Abstracts Archive - Page 1933 of 2607 - ACR Meeting Abstracts

Abstract Number: 929 • 2015 ACR/ARHP Annual Meeting
Diurnal Variation of Power Doppler in Metacarpophalangeal Joints of Patients with Rheumatoid Arthritis
Marwin Gutierrez¹, Emeline Minichiello², Alarico Ariani¹, Salima Challal², Emilio Filippucci¹, Marie-Christophe Boissier^2,3,4, Walter Grassi¹ and Luca Semerano^2,3,4, ¹Clinica Reumatologica, Università Politecnica delle Marche, Jesi, Italy, ²Service de Rhumatologie, Assistance Publique – Hôpitaux de Paris (AP-HP) Groupe hospitalier Avicenne - Jean Verdier – René Muret, Bobigny, France, ³Inserm UMR 1125, Bobigny, France, ⁴Sorbonne Paris Cité - Université Paris 13, Bobigny, France
Background/Purpose: In a preliminary study on 10 patients with active rheumatoid arthritis (RA) we showed for the first time that Power Doppler ultrasonography (PDUS) signal…
Abstract Number: 930 • 2015 ACR/ARHP Annual Meeting
Evaluation of Temporomandibular Joint Arthritis with Ultrasound in Juvenile Idiopathic Arthritis
Edward J. Oberle^1,2, James Nocton³ and Arthur Meyers⁴, ¹Pediatrics, Ohio State University, Columbus, OH, ²Pediatric Rheumatology, Nationwide Children's Hospital, Columbus, OH, ³Pediatrics, Medical College of Wisconsin, Milwaukee, WI, ⁴Radiology, Children's Hospital of Wisconsin, Milwaukee, WI
Background/Purpose: Temporomandibular joint (TMJ) arthritis is a common yet widely under recognized feature of Juvenile Idiopathic Arthritis (JIA). It is often clinically silent and difficult…
Abstract Number: 931 • 2015 ACR/ARHP Annual Meeting
mTOR Complex 1 Signaling Is Required for the Steady-State in Vivo Development of Inflammatory Monocytes
Pui Y. Lee¹, David Sykes², Sarah Ameri³, Allyn Morris⁴ and Peter A. Nigrovic⁵, ¹Division of Immunology, Boston Children's Hospital, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Monocytes and macrophages are essential to innate immunity but also propagate the inflammatory response in autoimmune arthritis and lupus nephritis. Spontaneous development of inflammatory…
Abstract Number: 932 • 2015 ACR/ARHP Annual Meeting
IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus
Michela Manni¹, Sanjay Gupta², Briana G. Nixon³ and Alessandra B. Pernis⁴, ¹Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, NY, ⁴Autoimmunity & Inflammation, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Interferon Regulatory Factors (IRFs) play fundamental roles in dendritic cell (DC) differentiation and function. In particular IRFs are critical transducers of Toll-like Receptors (TLR)…
Abstract Number: 933 • 2015 ACR/ARHP Annual Meeting
DEK-Targeting DNA Aptamers As Novel Therapeutics for Inflammatory Arthritis
Nirit Mor-Vaknin¹, Anjan K. Saha², Maureen Legendre¹, Carmelo Carmona-Rivera³, M. Asif Amin⁴, Bradley J. Rabquer⁵, Marta J. Gonzalez-Hernandez⁶, Julie M. Jorns⁷, Srilakshmi Yalavarthi⁸, Smriti Mohan⁹, Dave Pai¹⁰, Kristine Angevine¹¹, Barbara Adams¹², Jason S. Knight⁸, Alisa E. Koch^13,14,15, David Fox¹⁴, Dave Engelke¹⁶, Mariana J. Kaplan¹⁷ and David Markovitz⁴, ¹Infectious Diseases, University of Michigan, Ann Arbor, MI, ²Medical School, University of Michigan, Ann Arbor, MI, ³Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Internal Medicine, University of Michigan, Ann Arbor, MI, ⁵Albion College, Ann Arbor, MI, ⁶Graduate Program in Immunology, University of Michigan, Ann Arbor, MI, ⁷Pathology, University of Michigan, Ann Arbor, MI, ⁸Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Pediatric Rheumatology, University of Michigan, Ann Arbor, MI, ¹⁰Scripps Research Institute, San Diego, CT, ¹¹Appistry, Inc, St. Louis, MO, ¹²Pediatric Rheum PTD, Univ of Michigan Hlth System, Ann Arbor, MI, ¹³VA Medical Service, Ann Arbor, MI, ¹⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ¹⁵Internal Medicine, Veteran's Affairs and University of Michigan, Ann Arbor, MI, ¹⁶Biochemistry, University Michigan, Ann Arbor, MI, ¹⁷Systemic Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD
Background/Purpose: Aptamers are short single stranded DNA or RNA oligonucleotides that are specifically selected to bind and neutralize a wide range of biomedically relevant proteins.…
Abstract Number: 934 • 2015 ACR/ARHP Annual Meeting
Platelet-Independent Role of Megakaryocytes in Antibody-Mediated Murine Arthritis
Pierre Cunin¹, Loka Penke², Jonathan Thon³, Paul A. Monach⁴, Tatiana Jones⁵, Mary Chen², Yoichiro Iwakura⁶, Jerry Ware⁷, Michael Gurish², Joseph Italiano³, Eric Boilard⁸ and Peter A. Nigrovic^2,9, ¹Rheumatology, Immunology and Allergy, Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Department of Medicine, Hematology Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Department of Clinical Laboratory and Nutritional Science, University of Massachusetts Lowell, Lowel, MA, ⁶Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan, ⁷Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, ⁸Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Quebec, QC, Canada, ⁹Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Mice bearing mutations affecting Kit (stem cell factor receptor) exhibit multiple hematologic phenotypes, including mast cell deficiency, and have been used to assess the…
Abstract Number: 935 • 2015 ACR/ARHP Annual Meeting
Microrna-146a Provides Feedback Regulation of Monosodium Urate-Induced Gouty Arthritis in Mice By Targeting Tumor Necrosis Factor Receptor Associated Factor 6 and Interleukin-1 Receptor-Associated Kinase 1
Quan-Bo Zhang^1,2, Jing-Guo Zhou³, Cong-Cong Yin¹, Yu-Feng Qing⁴, Chang-Gui Li⁵, Li Zhou¹ and Qing-Sheng Mi⁶, ¹Immunology Program, Department of Dermatology, Henry Ford Health System, Detroit, MI, ²Geriatrics, Affliated hospital of North Sichuan Medical College, Nanchong, China, ³Department of Rheumatology and Immunology, Affliated hospital of North Sichuan Medical College, Nanchong, China, ⁴Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nanchong, China, ⁵Affiliated Hospital of Qingdao University, Qingdao, China, ⁶Immunology, Dermatology, Henry Ford Health System, Detroit, MI
Background/Purpose: MicroRNAs (miRNAs) have been shown to serve as important regulators for inflammatory and immune responses and are implicated in several immune disorders including gouty…
Abstract Number: 936 • 2015 ACR/ARHP Annual Meeting
IL-1 Receptor Antagonist Maintains Intestinal Microbial Homeostasis to Prevent Overt Toll-like Receptor 4-Dependent Intestinal Th17 Differentiation and Autoimmune Arthritis
Rebecca Rogier¹, Tom Ederveen¹, Jos Boekhorst², Harm Wopereis³, Johan Garssen⁴, Peter van der Kraan⁵, Sacha van Hijum², Marije Koenders⁶, Wim van den Berg⁶ and Shahla Abdollahi-Roodsaz^7,8, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ²Centre for Molecular Bioinformatics Nijmegen (CMBI), Radboud university medical center, Nijmegen, Netherlands, ³Danone Research, Wageningen, Netherlands, ⁴Danone Nutricia Research, Utrecht, Netherlands, ⁵Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁶Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁷Medicine, NYU School of Medicine, New York, NY, ⁸Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Interleukin-1 (IL-1) plays a pivotal role in inflammation and immunity. Activation of IL-1 receptor is physiologically inhibited by the IL-1 receptor antagonist (IL-1Ra). Mice…
Abstract Number: 937 • 2015 ACR/ARHP Annual Meeting
Safety and Efficacy of Canakinumab in Patients with CAPS: Interim Results from the Beta-Confident Registry
Jasmin B. Kuemmerle-Deschner¹, Hal M. Hoffman², Philip N. Hawkins³, T. van der Poll⁴, Ulrich A. Walker⁵, Antonio Speziale⁶ and Hugh H. Tilson⁷, ¹University Hospital Tuebingen, Tuebingen, Germany, ²Division of Rheumatology, Allergy, and Immunology, University of California at San Deigo, La Jolla, CA, ³University College London Medical School, London, United Kingdom, ⁴Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Rheumatology, University Hospital, Basel, Basel, Switzerland, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷University of North Carolina, Gillings School of Global Public Health, Chapel Hill, NC
Background/Purpose: Cryopyrin-associated periodic syndrome (CAPS), is a rare autoinflammatory disease encompassing a spectrum of 3 phenotypes with an estimated population frequency ranging from 1-3 per…
Abstract Number: 938 • 2015 ACR/ARHP Annual Meeting
Long-Term Efficacy and Safety of Canakinumab in Patients with Active Recurrent or Chronic TNF Receptor-Associated Periodic Syndrome
Marco Gattorno¹, Marco Cattalini², L. Obici³, Roberto Barcellona⁴, Antonio Speziale⁵, Yolandi Joubert⁵, Guido Junge⁵ and Helen Lachmann⁶, ¹Pediatric Rheumatology, G. Gaslini Institute, Genova, Italy, ²Pediatric Clinic, University of Brescia, Brescia, Italy, ³Amyloid Centre, Policlinico S. Matteo, Pavia, Italy, ⁴Hospital of Sciacca, Sciacca, Italy, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶UK National Amyloidosis Centre, University College London Medical School, London, United Kingdom
Background/Purpose: Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is a rare, dominantly inherited periodic fever syndrome characterized by recurrent attacks of fever associated with…
Abstract Number: 939 • 2015 ACR/ARHP Annual Meeting
Long-Term Efficacy and Safety of Canakinumab in Active Hyperimmunoglobulinemia D with Periodic Fever Syndrome
Juan Ignacio Arostegui¹, Jordi Anton², Inmaculada Calvo-Penedes³, Angel Robles⁴, Antonio Speziale⁵, Yolandi Joubert⁵, Guido Junge⁵ and Jordi Yagüe⁶, ¹Department of Immunology-CDB, Hospital Clínic, Barcelona, Spain, ²Unitat de Reumatologia Pediàtrica, Hospital Sant Joan de Déu, Barcelona, Spain, ³Hospital de La Fe, Valencia, Spain, ⁴Hospital La Paz, Madrid, Spain, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Immunology Department, Hospital Clinic Barcelona, Barcelona, Spain
Background/Purpose: Hyperimmunoglobulinemia D with periodic fever syndrome (HIDS) is a recessively inherited disorder characterized by periodic episodes of high fever, abdominal distress, joint pain, and…
Abstract Number: 940 • 2015 ACR/ARHP Annual Meeting
NOD2-Associated Autoinflammatory Disease: Therapy and Outcomes
Qingping Yao¹ and Bo Shen², ¹Cleveland Clinic, Cleveland, OH, ²Gastroenterology, Cleveland Clinic, Cleveland, OH
Background/Purpose: NOD2-associated autoinflammatory disease, now redesignated as Yao Syndrome(YS) is a newly described and increasingly recognized entity. It is characterized by periodic fever, dermatitis, polyarthritis, sicca-like…
Abstract Number: 941 • 2015 ACR/ARHP Annual Meeting
Relationship Between Colchine Plasma Level and Frequency of Familial Mediterranean Fever Attacks
Fadime Canbolat¹, Gulsen Ozen², Selma Ozilhan¹, Samet Gulturk³, Ayse Ozcetin⁴, Ali Ugur Unal², Nevsun Inanc², Pamir Atagunduz², Haner Direskeneli² and Tuncel Ozden¹, ¹Department of Pharmacology, Uskudar University Pharmacogenetic Laboratory, Istanbul, Turkey, ²Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Molecular Biology and Genetics, Uskudar University, Istanbul, Turkey, ⁴Department of Neuroscience, Uskudar University, Istanbul, Turkey
Background/Purpose: Colchicine is the mainstay of Familial Mediterranean Fever (FMF) treatment that reduces the frequency of attacks and prevents amyloidosis in the majority of patients. Colchicine,…
Abstract Number: 942 • 2015 ACR/ARHP Annual Meeting
Update in the Management of Biologic Response Modifiers and Disease-Modifying Antirheumatic Drugs Following Coccidioidomycosis
Usman Ajaz¹, Neil M. Ampel², Varun Bhalla³, Jeffrey R. Lisse⁴ and Dominick Sudano⁵, ¹Department of Medicine, University of Arizona, Tucson, AZ, ²Department of Infectious Disease, Southern AZ VA Medical Center, Tucson, AZ, ³University of Arizona, Tucson, AZ, ⁴Arizona Arthritis Center, University of Arizona, Tucson, AZ, ⁵Rheumatology, University of Arizona, Tucson, AZ
Background/Purpose: In the Southwestern United States, Coccidioidomycosis (cocci) or Valley fever is an endemic fungal infection. It typically presents as a self-limited pulmonary illness. Patients…
Abstract Number: 943 • 2015 ACR/ARHP Annual Meeting
Development of an Internationally Agreed Minimal Dataset for Juvenile Dermatomyositis (JDM) for Clinical and Research Use
Liza J. McCann¹, Lucy R Wedderburn², Clarissa Pilkington³, Adam M. Huber⁴, Angelo Ravelli⁵, Jamie Kirkham⁶, Paula Williamson⁶ and Michael W. Beresford⁷, ¹Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ²Infection, Inflammation and Rheumatology Section, UCL Institute for Child Health, London, United Kingdom, ³Department of Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, ⁴Pediatric rheumatology, IWK Health Centre, Halifax, NS, Canada, ⁵Pediatria-II, IRCCS G. Gaslini and University of Genova, Genova, Italy, ⁶Department of Biostatistics, University of Liverpool, MRC North West Hub for Trials Methodology Research, Liverpool, United Kingdom, ⁷Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare disease. International collaboration is essential for scrutiny of sufficient patient numbers. We aim to develop a core set…

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