Abstracts Archive - Page 1904 of 2425 - ACR Meeting Abstracts

Abstract Number: 2213 • 2014 ACR/ARHP Annual Meeting
Gene Expression Profiling of T Helper Subsets in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with Juvenile and Adult Dermatomyositis
Consuelo Lopez de Padilla¹, Molly S. Hein¹, Cynthia S. Crowson², Richard S. Pendegraft³, Erik J. Peterson⁴, Emily Baechler⁵ and Ann M. Reed¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Health Sciences Research, Mayo Clinic, Rochester, MN, ³Biomedical Statistics and informatics, Rochester, MN, ⁴University of Minnesota, Minneapolis, MN, ⁵Medicine, University of Minnesota, Minneapolis, MN
Background/Purpose: The molecular and cellular basis for juvenile and adult dermatomyositis (JDM and ADM) presumably is similar. However, important differences in the clinical features, outcome…
Abstract Number: 2214 • 2014 ACR/ARHP Annual Meeting
Power Doppler Ultrasonography for Detection of Abnormal Fascial Vascularity: A Potential Early Diagnostic Tool in Fasciitis of Dermatomyositis
Ken Yoshida¹, Makiko Nishioka², Satoshi Matsushima², Kensuke Joh³, Yosuke Oto¹, Yoshiga Masayuki¹, Kazuhiro Otani¹, Haruyash Ito¹, Kenichiro Hirai¹, Kazuhiro Furuya¹, Taro Ukichi¹, Kentaro Noda¹, Isamu Kingetsu¹ and Daitaro Kurosaka¹, ¹Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, ²Rheumatology, Jikei University School of Medicine, Tokyo, Japan, ³Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
Background/Purpose We have previously demonstrated that fasciitis is a common lesion of dermatomyositis (DM) detectable early after disease onset by en bloc biopsy combined with…
Abstract Number: 2215 • 2014 ACR/ARHP Annual Meeting
Clinical Characteristics and Prognosis of Malignancies Associated with Active Myositis
Sang Jin Lee¹, Eun Ha Kang², Yun Jong Lee², Eun Young Lee³ and Yeong Wook Song⁴, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine,Seoul National University Bundang Hospital, Seongnam, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ⁴Department of Molecular Medicine and Biopharmaceutical Sciences, BK 21 plus Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, South Korea
Background/Purpose: To examine the clinical features and prognosis of cancers associated with active myositis and to compare them with cancers found in patients with myositis…
Abstract Number: 2216 • 2014 ACR/ARHP Annual Meeting
Muscle Type I Interferon Gene Expression May Predict Therapeutic Responses to Rituximab in Myositis Patients
Kanneboyina Nagaraju^1,2, Svetlana Ghimbovschi³, Sree Rayavarapu^2,4, Aditi Phadke⁴, Lisa G Rider⁵, Eric Hoffman^2,4 and Frederick W. Miller⁶, ¹Research Center for Genetic Medicine, Children’s National Medical Center, Washington DC, DC, ²Department of Integrative Systems Biology, The George Washington University, Washington, DC, ³Research Center for Genetic Medicine, Children's National Medical Center, Washington DC, WA, ⁴Research Center for Genetic Medicine, Children's National Medical Center, Washington, DC, ⁵Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, ⁶Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD
Background/Purpose To identify muscle gene expression patterns that predict rituximab responses and assess the effects of rituximab on muscle gene expression in polymyositis (PM) and…
Abstract Number: 2217 • 2014 ACR/ARHP Annual Meeting
Ultrasonography Analysis of Carotid Parameters in Patients with Idiopathic Inflammatory Myopaties: Correlation with Demographic Profile and Disease Activity
Simone Barsotti¹, Maria Aurora Morales², Rosaria Talarico³, Claudia Ferrari¹, Nicole Di Lascio², Anna d'Ascanio¹, Elisabetta Bianchini², Stefano Bombardieri³ and Rossella Neri¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Institute of Clinical Physiology, CNR, Pisa, Italy, ³Rheumatology Unit, Pisa, Italy
Background/Purpose Subclinical cardiovascular (CV) involvement is frequent in patients with idiopathic inflammatory myositis (IIM). Growing interest exists on the role of markers of subclinical CV…
Abstract Number: 2218 • 2014 ACR/ARHP Annual Meeting
Endoplasmic Reticulum (ER) Stress-Induced Mitochondrial Dysfunction and Atrophy Can be Prevented By Pharmacological Upregulation of Heat Shock Protein 70 (HSP) in Cultured Murine Myotubes
Adam P. Lightfoot, Malcolm J. Jackson, Anne McArdle and Robert G. Cooper, Musculoskeletal Biology, University of Liverpool, Liverpool, United Kingdom
Background/Purpose: The symmetrical proximal muscle weakness typical of myositis often fails to improve completely with any treatment, due to irreversible muscle fibre degeneration. Although inflammatory…
Abstract Number: 2219 • 2014 ACR/ARHP Annual Meeting
Contribution of Tripartite Motif Proteins Modulating Membrane Repair to the Pathogenesis of Autoimmune-Mediated Myositis
Jenna Alloush¹, Nicholas A. Young², Kevin McElhanon¹, Wael N. Jarjour³ and Noah Weisleder¹, ¹Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: The idiopathic inflammatory myopathies are a heterogeneous group of diseases that result in autoimmunity toward muscles and lead to tissue destruction, but the pathogenesis…
Abstract Number: 2220 • 2014 ACR/ARHP Annual Meeting
Overexpression of Ankyrin Repeat Domain Containing Protein 1 Gene (ANKRD1) in Polymyositis Muscle Biopsies Is Correlated to Hypoxia
Samuel Katsuyuki Shinjo¹, Sueli Mieko Oba-Shinjo², Miyuki Uno² and Suely Kazue Nagahashi Marie², ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: ANKRD1 codes for ankyrin repeat domain containing protein 1, which belongs to the muscle ankyrin repeat protein family involved in a mechano-signaling pathway that…
Abstract Number: 2221 • 2014 ACR/ARHP Annual Meeting
Reduction of Ovarian Reserve in Adult Patients with Dermatomyositis
Fernando Henrique Carlos de Souza¹, Samuel Katsuyuki Shinjo¹, Lucas Yugo Shiguehara Yamakami², Vilma dos Santos Trindade Viana¹, Edmund Chada Baracat³, Eloisa Bonfa⁴ and Clovis Artur Almeida Silva⁵, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Gynecology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Gynecology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁵Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Dermatomyositis (DM) affects female gender during reproductive age, in which ovarian reserve and future fertility are major topics of interest. However, there is no…
Abstract Number: 2222 • 2014 ACR/ARHP Annual Meeting
Predictors of Myositis Treatments Received and Associated Treatment Responses in Myovision, a National Myositis Patient Registry
Abdullah Faiq¹, Payam Noroozi Farhadi¹, Jesse Wilkerson², Nastaran Bayat¹, Anna Jansen³, Kathryn Rose⁴, Lukasz Itert⁵, Anne Johnson⁶, Christine Parks⁷, Edward H. Giannini⁸, Hermine I. Brunner⁹, Bob Goldberg¹⁰, Richard Morris⁴, Frederick W. Miller¹ and Lisa G. Rider¹, ¹Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, ²Social and Scientific Systems, Inc., Research Triangle Park, NC, ³Environmental Autoimmunity Group, NIEHS / EAG, Bethesda, MD, ⁴Social and Scientific Systems, Inc., Durham, NC, ⁵Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Epidemiology Branch, NIEHS, NIH, Research Triangle Park, NC, ⁸Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹PRCSG, Cincinnati, OH, ¹⁰The Myositis Association, Alexandria, VA
Background/Purpose: Little is known about medications received for myositis and patients’ responses to therapies. We present information on self-reported myositis therapy use and responses from…
Abstract Number: 2223 • 2014 ACR/ARHP Annual Meeting
High Prevalence of Hepatitis C Virus Infection in a Japanese Inclusion Body Myositis Cohort
Akinori Uruha¹, Satoru Noguchi², Yukiko K. Hayashi³, Ikuya Nonaka² and Ichizo Nishino², ¹Department of Clinical Development, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo, Japan, ²Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan, ³Department of Neurophysiology, Tokyo Medical University, Tokyo, Japan
Background/Purpose There have been several case reports of inclusion body myositis (IBM) that appeared after chronic hepatitis C virus (HCV) infection. However, the relationship between…
Abstract Number: 2224 • 2014 ACR/ARHP Annual Meeting
Increased Immune Complex Levels in Children with Juvenile Dermatomyositis Are Not Associated with Levels of Von Willebrand Factor Antigen, C4, Duration of Illness, Disease Activity Score, or the Absolute NK Count
Lauren M. Pachman¹, Akadia Kachaochana², Gabrielle A. Morgan³, Dong Xu², Chiang-Ching Huang⁴ and Anil K. Chauhan⁵, ¹Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Program of Excellence in Cure-Juvenile Myositis (JM) Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ³Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, ⁴Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI, ⁵Rheumatology, Saint Louis University, St. Louis, MO
Background/Purpose: A potential mechanism for the vasculopathy of Juvenile Dermatomyositis (JDM), the most common pediatric inflammatory myopathy, has been attributed to complement mediated immune complex…
Abstract Number: 2225 • 2014 ACR/ARHP Annual Meeting
Does Previous Corticosteroid Treatment Affect the Inflammatory Infiltrate Found in Polymyositis Muscle Biopsies?
Mayara Mendes Pinhata¹, Juliana Jesus do Nascimento¹, Suely Kazue Nagahashi Marie² and Samuel Katsuyuki Shinjo¹, ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: We conducted this study because there have been no studies evaluating the effect of the use of corticosteroids (CE) on the presence of inflammatory…
Abstract Number: 2226 • 2014 ACR/ARHP Annual Meeting
Systemic Treatment for Clinically Amyopathic Dermatomyositis
Janice Lin¹, Alisa Femia², Mital Patel¹, Joseph Merola¹ and Ruth Ann Vleugels¹, ¹Dermatology, Brigham and Women's Hospital, Boston, MA, ²Dermatology, NYU Langone Medical Center, New York, NY
Background/Purpose: Clinically amyopathic dermatomyositis (CADM) is an important subset and accounts for approximately 20% of patients with dermatomyositis (DM). CADM is characterized by the presence…
Abstract Number: 2227 • 2014 ACR/ARHP Annual Meeting
Physical Impairment in Patients with Idiopathic Inflammatory Myopathies Is Predicted By the American College of Rheumatology Functional Status Measure
Laura Cleary¹, Leslie J. Crofford², Archana Srinivas¹, Heather Bush¹, Catherine Starnes¹, Qian Fan¹, Jidan Duan¹, Kirk Jenkins¹, Natasha Fraser¹, Matthew Rutledge¹ and Beatriz Hanaoka³, ¹University of Kentucky, Lexington, KY, ²Div of Rheumatology & Immunology, Vanderbilt University, Nashville, TN, ³Rheumatology, University of Kentucky, Lexington, KY
Background/Purpose The American College of Rheumatology classification criteria of functional status (ACR-FS) in Rheumatoid Arthritis is used as a measure of the consequences of impairment…

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