Abstract Number: 2168 • 2014 ACR/ARHP Annual Meeting
Extramedullary Myelopoiesis Drives Persistent Toll-like Receptor-Mediated Inflammation
Background/Purpose: Many rheumatic diseases are driven by chronic, repeated activation of Toll-like receptors (TLR) causing the initiation and perpetuation of disease. However, TLR-activated innate immune…Abstract Number: 2169 • 2014 ACR/ARHP Annual Meeting
Targeting ITGAM+ Cells Successfully Treats a Model of Anti-RNP-Associated Pulmonary Hypertension
Background/Purpose: Aggressive immunotherapy has shown modest effectiveness for pulmonary hypertension in anti-RNP Autoimmunity, but with high morbidity. We studied the ability of an ITGAM-targeted therapy…Abstract Number: 2170 • 2014 ACR/ARHP Annual Meeting
Human Tolerogenic Dendritic Cells Generated with Protein Kinase C Inhibitor Are Optimal for Regulatory T Cell Induction-a Comparative Study
Background/Purpose Tolerogenic dendritic cells (tDCs) are a promising tool for autoimmune diseases, transplantation and allergy. Actually, tDCs have been tried for the therapy of rheumatoid…Abstract Number: 2130 • 2014 ACR/ARHP Annual Meeting
Bone Microstructure in Patients with Cutaneous Psoriasis and No History of Psoriatic Arthritis Shows Bone Anabolic Changes at a Greater Extent Than in Healthy Controls
Background/Purpose Psoriasis (PSO) is a frequent disease which affects about 1-2% of the population and can be associated to arthritis (PsA). Skin disease often predates…Abstract Number: 2131 • 2014 ACR/ARHP Annual Meeting
the Impact of Patient-Reported Flares on Radiographic Progression in Rheumatoid Arthritis Patients with Low-Disease Activity: Secondary Analyses from a Randomized Trial
Background/Purpose Flares, potentially disabling and disease worsening even when a patient is in low disease activity, are common features in patients with rheumatoid arthritis (RA)…Abstract Number: 2132 • 2014 ACR/ARHP Annual Meeting
What Is Associated with X- Ray Progression at 5 Years in Rheumatoid Arthritis (RA) Patients in Low Disease Activity?
Background/Purpose Persistent inflammation on Power Doppler (PD) by ultrasound (US) was associated with relapse and structural progression after one year of follow up in a…Abstract Number: 2133 • 2014 ACR/ARHP Annual Meeting
Efficacy of Tocilizumab Therapy in Patients with Rheumatoid Arthritis Based on FDG-PET/CT
Background/Purpose: A humanized anti-interleukin-6 receptor (anti-IL-6R) antibody, tocilizumab (TCZ), is one of the biologics and the C-reactive protein (CRP) level and erythrocyte sedimentation rate (ESR)…Abstract Number: 2134 • 2014 ACR/ARHP Annual Meeting
Baseline Scintigraphic Detection of TNFá As a Predictor of Therapy Response after Treatment with Certolizumab Pegol in Rheumatoid Arthritis and Spondyloarthritis Patients
Background/Purpose: A major challenge in the biologic era is to predict clinical response. A large variability in the level of TNFα expression has been recognized…Abstract Number: 2135 • 2014 ACR/ARHP Annual Meeting
Patients with Moderate Disease Activity in the First 5 Years of Rheumatoid Arthritis Still Progress Radiographically Despite Conventional Disease Modifying Therapy
Background/Purpose: Patients with moderate disease are an important, and often poorly studied, patient subgroup. The extent to which traditional DMARD therapies adequately control the disease…Abstract Number: 2136 • 2014 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Erosion Detection and Measurement in Longitudinal Datasets Using High-Resolution Peripheral Quantitative Computed Tomography
Background/Purpose An operational case definition for identification of erosions imaged by HR-pQCT was achieved and tested in a first reliability exercise (RELEX-1) using cross-sectional data.…Abstract Number: 2137 • 2014 ACR/ARHP Annual Meeting
Linear Extrapolation of Missing Radiographic Progression Scores Does Not Spuriously overestimate overall Radiographic Progression in Rheumatoid Arthritis
Background/Purpose : Linear Extrapolation (LE) is a frequently applied method to impute missing radiographic data in trials. However, there is frequent critique that LE overestimates…Abstract Number: 2138 • 2014 ACR/ARHP Annual Meeting
Radiological Outcomes after Two Years of Remission Steered Treatment in Early Arthritis Patients
Background/Purpose: We investigated whether early, remission steered treatment can prevent damage progression in patients with early rheumatoid arthritis (RA) or undifferentiated arthritis (UA), and aimed…Abstract Number: 2139 • 2014 ACR/ARHP Annual Meeting
Predictors of Radiologic Disease Progression during the Rheumatoid Arthritis Comparison of Active Therapies Trial
Background/Purpose Halting joint damage is a central goal in the treatment of rheumatoid arthritis. Much research has been conducted to identify factors associated with progressive…Abstract Number: 2140 • 2014 ACR/ARHP Annual Meeting
Agreement Among FDG-PET/CT, Ultrasound and Physical Examination in Patients with Inflammatory Arthritis
Background/Purpose: The lack of tools to accurately measure and quantify joint inflammation is a challenging problem in the study of inflammatory arthritis. No gold standard…Abstract Number: 2141 • 2014 ACR/ARHP Annual Meeting
Sensitivity to Change of Joint Space Width Measurements in Hand Osteoarthritis in a Two Year Follow-up Study
Background/Purpose: Cartilage loss, represented by joint space width (JSW) on radiographs, is an important outcome measure in hand OA disease course. JSW can be assessed…
ACR Meeting Abstracts