Abstracts Archive - Page 1937 of 2425 - ACR Meeting Abstracts

Abstract Number: 1726 • 2014 ACR/ARHP Annual Meeting
Therapeutic Efficacy of Mesenchymal Stem Cells in Diffuse Murine Hypochlorite-Induced Systemic Sclerosis
Alexandre Maria¹, Claire Bony², Karine Toupet², Christian Jorgensen³, Philippe Guilpain⁴ and Daniele Noel⁵, ¹U844, Inserm, Montpellier, France, ²Inserm, Montpellier, France, ³Clinical Immunology and Osteoarticular Diseases Therapeutic Unit, CHU Lapeyronie., Montpellier, France, ⁴Department of Internal Medicine, Montpellier, France, ⁵Inserm U844, UM1, Montpellier, France
Background/Purpose Systemic sclerosis (SSc) is a rare intractable disease with unmet medical need and fibrosis-related mortality. Absence of efficient treatments has prompted to develop novel…
Abstract Number: 1724 • 2014 ACR/ARHP Annual Meeting
Loss of IRF5 Ameliorates Tissue Fibrosis in a Murine Model of Systemic Sclerosis
Ryosuke Saigusa¹, Yoshihide Asano¹, Takashi Taniguchi¹, Yohei Ichimura¹, Takehiro Takahashi¹, Tetsuo Toyama¹, Ayumi Yoshizaki¹, Tadatsugu Taniguchi² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations that result from fibrosis development, immune activation and vascular injuries. A genome-wide association…
Abstract Number: 1725 • 2014 ACR/ARHP Annual Meeting
The SYK Inhibitor Fostamatinib Limits Tissue Damage and Fibrosis in a Bleomycin-Induced Scleroderma MOUSE MODEL
Omer Nuri Pamuk¹, Guray Can², Suleyman Ayvaz³, Turan Karaca⁴, Gulsum Pamuk⁵, Selim Demirtas⁶ and George C. Tsokos⁷, ¹Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ²Gastroenterology, Trakya University Medical Faculty, Edirne, Turkey, ³Pediatric Surgery, Trakya University Medical Faculty, Edirne, Turkey, ⁴Histology, Trakya University Medical Faculty, Edirne, Turkey, ⁵Hematology, Trakya University Medical Faculty, Edirne, Turkey, ⁶Trakya University Medical Faculty, Edirne, Turkey, ⁷Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose The possible antifibrotic effects of various kinase inhibitors has been studied before in SSc. Spleen tyrosine kinase (Syk) is a protein tyrosine kinase which…
Abstract Number: 1717 • 2014 ACR/ARHP Annual Meeting
Endothelial to Mesenchymal Transition Contributes to the Development of Pulmonary Vasculopathy in Systemic Sclerosis PAH
Robert Good¹, Adrian Gilbane², Sarah Trinder², David Abraham³, Christopher Denton³ and Alan M. Holmes⁴, ¹Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, ²Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ³Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom
Background/Purpose Vascular complications in Scleroderma (SSc) patients are associated with high mortality, particularly in patients who develop pulmonary arterial hypertension (SSc-PAH). Vascular complications, thought to…
Abstract Number: 1716 • 2014 ACR/ARHP Annual Meeting
MHC Class I and Class II Genes Influence Systemic Sclerosis Susceptibility, Clinical Presentation and Autoantibody Profile in a Mexican Admixed Population
Tatiana Sofia Rodriguez-Reyna¹, Joaquin Zuniga², Julio Granados³, Pamela Mercado Velazquez⁴, Carlos Nunez Alvarez⁴, Neng Yu⁵, Sharon Alosco⁶, Alfredo Cruz Lagunas⁷ and Edmond Yunis⁸, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Immunology, Instituo Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico, Mexico, ³Transplantation, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubira, Mexico, Mexico, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico, Mexico, ⁵HLA laboratory, the American Red Cross Northeast division, American Red Cross Blood Services - Northeast Division, Dedham, MA, ⁶HLA Laboratory, American Red Cross Blood Services - Northeast Division, Dedham, MA, ⁷Immunology, Instituto Nacional de Enfermedades Respiratorias, Mexico, Mexico, ⁸Department of Cancer Immunology and AIDS, Dana Farber Cancer Institue, Boston, MA
Background/Purpose: Systemic Sclerosis (SSc) exhibits great clinical and serologic variability in different populations. Herein we determined MHC class I and II alleles and extended haplotypes…
Abstract Number: 1715 • 2014 ACR/ARHP Annual Meeting
Serum Levels of CD163/Tweak Predict Risk of Digital Ulcers in Patients with Systemic Sclerosis
Otylia M. Kowal-Bielecka¹, Marek Bielecki², Beata Trzcinska-Butkiewicz³, Malgorzata Michalska-Jakubus⁴, Marek Brzosko³, Dorota Krasowska⁴ and Krzysztof Kowal⁵, ¹Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ²Department of Orthopedics and Traumatology, Medical University of Bialystok, Bialystok, Poland, ³Department of Rheumatology and Internal Diseases, Pomeranian Medical University, Szczecin, Poland, ⁴Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland, ⁵Department of Allergology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland
Background/Purpose: TNF-like weak inducer of apoptosis (TWEAK) regulates inflammation, angiogenesis and tissue remodeling. CD163 molecule, a scavenger receptor and marker of alternatively activated macrophages, modulates…
Abstract Number: 1714 • 2014 ACR/ARHP Annual Meeting
IL-6 Trans-Signalling Activates M2 Macrophage Polarisation and Mediates Fibrotic Response in Scleroderma
Rebecca Alade, Shiwen Xu, Korsa Khan, Angela Tam, Christopher P. Denton and Voon H. Ong, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School Royal Free Campus, London, United Kingdom
Background/Purpose IL6 is a key mediator in activation of extracellular matrix (ECM) in scleroderma (SSc) fibroblasts and via its interplay with chemokines may modulate mononuclear…
Abstract Number: 1713 • 2014 ACR/ARHP Annual Meeting
Increased Number of CD206⁺cells in Peripheral Blood and Skin of Systemic Sclerosis Patients
Stefano Soldano¹, Paola Contini², Renata Brizzolara¹, Paola Montagna¹, Barbara Villaggio³, Alberto Sulli⁴, Carmen Pizzorni⁴, Sabrina Paolino¹, Bruno Seriolo⁴ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
Background/Purpose Systemic sclerosis (SSc) is characterised by microvascular damage, immune cell activation and fibrosis of the skin and internal organs. In SSc, the immune-inflammatory infiltrate…
Abstract Number: 1712 • 2014 ACR/ARHP Annual Meeting
Monocytic Angiotensin and Endothelin Receptor Imbalance Determines Secretion of the Profibrotic Chemokine Ligand CCL18
Judith Rademacher¹, Jeannine Guenther², Angela Kill³, Elise Siegert⁴ and Gabriela Riemekasten⁵, ¹Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, 10117 Berlin, Germany, ²Rheumatology/Clinical Immunology, Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany, Berlin, Germany, ³Rheumatology and clinical Immunology, Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, ⁴Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Germany, ⁵Charité University Hospital and German Rheumatism Research Centre, a Leibniz Institute, Berlin, Germany
Background/Purpose Circulating monocytes are progrenitor of extra-cellular matrix producing cells involved in fibrosis and show highest expression of angiotensin II (ATR) and endothelin receptors (ETR)…
Abstract Number: 1711 • 2014 ACR/ARHP Annual Meeting
The Relationship Between Vascular Biomarkers and Disease Characteristics in Systemic Sclerosis: Elevated MCP-1 Is Associated with Predominantly Fibrotic Manifestations
Yasemin Yalcinkaya¹, Suzan Cinar², Sevil Kamali¹, Lale Ocal¹, Gunnur Deniz² and Murat Inanc³, ¹Istanbul Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul, Turkey, ²DETAE, Istanbul University, Istanbul, Turkey, ³Division of Rheumatology, Department of Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Background/Purpose: To determine the relationship between vascular biomarkers reflecting the vascular injury and organ involvement in systemic sclerosis (SSc). Methods : Seventy-two SSc patients (66…
Abstract Number: 1710 • 2014 ACR/ARHP Annual Meeting
Endothelin-1 Is a Downstream Mediator of Profibrotic Effects by Transforming Growth Factor-β1 in Systemic Sclerosis Skin Fibroblasts
Tomoaki Higuchi¹, Yasushi Kawaguchi¹, Akiko Tochimoto¹, Yuko Ota², Yasuhiro Katsumata¹, Takahisa Gono¹, Masanori Hanaoka¹, Yuko Okamoto¹, Hidenaga Kawasumi¹ and Hisashi Yamanaka³, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²10-22 Kawada-Cha Shinjuku-Ku, Tokyo Women's Medical University, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by excess collagen deposition, vascular changes and production of autoantibodies that affects multiple organs.…
Abstract Number: 1708 • 2014 ACR/ARHP Annual Meeting
The Pathogenic Role of Immune Complexes Containing Scleroderma-Specific Autoantibodies in the Inductor Phase of the Disease
Cecilia B. Chighizola¹, Elena Raschi², Laura Cesana², Silvana Zeni³, Maria Orietta Borghi⁴ and Pier Luigi Meroni^5,6, ¹Rheumatology, Istituto Auxologico Italiano, University of Milan, Cusano Milanino, Italy, ²Istituto Auxologico Italiano, Milan, Italy, ³Division of Rheumatology, Istituto G. Pini, Milano, Italy, ⁴Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, ⁵Department of Clinical Sciences and Community Health, Division of Rheumatology, Istituto G. Pini, Milan, Italy, ⁶Chair and Division of Rheumatology, Gaetano Pini Institute, University of Milan, Milan, Italy
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune condition characterized by excessive tissue fibrosis, microvascular alterations and immune dysfunction with the production of peculiar autoantibodies.…
Abstract Number: 1707 • 2014 ACR/ARHP Annual Meeting
High Oxidative Stress in Fibrotic and Non-Fibrotic Skin of Patients with Systemic Sclerosis
Khalil I. Bourji¹, Alain Meyer^2,3, Emmanuel Chatelus², Erika Pigatto¹, François Singh³, Bernard Geny³, Leonardo Punzi¹, Jacques-Eric Gottenberg², Franco Cozzi¹ and Jean Sibilia², ¹Division of Rheumatology, University Hospital of Padova, Padova, Italy, ²Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ³Physiology and Functional Explorations, University Hospital of Strasbourg, Strasbourg, France
Background/Purpose Systemic Sclerosis (SSc) is a chronic multisystemic connective tissue disease characterized by progressive fibrosis affecting skin and internal organs. Despite serious efforts to unveil…
Abstract Number: 1706 • 2014 ACR/ARHP Annual Meeting
Prevention of SU5416-Induced Pulmonary Hypertension in a TGFβ Dependent Genetic Mouse Model of Scleroderma Using the Endothelin Receptor Antagonist Macitentan
Emma C. Derrett-Smith¹, Vincent Sobanski², Sarah Trinder³, Adrian J Gilbane³, Marc Iglarz⁴, David J. Abraham³, Alan M. Holmes⁵ and Christopher P Denton⁶, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School Royal Free Campus, London, United Kingdom, ²UCL Medical School, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁴Actelion Pharmaceuticals Ltd., Allschwil, Switzerland, ⁵Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, ⁶Centre for Rheumatology and Connective Tissue Disease, UCL Medical School Royal Free Campus, London, United Kingdom
Background/Purpose: Pulmonary arterial hypertension (PAH) is an important complication of systemic sclerosis (SSc) that occurs in around 10% of cases. We have previously shown that…
Abstract Number: 1705 • 2014 ACR/ARHP Annual Meeting
The Lectin Pathway of Complement – a Potential Role in the Pathogenesis and Disease Manifestations of Systemic Sclerosis
Michael Osthoff^1,2, Gene-Siew Ngian^2,3,4, Melinda Dean⁵, Mandana Nikpour⁶, Wendy Stevens⁷, Susanna Proudman⁸, Damon Eisen¹ and Joanne Sahhar^3,9, ¹Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia, ²Department of Medicine, The University of Melbourne, Melbourne, Australia, ³Department of Rheumatology, Monash Medical Centre, Clayton, Australia, ⁴Department of Rheumatology, Royal Melbourne Hospital, Parkville, Australia, ⁵Research and Development, Australian Red Cross Blood Service, Brisbane, Australia, ⁶Department of Medicine (St Vincent's Hospital), University of Melbourne, Fitzroy, Australia, ⁷Department of Rheumatology, St. Vincent’s Hospital, Fitzroy, Australia, ⁸Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁹Monash Health, Melbourne, Australia
Background/Purpose: Repetitive episodes of ischemia and reperfusion (I/R) are a cardinal feature of the pathogenesis of systemic sclerosis (SSc), which precedes tissue fibrosis. The complement…

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