Abstracts Archive - Page 1955 of 2607 - ACR Meeting Abstracts

Abstract Number: 1260 • 2015 ACR/ARHP Annual Meeting
Differential DNA Methylation and Reduced Expression of Transcription Factors in Human OA Cartilage
Oscar Alvarez-Garcia¹, Kathleen M. Fisch¹, Ryuichiro Akagi^2,3, Masahiko Saito⁴, Takahisa Sasho⁴, Andrew I. Su⁵ and Martin K. Lotz⁶, ¹The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, San Diego, CA, ³Department of Orthopaedic Surgery, School of Medicine, Chiba University, Chiba, Japan, ⁴Orthopaedic Surgery, Chiba University, Chiba, Japan, ⁵Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁶Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: DNA methylation is the most characterized epigenetic mechanism and has been recently linked to knee osteoarthritis (OA) pathogenesis. The present study was design to…
Abstract Number: 1261 • 2015 ACR/ARHP Annual Meeting
Molecular Analysis of Vascular Smooth Muscle Cells from Patients with Giant Cell Arteritis: Targeting Endothelin-1 Receptor to Control Proliferation
Alexis Regent¹, Kim Heang Ly², Matthieu Groh³, Chabha Khifer⁴, Sebastien Lofek⁵, Mathieu Tamby⁶, Guilhem Clary⁷, Philippe Chafey⁷, Véronique Baud⁸, Cédric Broussard⁹, Christian Federici⁷, Francois Labrousse¹⁰, Laura Mesturoux¹¹, Claire Le Jeunne¹², Elisabeth Vidal¹³, Antoine P. Brezin¹⁴, Veronique Witko-Sarsat¹⁵, Loïc Guillevin¹² and Luc Mouthon¹⁵, ¹Service de médecine interne, Hôpital Cochin, Paris, France, ²CHU Dupuytren, Limoges, Limoges, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁴Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵Université Paris Descartes, Paris, France, ⁶Institut Cochin, U1016, Paris, France, ⁷Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, ⁸Institut cochin, U1016, Paris, France, ⁹Inserm U 567, CNRS UMR 8104, Cochin Institute, Paris, France, ¹⁰Department of Pathology, Limoges University Hospital, Limoges, France, ¹¹CHU Limoges, Limoges, France, ¹²Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ¹³Internal Medecine, Limoges hospital, Paris, France, ¹⁴Université Paris Descartes, Hôpital Cochin, Paris, France, ¹⁵Labex Inflamex, Université Sorbonne Paris Cité, Paris, France
Background/Purpose: Vascular remodeling play a major role in the pathophysiology of giant cell arteritis (GCA) and the mechanisms underlying it are poorly understood. Methods: Vascular…
Abstract Number: 1262 • 2015 ACR/ARHP Annual Meeting
Epigenome-Wide DNA Methylation Patterns Associated with Fatigue in Primary Sjögren’s Syndrome
Katrine B Norheim¹, Juliana Imgenberg-Kreuz², Kristin Jonsdottir³, Emiel Janssen⁴, Ann-Christine Syvänen², Johanna K Sandling², Gunnel Nordmark⁵ and Roald Omdal⁶, ¹Dept of Internal Medicine, Clinical immunology Unit, Stavanger, Norway, ²Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ³Dept. of Pathology, Stavanger University Hospital, Stavanger, Norway, ⁴Dept. of Pathology, Stavanger university Hospital, Stavanger, Norway, ⁵Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ⁶Department of internal medicine, Clinical Immunology unit, Stavanger, Norway
Background/Purpose: Chronic fatigue is a common, often disabling, and poorly understood phenomenon of many diseases. Recent studies indicate that epigenetic mechanisms may be involved in…
Abstract Number: 1263 • 2015 ACR/ARHP Annual Meeting
Applications of Protein Microarray for Saliva Diagnostics in Autoimmune Diseases
Yeon-Ah Lee¹, Yong-Gil Kim², Seung-Jae Hong¹ and Paul J. Utz³, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: There have been many reports showing that saliva could be a source of biomarkers capable of detecting certain diseases. However, very few studies have…
Abstract Number: 1264 • 2015 ACR/ARHP Annual Meeting
Residential Proximity to Highways, DNA Methylation and Systemic Lupus Erythematosus
Cristina Lanata¹, Renuka Nayak², Joanne Nitiham¹, Kimberly Taylor³, Lisa F. Barcellos⁴, Sharon A. Chung⁵ and Lindsey A. Criswell^6,7, ¹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Department of Medicine, UCSF, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴Genetic Epidemiology and Genomics Laboratory, University of California, Berkeley, Berkeley, CA, ⁵School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁶Rheumatology, UCSF, SAN FRANCISCO, CA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by autoantibody formation in which multiple genetic, epigenetic and environmental risk factors have been implicated. We…
Abstract Number: 1265 • 2015 ACR/ARHP Annual Meeting
Genetic and Epigenetic Mapping of Very Early RA Synovial Fibroblasts
Emmanuel Karouzakis¹, Andrew Filer², Stephen Eyre³, Karim Raza⁴, Christoph Kolling⁵, Renate E. Gay¹, Beat A. Michel¹, Jane Worthington³, Christopher Buckley⁶, Steffen Gay¹, Michel Neidhart¹ and Caroline Ospelt¹, ¹University Hospital Zurich, Center of Experimental Rheumatology, Switzerland, Zurich, Switzerland, ²University of Birmingham, Birmingham, United Kingdom, ³University of Manchester,Institute of Inflammation and Repair, United Kingdom, Manchester, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, ⁵Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ⁶University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
Background/Purpose: Genome wide association studies (GWAS) studies from rheumatoid arthritis patients have identified SNPs, which are associated with changes in gene expression levels. Recent studies…
Abstract Number: 1266 • 2015 ACR/ARHP Annual Meeting
Rheumatologic Diagnoses, Characteristics and Needs of Somali Patients Referred to a Rheumatology Clinic Serving the Somali Population
Elizabeth Miller¹, Elie Gertner², Rosemary Quirk¹ and Maribet McCarty¹, ¹Hennepin County Medical Center, Minneapolis, MN, ²Section of Rheumatology, Regions Hospital and University of Minnesota, St. Paul, MN
Background/Purpose: With the growing immigrant and refugee population in the United States, the landscape of medicine is constantly changing. In order to provide quality healthcare,…
Abstract Number: 1267 • 2015 ACR/ARHP Annual Meeting
Drug Survival of Second Biologic DMARD Therapy in Patients with Rheumatoid Arthritis: Comparison of a Second Anti-TNF with a Second Non-Anti-TNF after Discontinuation of a First Anti-TNF
T Wilke¹, S Mueller¹, I Majer², M Heisen², A Fuchs³ and U Maywald³, ¹Institut für Pharmakoökonomie und Arzneimittellogistik (IPAM), Hochschule Wismar, Germany, ²Pharmerit International, Rotterdam, Netherlands, ³AOK PLUS, Dresden, Germany
Background/Purpose: There is limited information on drug survival (i.e., continuation versus discontinuation of drug treatment) of RA patients who received a 2nd bDMARD therapy after…
Abstract Number: 1268 • 2015 ACR/ARHP Annual Meeting
Utilization of Viscosupplementation: 2011 – 2013
Gurjit S. Kaeley¹, Myint Thway¹ and Sunita Dodani², ¹Rheumatology, University of Florida College of Medicine, Jacksonville, Jacksonville, FL, ²Cardiology and Epidemiology, University of Florida College of Medicine, Jacksonville, Jacksonville, FL
Background/Purpose: Viscosupplementation (VS) is approved in the USA as an option for knee osteoarthritis (OA) pain. Recent American Academy of Orthopedic Surgeons (AAOS) guidelines have…
Abstract Number: 1269 • 2015 ACR/ARHP Annual Meeting
Measuring the Rheumatologist Workforce in Canada: Preliminary Results of the Stand up and be Counted Survey
Claire E H Barber¹, Lauren Jewett², Vandana Ahluwalia³, Cory Baillie^4,5, Dianne Mosher⁶, Michel Zummer⁷, J Carter Thorne⁸, Janet Ellsworth⁹, Henry Averns¹⁰, Cheryl Barnabe¹¹, Alfred Cividino¹², Janet E. Pope¹³, Elizabeth M. Badley^14,15, Deborah M. Levy¹⁶, Thanu Ruban¹⁴, Katie Lundon¹⁷, Robert McDougall¹⁸, Julie Brophy¹, Diane Lacaille¹⁹, Deborah Marshall² and The Canadian Rheumatology Association (CRA) Human Resources Committee, ¹Rheumatology, University of Calgary, Calgary, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³William Osler Health Center, Brampton, ON, Canada, ⁴Canadian Rheumatology Association (President), Winnipeg, MB, Canada, ⁵University of Manitoba, Winnipeg, MB, Canada, ⁶Med, University of Calgary, Calgary, AB, Canada, ⁷Université de Montréal, Quebec, QC, Canada, ⁸Southlake Regional Health Centre, Newmarket, ON, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Consultant Rheumatologist Kingston Ontario, Kingston, ON, Canada, ¹¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ¹²Department of Medicine, McMaster University, Hamilton, AB, Canada, ¹³University of Western Ontario, London, ON, Canada, ¹⁴University of Toronto, Toronto, ON, Canada, ¹⁵Toronto Western Research Institute, Toronto, ON, Canada, ¹⁶Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹⁷Medicine, University of Toronto, Toronto, ON, Canada, ¹⁸University of Saskatchewan, Regina, SK, Canada, ¹⁹Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Given the rising burden of arthritis care, there is concern about access to rheumatologists in many regions. To better characterize the rheumatologist workforce, the…
Abstract Number: 1270 • 2015 ACR/ARHP Annual Meeting
Low Socioeconomic Status As a Predictor of Long-Term Direct Medical Costs Following Diagnosis of Granulomatosus with Polyangiitis: A General Population-Based Cohort Study
Natalie McCormick¹, Carlo Marra² and J Antonio Avina-Zubieta³, ¹Faculty of Pharmaceutical Sciences, University of British Columbia/Arthritis Research Canada, Vancouver, BC, Canada, ²Pharm Sciences, Univ of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Estimates of the healthcare costs of Granulomatosus with polyangiitis (GPA) and predictors of costs are scarce. In particular, while socioeconomic status (SES) is associated…
Abstract Number: 1271 • 2015 ACR/ARHP Annual Meeting
Cost Savings and Interest in Pediatric Rheumatology Telemedicine Visits
Elizabeth A Kessler¹, Chelsey Smith¹, Ashley Sherman² and Mara L Becker¹, ¹Rheumatology, Children's Mercy Kansas City, Kansas City, MO, ²Research Development and Clinical Investigation, Children's Mercy Kansas City, Kansas City, MO
Background/Purpose: Nearly 1 in 250 children live with arthritis, yet less than 300 board certified, practicing pediatric rheumatologists exist in the United States, approximately 90%…
Abstract Number: 1272 • 2015 ACR/ARHP Annual Meeting
Utilization of Ambulatory Physician Encounters, Emergency Room Visits and Hospitalizations By SLE Patients: A 13 Year Population Health Study
John G. Hanly¹, Chris Skedgel² and Kara Thompson³, ¹Rheumatology, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ²Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, ³Nova Scotia Rehab Site, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada
Background/Purpose: Resource utilization has been examined in various geographic locations and utilizing different research methodologies including secondary use of heath care administrative data. Our objective…
Abstract Number: 1273 • 2015 ACR/ARHP Annual Meeting
Uptake of the First Biosimilar Infliximab Since Its Approval in South Korea
Seoyoung C. Kim¹, Nam-Kyong Choi², Joongyub Lee², Kyoung-Eun Kwon³, Wesley Eddings⁴, Yoon-Kyoung Sung⁵, Hong Ji Song⁶, Aaron K. Kesselheim⁴ and Daniel H. Solomon⁷, ¹Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Seoul National University Hospital, Seoul, South Korea, ³Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, MA, ⁵Hospital for Rheumatic Disease, Hanyang Univ Medical Center, Seoul, South Korea, ⁶Hallym University Sacred Heart Hospital, Anyang, South Korea, ⁷Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Development of tumor necrosis factor (TNF) inhibitors has been a major advance in treatment of systemic inflammatory diseases, such as rheumatoid arthritis. While TNF…
Abstract Number: 1274 • 2015 ACR/ARHP Annual Meeting
Factors That Impact Job Selection in Pediatric Rheumatology
Mara L Becker¹, Meredith Riebschleger², Holly S. Ruch-Ross³, 'Laura Laskosz⁴, Carrie Radabaugh⁵, Polly J. Ferguson⁶, Kenneth N. Schikler⁷ and Sandy D. Hong⁸, ¹Rheumatology, Children's Mercy Kansas City, Kansas City, MO, ²Pediatric Rheumatology & Health Services Research, University of Michigan, Ann Arbor, MI, ³Independent Research and Evaluation Consultant, Evanston, IL, ⁴Division of Technical and Medical Services, The American Academy of Pediatrics, Elk Grove Village, IL, ⁵Department of Education, American Academy of Pediatrics, Elk Grove Village, IL, ⁶Dept of Pediatrics--Rheum, University of Iowa, Iowa City, IA, ⁷Pediatrics, University of Louisville, Louisville, KY, ⁸Pediatrics-Rheumatology, U of Iowa Children's Hosp, Iowa City, IA
Background/Purpose: There remain valid concerns about the capability of the pediatric rheumatology (PR) workforce to meet the clinical needs of U.S. children and to absorb…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].