Abstract Number: 1922 • 2014 ACR/ARHP Annual Meeting
Hydroxylchloroquine Use Is Associated with Decreased Soluble TNF Receptor Levels in SLE Patient Samples
Background/Purpose Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disorder with a waxing and waning clinical course. Hydroxychloroquine (HCQ) is a well-tolerated and effective…Abstract Number: 1921 • 2014 ACR/ARHP Annual Meeting
The Deposition of Complement C4d Split Product on Platelets and Erythrocytes Correlate with Disease Activity and Improvement in Systemic Lupus Erythematosus
Background/Purpose: We sought to evaluate the usefulness of cell bound complement activation products (C4d deposition on erythrocytes [EC4d] and platelets [PC4d]) in the monitoring of…Abstract Number: 1920 • 2014 ACR/ARHP Annual Meeting
Predicting SLE Disease Activity in the Next Year Based on Measures of Four Gene Transcripts and Two Proteins
Background/Purpose Multiple gene transcripts and proteins in blood or urine have been observed to correlate with disease activity in SLE. However some observed associations might…Abstract Number: 1919 • 2014 ACR/ARHP Annual Meeting
HLA-B27 Expression Shapes the Intestinal Microbiota
Background/Purpose The intestinal microbiota plays a central role in both health and disease. Beyond shaping local immune responses in the gut, it is increasingly clear…Abstract Number: 1918 • 2014 ACR/ARHP Annual Meeting
IL23 Overexpression Demonstrates Gut-Joint Inflammation Link and Increased Expression of Spondyloarthopathy Associated Genes In Vivo
Background/Purpose: It has been well established that a close relationship exists between gut inflammation and spondyloarthropathies. Polymorphisms in the receptor for IL23 are associated not…Abstract Number: 1917 • 2014 ACR/ARHP Annual Meeting
IL-23 Expression and Activation of Autophagy in Synovium and PBMCs of HLA-B27 Positive Patients with Ankylosing Spondylitis
Background/Purpose: IL-23 may play a key role in the pathogenesis of ankylosing spondylitis (AS). Some studies describe indeed increased serum levels of IL-23 in AS…Abstract Number: 1916 • 2014 ACR/ARHP Annual Meeting
Stromal Overexpression of Transmembrane TNF Induces Spa-like Arthritis and Spondylitis in Mice
Background/Purpose: The immunopathology of spondyloarthritis (SpA) is determined by inflammation and structural damage, in particular osteoproliferation, of axial and peripheral joints. The failure of TNF…Abstract Number: 1915 • 2014 ACR/ARHP Annual Meeting
IL-17 Gene Transfer induces Myeloid Precursor Cells That Initiate Epidermal Hyperplasia Independently of IL-23R+/CD4+ and γδ T Cells
Background/Purpose: IL-17 is elevated in both the lesional skin and arthritic joints of psoriatic arthritis (PsA) patients. Although the IL-23/IL-17 axis has been linked with…Abstract Number: 1914 • 2014 ACR/ARHP Annual Meeting
IL-17A Deficiency Promotes Periosteal Bone Formation in a Model of Inflammatory Arthritis
Background/Purpose: Enthesial and periosteal bone formation in spondyloarthropathies (SpAs) are important sequelae of disease that contribute to patient morbidity. Anti-TNF therapies do not significantly alter…Abstract Number: 1913 • 2014 ACR/ARHP Annual Meeting
Rosuvastatin Induced Carotid Plaque Regression in Patients with Inflammatory Joint Diseases
Background/Purpose Patients with rheumatoid arthritis (RA) and carotid artery plaques (CP) have increased risk of acute coronary syndromes. Statin treatment with low density lipoprotein cholesterol…Abstract Number: 1912 • 2014 ACR/ARHP Annual Meeting
Tocilizumab Therapy for Rheumatoid Arthritis Patients with Chronic Renal Insufficiency
Background/Purpose: Renal involvement is relatively common in rheumatoid arthritis (RA) patients. Recent randomized controlled trials of anti-tumor necrosis factor-α (anti-TNFα) showed that the concomitant administration…Abstract Number: 1911 • 2014 ACR/ARHP Annual Meeting
Disease Modifying Anti-Rheumatic Drug Use and the Risk of Incident Hyperlipidemia in Patients with Early Rheumatoid Arthritis: A Retrospective Cohort Study
Background/Purpose: Rheumatoid arthritis (RA) increases patients' risk of developing cardiovascular diseases (CVD). Hyperlipidemia is an important CVD risk factor in the general population. The objective…Abstract Number: 1910 • 2014 ACR/ARHP Annual Meeting
Risk of Hypersensitiviy Among Medicare Patients with Rheumatoid Arthritis Who Were Taking Biologics
Background/Purpose: Healthcare providers have been alerted to the potential drug hypersensitivity reactions (HSRs, an adverse drug reaction that are uncommon but may be severe and…Abstract Number: 1909 • 2014 ACR/ARHP Annual Meeting
Incidence of Congestive Heart Failure in Subjects with Rheumatoid Arthritis Receiving Anti-Tumour Necrosis Factor Drugs: Results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
Background/Purpose Subjects with rheumatoid arthritis (RA) are at a higher risk of developing cardiovascular (CV) disease compared to the general population, with an increased incidence…Abstract Number: 1927 • 2014 ACR/ARHP Annual Meeting
A Retrospective Look at the Recurrence of Digital Ulcers in Patients with Scleroderma after Discontinuation of Oral Treprostinil
Background/Purpose Ischemic digital ulcers (DU) occur in over 40% of systemic sclerosis (SSc) patients. Treprostinil diolamine, a newer prostacyclin analog that has been developed for…
ACR Meeting Abstracts