Abstracts Archive - Page 1946 of 2607 - ACR Meeting Abstracts

Abstract Number: 1124 • 2015 ACR/ARHP Annual Meeting
Bruton’s Tyrosine Kinase Levels Are Increased in B Cells from Patients with Primary Sjögren’s Syndrome
Odilia B.J. Corneth¹, Gwenny Verstappen², Marjolein de Bruijn¹, Erlin A. Haacke³, Arjan Vissink⁴, Hendrika Bootsma⁵, Frans G.M. Kroese² and Rudi W. Hendriks¹, ¹Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Pathology, University Medical Center Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁵Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Upon B cell receptor stimulation, B cells increase protein expression levels of the key downstream signaling molecule Bruton’s tyrosine kinase (BTK). BTK-transgenic mice that…
Abstract Number: 1125 • 2015 ACR/ARHP Annual Meeting
Next-Generation Sequencing Demonstrates Dynamic Recirculation of B Cell Clones in Ectopic Lymphoid Structures of Sjögren’s Syndrome
William Murray-Brown¹, Emanuela Carlotti¹, Anwar Tappuni², Nurhan Sutcliffe³, Costantino Pitzalis⁴ and Michele Bombardieri⁵, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ²Oral Medicine Department, Institute of Dentistry, QMUL, London, United Kingdom, ³Rheumatology, Barts Health NHS Trust, London, United Kingdom, ⁴Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, ⁵Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom
Background/Purpose: B cells play a central role in Sjogren’s syndrome (SS) pathogenesis whereby autoreactive B-cells populate ectopic germinal centres (eGC) in SS-salivary glands (SG) and…
Abstract Number: 1126 • 2015 ACR/ARHP Annual Meeting
Pyrrolopyrimidine Derivatives That Inhibit BAFF Binding to Its Receptor, BR3, Decrease IgG Production By B Cells in Vitro and in Vivo Model of Autoimmune Diseases
Keiko Yoshimoto¹, Eriko Ishioka², Ayumi Nishikawa¹, Katsuya Suzuki¹, Kunio Sugahara³ and Tsutomu Takeuchi⁴, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, ³Department I, Immunology, Pharmacology Research laboratories I, Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, ⁴Keio University School of Medicine, Tokyo, Japan
Background/Purpose: We have found that the expression level of BAFF receptor (BR3) is abnormally enhanced in peripheral monocytes of patients with pSS, and BAFF robustly…
Abstract Number: 1127 • 2015 ACR/ARHP Annual Meeting
Downregulation of nuclear Factor-Erythroid 2-Related Factor (Nrf2)/Heme Oxygenase-1 Axis in Diabetic Cartilage: Towards a Better Phenotyping of diabetes-Related Osteoarthritis
Carlos Vaamonde Garcia^1,2, Ayah Langar², Marie-Charlotte Laiguillon², Alice Courties², Xavier Houard², Saadia Kerdine-Romer³, Francis Berenbaum^2,4 and Jeremie Sellam^2,4, ¹Tissue Engineering and Cellular Therapy Group. Medicine Department. University of A Coruña, A Coruña, Spain, ²Inserm UMRS_938, CDR St-Antoine, Univ Paris 06 UPMC, Paris, France, ³UniverSud, Paris-Saclay, INSERM UMR-S 996, Châtenay-Malabry, France, ⁴Department of Rheumatology, Assistance Publique – Hôpitaux de Paris, Saint-Antoine Hospital, Paris, France
Background/Purpose: Epidemiological findings support the hypothesis that type 2 diabetes (DB) is an independent risk factor of osteoarthritis (OA). Likewise, we have recently reported a…
Abstract Number: 1128 • 2015 ACR/ARHP Annual Meeting
Insulin-Induced Cartilage Degradation in Osteoarthritis Is Associated to Defective Autophagy
Beatriz Carames¹, Madalena Ribeiro^1,2, Paloma Lopez de Figueroa¹, Alexandrina Mendes² and Francisco J. Blanco¹, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Centre for Neuroscience and Cell Biology, University of Coimbra; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal
Background/Purpose: Autophagy, a key cellular quality control mechanism, is defective in Osteoarthritis (OA) and Type 2 Diabetes (T2D). T2D has been proposed as a risk…
Abstract Number: 1129 • 2015 ACR/ARHP Annual Meeting
Transthyretin Deposition Accelerates the Development of Experimental Osteoarthritis in Mice
Tokio Matsuzaki¹, Oscar Alvarez-Garcia², Yukio Akasaki³, Natalia Reixach⁴, Joel Buxbaum² and Martin K. Lotz⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²The Scripps Research Institute, La Jolla, CA, ³Kyushu University, Fukuoka, Japan, ⁴Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ⁵Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Deposition of amyloid is a common aging-associated phenomenon and a key factor in the pathogenesis of several aging-related diseases. Osteoarthritis (OA) is the most…
Abstract Number: 1130 • 2015 ACR/ARHP Annual Meeting
Global DNA Methylation Analysis of Osteoarthritic Subchondral Bone Reveals Significant Regional Variation and Similarity to Overlying Cartilage
Matlock A. Jeffries^1,2, Madison Andrews³, Mary Beth Humphrey¹, Judith A. James⁴ and Amr H. Sawalha⁵, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Association, Oklahoma City, OK, ³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Univers, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic disability affecting a majority of individuals over age 70. Outside of cartilage, little is known regarding…
Abstract Number: 1131 • 2015 ACR/ARHP Annual Meeting
A Histone Deacetylase Inhibitor SAHA Induce MCPIP1 Expression and Suppress IL-6 Expression By Upregulating Cebpα Expression and Downregulating the Expression of Mir-9 in Human OA Chondrocytes
Mohammad Shahidul Makki¹ and Tariq Haqqi², ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Histone deacetylase inhibitors (HDACi) are a class of compounds that inhibits the histone deacetylase activity. MCPIP1 is a negative regulator of IL-6 expression…
Abstract Number: 1132 • 2015 ACR/ARHP Annual Meeting
Altered Histone 3 Dynamics at the Matrix Metalloproteinase 1 (MMP1) Transcription Start Site Contributes to MMP1 Suppression in Betaine Supplemented Synovial Fibroblasts in Rheumatoid Arthritis
Selene Glück¹, Niharika Gaur¹, Michelle Trenkmann^1,2, Emmanuel Karouzakis¹, Fangfang Sun¹, Christoph Kolling³, Beat A. Michel¹, Renate E. Gay¹, Steffen Gay¹, Michel Neidhart¹ and Mojca Frank Bertoncelj¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ²St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ³Schulthess Clinic, Zurich, Switzerland, Zurich, Switzerland
Background/Purpose: Synovial fibroblasts (SF) produce elevated levels of matrix degrading enzymes, including matrix metalloproteinase 1 (MMP1), in the joints of rheumatoid arthritis (RA) patients, leading…
Abstract Number: 1133 • 2015 ACR/ARHP Annual Meeting
Microrna-128 Interference Mitigates the Progression of Keen Osteoarthritis By Regulating Sirtuin-1
Feng-Sheng Wang¹, Yi-Chih Sun¹, Yu-Shan Chen¹ and Jih-Yang Ko², ¹Core Facility for Phenomics & Diagnostics, Department of Medical Research, Core Facility for Phenomics & Diagnostics, Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan, ²Department of Orthopedic Surgery, Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan, Kaohsiung, Taiwan
Background/Purpose: MicroRNAs, non-coding small RNAs, reportedly regulate development, remodeling and pathogenesis activities in various tissues through silencing mRNA targets and protein translation. This study is…
Abstract Number: 1134 • 2015 ACR/ARHP Annual Meeting
Identification of Novel Micro-RNAs in IL-1β-Stimulated OA Chondrocytes By Next-Generation Sequencing
Mohammad Shahidul Makki¹ and Tariq Haqqi², ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Osteoarthritis (OA) is a chronic and debilitating disease of articulating joints. Mechanical stress, genetic and environmental factors play critical role in the pathogenesis of…
Abstract Number: 1135 • 2015 ACR/ARHP Annual Meeting
Krüppel-like Factors (Klfs), Novel Transcriptional Regulators of Articular Chondrocytes That Are Abnormally Expressed in Osteoarthritic Cartilage
Takeshi Teramura¹, Joe Hasei², Hiroshi Asahara^1,3,4 and Martin K. Lotz⁵, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Molecular and Exerpimental Medicine, The Scripps Research Institute, La Jolla, CA, ³Tokyo Medical and Dental University, Tokyo, Japan, ⁴National Research Institute for Child Health and Development, Tokyo, Japan, ⁵Division of Arthritis, The Scripps Research Institute, La Jolla, CA
Background/Purpose: Krüppel-like factors (Klfs) are known to play key roles in cell cycle regulation, definition of cell fate and regulation of terminal differentiation. There is…
Abstract Number: 1136 • 2015 ACR/ARHP Annual Meeting
IL-1β-Induced Stress Granules Sequester COX-2 mRNA and Regulates Its Expression in Human OA Chondrocytes
Mohammad Ansari¹ and Tariq Haqqi², ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Stress granules (SGs) are ribonucleoprotein complexes assembled in the cytoplasm of eukaryotic cells to respond adequately to stress (e.g. heat shock, UV irradiation, oxidative…
Abstract Number: 1137 • 2015 ACR/ARHP Annual Meeting
Low Molecular Weight Polyphenol Harpagoside Inhibits IL-1β-Induced Expression of IL-6 By Blocking the Expression and Activity of c-Fos in Primary Human Osteoarthritis Chondrocytes
Abdul Haseeb^1,2, Mohammad Ansari³ and Tariq Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH
Background/Purpose: Osteoarthritis (OA) is a multifactorial disease and is characterized by focal degradation of articular cartilage. Several components of the inflammatory pathway, such as IL-6,…
Abstract Number: 1138 • 2015 ACR/ARHP Annual Meeting
Suppressor of Cytokine Signaling 1 Inhibits Interleukin-1β Induced Matrix Metalloproteinases Expression in Human Chondrocytes By Modulating p38-CREB- C/Ebpβ Pathway
You Jung Ha¹, Yong Seok Choi², Eun Ha Kang³, Kichul Shin⁴, Jaehyung Hur¹, Yeong Wook Song⁵ and Yun Jong Lee², ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ²Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ³Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea, ⁴Rheumatology, SMG-SNU Boramae Medical Center, Seoul, South Korea, ⁵Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea
Background/Purpose: CAAT/enhancer-binding protein-beta (C/EBPb) is known to be a transcription factor regulating IL-1b-induced catabolic pathways, including the expression of matrix metalloproteinases (MMPs), in chondrocytes. Suppressor…

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