Abstracts Archive - Page 1912 of 2425 - ACR Meeting Abstracts

Abstract Number: 2103 • 2014 ACR/ARHP Annual Meeting
Benefits of Early Onset of DAS28 (CRP) <2.6 on Physical Functioning, Quality of Life and Resource Use Among RA Patients in a Clinical Practice Setting
E Alemao¹, S Joo², H Kawabata¹, S Banerjee¹, M Frits³, C Iannaccone³, N Shadick³ and M Weinblatt³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Bristol-Myers Squibb, Hopewell, NJ, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Guidelines in RA recommend that treatment should be aimed at reaching a target of remission or low disease activity (LDA) as soon as possible,…
Abstract Number: 2102 • 2014 ACR/ARHP Annual Meeting
A Tissue-Specific Lincrna in the TRAF1-C5 Risk Locus As a Putative Cis-Regulator, Bridging Genetics and Disease
Tobias Messemaker¹, Rute Marques¹, Tom Huizinga¹, Alwin Adriaans¹, Aleida Bakker¹, Arend Berendsen¹, Nina Daha², R E M Toes¹, Harald Mikkers³ and Fina Kurreeman¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Molecular Cell Biology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose In the last decade genome wide association studies (GWAS) have identified genetic polymorphisms that associate with Rheumatoid arthritis (RA). However, the way these genetic…
Abstract Number: 2101 • 2014 ACR/ARHP Annual Meeting
Epigenetic Study of Advanced Ankylosis in Patients with Ankylosing Spondylitis
Darren O'Reilly¹, Yuhua Zhang², Nayef Al Ghanim³, Rose Ardern³, Alexandra Munn³, Sean Hamilton³, Guangju Zhai² and Proton Rahman³, ¹Memorial University of Newfoundland, St. John's, NF, Canada, ²Discipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ³Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory spinal disease characterized by ankylosis of the spine. A subset of patients develops significant ankylosis resulting in mobility…
Abstract Number: 2100 • 2014 ACR/ARHP Annual Meeting
Activation of NFkβ Pathways in Sjögren’s Syndrome Related Lymphomagenesis-Role of the His159Tyr Mutation of the BAFF-R Receptor
Clio Mavragani¹, Adrianos Nezos², Aristea Papageorgiou³, Haralampos M. Moutsopoulos³, Athanasios G. Tzioufas⁴ and Michael Voulgarelis³, ¹Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ³Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ⁴Pathophysiology, School of Medicine, National University of Athens, Athens, Greece
Background/Purpose: Sjögren’s Syndrome (SS) bears the highest risk for lymphoma development among all autoimmune diseases. A growing body of evidence suggests activation of NFκB pathways…
Abstract Number: 2099 • 2014 ACR/ARHP Annual Meeting
Serum C-X-C Motif Chemokine 10 (CXCL10) Is Elevated in Psoriasis Patients Prior to Psoriatic Arthritis Onset
Remy Pollock¹, Fatima Abji¹, Husain Shakil¹, Kun Liang², Vinod Chandran¹ and Dafna D. Gladman^1,3, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a potentially destructive disease that develops in about 30% of patients with cutaneous psoriasis. Biomarkers that can predict which psoriasis…
Abstract Number: 2098 • 2014 ACR/ARHP Annual Meeting
Genetic Variants of the NLRP3 Inflammasome Are Associated with Stroke in Patients with Rheumatoid Arthritis
Alf Kastbom¹, Lisbeth Ärlestig² and Solbritt M. Rantapää-Dahlqvist³, ¹Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ²Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ³Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden
Background/Purpose Inflammasomes are intra-cellular protein complexes important for the production of pro-inflammatory cytokines such as interleukin-(IL-)1β and IL-18. Cardiovascular disease is over-represented in patients with…
Abstract Number: 2097 • 2014 ACR/ARHP Annual Meeting
Identification of Diagnostic and Activity Metabolomic Urine Biomarkers in Six Immune-Mediated Inflammatory Diseases
Arnald Alonso¹, Jesús Tornero², Antonio Fernandez Nebro³, Juan D. Cañete⁴, Eugeni Domènech⁵, Javier P. Gisbert⁶, Carlos Ferrándiz⁵, Eduardo Fonseca⁷, Valle García⁸, Francisco Blanco⁷, Jesus Rodriguez⁹, Jordi Gratacós¹⁰, Patricia Carreira¹¹, Toni Julia¹, Raül Tortosa¹, María América López-Lasanta¹, Xavier Correig¹² and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Hospital Universitario Guadalajara, Guadalajara, Spain, ³Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, ⁴Rheumatology, Hospital Clinic, Barcelona, Spain, ⁵Hospital Universitari Germans Trias I Pujol, Badalona, Spain, ⁶Hospital Universitario de la Princesa, Madrid, Spain, ⁷Complejo Hospitalario Juan Canalejo, A Coruña, Spain, ⁸Hospital Universitario Reina Sofía, Córdoba, Spain, ⁹Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ¹⁰Hospital Parc Taulí, Sabadell, Spain, ¹¹Hospital Universitario 12 de Octubre, Department of Rheumatology, Madrid, Spain, ¹²CIBERDEM, Metabolomics Platform, Reus, Spain
Background/Purpose: Metabolomics is an emergent research field within the omics sciences aimed at characterizing the metabolome in complex biological samples. It provides a powerful approach…
Abstract Number: 2096 • 2014 ACR/ARHP Annual Meeting
Assessment of RA Heterogeneity in Two Independent Cohorts of Patients
Joshua Joung, Yauheniya Cherkas and Sarah Lamberth, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose RA is known to be a heterogeneous disease, with heterogeneity existing in both clinical symptoms and responses to therapies. Molecular assessment of this heterogeneity…
Abstract Number: 2095 • 2014 ACR/ARHP Annual Meeting
Two Novel Serum Urate Levels Associated Genetic Loci Identified By GWAS in European Were Confirmed in Chinese Han Population
Minhui Hua¹, Wenfeng Tan² and Miaojia Zhang³, ¹the first affliated hospital with Nanjing medical university, nanjing, China, ²RHEUMATOLOGY DEPT. 300 GUANGZH, THE FIRST AFFILIATED HOSPITAL OF NANJING MEDI, NANJING, China, ³the first affliated hospital with nanjing medical univercity, nanjing, China
Background/Purpose Previous GWAS have identified four novel loci (SNP rs11264341, rs6770152, rs2941484 and rs7224610) were significant with serum urate levels in European . Here, we…
Abstract Number: 2094 • 2014 ACR/ARHP Annual Meeting
Deep Sequencing Reveals Differential RNA Expression during Malignant Transformation in Major Salivary Glands in a Mouse Model of Sjogren’s Syndrome
Kaiyu Jiang¹, Long Shen², Zihua Hu³, Julian Ambrus⁴ and James Jarvis⁵, ¹415 Carmen Road, Apt. 1, The University at Buffalo, Buffalo, NY, ²Department of Medicine, SUNY at Buffalo, Buffalo, NY, ³Center for Computational Research, University at Buffalo, Buffalo, NY, ⁴100 High St., University Of Buffalo, Buffalo, NY, ⁵Pediatrics, SUNY Buffalo School of Medicine, Buffalo, NY
Background/Purpose – Sjšgren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that targets salivary and lacrimal glands and may be accompanied bymultiorgan systemic manifestations. To further…
Abstract Number: 2093 • 2014 ACR/ARHP Annual Meeting
Improvement of Rituximab Response Prediction in Rheumatoid Arthritis Via Correction for Prednisone-Related Suppression of Type I Interferon Response Gene Expression
Tamarah D. de Jong¹, Saskia Vosslamber¹, Marjolein Blits¹, Gertjan Wolbink², Michael T. Nurmohamed^2,3, Connie J. van der Laken⁴, Gerrit Jansen⁵, Alexandre E. Voskuyl⁵ and Cornelis L. Verweij⁶, ¹Pathology, VU University Medical Center, Amsterdam, Netherlands, ²Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ³VU University Medical Center, Amsterdam, Netherlands, ⁴Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁵Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ⁶Pathology and Rheumatology, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose Elevated type I IFN response gene (IRG) expression has been described to be clinically relevant in predicting the non-response to rituximab in rheumatoid arthritis…
Abstract Number: 2092 • 2014 ACR/ARHP Annual Meeting
Proteomic Phenotyping of Rheumatoid Arthritis Disease Activity
Yauheniya Cherkas, Sarah Lamberth, Carrie Brodmerkel and Mark Curran, Janssen Research & Development, LLC., Spring House, PA
Background/Purpose The use of objective biomarkers of clinical disease characteristics such as disease activity would be beneficial in informing patients, physicians and payers. Recently, a…
Abstract Number: 2091 • 2014 ACR/ARHP Annual Meeting
Plasma Microparticle Protein Features Distinctively Classify Systemic Lupus Erythematosus and Systemic Sclerosis and Their Clinical Phenotype
Ole Østergaard¹, Christoffer T. Nielsen², Line V. Iversen³, Anders A. Bengtsson⁴, Søren Jacobsen⁵ and Niels H. H. Heegaard⁶, ¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institute, Copenhagen S, Denmark, ²Infectious Diseases and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark, ³Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁵Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ⁶Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose Plasma microparticles (MPs) comprise a heterogenous population of submicron membraneous vesicles shed from the cell-surface both constitutively and as a consequence of pathological processes.…
Abstract Number: 2090 • 2014 ACR/ARHP Annual Meeting
Contribution of MTHFR Gene Polymorphisms in Sjogren’s Syndrome Related Lymphomagenesis
Sofia Fragkioudaki¹, Adrianos Nezos², Aristea Papageorgiou³, Michael Voulgarelis³, Mary K. Crow⁴, Haralampos M. Moutsopoulos³ and Clio Mavragani¹, ¹Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ³Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece, ⁴Department of Medicine, Hospital for Special Surgery, New York, NY
Background/Purpose: Sjogren’s syndrome (SS) exhibits the highest susceptibility, among systemic autoimmune diseases, to non-Hodgkin lymphoma (NHL) development. Genetic instability and DNA methylation have been previously…
Abstract Number: 2089 • 2014 ACR/ARHP Annual Meeting
The APOL1 Gene Is Not Associated with Lupus Nephritis in Individuals with Enriched Amerindian Ancestry
Julio Molineros¹, Hannah Ainsworth², Robert Kimberly³, Michelle Petri⁴, Rosalind Ramsey-Goldman⁵, Luis M. Vilá⁶, John D. Reveille^7,8, Elizabeth E. Brown⁹, Swapan Nath¹, Carl D. Langfeld¹⁰, Bernardo Pons-Estel on behalf of GENLES¹¹, Graciela S. Alarcon¹² and Marta E. Alarcon Riquelme¹, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Wake Forest, Winston-Salem, NC, ³University of Alabama, Birmingham, AL, ⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Rheumatology, Northwestern University and Feinberg School of Medicine, Chicago, IL, ⁶Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ⁷Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁸Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰Department of Biostatistics, Wake Forest University Health Sciences, Winston-Salem, NC, ¹¹Sanatorio Parque, Rosario, Argentina, ¹²Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
The APOL1 Gene is not Associated with Lupus Nephritis in Individuals with Enriched Amerindian AncestryBackground/Purpose: The APOL1 gene coding variants G1 and G2 have been…

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