Abstract Number: 1987 • 2014 ACR/ARHP Annual Meeting
Simulation in Continuing Education: Improving Evidence-Based Decisions for Rheumatoid Arthritis Management
Background/Purpose In many patients with rheumatoid arthritis (RA), the disease is not adequately controlled, and only a minority of patients attain the goal of consistent…Abstract Number: 1984 • 2014 ACR/ARHP Annual Meeting
Implementation and Performance of an Objective Structured Clinical Examination (OSCE) in a National Certification Process of Trainees in Rheumatology. Two Years of Experience
Background/Purpose We developed and conducted an OSCE to assess clinical skills of trainees in rheumatology (TRs) and determine its performance at two consecutive annual evaluations…Abstract Number: 1983 • 2014 ACR/ARHP Annual Meeting
Improving Resident Confidence with the Musculoskeletal Exam through a Rheumatology-Dedicated Musculoskeletal Workshop
Background/Purpose Musculoskeletal (MSK) complaints are among the most common complaints evaluated by primary care physicians. Thus, it is imperative that Internal Medicine (IM) residents learn…Abstract Number: 1981 • 2014 ACR/ARHP Annual Meeting
A Qualitative Analysis of Methotrexate Injection Videos on Youtube
Background/Purpose: Methotrexate (MTX) is one of the most commonly prescribed disease modifying antirheumatic drugs for rheumatoid arthritis. While data suggests subcutaneously administered methotrexate is more…Abstract Number: 1980 • 2014 ACR/ARHP Annual Meeting
Thrombospondin-1 Is Elevetad in the Plasma of Patients with Antiphospholipid Syndrome and Is Correlated with Soluble Fas Ligand and Free Active TGF-B levels
Background/Purpose Antiphospholipid syndrome (APS) is an acquired thombophillia characterized by recurrent thromboembolism and pregnancy morbidity. Thrombospondin (TSP-1) is a matricellular glycoprotein with antiangiogenic and proapoptotic…Abstract Number: 1979 • 2014 ACR/ARHP Annual Meeting
Pseudostarvation By AMPK Activator Therapy Is Associated with Reduced Disease Activity and Downregulation of Pro-Inflammatory Responses in Rheumatoid Arthritis (RA)
Background/Purpose AMP-activated protein kinase (AMPK) is a highly conserved, regulator of cellular energy status. In inflammation, AMPK inactivation is associated with increased glucose consumption through…Abstract Number: 1977 • 2014 ACR/ARHP Annual Meeting
The Proangiogenic Function of the Epigenetic Regulator EZH2 in Synovial Tissue Is Mediated By Fibroblasts in Rheumatoid Arthritis
Background/Purpose The histone methyltransferase Enhancer of Zeste 2 (EZH2) is overexpressed in solid tumors and is associated with invasion, malignancy and tumor angiogenesis. EZH2 expression…Abstract Number: 1976 • 2014 ACR/ARHP Annual Meeting
Elevation and Functional Activity of Interferon Omega in Human Systemic Lupus Erythematosus
Background/Purpose IFNα is emerging as a clinically validated target in SLE yet it is currently unclear if other type I IFNs are contributing to the…Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting
Profiling 14-3-3η in Human Primary Cell Based BioMAP® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology
Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions. The 14-3-3 eta…Abstract Number: 1974 • 2014 ACR/ARHP Annual Meeting
Sex Steroids, Interleukin-1, and Interleukin-10 Inhibit interferon–gamma (IFN-γ) Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) in Human Synovial Fibroblasts
Background/Purpose B cell activating factor of the tumor necrosis factor family (BAFF) is a cytokine important for the stimulation and survival of autoreactive B cells…Abstract Number: 1973 • 2014 ACR/ARHP Annual Meeting
Ectopic Lymphoid Neogenesis Is Strongly Associated with Activation of the IL-23/IL-17 Pathway in Rheumatoid Synovitis
Background/Purpose : The functional relevance of synovial ectopic lymphoid neogenesis (ELN) in rheumatoid arthritis (RA) remains unknown. As ELN correlates with the degree of tissue…Abstract Number: 1972 • 2014 ACR/ARHP Annual Meeting
Analysis of Anakinra in Primary Human Cell Systems Reveals an in Vitro Signature for Skin-Related Side Effects
Background/Purpose The therapeutic options for treatment of rheumatic diseases have grown and now include a variety of inflammatory pathway inhibitors, with diverse mechanisms, but having…Abstract Number: 1971 • 2014 ACR/ARHP Annual Meeting
The Role of the Proinflammatory Mediator High-Mobility Group Box Protein 1 (HMGB1) in Anti-Collagen-Antibody-Induced Arthritis Is Dependent on Vascular Endothelial Growth Factor (VEGF)
Background/Purpose High-mobility group box 1 (HMGB1) is a non-histone nuclear protein that is released extracellulary and has been implicated in rheumatoid arthritis (RA) and angiogenesis.…Abstract Number: 1970 • 2014 ACR/ARHP Annual Meeting
TH17 Inflammatory Responses Occur in a Subset of Patients with Erythema Migrans or Lyme Arthritis, but Are Not Predominant Responses in Joints
Background/Purpose Lyme disease usually begins with an expanding skin lesion, erythema migrans (EM), whereas arthritis is a late disease manifestation. The infection usually resolves with…Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting
Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential
Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…
ACR Meeting Abstracts