Abstracts Archive - Page 1933 of 2425 - ACR Meeting Abstracts

Abstract Number: 1792 • 2014 ACR/ARHP Annual Meeting
Clinical-Biological and Pathological Spectrum and Outcome of IgA Vasculitis in Adults: A French Study
Alexandra Audemard¹, Evangeline Pillebout², Patrice Cacoub³, Noémie Jourde-Chiche Sr.⁴, Zahir Amoura⁵, Noemie Le Gouellec⁶, Francois Maurier⁷, Boris Bienvenu⁸, Geoffrey Urbanski⁹, Sébastien Sanges¹⁰, Aurélie Hummel¹¹, Alban Deroux¹², Loic Raffray¹³, Luc Mouthon¹⁴, Loïc Guillevin for the French Vasculitis Study Group¹⁴, Eric Thervet¹⁵ and Benjamin Terrier¹⁶, ¹Internal Medicine, Centre Hospitalier Universitaire de Caen, Caen, France, ²Nephrology, Saint Louis, Paris, France, ³Groupe Hospitalier Pitié Salpétrière, Service de Médecine Interne, DHU i2B, Paris, France, ⁴Nephrology, CHU, Marseille, France, ⁵Internal medicine 2, French National Reference Center for Systemic Lupus and Antiphospholipid Syndrome, Pitié-Salpêtrière Hospital (AP-HP), Paris, France, ⁶Internal Medicine, Lille, France, ⁷HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁸Médecine interne, CHU Côte de Nacre, CAEN, France, ⁹Internal Medicine, CHRU, Lille, France, ¹⁰Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, ¹¹Nephrology, Necker Hospital, Paris, France, ¹²Internal Medicine, CHU Grenoble, Grenoble, France, ¹³INTERNAL MEDICINE, bordeaux, France, ¹⁴National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ¹⁵Nephrology, Hopital Européen Georges Pompidou, APHP, PARIS, France, ¹⁶National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France
Background/Purpose IgA vasculitis is an immune-complex small-vessel vasculitis that mainly affects children and, more rarely, adults, in whom it seems to be more severe, because…
Abstract Number: 1804 • 2014 ACR/ARHP Annual Meeting
Increased Mortality in Ankylosing Spondylitis – Results from a National Population Based Study
Sofia Exarchou¹, Elisabeth Lie², Johan Askling³, Helena Forsblad-d'Elia², Carl Turesson¹, Lars Erik Kristensen⁴ and Lennart T. Jacobsson², ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ³Clinical Epidemiology Unit, Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden
Background/Purpose: Ankylosing spondylitis (AS) is characterized both by inflammation of the axial skeleton and systemic inflammation, and may also involve joints, entheses and other organs.…
Abstract Number: 1800 • 2014 ACR/ARHP Annual Meeting
Objectively Measured Sedentary Behavior Is a Distinct Risk Factor from Low Moderate-to-Vigorous Activity in Predicting Subsequent Frailty: Evidence from Osteoarthritis Initiative
Jing Song¹, Lee A. Lindquist¹, Rowland W. Chang¹, Pamela A. Semanik², Linda S. Ehrlich-Jones³, Jungwha Lee⁴, Min-Woong Sohn¹ and Dorothy D. Dunlop¹, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rush University Medical Center, Chicago, IL, ³Rehabilitation Institute of Chicago, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Physical frailty represents a state of high vulnerability for adverse health outcomes including disability and mortality. Physical activity interventions to improve health have largely…
Abstract Number: 1777 • 2014 ACR/ARHP Annual Meeting
Staphylococcus Aureus Nasal Carriage and Relapses, Bvas, ANCA-Positivity and Cotrimoxazole Use in ANCA-Associated Vasculitis
Boun Kim Tan¹, Yoann Crabol¹, Jason Tasse^2,3, Frederic Laurent^2,3, Xavier Puechal^4,5, Christine Vinter⁶ and Loïc Guillevin^1,5, ¹Internal Medicine, Hôpital Cochin, University Paris V Descartes, Paris, France, ²Laboratoire de Bactériologie de l'hôpital de la Croix-Rousse, National Reference Centre for Staphylococci, Lyon, France, ³INSERM U1111, CNRS UMR5308, International Centre for Research in Infectious Diseases, Lyon, France, ⁴Internal Medicine, Hôpital Cochin, Paris, France, ⁵French Vasculitis Study Group (FVSG), Paris, France, ⁶Internal Medecine, Hôpital Cochin, Paris, France
Background/Purpose Staphylococcus aureus (SA) nasal carriage has been reported to be more frequent and associated with persistent ANCA-positivity and relapse in patients with granulomatosis with…
Abstract Number: 1776 • 2014 ACR/ARHP Annual Meeting
Factors Predictive of ANCA-Associated Vasculitis Relapse in Patients Given Rituximab-Maintenance Therapy
Benjamin Terrier¹, Christian Pagnoux², Guillaume Geri³, Alexandre Karras⁴, Chahéra Khouatra⁵, Olivier Aumaitre⁶, Pascal Cohen⁷, Francois Maurier⁸, Olivier Decaux⁹, Hélène Desmurs-Clavel¹⁰, Pierre Gobert¹¹, Thomas Quemeneur¹², Claire Blanchard-Delaunay¹³, Pascal Godmer¹⁴, Xavier Puéchal⁷, Luc Mouthon⁷ and Loïc Guillevin for the French Vasculitis Study Group⁷, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ²Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ³Intensive Care Unit, Cochin Hospital, Paris, France, ⁴Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, ⁵CHU Louis Pradel, Lyon, Lyon, France, ⁶Internal Medicine, CHU, Clermont-Ferrand, France, ⁷National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁸HP Metz Belle Isle Hospital, Department of Internal Medicine, Metz, France, ⁹Department of Internal Medicine, Rennes University Hospital, Rennes, France, ¹⁰University of Lyon, LYON, France, ¹¹Nephrology, Centre Hospitalier d'Avignon, Avignon, France, ¹²Internal Medicine, CH, Valenciennes, France, ¹³Internal Medicine, Hôpital de Niort, Niort, France, ¹⁴Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France
Background/Purpose Rituximab (RTX) was shown to be as effective as cyclophosphamide to induce remission in patients with ANCA-associated vasculitis (AAV). The prospective MAINRITSAN trial compared…
Abstract Number: 1775 • 2014 ACR/ARHP Annual Meeting
Predicting Relapse in Patients with Granulomatosis with Polyangiitis – the Potential Use of Monitoring in Vitro ANCA Production
Judith Land¹, Wayel H. Abdulahad¹, Coen A. Stegeman², Peter Heeringa³ and Abraham Rutgers¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Nephrology, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose Patients with granulomatosis with polyangiitis (GPA) suffer from frequent disease relapses, with up to 50% of patients relapsing within 5 years. Several risk factors…
Abstract Number: 1774 • 2014 ACR/ARHP Annual Meeting
Granulomatosis with Polyangiitis (Wegener’s): Endoscopic Management of Tracheobronchial Stenosis – Results from a Multicenter Experience in 47 Patients
Benjamin Terrier¹, Agnes Dechartres², Charlotte Girard³, Stéphane Jouneau⁴, Jean-Emmanuel Kahn⁵, Robin Dhote⁶, Jean Cabane⁷, Estibaliz Lazaro⁸, Thomas Papo⁹, Nicolas Schleinitz¹⁰, Guillaume Le Guenno¹¹, Luc Mouthon¹² and Loïc Guillevin for the French Vasculitis Study Group¹², ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ²Biostatistics, Hotel Dieu, Paris, France, ³Internal Medicine, CHU, Lyon, France, ⁴Pulmonology, CHU, Rennes, France, ⁵Internal Medicine, Foch Hospital, Suresnes, France, ⁶Internal Medicine, Avicenne University Hospital, Bobigny, France, ⁷Internal Medicine, Saint-Antoine, Paris, France, ⁸Centre François Magendie, CHU, Pessac, France, ⁹Internal Medicine, Bichat Hospital, Paris, Paris, France, ¹⁰internal medicine, APHM, marseille, France, ¹¹Internal Medicine department, Clermont-Ferrand, France, ¹²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France
Background/Purpose Tracheobronchial stenosis (TBS) is noted in 12 to 23% in patients with granulomatosis with polyangiitis (GPA), and includes subglottic stenosis (SGS) and bronchial stenosis.…
Abstract Number: 1773 • 2014 ACR/ARHP Annual Meeting
Otolaryngologic Lesions Are Not Rare and Closely Related with Pachymeningitis and Cranial Neuropathy in MPO-ANCA Associated Vasculitis
Takahiro Nunokawa¹, Naoto Yokogawa², Kota Shimada¹ and Shoji Sugii², ¹Department of Rheumatic diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, ²Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan
Background/Purpose: Recently several case reports of serous otitis media (SOM), hypertrophic pachymeningitis (HP) and cranial neuropathy (CN) have been reported in connection with MPO-ANCA associated…
Abstract Number: 1772 • 2014 ACR/ARHP Annual Meeting
Venous Thromboembolic Events in Eosinophilic Granulomatosis with Polyangiitis (EGPA)
Chiara Baldini¹, Francesco Ferro¹, Nicoletta Luciano¹, Antonio Tavoni², Francesca Sernissi¹, Daniela Martini¹, Sara L'Abbate¹, Marta Mosca³ and Stefano Bombardieri³, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²University of Pisa, Immunoallergology Unit, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Previous studies have documented an increased risk of venous thromboembolic events in patients with antineutrophil cytoplasmic antibodies (ANCA) associated vasculitides (AAV) as compared to…
Abstract Number: 1771 • 2014 ACR/ARHP Annual Meeting
Arterial Thrombotic Events in Systemic Vasculitis
Alexander Tsoukas¹, Sasha Bernatsky², Lawrence Joseph³, David Buckeridge⁴, Patrick Belisle⁵ and Christian A. Pineau¹, ¹Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³McGill University, Montreal, QC, Canada, ⁴Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada, ⁵Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose To estimate the incidence rate of clinically apparent arterial thrombotic events and associated comorbidities in patients with primary systemic vasculitis. Methods Using large-cohort administrative…
Abstract Number: 1770 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Chronic Obstructive Pulmonary Disease in Granulomatosis with Polyangiitis: A General Population-Based Study
Neda Amiri¹, Mohsen Sadatsafavi², Eric C. Sayre³, John M. Esdaile⁴ and J. Antonio Avina-Zubieta^2,5, ¹Rheumatology, University of British Columbia, Vancouver, BC, Canada, ²University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose Chronic obstructive pulmonary disease (COPD) is increasingly recognized as an inflammatory condition. We aimed to identify the risk of newly recorded COPD among…
Abstract Number: 1769 • 2014 ACR/ARHP Annual Meeting
Abdominal Visceral Adipose Tissue Measured By DXA As a Novel Surrogate Marker of Cardiovascular Risk in Primary Necrotizing Vasculitides
Bertrand Dunogué¹, Karine Briot², Sami Kolta³, Alexis Regent⁴, Pascal Cohen⁵, Alice Berezne⁶, Xavier Puéchal⁵, Claire Le Jeunne⁵, Luc Mouthon⁵, Christian Roux⁷, Loïc Guillevin for the French Vasculitis Study Group⁵ and Benjamin Terrier⁸, ¹Internal Medicine, Hôpital Cochin, Paris, France, ²Cochin Hospital, Paris Descartes University, Paris, France, ³Rheumatology B, Paris Descartes University, Cochin hospital, Paris, France, ⁴Internal Medicine, Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes, Paris, France, Paris, France, ⁵National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁶Paris Descartes University, Internal Medicine department, Cochin Hospital, Paris, France, ⁷Paris Descartes University, Cochin Hospital, Paris, France, ⁸National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France
Background/Purpose Studies have shown a strong prevalence of cardiovascular events among patients with primary necrotizing vasculitides. Recent studies indicate that visceral adipose tissue (VAT) is…
Abstract Number: 1768 • 2014 ACR/ARHP Annual Meeting
Cardiac Involvement in Granulomatosis with Polyangiitis: A Magnetic Resonance Imaging Study of 31 Consecutive Patients
Grégory Pugnet^1,2, Xavier Puéchal¹, Benjamin Terrier¹, Hervé Gouya³, Andre Kahan⁴, Paul Legmann³, Loïc Guillevin¹ and Olivier Vignaux⁵, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ²Toulouse University Hospital, Internal Medicine Department, Toulouse, France, ³AP-HP Cochin Hospital, Department of Radiology B, Paris, France, ⁴Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, ⁵Radiology, Cochin University Hospital, Paris, France
Background/Purpose Cardiac manifestations in granulomatosis with polyangiitis (GPA) patients are usually considered to be rare but may be life-threatening. However specific cardiac involvement in GPA is…
Abstract Number: 1767 • 2014 ACR/ARHP Annual Meeting
Granulomatosis with Polyangiitis (Wegener’s) According to Geographic Origin and Ethnicity: Clinical-Biological Presentation and Outcome
Benjamin Terrier¹, Christophe Deligny², Xavier Puéchal³, Pascal Godmer⁴, Pierre Charles⁵, Gilles Hayem⁶, Bertrand Dunogué⁷, Pascal Cohen³, Serge Arfi⁸, Luc Mouthon³ and Loïc Guillevin for the French Vasculitis Study Group³, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ²Internal Medicine, CHU Fort de France, Fort de France, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, ⁴Department of Internal Medicine, Centre Hospitalier Bretagne Atlantique de Vannes, Vannes, France, ⁵Internal Medicine, Institut Mutualiste Montsouris, Paris, France, ⁶Rhumatologie, Hopital Bichat, Paris Cedex 18, France, ⁷Internal Medicine, Hôpital Cochin, Paris, France, ⁸Rhumatologie Et Médecine Interne, Centre hospitalier Universitaire de Fort de France, Fort de France, Martinique
Background/Purpose Granulomatosis with polyangiitis (Wegener’s) (GPA) is an ANCA-associated vasculitis (AAV) predominantly affecting small-sized vessels, involving mainly the upper and lower respiratory tracts and kidneys.…
Abstract Number: 1766 • 2014 ACR/ARHP Annual Meeting
Comparison of Clinicopathologically- and Serologically-Based Classification Systems for ANCA-Associated Vasculitis
Sebastian Unizony¹, Eli M. Miloslavsky¹, Miguel Villarreal², Peter A. Merkel³, Paul Monach⁴, E. William St. Claire⁵, Cees Kallenberg⁶, David Ikle², Robert F. Spiera⁷, Nadia Tchao⁸, Deborah J. Phippard⁸, Linna Ding⁹, Carol A. Langford¹⁰, Philip Seo¹¹, Gary S. Hoffman¹², John H. Stone¹ and Ulrich Specks¹³, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Rho, Chapel Hill, NC, ³University of Pennsylvania, Philadelphia, PA, ⁴Rheumatology, Boston University, Boston, MA, ⁵Rheumatology, Duke University School of Medicine, Durham, NC, ⁶Rheumatology and Clinical Immunology, University of Groningen, Groningen, Netherlands, ⁷Rheumatology, Hospital for Special Surgery, New York, NY, ⁸Immune Tolerance Network, Bethesda, MD, ⁹NIAID, Bethesda, MD, ¹⁰Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, ¹¹Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, ¹²Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ¹³Frederichs Dr NW, Mayo Clinic, Rochester, MN
Background/Purpose Genome-wide association studies suggest that PR3-ANCA-positive ANCA-associated vasculitis (AAV) is genetically distinct from MPO-ANCA AAV. We evaluated patients enrolled in the RAVE trial according…

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