Abstracts Archive - Page 1924 of 2607 - ACR Meeting Abstracts

Abstract Number: 793 • 2015 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Promote the Generation of CD206+ Macrophage and Increase Its Phagocytic Activity in Systemic Lupus Erythematosus
Wei Deng, Weiwei Chen, Zhuoya Zhang, Saisai Huang, Wei Kong, Yue Sun, Xuebing Feng, Xiaojun Tang, Genhong Yao and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Umbilical cord (UC)-derived mesenchymal stem cells (MSCs) have been confirmed to exert therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…
Abstract Number: 794 • 2015 ACR/ARHP Annual Meeting
CD163+ Macrophages Display Mixed Polarizations in Discoid Lupus Skin
Benjamin Chong¹, Lin-chiang Tseng¹, Gregory Hosler², Noelle Teske¹, Song Zhang³, David R. Karp⁴, Nancy J. Olsen⁵ and Chandra Mohan⁶, ¹Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, ²Propath, Dallas, TX, ³Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, ⁴UT Southwestern Medical Center, Dallas, TX, ⁵Divsion of Rheumatology, Department of Medicine, Penn State MS Hershey Medical Center, Hershey, PA, ⁶Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Discoid lupus erythematosus (DLE) is the most common form of chronic cutaneous lupus. Lesional skin of DLE patients contains macrophages that may transition from…
Abstract Number: 795 • 2015 ACR/ARHP Annual Meeting
High Mobility Group Box-1 (HMGB1) Affects Macrophage Polarization and Phagocytosis in Systemic Lupus Erythematosus Patients
Fleur Schaper¹, Gerda Horst¹, Karina de Leeuw¹, Hendrika Bootsma¹, Pieter C Limburg², Peter Heeringa³, Marc Bijl⁴ and Johanna Westra⁵, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁴Internal Medicine and Rheumatology, Martini Hospital, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
High mobility group box-1 (HMGB1) affects macrophage polarization and phagocytosis in systemic lupus erythematosus patients. F Schaper, G Horst, K de Leeuw, H Bootsma, PC…
Abstract Number: 796 • 2015 ACR/ARHP Annual Meeting
Single Cell Gene Expression Studies in Lupus Patient Monocytes Reveal a Unique Anti-Inflammatory Population of Non-Classical Monocytes Associated with Clinical Quiescence
Zhongbo Jin¹, Wei Fan^2,3, Mark A. Jensen⁴, Jessica M. Dorschner¹, Danielle Vsetecka¹, Shreyasee Amin⁵, Ashima Makol⁶, Floranne C. Ernste⁷, Thomas Osborn⁷, Kevin G. Moder⁵, Vaidehi Chowdhary⁵ and Timothy B. Niewold¹, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China, ³Mayo Clinic, Rochester, MN, ⁴Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Our previous gene expression studies in sorted immune cell populations in SLE has shown that different cell types from the same blood sample demonstrate…
Abstract Number: 797 • 2015 ACR/ARHP Annual Meeting
Divergent Phenotypic Patterns Between Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive Individuals Reveal Distinct Differences in B Cell and Myeloid Populations Among Ethnicities
Samantha Slight-Webb¹, Rufei Lu², Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge¹ and Judith A. James⁵, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder that arises from genetic and environmental factors. Thus, patients with different ancestral backgrounds display differences in…
Abstract Number: 798 • 2015 ACR/ARHP Annual Meeting
Keratinocyte-Associated IL-6 Is Elevated in Cutaneous Lupus Rashes and Production of IL-6 By Keratinocytes Is Enhanced in Non-Involved Lupus Skin
Jasmine Stannard¹, Emily Myers², Tamra J. Reed³, Lori Lowe⁴ and J. Michelle Kahlenberg⁵, ¹Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ²Georgetown University, Washington, DC, ³Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus (SLE) is a devastating autoimmune disease with severe complications such as immune-complex mediated nephritis and scarring skin lesions. Treatment modalities for…
Abstract Number: 799 • 2015 ACR/ARHP Annual Meeting
Transcriptional Profiling of Cutaneous Lupus Reveals Pronounced Changes in Keratinocyte and Myeloid Lineage Expressed Genes and Demonstrates Uniquely Regulated Interferon Pathways Between Rash Subtypes
Celine C. Berthier¹, Jasmine Stannard², Emily Myers³, William Swindell⁴, Lori Lowe⁴, Tamra J. Reed⁵, Johann Gudjonsson⁴ and J. Michelle Kahlenberg⁶, ¹Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ²Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Rheumatology, Georgetown University, Washington, DC, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ⁶Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous lupus rashes can be substantial, disfiguring, and often refractory to usual lupus therapies. Phenotypic presentation and risk of systemic lupus manifestations differs by…
Abstract Number: 800 • 2015 ACR/ARHP Annual Meeting
A High-Throughput System for Quantification of in Vitro Neutrophil Extracellular Trap Formation with Fluorescence Immunocytochemistry
Tineke Kraaij¹, Sylvia Kamerling¹, Ton Rabelink¹, René E. M. Toes², Cees van Kooten¹ and Onno Teng¹, ¹Nephrology, LUMC, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Neutrophil extracellular traps (NETs) consist of decondensed chromatin and antimicrobial peptides and are able to trap and kill pathogens. Several studies suggest a pathogenic…
Abstract Number: 801 • 2015 ACR/ARHP Annual Meeting
Artesunate Modulates Atherosclerosis Related Factors through the Inhibition of STAT1
Xuebing Feng¹, Weiwei Chen², Lihui Xiao¹ and Lingyun Sun², ¹Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: While type I interferon (IFN) has been linked to atherosclerosis progression in systemic lupus erythematosus (SLE), little is known about its regulation and intervention.…
Abstract Number: 802 • 2015 ACR/ARHP Annual Meeting
Identification of Cyclin-Dependent Kinase 1 As a Novel Regulator for Controlling Type I Interferon Signaling in Systemic Lupus Erythematosus
Lingling Wu¹, Bo Qu¹, Yuting Qin¹ and Nan Shen^1,2, ¹Shanghai Institute of Rheumatology,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²The Center for Autoimmune Genomics and Etiology (CAGE),Cincinnati Children’s Hospital Medical Center,Cincinnati, Ohio, United States of America, Cincinnati, OH
Background/Purpose: Type I interferon (IFN) signaling has been a central pathogenic pathway in systemic lupus erythematosus (SLE). The application of specific inhibitors of IFN pathway has emerged…
Abstract Number: 803 • 2015 ACR/ARHP Annual Meeting
Interferon-Alpha Mediated Lowering of Pentraxin-3 Levels in Systemic Lupus Erythematosus?
Lina Wirestam¹, Helena Enocsson², Christopher Sjöwall², Thomas Skogh², Maija-Leena Eloranta³, Lars Rönnblom³ and Jonas Wetterö², ¹Department of Clinical & Experimental Medicine, Rheumatology/AIR, Linkoping, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping, Sweden, ³Medical Sciences, Rheumatology clinic, Uppsala, Sweden
Background/Purpose: The type I interferon (IFN) system is important in the pathogenesis of systemic lupus erythematosus (SLE). We have previously shown an inhibitory effect of…
Abstract Number: 804 • 2015 ACR/ARHP Annual Meeting
Prolactin Induces Interferon Regulatory Factor 1 Activation and Histone H4 Hyperacetylation in Primary Monocytes Comparable to Changes Seen in Monocytes from Systemic Lupus Erythematosus Patients
Yiu Tak Leung¹, Kathleen E. Sullivan², Kelly Maurer³, Li Song⁴ and Lihua Shi³, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: : Epigenetic changes have been described in systemic lupus erythematosus (SLE) and offer a potential explanation for the chronicity of disease. We previously found…
Abstract Number: 805 • 2015 ACR/ARHP Annual Meeting
Interferon Activity in Early and Established SLE: Interferon Score Is Lower in Early Disease and Not Seen without Antibodies to Extractable Nuclear Antigens
Alaa A A Mohamed^1,2,3, Md Yuzaiful Md Yusof^1,4, Yasser El-Sherbiny⁵, Paul Emery^5,6 and Edward M. Vital^2,5, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Rheumatology and Rhabilitation, Assiut University, Assiut, Egypt, ⁴NIHR Leeds Musculoskeletal Biomedical Research Unit,Leeds Teaching Hospital NHS Trust, Leeds University, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds University, Leeds, United Kingdom, ⁶3. NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospital NHS Trust, Leeds University, Leeds, United Kingdom
Background/Purpose: SLE patients have increased expression of interferon-stimulated genes (ISG) and multiple autoantibodies. Some patients initially present with early incomplete SLE (E-ILE) with ANA but…
Abstract Number: 806 • 2015 ACR/ARHP Annual Meeting
STAT1 Activation Promotes TLR8 Overexpression and Facilitates Mirokine Signaling Via Exosomes Containing a Mir-21 Endogenous Ligand: A Novel Innate Inflammatory Pathway in Systemic Lupus Erythematosus
Giancarlo R. Valiente^1,2, Nicholas A. Young², Lai-Chu Wu^3,4, Jeffrey Hampton⁵, Mary Severin⁶, Amy Lovett-Racke⁶ and Wael N. Jarjour⁷, ¹Medical Scientist Training Program, The Ohio State University College of Medicine, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Biological Chemistry and Pharmacology, The Ohio State University College of Medicine, Columbus, OH, ⁵Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ⁶Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH, ⁷Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The adaptive arm of the immune system plays a significant role in the pathophysiology of Systemic Lupus Erythematosus (SLE). However, recent studies suggest that…
Abstract Number: 807 • 2015 ACR/ARHP Annual Meeting
High Levels of Serum IFN-Alpha Mark a Subgroup of SLE Patients with Distinct Immunophenotypic Features and Hyperresponsiveness to Toll-like Receptor Stimulation
Uma Thanarajasingam¹, Mark A. Jensen², Jessica M. Dorschner³ and Timothy B. Niewold³, ¹Division of Rheumatology, Mayo Clinic, Rochester, MN, ²Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: IFN-alpha is a pathogenic factor in SLE. High serum interferon activity (IFN-high) marks a subgroup of SLE patients strongly associated with increased disease severity…

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