Abstracts Archive - Page 1943 of 2607 - ACR Meeting Abstracts

Abstract Number: 1079 • 2015 ACR/ARHP Annual Meeting
The Potential Effect on Recruitment of Restricting Skin Scores Eligibility Criteria in Early Diffuse Scleroderma Trials
Robyn T. Domsic¹, Dinesh Khanna², Mary Lucas³, Virginia D. Steen⁴, Daniel E. Furst⁵, Robert Lafyatis⁶ and Thomas A. Medsger Jr.⁷, ¹Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Medicine, University of Pittsburgh Scleroderma Center, Pittsburgh, PA, ⁴Rheumatology, Georgetown University Medical Center, Washington, DC, ⁵Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁶Boston University School of Medicine, Boston, MA, ⁷Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: There is increasing interest in cohort enrichment for clinical trials of early diffuse SSc (dcSSc). Recent EUSTAR database analysis (Maurer et al. 2015)…
Abstract Number: 1080 • 2015 ACR/ARHP Annual Meeting
Modified Rodnan Skin Score Thresholds for the Optimization of Cohort Enrichment in Clinical Trials in Skin Fibrosis in Patients with Diffuse Cutaneous Systemic Sclerosis
Rucsandra Dobrota¹, Britta Maurer¹, Nicole Graf², Suzana Jordan³, Carmen Marina Mihai⁴, Otylia Kowal-Bielecka⁵, Yannick Allanore⁶, Oliver Distler¹ and EUSTAR co-authors, ¹Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²graf biostatistics, Winterthur, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Internal Medicine and Rheumatology, Cantacuzino Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, ⁵Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ⁶Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France
Background/Purpose: The modified Rodnan skin score (mRSS) is the major outcome measure for skin fibrosis in clinical trials (CT) in diffuse cutaneous scleroderma (dcSSc). Traditionally,…
Abstract Number: 1081 • 2015 ACR/ARHP Annual Meeting
Administration of Patient Reported Outcome Measurement Information System (PROMIS) Instruments By Computer Adaptive Testing in Patients with Systemic Vasculitis
Gunnar Tomasson¹, John T. Farrar², David Cuthbertson³, Carol McAlear⁴, Susan Asdown⁵, Don Gebhart⁶, Georgia Lanier⁷, Nataliya Milman⁸, Jacqueline Peck⁹, Joanna Robson¹⁰, Simon Carette¹¹, Gary S. Hoffman¹², Nader A. Khalidi¹³, Curry L. Koening¹⁴, Carol A. Langford¹², Larry W. Moreland¹⁵, Paul A. Monach¹⁶, Christian Pagnoux¹¹, Ulrich Specks¹⁷, Antoine G. Sreih¹⁸, Steven R. Ytterberg¹⁹ and Peter A. Merkel⁴, ¹Dept of Public Health Sciences, University of Iceland, Reykiavik, Iceland, ²Universitiy of Pennsylvania, Philadelphia, PA, ³Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁴Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵NONE, Branbury, United Kingdom, ⁶NONE, Columbus, OH, ⁷NONE, Framingham, MA, ⁸Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada, ⁹Oxford University, Oxford, United Kingdom, ¹⁰Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, University of Oxford, Oxford, United Kingdom, ¹¹Mount Sinai Hospital, Toronto, ON, Canada, ¹²Rheumatology, Cleveland Clinic, Cleveland, OH, ¹³McMaster University, Hamilton, ON, Canada, ¹⁴Division of rheumatology, George E. Wahlen Department of Veterans Affairs Medical Center Salt Lake City and University of Utah, University of Utah School of Medicine, Salt Lake City, UT, ¹⁵Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁶Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁷Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, ¹⁸Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁹Rheumatology Division, Mayo Clinic, Rochester, MN
Background/Purpose: Currently-used outcome measures in vasculitis insufficiently capture the life impact of systemic vasculitis from patients' perspectives. The Patient Reported Outcome Measurement Information System…
Abstract Number: 1082 • 2015 ACR/ARHP Annual Meeting
ANCA-Negative and Myeloperoxidase-ANCA-Positive Patients with Granulomatosis with Polyangiitis: Clinical Manifestations and Risk of Relapse
Eli Miloslavsky¹, Na Lu², Sebastian Unizony³, Hyon K. Choi³, Peter A. Merkel⁴, Philip Seo⁵, Robert F. Spiera⁶, Carol A. Langford⁷, Gary S. Hoffman⁷, Cees Kallenberg⁸, E. William St.Clair⁹, Nadia Tchao¹⁰, Fernando Fervenza¹¹, Paul A. Monach¹², Ulrich Specks¹³ and John H. Stone¹⁴, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Division of Rheumatology, Johns Hopkins, Baltimore, MD, ⁶Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Rheumatology, Cleveland Clinic, Cleveland, OH, ⁸Rheumatology/Clin Immunol AA21, Univer Med Center Groningen, Groningen, Netherlands, ⁹Rheumatology and Immunology, Duke University, Durham, NC, ¹⁰ITN, San Francisco, CA, ¹¹Mayo Clinic, Rochester, MN, ¹²Rheumatology, Boston University School of Medicine, Boston, MA, ¹³Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, ¹⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: Recent studies in ANCA-associated vasculitis (AAV) have suggested that classification based on ANCA type (PR3 versus MPO) may represent a more clinically relevant division…
Abstract Number: 1083 • 2015 ACR/ARHP Annual Meeting
Nationwide Trends in Hospitalization and in-Hospital Mortality Associated with Granulomatosis with Polyangiitis (GPA)
Zachary Wallace¹, John H. Stone², Hyon K. Choi³, Na Lu³, Sebastian Unizony³ and Eli Miloslavsky⁴, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ³Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Massachusetts General Hopsital, Boston, MA
Background/Purpose: Granulomatosis with polyangiitis (GPA) is associated with severe end-organ damage (e.g., renal failure) and treatment-related complications (e.g., severe infection) which often lead to hospitalization…
Abstract Number: 1084 • 2015 ACR/ARHP Annual Meeting
Improved Survival in Granulomatosis with Polyangiitis: A General Population-Based Study
Zachary Wallace¹, Sebastian Unizony², Na Lu², Hyon K. Choi² and John H. Stone³, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, ²Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: Granulomatosis with polyangiitis (GPA) is associated with an increased risk of mortality. Advances in diagnosis and treatment strategies are thought to improve outcomes in…
Abstract Number: 1085 • 2015 ACR/ARHP Annual Meeting
Levamisole Triggers Neutrophil Extracellular Trap Formation through Muscarinic Receptors in Patients with Drug-Induced Vasculitis
Peter C. Grayson¹, Carmelo Carmona-Rivera², Meryl Waldman³, Karran Phillips⁴, Venkataraman Subramaniam⁵, Paul Thompson⁶, Jonathan D. Graf⁷ and Mariana J. Kaplan¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Systemic Autoimmunity Branch/ NIAMS, National Institutes of Health, Bethesda, MD, ³NIDDK, National Institutes of Health, Bethesda, MD, ⁴NIDA, National Institutes of Health, Baltimore, MD, ⁵Biochemistry and Molecular Pharmacology, University of Massachusetts, Worcester, MA, ⁶Biochemistry and Molecular Pharmacology, University of Masshachussetts, Worcester, MA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Levamisole, an anti-helminth drug, has been implicated in cases of drug-induced autoimmunity in humans exposed to adulterated cocaine. Clinical manifestations of levamisole-induced autoimmunity include…
Abstract Number: 1086 • 2015 ACR/ARHP Annual Meeting
Does Adding Azathioprine to Glucocorticoid Induction Increase the Remission Rate and Prevent Relapses in Patients with Systemic Necrotizing Vasculitides without Poor-Prognosis Factors? a Multicenter, Double-Blind Randomized Controlled Trial
Xavier Puéchal¹, Christian Pagnoux², Gabriel Baron³, Thomas Quémeneur⁴, Antoine Néel⁵, Christian Agard⁵, François Lifermann⁶, Eric Liozon⁷, Marc Ruivard⁸, Pascal Godmer⁹, Nicolas Limal¹⁰, Arsène Mékinian¹¹, Thomas Papo¹², Anne-Marie Ruppert¹³, Anne Bourgarit-Durand¹⁴, Boris Bienvenu¹⁵, Loïck Geffray¹⁶, Jean-Luc Saraux¹⁷, Elisabeth Diot¹⁸, Bruno Crestani¹², Xavier Delbrel¹⁹, Laurent Sailler²⁰, Pascal Cohen¹, Véronique Le Guern²¹, Benjamin Terrier¹, Matthieu Groh²¹, Claire Le Jeunne²¹, Luc Mouthon²¹, Philippe Ravaud³ and Loïc Guillevin for The French Vasculitis Study Group²¹, ¹Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ²Mount Sinai Hospital, Toronto, ON, Canada, ³Hôpital Hôtel Dieu, Paris, France, ⁴CH Valenciennes, Valenciennes, France, ⁵CHU Nantes, Nantes, France, ⁶CH Dax, Dax, France, ⁷CHU Limoges, Limoges, France, ⁸CHU Clermont-Ferrand, Clermont–Ferrand, France, ⁹CH Vannes, Vannes, France, ¹⁰CHU Créteil, Créteil, France, ¹¹Service de médecine interne. Hôpital Saint-Antoine., Paris, France, ¹²CHU Bichat, Paris, France, ¹³CHU Tenon, Paris, France, ¹⁴CHU Bondy, Bondy, France, ¹⁵Internal Medicine, Hospital Caen, Caen, France, ¹⁶CH Lisieux, Lisieux, France, ¹⁷CH Eaubonne, Eaubonne, France, ¹⁸CHU Tours, Tours, France, ¹⁹CH Pau, Pau, France, ²⁰CHU Toulouse, Toulouse, France, ²¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Glucocorticoids (GC) achieve remission in most patients with systemic necrotizing vasculitides (SNVs) without poor-prognosis factors based on the 1996 Five-Factor Score (FFS; comprising creatininemia…
Abstract Number: 1087 • 2015 ACR/ARHP Annual Meeting
“It Was Just My Right Pace”: A Qualitative Study Exploring Yoga Practice in Adults with Rheumatoid Arthritis
Heather Greysen, School of Nursing, University of California San Francisco, San Francisco, CA
Background/Purpose: Physical activity is reported to improve physical function and reduce disease symptoms in adults with rheumatoid arthritis (RA); however adults with RA are less…
Abstract Number: 1088 • 2015 ACR/ARHP Annual Meeting
Effect of Training on Knee Torsional Stiffness and Its Relationship to Tibial Compressive and Anterior Shear Forces in Recreational Female Runners
Bhushan Thakkar¹ and D. S. Blaise Williams III², ¹PHYSICAL THERAPY, VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA, ²Physical Therapy, Virginia Commonwealth University, Richmond, VA
Background/Purpose: 42 million Americans participate annually in running. In 2014, the half marathon was the most popular distance with a total of 61% females (1.2…
Abstract Number: 1089 • 2015 ACR/ARHP Annual Meeting
Responsiveness of Physical Activity Measures Following Exercise Intervention in Individulas after Total Knee Arthroplasty
Gustavo J. Almeida¹, James J. Irrgang² and Sara R. Piva¹, ¹Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ²Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Few instruments that measure physical activity (PA) can accurately quantify PA performed at light and moderate intensities, which is particularly relevant to older adults…
Abstract Number: 1090 • 2015 ACR/ARHP Annual Meeting
Characteristics and Trajectories of Child Pain, Function, and Psychological Outcomes Associated with Conversion Disorder in Intensive Interdisciplinary Pediatric Pain Rehabilitation
Cara Hoffart¹ and Dustin Wallace², ¹Rheumatology and Integrative Pain Management, Children's Mercy Hospital, Kansas City, MO, ²Integrative Pain Management and Developmental and Behavioral, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Given the degree of compromise in quality of life, there is a critical need to identify the natural history of pain and disability in…
Abstract Number: 1091 • 2015 ACR/ARHP Annual Meeting
Effectiveness of Multidisciplinary Pain Rehabilitation Programs for Patients with Fibromyalgia Syndrome: A Systematic Review
Niall Halliday^1,2, Caroline Treanor², Rose Galvin³ and Jason Brooks⁴, ¹Medicine, Dentistry and Biomedical Sciences, Queens University Belfast, Belfast, Northern Ireland, ²Physiotherapy, Beaumont Hospital, Dublin, Ireland, ³Clinical Therapies, University of Limerick, Limerick, Ireland, ⁴Medicine, Dentistry and Biomedical Sciences, Queens University Belfast, Belfast, Ireland
Background/Purpose: Fibromyalgia syndrome (FMS) is a common, chronic pain condition with complex multiple symptoms. Combinations of therapies in a multidisciplinary pain rehabilitation program (MPRP) are…
Abstract Number: 1092 • 2015 ACR/ARHP Annual Meeting
Illicit Drug Use in US Adults with Chronic Low Back Pain: Nhanes 2009-2010
Anna Shmagel¹ and Robert Foley², ¹Rheumatic & Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ²Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN
Background/Purpose: Addictive medications, such as opiates and benzodiazepines are frequently prescribed to patients with chronic low back pain (cLBP). Little is known about illicit drug…
Abstract Number: 1093 • 2015 ACR/ARHP Annual Meeting
Activation of Syk-Btk Signal in Peripheral Blood B Cells in Patients with Rheumatoid Arthritis: A Potential Target for Abatacept Therapy
Shigeru Iwata¹, Shingo Nakayamada², Shunsuke Fukuyo¹, Sheau-Pey Wang¹, Satoshi Kubo², Maiko Yoshikawa¹, Kazuyoshi Saito³ and Yoshiya Tanaka³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ³The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Background/Purpose: B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although Syk function as a key molecule in BCR signaling, the pathological…

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