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  • Abstract Number: 506 • 2015 ACR/ARHP Annual Meeting

    Evaluation of Persistence and Outcomes in Patients Treated with TNF and Non-TNF Biologics Following Treatment Clinical Pathway in Rheumatoid Arthritis

    Alan K. Matsumoto1, Herbert S. B. Baraf2, Janna Radtchenko3, Jason Drenning4 and Bruce Feinberg5, 1Rheumatology, Arthritis & Rheumatism Assoc, Wheaton, MD, 2The Center for Rheumatology and Bone Research, Wheaton, MD, 3Health Care Analytics, Cardinal Health, Dallas, TX, 4Healthcare Analytics, Cardinal health, Dallas, TX, 5Cardinal Health, Dublin, OH

    Background/Purpose: Use of biologic agents for the treatment of rheumatoid arthritis continues to grow rapidly, with the cost of these agents putting a significant strain…
  • Abstract Number: 507 • 2015 ACR/ARHP Annual Meeting

    Meta-Analysis of the Time Course of the Response to Adalimumab Plus Methotrexate or Methotrexate Monotherapy in Clinical Trials of Patients with Rheumatoid Arthritis

    Xin Wang1, Arthur Kavanaugh2, Désirée van der Heijde3, Maxime Dougados4, Stefan Florentinus1, Yihan Li1, Iain Sainsbury1 and Josef S. Smolen5, 1AbbVie Inc., North Chicago, IL, 2University of California San Diego, La Jolla, CA, 3Leiden University Medical Center, Leiden, Netherlands, 4René Descartes University and Hôpital Cochin, Paris, France, 5Medical University of Vienna and Hietzing Hospital, Vienna, Austria

    Background/Purpose: Adalimumab (ADA) plus methotrexate (MTX) and MTX treatments for rheumatoid arthritis (RA) have been assessed in phase 2–4 clinical trials. This meta-analysis used 5…
  • Abstract Number: 508 • 2015 ACR/ARHP Annual Meeting

    Impact of Race on Patient Global Scores and the Misclassification of Disease Activity

    Shriyanka Jain1, Uzma Khan1, Amy Lundholm2 and Martin Bergman3, 1Internal Medicine, Mercy Catholic Medical Center, Darby, PA, 2Rheumatology, Roger Williams Medical Center, Providence, RI, 3Medicine, Drexel University College of Medicine, Philadelphia, PA

    Background/Purpose: Disease activity measurement is a cornerstone of the Treat to Target strategy. However, all currently used measures include a Patient Global Score (PtGLB )…
  • Abstract Number: 509 • 2015 ACR/ARHP Annual Meeting

    In Early Undifferentiated Polyarthritis, 14-3-3η Seroreversion or Sustained Negativity Is Associated with Better Radiographic Outcomes, Even in DAS-28 Remitters

    Gilles Boire1,2, Nathalie Carrier3, Artur de Brum-Fernandes1,4, Patrick Liang1,4, Ariel Masetto2,5, Yuan Gui6, Jane Savill6, Sara Michienzi6, Henri Ménard7, Walter Maksymowych8 and Anthony Marotta6, 1Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 2Department of Medicine/Division of Rheumatology, University of Sherbrooke, Sherbrooke, QC, Canada, 3Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 4Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 5Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada, 6Augurex Life Sciences Corp., Vancouver, BC, Canada, 7MSK Research Axis, McGill University Health Center Research Institute, Montreal, QC, Canada, 8Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Advancements in RA treatment approaches with DMARDs and biological agents have enabled disease remission goals that were previously considered unattainable. The concept of "tight…
  • Abstract Number: 510 • 2015 ACR/ARHP Annual Meeting

    Histologic Scoring of Arthroplasty Synovial Samples May Predict RA Flare

    Susan M. Goodman1, Rivka Friedlander2, Caroline Figgie2, Alessandra B. Pernis3, Cristina T. Rozo4, Ellen M. Gravallese5, Edward F. DiCarlo6, Laura T. Donlin7, Mark P. Figgie8, Reena Khianey9, Anh Hoang1, Kathleen Andersen10, Luvana Chowdhury11 and VP Bykerk12, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Research, Hospital for Special Surgery, New York, NY, 3Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, 4535 East 70th Street, Hospital for Special Surgery, New York, NY, 5Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 8Orthopaedics, Hospital for Special Surgery, New York, NY, 9Medicine, Hospital for Special Surgery, New York, NY, 10Hospital for Special Surgery, New York, NY, 11Autoimmunity and Inflammation Program/Research, Hospital for Special Surgery, New York, NY, 12Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with established RA undergoing total joint arthroplasty (TJA) frequently experience a disease flare within 6 weeks of surgery. This study aims to determine…
  • Abstract Number: 511 • 2015 ACR/ARHP Annual Meeting

    Pretreatment Prediction of Response to Anti-Cytokine Therapy Using Serum Cytokine/Chemokine/Soluble Receptors in Individual Rheumatoid Arthritis Patient

    KAZUYUKI YOSHIZAKI, Organic Fine Chemicals, The Institute of Scientific and Industrial Research, Osaka University, Suita, Japan

    Background/Purpose: In clinical practice in rheumatoid arthritis (RA), it has been noted that each anti-rheumatic therapy delivers a different outcome for individual RA patients and…
  • Abstract Number: 512 • 2015 ACR/ARHP Annual Meeting

    Physical Function and Inflammatory Activity in Rheumatoid Arthritis Patients. Is Disease Duration Important?

    Emmanuel Bertiller1, Facundo Vergara1, Maria de los Angeles Gallardo1, Javier Rosa2, Erika Catay3, Marina Scolnik1, Maria Victoria Garcia4, Mirtha Sabelli5 and Enrique R. Soriano6, 1Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 2Rheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio,, Buenos Aires, Argentina, 4Internal Services, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 5Cabrera 2964 Piso 6, Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Buenos Aires, Argentina, 6Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: HAQ (Health Assessment Questionnaire) assesses functional disability in rheumatoid arthritis (RA) patients. Correlation between HAQ and disease activity might change according to the length…
  • Abstract Number: 513 • 2015 ACR/ARHP Annual Meeting

    Cumulative Association of Genetic Variants with Rheumatoid Joint Damage Progression in Mexican Americans and European Americans

    Rector Arya1, Inmaculada del Rincon2, Jose Felix Restrepo3, Vidya S Farook4, Christopher P Jenkinson5, Ravindranath Duggirala6 and Agustin Escalante7, 1Pediatrics, University of Texas Health Science Center at San Antonio, San Antonio, TX, 2Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 3Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX, 4Genetics, Texas Biomedical Research Institute, San Antonio, TX, 5University of Texas Health Science Center at San Antonio, San Antonio, TX, 6Regional Academic Health Center, Harlingen, TX, 7Dept. of Medicine-Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX

    Background/Purpose: Genealogical and genetic association studies have suggested that joint damage in rheumatoid arthritis (RA) may be heritable. We and others have found a number…
  • Abstract Number: 514 • 2015 ACR/ARHP Annual Meeting

    MRI Bone Oedema at Enrollment Predicts the Development of Rapid Radiographic Progression at 1 Year Toward Patients with Early-Stage Rheumatoid Arthritis: Results from Nagasaki University Early Arthritis Cohort       

    Yoshikazu Nakashima1, Mami Tamai2, Toru Michitsuji3, Toshimasa Shimizu2, Shoichi Fukui4, Masataka Umeda1, Ayako Nishino1, Tomohiro Koga3, Shin-ya Kawashiri5, Naoki Iwamoto2, Kunihiro Ichinose2, Yasuko Hirai4, Hideki Nakamura4, Tomoki Origuchi6 and Atsushi Kawakami4, 1Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, 2Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 3Department of Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, 4Nagasaki University, Nagasaki, Japan, 5Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan, 6Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan

    Background/Purpose: To clarify whether MRI bone oedema predicts the development of rapid radiographic progression (RRP) in Nagasaki University Early Arthritis Cohort patients with early-stage rheumatoid…
  • Abstract Number: 515 • 2015 ACR/ARHP Annual Meeting

    Are Changes in Autoantibody Levels Reflecting Change in Prognosis of Rheumatoid Arthritis?

    Manuel Unger1, Farideh Alasti1, Paul Studenic1, Josef S. Smolen2,3 and Daniel Aletaha1, 1Department of Internal Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria, 22nd Department of Medicine, Hietzing Hospital, Vienna, Austria, 3Department of Medicine 3, Division of Rheumatology, Medical University Vienna, Vienna, Austria

    Background/Purpose: The presence of rheumatoid factor (RF) and antibodies against citrullinated peptides (ACPA) is associated with progression of joint damage in patients with rheumatoid arthritis…
  • Abstract Number: 516 • 2015 ACR/ARHP Annual Meeting

    Immunological and Ultrasound Characteristics of Patients with Rheumatoid Arthritis in Clinical Remission – Can We Use These to Predict Outcomes?

    Hanna Gul1, Maria Jesus Isorna Porto2, Elizabeth M.A. Hensor3, Frederique Ponchel4, Richard J. Wakefield5 and Paul Emery6, 1Rheumatology, Leeds Institute of Rheumatology and Musculoskeletal Medicine, Leeds, United Kingdom, 2Internal Medicine, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain, 3NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 4Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom, 5University of Leeds, Leeds, United Kingdom, 6Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Remission is the key treatment goal in rheumatoid arthritis (RA).  Although clinical remission is increasingly achieved, many patients progress both structurally and functionally. We…
  • Abstract Number: 517 • 2015 ACR/ARHP Annual Meeting

    Investigating Psychological Predictors of Biologic Treatment Response in Patients with Severe Active Rheumatoid Arthritis

    Bethan England1, Lis Cordingley2, Darren Plant3, Ann Morgan4, Anthony Wilson5, Kimme L. Hyrich6, Anne Barton7 and BRAGGSS Syndicate, 1University of Manchester, Manchester, United Kingdom, 2School of Community Based Medicine, University of Manchester, Manchester, United Kingdom, 3arc Epidemiology Unit, Manchester, United Kingdom, 4Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, 5Genomic Medicine, The University of Sheffield, Sheffield, United Kingdom, 6Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, 7NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Biologic therapy is now a cornerstone of RA management, but treatment response is variable, failing in up to 40% of patients. To direct appropriate…
  • Abstract Number: 518 • 2015 ACR/ARHP Annual Meeting

    Antibody Responses to Citrullinated Porphyromonas Gingivalis Peptidylarginine Deiminase: Associations with Disease Risk Factors and Severity in Rheumatoid Arthritis

    Priyanka Vashisht1, Jeffrey Payne2, Geoffrey M. Thiele3, Harlan Sayles4, Fang Yu5, Michael J. Duryee6, Carlos D. Hunter6, Benjamin Wiese1, Anne-Marie Quirke7, Patrick Venables7 and Ted R. Mikuls8, 1Internal Medicine - Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 3Research Services 151, Omaha VA Medical Center, Omaha, NE, 4University of Nebraska Medical Center, Omaha, NE, 5Public Health, University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 7Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 8Medicine, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoimmunity to citrullinated proteins. Porphyromonas gingivalis (Pg) has been proposed as an epidemiologic link between RA and periodontitis…
  • Abstract Number: 519 • 2015 ACR/ARHP Annual Meeting

    In Indigenous North Americans at High Risk for RA Complement C5 Level Is Associated with ACPA Positivity and C5a with Transition to Synovitis Even after Correcting for in Vitro Complement Activation Found with Prolonged Sample Storage

    Ceri Richards1, Carol Hitchon2, Xiaobo Meng3, Irene Smolik4, David Robinson4 and Hani S. El-Gabalawy4, 1Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, 2Department of Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 3University of Manitoba, Winnipeg, MB, Canada, 4Arthritis Center, University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Complement activation, a key component of innate immunity and activator of adaptive immunity has been linked to RA pathogenesis. Anti-citrullinated peptide antibody (ACPA) and…
  • Abstract Number: 520 • 2015 ACR/ARHP Annual Meeting

    Antibody to Porphyromonas Gingivalis in Pre-Clinical Rheumatoid Arthritis

    Brian Coburn1, Kevin D. Deane2, Jess D. Edison3, Geoffrey M. Thiele1, Michael J. Duryee4, Carlos D. Hunter4, Jeffrey Payne5, Fang Yu6, Harlan Sayles6, V. Michael Holers2, Jill M. Norris7, William R Gilliland8, Jeremy Sokolove9, WH Robinson9 and Ted R. Mikuls1, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 3Walter Reed National Military Medical Center, Bethesda, MD, 4Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 5College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, 6University of Nebraska Medical Center, Omaha, NE, 7Epidemiology, University of Colorado Denver, Aurora, CO, 8Rheumatology Service, Walter Reed National Military Medical Center, Bethesda, MD, 9VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA

    Background/Purpose: Periodontitis (PD) has been implicated as an etiologic risk factor in rheumatoid arthritis (RA), an association that is speculated to be related to the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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