Abstracts Archive - Page 1928 of 2607 - ACR Meeting Abstracts

Abstract Number: 853 • 2015 ACR/ARHP Annual Meeting
Evaluation and Validation of Case-Finding Algorithms for the Identification of Patients with Granulomatosis with Polyangiitis in Large Healthcare Administrative Databases
Antoine G. Sreih¹, Narender Annapureddy², Kevin Byram³, George Casey⁴, Vince Frangiosa⁵, Michael George⁶, Sapna Sangani⁷, Rebecca Sharim⁵ and Peter A. Merkel⁸, ¹Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology and Immunology, Vanderbilt University, Nashville, TN, ³Internal Medicine, Vanderbilt University, Nashville, TN, ⁴The Vasculitis Foundation, Kansas City, MO, ⁵Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁶Department of Rheumatology, Hospital of the University of Pennsylvania, Philadelphia, PA, ⁷Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: To facilitate clinical care and research, validated algorithms are needed to accurately identify patients with granulomatosis with polyangiitis (GPA; Wegener's). This study, sought to…
Abstract Number: 854 • 2015 ACR/ARHP Annual Meeting
Nationwide Incidence of Anti Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis in Iceland
Þórunn Bjarnadóttir¹, Árni Jón Geirsson², Kristján Steinsson³, Jóhannes Björnsson⁴, Gunnar Tomasson⁵ and Björn Rúnar Lúdvíksson^6,7, ¹Landspitali University Hosptital, Reykjavík, Iceland, ²Rheumatology, Department of Rheumatology, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland, ³Rheumatology, Univ. Hospital, Reykjavik, Iceland, ⁴Department of Pathology, Akureyri Hospital, Akureyri, Iceland, ⁵Rheumatology Section, Boston University, Boston, MA, ⁶Department of Immunology, University of Iceland, Reykjavik, Iceland, ⁷Landspitali University Hosptital, Reykjavik, Iceland
Background/Purpose: The Icelandic population is geographically isolated, genetically homogenous and with distinct environmental exposures. Deviations in disease occurrence compared to other Western countries might provide…
Abstract Number: 855 • 2015 ACR/ARHP Annual Meeting
Seasonality in ANCA-Associated Vasculitis
Luciano Enrique Pompermayer¹, Marina Scolnik¹, Valeria Scaglioni², Maria de los Angeles Gallardo¹ and Enrique R. Soriano³, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Rheumatology, Hospital Italiano, Buenos Aires, Argentina, ³Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: pathogenesis of ANCA-associated vasculitis (AAV) is multifactorial and most likely involves the interaction of environmental and genetic factors. Environmental seasonal exposures may play a role in the manifestation…
Abstract Number: 856 • 2015 ACR/ARHP Annual Meeting
Elderly Versus Younger Patients with ANCA-Associated Vasculitis
Maria de los Angeles Gallardo¹, Marina Scolnik¹, Luciano Enrique Pompermayer¹, Valeria Scaglioni² and Enrique R. Soriano³, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Rheumatology, Hospital Italiano, Buenos Aires, Argentina, ³Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Clinical characteristics of elderly patients with ANCA- associated vasculitis (AAV) have not been fully elucidated. Advancing age is a risk factor for treatment-related side effects…
Abstract Number: 857 • 2015 ACR/ARHP Annual Meeting
Prognosis Value of Geriatric Assessment Scales in Older Adults with New Onset ANCA-Associated Vasculitis: A Pilot Retrospective Study
Antoine Néel¹, Josephine Thomazeau¹, Christelle Volteau², Laure De Decker³, Christian Agard¹, Marie Lino⁴, Julie Graveleau¹, Fadi Fakhouri⁴ and Mohamed Hamidou¹, ¹Internal Medicine Department, Nantes University Hospital, Nantes, France, ²Clinical Research Department, Nantes University Hospital, Nantes, France, ³Department of Geriatrics, Nantes University Hospital, Nantes, France, ⁴Nephrology, Nantes University Hospital, Nantes, France
Background/Purpose: 1/to assess the prognostic value of comorbidities, frailty and dependency as measures by dedicated geriatric scales, in older adults with ANCA-associated vasculitis (AAV). 2/…
Abstract Number: 858 • 2015 ACR/ARHP Annual Meeting
Stimulated Renal Glomerular Endothelial Cells Were Damaged By Fiber-like NETs Released By Neutrophils in ANCA-Associated Vasculitis
Yoshinori Komagata¹, Kanako Murakami¹, Chimako Kida¹, Kazuhito Fukuoka¹, Miho Karube², Shinya Kaname¹ and Yoshihiro Arimura¹, ¹First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ²Kyorin University School of Medicine, Tokyo, Japan
Background/Purpose: NETosis, a unique form of cell death of neutrophils, is characterized by the active release of chromatin fibers called NETs, that trap and kill…
Abstract Number: 859 • 2015 ACR/ARHP Annual Meeting
Predictors of Renal Histopathology in Antineutrophil Cytoplasmic Antibody Associated Glomerulonephritis
Sophia Lionaki¹, Clio Mavragani², George Liapis³, George Somarakis⁴, John Boletis¹, Alexandros A. Drosos⁵, Athanasios G. Tzioufas⁶ and Haralampos M. Moutsopoulos⁶, ¹Nephrology, Laiko Hospital, Department of Nephrology, Athens, Greece, ²Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ³Pathology, Laiko Hospital, Department of Pathology, Athens, Greece, ⁴Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, University of Ioannina, Rheumatology Clinic, Ioannina, Greece, ⁵Dept of Internal Medicine, University of Ioannina, Rheumatology Clinic, Ioannina, Greece, ⁶Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece
Background/Purpose: Prompt, aggressive therapy is vital for anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). In this regard, we aimed to identify predictors of distinct renal histopathological…
Abstract Number: 860 • 2015 ACR/ARHP Annual Meeting
Neutrophil/Lymphocyte Ratio: Could It be a Prognostic Indicator for Renal Outcome in Patients with Granulomatosis with Polyangiitis?
Berna Goker¹, Seminur Haznedaroglu¹, Hamit Kucuk¹, Ozkan Varan¹, Berivan Bitik¹, Abdurrahman Tufan¹, Ridvan Mercan¹ and Yasemin Erten², ¹Internal Medicine-Rheumatology, Gazi University Medical School, Ankara, Turkey, ²Internal Medicine-Nephrology, Gazi University Medical School, Ankara, Turkey
Background/Purpose: Neutrophil/lymphocyte ratio (NLR) has recently been extensively studied as a prognostic indicator in various malignancies, as well as an indicator of severity in cardiovascular…
Abstract Number: 861 • 2015 ACR/ARHP Annual Meeting
ANCA-Associated Pauci-Immune Glomerulonephritis: ¿Always Pauci-Immune?
Valeria Scaglioni¹, Marina Scolnik¹, Luis J. Catoggio¹, Carlos Federico Varela², Gustavo Greloni², Silvia Christiansen³ and Enrique R. Soriano⁴, ¹Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, ²Nephrology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³Pathology Service. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁴Internal Medicine, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina
Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) is considered a “pauci-immune” disease, characterized by absent or mild glomerular tuft staining for immunoglobulin and/or complement. However,…
Abstract Number: 862 • 2015 ACR/ARHP Annual Meeting
Discriminative Performance of Nasal Endoscopic Findings and History Items in Patients with Granulomatosis with Polyangiitis
Erdem Eren¹, Toygar Kalkan², Secil Arslanoglu¹, Mustafa Ozmen³, Kazim Onal¹, Emine Figen Tarhan³ and Servet Akar⁴, ¹Head and Neck Surgery, Izmir Ataturk Research and Training Hospital, Izmir, Turkey, ²Internal Medicine, Izmir Ataturk Research and Training Hospital, Izmir, Turkey, ³Rheumatology, Izmir Ataturk Research and Training Hospital, Izmir, Turkey, ⁴Department of Internal Medicine, Division of Rheumatology, Izmir Katip Celebi University School of Medicine, Izmir, Turkey
Background/Purpose: Granulomatosis with polyangiitis (Wegener's granulomatosis, GPA) is a systemic vasculitis of unknown etiology. It is characterized by necrotizing granulomatous inflammation and affects predominantly small…
Abstract Number: 863 • 2015 ACR/ARHP Annual Meeting
Contribution of MPO-/PR3-ANCA Tests to the Diagnosis of ANCA-Associated Vasculitis in a Community Hospital: Evaluation of 2,782 Samples
Eishi Uechi, Chiai Nakata, Tomoo Murayama and Yoshiki Shiohira, Rheumatology, Tomishiro Central Hospital, Okinawa, Japan
Background/Purpose: The purpose of this study was to evaluate the contribution of MPO-/PR3-ANCA tests to the diagnosis of ANCA-associated vasculitis (AAV). Methods: We extracted patients…
Abstract Number: 864 • 2015 ACR/ARHP Annual Meeting
Anticytokine Autoantibody Profiling in Five Types of Systemic Vasculitis
Sarthak Gupta^1,2, Seema K. Patel², Mary Blake², Massimo G. Gadina², Wanxia L. Tsai², Simon Carette³, David Cuthbertson⁴, Gary S. Hoffman⁵, Nader A. Khalidi⁶, Curry L. Koening⁷, Carol A. Langford⁵, Carol A. McAlear⁸, Larry W. Moreland⁹, Paul A. Monach¹⁰, Christian Pagnoux³, Philip Seo¹¹, Ulrich Specks¹², Antoine G. Sreih¹³, Steven R. Ytterberg¹⁴, Sarah K. Browne^1,15, Steven M. Holland¹, Mariana J. Kaplan², Peter A. Merkel¹⁶, Peter C. Grayson² and Vasculitis Clinical Research Consortium, ¹Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁴Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁵Rheumatology, Cleveland Clinic, Cleveland, OH, ⁶Division of Rheumatology, St. Joseph’s Health Care, McMaster University, Hamilton, ON, Canada, ⁷Division of Rheumatology, University of Utah, Salt Lake City, UT, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹⁰Rheumatology, Boston University School of Medicine, Boston, MA, ¹¹Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ¹²Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN, ¹³Department of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁴Rheumatology Division, Mayo Clinic, Rochester, MN, ¹⁵Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, ¹⁶Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Anticytokine autoantibodies (ACAs) are pathogenic in many hematologic, pulmonary and infectious diseases. Evaluation in autoimmune diseases, including systemic lupus erythematosus (SLE), shows that ACAs…
Abstract Number: 865 • 2015 ACR/ARHP Annual Meeting
Abdominal Visceral Adipose Tissue Measured By Dual Energy X-Ray Absorptiometry (DXA) As a Novel Surrogate Marker of Cardiovascular Risk in Primary Necrotizing Vasculitides
Bertrand Dunogué¹, Karine Briot², Sami Kolta², Alexis Regent¹, Pascal Cohen¹, Alice Berezne¹, Xavier Puéchal¹, Claire Le Jeunne¹, Luc Mouthon¹, Christian Roux², Loïc Guillevin¹ and Benjamin Terrier¹, ¹Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, ²Rheumatology B Department, Hôpital Cochin, Paris, France
Background/Purpose: Studies have shown a strong prevalence of cardiovascular events among patients with systemic necrotizing vasculitides (SNV). Recent studies indicate that visceral adipose tissue (VAT)…
Abstract Number: 866 • 2015 ACR/ARHP Annual Meeting
High Rate and Bimodal Pattern of Severe Infection in a Selected ANCA Associated Vasculitis Cohort
Esra Aydın¹, Bahtiyar Toz², Burak Erer², Mustafa Erelel³, Ahmet Gocmez⁴, Ahmet Gul⁵, Murat Inanc², Lale Ocal⁵ and Sevil Kamali², ¹Department of Internal Medicine,, istanbul faculty of medicine, istanbul, Turkey, ²Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ³Department of Pulmonology, Istanbul University Istanbul Faculty of Medicine Department of Pulmonology, istanbul, Turkey, ⁴Department of Radiology, Istanbul University Istanbul Faculty of Medicine, istanbul, Turkey, ⁵Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Background/Purpose : Increased rate of severe infection (SI) in patients who exposed to immunosuppressive drugs has been a well-known complication in inflammatory rheumatic diseases. However,…
Abstract Number: 867 • 2015 ACR/ARHP Annual Meeting
Simultaneous Measurement of 25-Hydroxyvitamin D and Procalcitonin in Granulomatosis with Polyangiitis (GPA): Differentiation of Activity from Infection?
Mariana O Perez¹, Ricardo M. Oliveira², Valéria Caparbo^3,4, Mauricio Levy-Neto⁵, Eloisa Bonfá⁴ and Rosa M R Pereira³, ¹Rheumatology Divison, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²RDO Diagnósticos Médicos, São Paulo, Brazil, ³Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology DIvision, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Vitamin D acts as innate and adaptive immune response immunomodulator. 25-hydroxyvitamin D (25OHD) deficiency was reported to be associated with autoimmune diseases flares and…

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