Abstracts Archive - Page 1944 of 2425 - ACR Meeting Abstracts

Abstract Number: 1614 • 2014 ACR/ARHP Annual Meeting
Functional Analysis of Interferon Responsiveness in PBMC from SLE Donors Identifies Subgroups with Higher and Lower Disease Activity
Rachael Hawtin¹, Wouter Korver², Erik Evensen², Diane Longo², Drew Hotson², Nikil Wale², Andy Conroy², Alessandra Cesano², Barbara Mittleman², Tsung Lin³, Vikram R. Rao⁴, Elena Peeva⁵, Stephen Benoit⁵, Martin Hodge³, James D. Clark³, Aaron R. Winkler⁶ and Jean-Baptiste Telliez³, ¹Nodality Inc., South San Francisco, CA, ²Nodality, Inc., South San Francisco, CA, ³Immunoscience, Pfizer Biotherapeutics Research and Development, Cambridge, MA, ⁴Inflammation & Remodeling, Pfizer, Cambridge, MA, ⁵Precision Medicine, Pfizer Biotherapeutics Research and Development, Cambridge, MA, ⁶Inflammation and Remodeling, Pfizer Biotherapeutics Research and Development, Cambridge, MA
Background/Purpose: Interferons (IFN) reportedly are central to SLE pathogenesis and increased expression of IFN regulated genes (the ‘IFN signature') is associated with active disease. Clinical…
Abstract Number: 1613 • 2014 ACR/ARHP Annual Meeting
Circulating microRNAs As Candidate Biomarkers of Diagnosis in Systemic Lupus Erythematosus
Juyang Jung¹, Ja-Young Jeon², Bong-Sik Kim³, Hyoun-Ah Kim² and Chang-Hee Suh⁴, ¹Ajou university of medical school, Suwon, South Korea, ²Department of Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ³Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ⁴Rheumatology, Ajou University School of Med, Suwon, South Korea
Background/Purpose : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by polyclonal B-cell activation and elevated production of pathogenic autoantibodies. MicroRNAs (miRNAs) are short,…
Abstract Number: 1612 • 2014 ACR/ARHP Annual Meeting
Deficient Repair of DNA Double-Strand Breaks and Increased Apoptosis in Patients with Lupus Nephritis
Vassilis Souliotis¹ and Petros P. Sfikakis², ¹Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens, Greece, Athens, Greece, ²First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece
Background/Purpose: Accumulation of apoptotic cells leads to excessive autoantigen presentation and autoantibody formation in autoimmunity, whereas mandatory to avoid apoptosis is the efficient repair of…
Abstract Number: 1611 • 2014 ACR/ARHP Annual Meeting
Modular Transcriptional Neutrophil Signature As Predictive of Nephritis and of Its Severity in SLE Patients
Noémie Jourde-Chiche Sr.¹, Stéphane Burtey², Nathalie Bardin³, Elizabeth Whalen⁴, Bertrand Gondouin⁵, Scott Presnell⁶, Bertrand Dussol⁷, Gilles Kaplanski⁸, Jean-Robert Harle⁹, Yvon Berland², Virginia Pascual¹⁰, Damien Chaussabel⁴ and Laurent Chiche¹¹, ¹Nephrology, Aix-Marseille Université - APHM, Marseille, France, ²Nephrology, APHM, Marseille, France, ³Hopital de la Conception, Marseille, France, ⁴BRI, seattle, WA, ⁵Department of Nephrology, APHM, Marseille, France, ⁶bri, seattle, WA, ⁷AP Marseille, Marseille, France, ⁸INSERM U608, Marseille, France, ⁹Internal Medicine, APHM, Marseille, France, ¹⁰Baylor University, Dallas, TX, ¹¹147 Boulevard Baille, CHU Marseille, Marseille, France
Background/Purpose: Lupus nephritis (LN) is a serious complication of SLE. Reliable biomarkers to assess and/or predict renal involvement in SLE patients are needed. The aim…
Abstract Number: 1610 • 2014 ACR/ARHP Annual Meeting
New Autoantigens Associated with Lupus Nephritis
Sachiko Onishi¹, Yuki Tanaka², Tatsuhiko Miyazaki³, Jun Ishizaki¹, Takuya Matsumoto¹, Endy Adnan¹, Hitoshi Yamasaki⁴, Koichiro Suemori¹, Takafumi Okura⁵, Masaki Yasukawa¹ and Hitoshi Hasegawa⁶, ¹Department of Hematology, Clinical Immunology, and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan, ²Integrated Center for Sciences, Ehime University, Toon, Japan, ³Division of Pathology, Gifu University Hospital, Gifu, Japan, ⁴Department of Hematology, Clinical Immunology, and Infectious Disease, Ehime University Graduate School of Medicine, Toon, Japan, ⁵Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Japan, ⁶Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Toon, Japan
[Background/Purpose ] Systemic lupus erythematosus (SLE) is characterized by the production of a variety of autoantibodies and is considered a prototype immune complex disease. Anti-dsDNA…
Abstract Number: 1609 • 2014 ACR/ARHP Annual Meeting
Dissection of the Type I Interferon Response in Systemic Lupus Erythematosus : Serum IFNα Is Elevated in Lupus Nephritis and Correlates with IFN Score; IFNβ Is Elevated in Mucocutaneous Disease
Julie Ducreux¹, Fabien Colaone², Séverine Nieuwland³, Patrick Blanco⁴, Thierry Defrance⁵, Pierre Vandepapeliere², Géraldine Grouard-Vogel², Frédéric A. Houssiau¹ and Bernard R. Lauwerys¹, ¹Institut de Recherche Expérimentale et Clinique, Pôle de Maladies Rhumatismales, Université catholique de Louvain, Brussels, Belgium, ²NEOVACS SA, Paris, France, ³Institut de Recherche Expérimentale et Clinique, Pôle de pathologies rhumatismales, Université catholique de Louvain, Brussels, Belgium, ⁴CHU Bordeaux, Bordeaux, France, ⁵INSERM, Lyon, France
Background/Purpose: Type I interferons play a role in the pathogenesis of systemic lupus erythematosus (SLE), but their mechanisms of action are still not fully understood.…
Abstract Number: 1608 • 2014 ACR/ARHP Annual Meeting
Erythrocyte C4d and Antibodies to Anti-C1q Are Associated with Proteinuria in Lupus Nephritis
Jill P. Buyon¹, R. Ramsey-Goldman², Richard Furie³, Chaim Putterman⁴, Kenneth Kalunian⁵, John Conklin⁶, Tyler O'Malley⁷, Derren Barken⁸ and Thierry Dervieux⁹, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, North Shore-LIJ Health System, Great Neck, NY, ⁴The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁵UCSD School of Medicine, La Jolla, CA, ⁶1261 Liberty Way Suite C, Exagen Diagnostics, Inc., Vista, CA, ⁷Research and Development, Exagen Diagnostics, Inc., Vista, CA, ⁸Exagen Diagnostics, Inc., Vista, CA, ⁹rd, Exagen Diagnostics, Inc., Vista, CA
Background/Purpose: Biomarkers of renal response in patients with systemic lupus erythematosus (SLE) may provide clues to pathogenesis and drive translation to treatment. This study was…
Abstract Number: 1607 • 2014 ACR/ARHP Annual Meeting
B Cell and Neutrophil-Related Transcripts Predict and Characterize a Lupus Flare
Mikhail Olferiev¹, Kyriakos A. Kirou² and Mary K. Crow³, ¹Research, HSS, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Department of Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose Lupus flare reflects an increase of disease activity that is associated with significant morbidity and accumulation of tissue damage. Prediction and prevention of lupus…
Abstract Number: 1606 • 2014 ACR/ARHP Annual Meeting
Profiling a Broad Range of Autoantibodies in Healthy and Systemic Lupus Erythematosis Revealed Autoantibody Patterns Associated with Autoantibody Transition and Disease Activity
Quan-Zhen Li Li¹, Edward Wakeland², Prithvi Raj³, Honglin Zhu², Xiaoxia Zuo⁴, Mei Yan⁵ and Indu Raman⁶, ¹Immunology and internal medicine, University of Texas Southwestern Medical Center, Dallas, TX, ²Immunology, University of Texas Southwestern Medical Center, Dallas, TX, ³Immunology, University of Texas Southwestern Medical Center, dallas, TX, ⁴Rheumatology, Xiangya Hospital of Hunan Medical Univ, Changsha, China, ⁵Internal Medicine/Division of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, ⁶Department of Immunology and Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX
Background/Purpose: Autoantibodies targeting to nuclear antigens are serological hallmarks of SLE, however, the processing of autoantibody production during the transition from normal to autoimmunity and…
Abstract Number: 1605 • 2014 ACR/ARHP Annual Meeting
Elevated Regulatory Mediators and Interferon Gamma Associated Responses, but Not Interferon Alpha, BLyS or IP-10, Accompany High-Titer Anti-Ro Autoantibodies in Asymptomatic Mothers of Children with Neonatal Lupus
Peter M. Izmirly¹, Robert M. Clancy², Melissa Munroe³, Sara Rasmussen², Amit Saxena^2,4, Jose U. Scher², Aikaterini Thanou⁵, Stan Kamp⁶, Joan T. Merrill⁷, Jill P. Buyon² and Judith James⁸, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Rheumatology, New York University School of Medicine, New York, NY, ⁵Arthritis and Clinical Immunology Reseach Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Mothers of children with neonatal lupus offer a unique opportunity to study the drivers and consequences of autoantibody production in the absence of ongoing…
Abstract Number: 1604 • 2014 ACR/ARHP Annual Meeting
IFN-γ (Th₁), IL4 (Th₂), and IL5 (Th₂) Are Elevated in Pre-Clinical SLE and Predict Transition to Classified Disease Prior to Appearance of Autoantibodies or Clinical Criteria
Rufei Lu^1,2, Melissa E. Munroe³, Joel M. Guthridge², Krista M. Bean², Dustin Fife², John B. Harley⁴, Judith A. James⁵ and Michael P. Keith⁶, ¹Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD
Background/Purpose Systemic Lupus Erythematosus (SLE) is a clinically diverse autoimmune disease that often begins with a pre-disease period of autoantibody production and symptom accrual.…
Abstract Number: 1603 • 2014 ACR/ARHP Annual Meeting
Effect of Methotrexate on the Immunogenicity of TNF Inhibitors in Spondyloarthritis Patients
Alejandro Villalba¹, Chamaida Plasencia-Rodriguez¹, Diana Peiteado¹, Laura Nuño², Gema Bonilla³, Alejandro Balsa⁴, Emilio Martín-Mola⁵ and Dora Pascual-Salcedo⁶, ¹Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ²Hospital La Paz-IdiPaz, Madrid, Spain, ³Rheumatology, Hospital La Paz, Madrid, Spain, ⁴Reumatology, Hospital Universitario La Paz, Madrid, Spain, ⁵Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ⁶Immunology, La Paz University Hospital, Madrid, Spain
Background/Purpose: The spondyloarthritis (SpA) patients treated under TNF inhibitors (TNFi) with detectable antidrug antibodies (ADA) often develop loss of efficacy. Concomitant therapy with methotrexate (MTX)…
Abstract Number: 1622 • 2014 ACR/ARHP Annual Meeting
Th1 and Th2 Cytokines Are Associated with Cerebral Atrophy in Systemic Lupus Erythematosus
Mariana Postal¹, Aline T. Lapa¹, Karina de Oliveira Peliçari², Nailu A. Sinicato¹, Fernando Augusto Peres¹, Wesley Geraldo Ferreira², Roberto Marini², Lilian Costallat³, Fernando Cendes⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, United Kingdom, ⁴Neurology, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Cerebral atrophy has been described to occur in systemic lupus erythematosus (SLE) with variable frequency. The pathophysiology of central nervous system (CNS) involvement in…
Abstract Number: 1620 • 2014 ACR/ARHP Annual Meeting
Antibody to Malondialdehyde-Acetaldehyde Adducts (MAA) As a Potential Biomarker of Inflammation in Systemic Lupus Erythrematosus (SLE)
Andy Hollins¹, Michael Duryee², Michelene Hearth-Holmes³, Ted R. Mikuls¹, Zhixin Zhang⁴, Kaihong Su⁵ and Geoffrey M. Thiele⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine/Rheumatology Division, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ⁵Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose Studies have shown that malondialdehyde-acetaldehyde (MAA) is formed as a result of lipid peroxidation of cellular membranes and is capable of binding or adducting…
Abstract Number: 1621 • 2014 ACR/ARHP Annual Meeting
A Shift Towards Trans-Signalling Explains Relatively Low CRP Despite an Active Interleukin-6 (IL-6)/IL-6-Receptor (IL-6R) System in SLE
Martyna Skwarek, Babett Heschel, Julia Fantana and Martin Aringer, Medicine III, University Medical Center and Faculty of Medicine at the TU Dresden, Dresden, Germany
Background/Purpose IL-6 has been found increased in SLE, while CRP, which is directly stimulated by IL-6, usually remains low. We therefore analyzed the IL-6/ IL-6…

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