Abstract Number: 1947 • 2014 ACR/ARHP Annual Meeting
Prolactin Promotes Survival of Immature B Cells from MRL/Lpr Mice
Background/Purpose Prolactin (PRL) plays an important role in modulating the immune response. PRL is secreted by the pituitary gland as well as many other organs…Abstract Number: 1946 • 2014 ACR/ARHP Annual Meeting
CD22 Is Required for Formation of Memory B Cell Precursors within Germinal Centers
Background/Purpose CD22 is a sialic-acid binding co-receptor expressed primarily on B cells that has a number of functions including adhesion, regulation of B cell homeostasis and…Abstract Number: 1945 • 2014 ACR/ARHP Annual Meeting
Pharmacodynamic Effects of the CD22-Targeted Monoclonal Antibody Epratuzumab on B Cells in Patients with Systemic Lupus Erythematosus
Background/Purpose Epratuzumab is a humanized monoclonal antibody (mAb) that targets the B cell-specific protein CD22 and is currently in Phase 3 clinical trials in patients…Abstract Number: 1944 • 2014 ACR/ARHP Annual Meeting
Targeting CD22 with Epratuzumab Impacts Cytokine Production By B Cells
Background/Purpose CD22 is a negative co-receptor of the B-cell receptor (BCR) and, when targeted by epratuzumab, partially inhibits BCR signaling, for example by reducing Syk…Abstract Number: 1943 • 2014 ACR/ARHP Annual Meeting
In Vivo Effects of Epratuzumab, a Monoclonal Antibody Targeting Human CD22, on B Cell Function in Human CD22 Knock-in (Huki) Mice
Background/Purpose Epratuzumab is a humanized monoclonal antibody that targets the B cell-specific protein CD22 currently in Phase 3 clinical trials in patients (pts) with systemic…Abstract Number: 1942 • 2014 ACR/ARHP Annual Meeting
Regulation of the Responses of Human B Cell Subsets to Innate Immune Signals By Epratuzumab, a Humanized Monoclonal Antibody Targeting CD22
Background/Purpose The B cell-associated receptor, CD22, functions to regulate adhesion and signaling through both the B cell receptor (BCR) and Toll-like receptors (TLRs) expressed in…Abstract Number: 1941 • 2014 ACR/ARHP Annual Meeting
Neuropsychiatric Lupus Is Substantially Unaffected By B-Cell Deficiency
Background/Purpose: Neuropsychiatric lupus (NPSLE) is one of the earliest clinical manifestations in human lupus. However, its mechanisms are not fully understood. In lupus, a compromised…Abstract Number: 1940 • 2014 ACR/ARHP Annual Meeting
A Novel Murine Model of B Cell-Mediated Glomerular Injury Is Mediated By Cytokines
Background/Purpose Lupus nephritis (LN) remains the leading cause of mortality for SLE patients, and is associated with proteinuria and foot process effacement. Podocyte foot process effacement…Abstract Number: 1939 • 2014 ACR/ARHP Annual Meeting
Development of Cell–Based Enzyme–Linked Immunosorbent Assay for the Quantification of Anti–M–type phospholipase–a–receptor Antibodies and Its Clinical Usefulness in Patients with Membranous Nephropathy
Background/Purpose : Better risk prediction is needed to identify patients who will benefit from immunosuppressive therapy with idiopathic membranous nephropathy (MN) due to the variable…Abstract Number: 1938 • 2014 ACR/ARHP Annual Meeting
Effects of Mesenchymal Stem Cells on Human B Cell Proliferation
Background/Purpose: Human mesenchymal stem cells (MSC) are progenitor cells that have immunomodulatory properties. MSCs have been used to treat a variety of autoimmune diseases, including…Abstract Number: 1937 • 2014 ACR/ARHP Annual Meeting
Model Examining Factors Related to Physicians’ Ratings of Disease Activity in Patients with RA
Background/Purpose: The purpose of this study was to examine a multidimensional, integrated model describing the interrelations among rheumatoid arthritis (RA) objective disease activity, patient-rated disease…Abstract Number: 1936 • 2014 ACR/ARHP Annual Meeting
Ageism, Fear, and Competing Co-Morbidities – Why Older Patients May Not Seek Care for Restricting Back Pain: A Qualitative Study
Background/Purpose: Back pain is highly prevalent among older adults and often undertreated. The reasons for this gap in care are poorly understood, especially in older…Abstract Number: 1935 • 2014 ACR/ARHP Annual Meeting
Racial Disparities in Attitude Towards Treatment in Young Women
Background/Purpose: Previous research has found that young minority women tend to be more risk averse compared to their Caucasian counterparts. The reasons underlying these differences,…Abstract Number: 1908 • 2014 ACR/ARHP Annual Meeting
Pregnancy Outcomes in the Tofacitinib RA Safety Database through April 2014
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Its effect in pregnant women is of interest, as tofacitinib…Abstract Number: 1923 • 2014 ACR/ARHP Annual Meeting
Vitamin D Restores Lupus Myeloid Angiogenic Cell Function Via Down-Regulation of IP-10/CXCL-10
Background/Purpose Endothelial repair is important for the maintenance of vascular integrity and is impaired in patients with SLE. Myeloid angiogenic cells (MACs) contribute to endothelial…
ACR Meeting Abstracts