, Canada
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased risk of atherosclerotic cardiovascular (CV) disease that is underestimated by the Framingham risk score (FRS). We hypothesized…
Abstract Number: 1462 • 2014 ACR/ARHP Annual Meeting
Cadherin-11 mRNA Expression in the Peripheral Blood of Rheumatoid Arthritis Patients As a Marker of Active Polyarthritis
Petros P. Sfikakis¹, Panagiotis F. Christopoulos^1,2, Aristeidis G. Vaiopoulos^1,2, Kalliopi Fragkiadaki¹, Christina Katsiari³, Violetta Kapsimali⁴, George Lallas¹, Panayiotis Panayiotidis⁴, Pinelopi Korkopoulou⁵ and Michael Koutsilieris², ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²Department of Physiology, Athens University Medical School, Athens, Greece, ³Department of Rheumatology, School of Health Sciences, University of Thessaly, Larissa, Greece, ⁴Department of Microbiology, Athens University Medical School, Athens, Greece, ⁵Department of Pathology, Athens University Medical School, Athens, Greece
Background/Purpose: Human rheumatoid arthritis synovial fibroblasts (RASF) implanted subcutaneously in immunodeficient mice trans-migrate through the vasculature and drive the progression from oligo- to poly-articular disease.…
Abstract Number: 1461 • 2014 ACR/ARHP Annual Meeting
Quantitave Analysis of Cadherin-11 and Beta-Catenin Signaling during Proliferation of Rheumatoid Arthritis-Derived Synovial Fibroblast Cells
Ryosuke Yoshioka, Yasuhiro Kita, Asako Nagahira, Atsushi Manno, Naoyuki Makita, Urara Tomita and Masao Murakawa, Asubio Pharma Co., Ltd., Kobe, Japan
[Background/Purpose ] Cadherin-11 (CDH11) is a cadherin adhesion molecule that anchors b-catenin, and is involved with various functions of synovial fibroblast cells (SFCs) during the development…
Abstract Number: 1460 • 2014 ACR/ARHP Annual Meeting
Midkine, a Growth Factor, May Play a Pathophysiological Role in Patients with Rheumatoid Arthritis
Emiko Shindo, Tomoko Hasunuma, Shotaro Masuoka, Mai Kawazoe, Hiroshi Sato, Natsuki Fujio, Kotaro Shikano, Makoto Kaburaki, Sei Muraoka, Nahoko Tanaka, Kaichi Kaneko, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan
Background/Purpose: Midkine (MK) is known as a heparin-binding growth factor. Recent studies revealed that MK has various functions such as cell proliferation, differentiation, and apoptosis…
Abstract Number: 1459 • 2014 ACR/ARHP Annual Meeting
IL-22 Secreted By NKp44+NK Cells Promote the Proliferation of Synovium in Patients with Rheumatoid Arthritis By Activation of STAT3
Junqing Zhu¹, Juan Li¹ and Xiaoguang Chen², ¹Nanfang Hospital, College of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China, ²School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China
Background/Purpose: Although CD3-CD56+NKp44+ natural Killer cells (NKp44+NK cells) have been linked to autoimmune diseases including inflammatory bowel disease, ankylosing spondylitis, and primary Sjogren's syndrome, the…
Abstract Number: 1458 • 2014 ACR/ARHP Annual Meeting
Functional Phenotype of Synovial Monocytes Modulating Inflammatory T-Cell Response in Rheumatoid Arthritis
Seong-Wook Kang¹, Seung-Cheol Shim¹, Jinhyun Kim¹, In-Seol Yoo², Su-Jin Yoo², Seung-Taek Song¹, Bo-Ruem Yoon³ and Won-Woo Lee³, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose Monocytes function as crucial innate effectors during inflammation. Human monocytes can be divided into three distinct subsets based on CD14 and CD16 expression. Accumulating…
Abstract Number: 1457 • 2014 ACR/ARHP Annual Meeting
Stem Cell Growth Factor Expression in Rheumatoid Arthritis
Youn Jung Woo¹, Young Ae Baik¹, Yong-Beom Park², Soo-Kon Lee³, William H. Robinson⁴ and Jason Jungsik Song³, ¹Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁴Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Stem cell growth factor (SCGF) is a member of the C-type lectin superfamily, encoded by gene CLEC11A. SCGF is not related to stem cell…
Abstract Number: 1456 • 2014 ACR/ARHP Annual Meeting
Foxp3+ Regulatory T Cells in Peripheral Blood and Synovial Fluid of Patients with RA: A Comparative Phenotypic Analysis
Jun Saegusa¹, Fumichika Matsuki², Yasushi Miura³, Goichi Kageyama², Seiji Kawano², Shunichi Kumagai⁴ and Akio Morinobu², ¹Kobe University Graduate School of Medicine, Kobe, Japan, ²Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ⁴Center for Rheumatic Disease, Shinko Hospital, Kobe, Japan
Background/Purpose: Human regulatory T (Treg) cells play an indispensable role for the maintenance of self tolerance and immune homeostasis. Numerous studies dealt with Treg population…
Abstract Number: 1455 • 2014 ACR/ARHP Annual Meeting
Ex Vivo-Expanded, but Not in Vitro-Induced, Human Regulatory T Cells Are Suitable for Cell Therapy in Rheumatological Autoimmune Diseases Thanks to Stable FOXP3 Demethylation
Maura Rossetti¹, Roberto Spreafico¹, Maryam Moshref², Jorg van Loosdregt³ and Salvatore Albani¹, ¹SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Duke-NUS Graduate Medical School, Translational Research Unit, Sanford-Burnham Medical Research Institute, Singapore, Singapore, ²Translational Research Unit, Sanford-Burnham Medical Research Institute, La Jolla, CA, ³Translational Research Unit, Sanford-Burnham Medical Research Institute, San Diego, CA
Background/Purpose: Treg cell therapy is a promising approach for transplant rejection and severe autoimmunity. Unfortunately, sufficient Treg numbers can be obtained only upon in vitroculture. Functional…
Abstract Number: 1454 • 2014 ACR/ARHP Annual Meeting
Quantitative and Qualitative Tracking of Expanded CD4⁺ T Cell Clones in Rheumatoid Arthritis Patients
Kazuyoshi Ishigaki¹, Hirofumi Shoda², Yuta Kochi³, Tetsurou Yasui⁴, Yuho Kadono⁴, Sakae Tanaka⁴, Keishi Fujio² and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan, ³Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ⁴Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Background/Purpose The purpose of this study is to elucidate the characteristics of expanded CD4+ T cell clones (ECs) in peripheral blood and synovium of rheumatoid…
Abstract Number: 1429 • 2014 ACR/ARHP Annual Meeting
Systemic Inflammation in Alzheimer’s Disease: Relevance to Patients with Rheumatoid Arthritis
M. Elaine Husni¹, Colin O'Rourke², Travis Moore³ and Jagan Pillai⁴, ¹Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH, ²Quantitative Health Sciences, JJN3-01, Cleveland Clinic, Cleveland, OH, ³ITD Analytics & Reporting - eResearch, Cleveland Clinic, Cleveland, OH, ⁴Lou Ruvo Center for Brain Health - Neurologic Institute, Cleveland Clinic, Cleveland, OH
Background/Purpose Alzheimer’s disease (AD) dementia is the most common form of dementia affecting > 25 million people worldwide without known cure. Research regarding involvement of…
Abstract Number: 1428 • 2014 ACR/ARHP Annual Meeting
Comparison of Application of the European Society Cardiology, Adult Treatment Panel III, and ACC/AHA Guidelines for Cardiovascular Disease Prevention in a French Cohort of Rheumatoid Arthritis
Martin Soubrier¹, Zuzana Tatar², Maxime Chevreau³, Bruno Pereira⁴, Laure Gossec⁵, P Gaudin⁶ and Maxime Dougados⁷, ¹COMEDRA trial group, Paris, France, ²Centre Jean Perrin, Clermont Ferrand, France, ³Rheumatology, CHU Sud Hospital, Grenoble, France, ⁴Clinical research department, Clermont-Ferrand, France, ⁵Sorbonne Universités, UPMC Univ Paris 06, GRC-08, Institut Pierre Louis d’Epidémiologie et de Santé Publique, paris, France, ⁶CHU Hôpital Sud, Grenoble, France, ⁷RAID working group for EULAR, Zurich, Switzerland
Background/Purpose Cardiovascular risk (CVR) is increased in RA and should be evaluated annually. EULAR recommends using the SCORE equation to calculate risk, after applying a…

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