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  • Abstract Number: 476 • 2015 ACR/ARHP Annual Meeting

    Clinical Disease Activity Measures Change Substantially and Irregularly over Time in Individual Rheumatoid Arthritis Patients Considered to be in Steady State

    Ole Rintek Madsen1,2 and Emilie Lund Egsmose3, 1Department of Reumatology/C, Copenhagen University Hospital Gentofte, Hellerup, Denmark, 2The DANBIO registry, Copenhagen University Hospital Glostrup Rigshospitalet, Glostrup, Denmark, 3Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup, Denmark

    Background/Purpose: Assessment of clinical markers of disease activity is routine in monitoring patients with rheumatoid arthritis (RA) in daily practice. Changes in clinical measures may…
  • Abstract Number: 477 • 2015 ACR/ARHP Annual Meeting

    On-Demand Use of Etanercept Only for Disease Flares Reduced the Disease Activity Score and Structural Damage Equivalent to Fully-Use of Etanercept in RA Patients

    Kentaro Inui1, Tatsuya Koike2, Masahiro Tada3, Yuko Sugioka2, Kenji Mamoto4, Tadashi Okano4, Akira Sakawa5, Kenzo Fukushima6 and Hiroaki Nakamura4, 1Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 2Center for Senile Degenerative Disorders (CSDD), Osaka City University Graduate School of Medicine, Osaka, Japan, 3Orthopaedic Surgery, Osaka City General Hospital, OSAKA, Japan, 4Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 5Orthopaedic Surgery, Osaka City Juso Hospital, Osaka, Japan, 6Orthopaedic Surgery, Fujiidera Municipal Hospital, Fujiidera, Japan

    Background/Purpose: Biological disease-modifying antirheumatic drugs (bDMARDs) are essential in the treatment of rheumatoid arthritis (RA). Biological DMARDs are particularly recommended for patients with active RA…
  • Abstract Number: 478 • 2015 ACR/ARHP Annual Meeting

    Impact of Comorbidities on the Multi-Biomarker Disease Activity Test in Rheumatoid Arthritis Patients

    Jeffrey R. Curtis1, Jeffrey D. Greenberg2, Leslie Harrold3 and J. Lynn Palmer4, 1University of Alabama at Birmingham, Birmingham, AL, 2Corrona, LLC, Southborough, MA, 3Department of Medicine, UMass Memorial Medical Center, Worcester, MA, 4Corrona Research Foundation, Albany, NY

    Background/Purpose: The multi-biomarker disease activity (MBDA) score [Vectra] has been evaluated in a number of settings, yet has only limited data evaluating whether it is…
  • Abstract Number: 479 • 2015 ACR/ARHP Annual Meeting

    How to Recruit Anti-CCP Positive Patients from Primary Care

    Jackie L. Nam1, Laura Hunt1, Elizabeth M.A. Hensor1 and Paul Emery1,2, 1NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom

    Background/Purpose: Around 1% of the population test positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies. This biomarker predicts progression to rheumatoid arthritis (RA) but over a…
  • Abstract Number: 480 • 2015 ACR/ARHP Annual Meeting

    Comparative 10-Year Retention Rates of Adalimumab Used in Mono and Combination Therapy in Rheumatoid Arthritis (RA) Patients from the Rhumadata Clinical Database and Registry

    Denis Choquette1, Louis Bessette2, Jacques Brown3, Boulos Haraoui1, Frédéric Massicotte1, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard4, Diane Sauvageau1, Angèle Turcotte3, Édith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, 3Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada, 4Rhumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada

    Background/Purpose: The recent publication of the concerto trial comparing the use of adalimumab in monotherapy versus in association with methotrexate (MTX) at dose varying from…
  • Abstract Number: 481 • 2015 ACR/ARHP Annual Meeting

    Time to Disease-Modifying Anti-Rheumatic Drug Treatment for New Patients with Rheumatoid Arthritis – Single Center Experience

    Rok Ješe1, Aleš Ambrožič1, Natasa Gaspersic2, Alojzija Hocevar1, Boris Lestan1, Martina Plešivčnik Novljan2, Sonja Praprotnik1, Ziga Rotar1, Alenka Šipek Dolničar1 and Matija Tomšič1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia

    Background/Purpose: In early rheumatoid arthritis (RA), initiation of disease-modifying anti-rheumatic drugs (DMARD) within 12 weeks of symptom onset is associated with a significant benefit in…
  • Abstract Number: 482 • 2015 ACR/ARHP Annual Meeting

    Erosions in the Foot at Baseline Are Predictive of Orthopedic Shoe Use after 10 Years of Treat to Target Therapy

    Sytske Anne Bergstra1, Rosaline van den Berg2, Naghmeh Riyazi3, Gerda M. Steup-Beekman4, Peter A.H.M. van der Lubbe5, Pit J.S.M. Kerstens6, Willem F. Lems7, T. W. J. Huizinga8, Robert B.M. Landewé9,10 and Cornelia F. Allaart1, 1Department of Rheumatology, Leiden Universitary Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Rheumatology, Haga Hospital, The Hague, Netherlands, 4Rheumatology, Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Vlietland Hospital, Schiedam, Netherlands, 6Department of Rheumatology, Reade, Amsterdam, Netherlands, 7Department of Rheumatology, VU Universitary Medical Center, Amsterdam, Netherlands, 8Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 9Amsterdam Rheumatology & Immunology Center, Academic Medical Center, Amsterdam, Netherlands, 10Atrium Medical Center, Heerlen, Netherlands

    Background/Purpose: Orthopaedic shoes (OS) may help to reduce pain and increase activity participation in rheumatoid arthritis (RA) patients, but should ideally not be needed. We…
  • Abstract Number: 483 • 2015 ACR/ARHP Annual Meeting

    Antibody to Malondialdehyde-Acetaldehyde (MAA) Adducts Serve As Biomarkers of Treatment Response in Rheumatoid Arthritis

    Ted R. Mikuls1, Brian Coburn1, Harlan Sayles2, Fang Yu3, Mary Brophy4, James R. O'Dell1, Lynell W. Klassen5 and Geoffrey M. Thiele1, 1Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Omaha, NE, 3Public Health, University of Nebraska Medical Center, Omaha, NE, 4VA Boston Heathcare System, Boston, MA, 5Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Previous reports have demonstrated that malondialdehyde-acetaldehyde (MAA) adducts are produced as a byproduct of oxidative stress and lipid peroxidation and are expressed in…
  • Abstract Number: 484 • 2015 ACR/ARHP Annual Meeting

    Race Plays a Role in Influencing the Modest Lipid Lowering Effects of Hydroxychloroquine in Patients with Rheumatoid Arthritis, Independent of Statin Use

    Myriam Guevara1, Bernard NG1 and Nancy Gove2, 1Rheumatology, University of Washington, Seattle, WA, 2Biostatistics, Seattle Children's, Seattle, WA

    Background/Purpose: Despite remarkable improvements in RA treatment, there is evidence indicating that the mortality gap between RA patients and the general population is not closing.…
  • Abstract Number: 485 • 2015 ACR/ARHP Annual Meeting

    Evaluate the Dose Efficacy Response Relationship of Baricitinib in Patients with Rheumatoid Arthritis

    Xin Zhang, Laiyi Chua, C. Steven Ernest II, William Macias, Terence Rooney and Lai San Tham, Eli Lilly and Company, Indianapolis, IN

    Background/Purpose: Baricitinib (Bari) is an oral inhibitor of Janus kinases (JAK) selective for JAK 1 and 2. It has demonstrated dose-dependent efficacy in patients with…
  • Abstract Number: 486 • 2015 ACR/ARHP Annual Meeting

    Persistence Among Rheumatoid Arthritis Patients Initiating Intravenous or Subcutaneous Anti-Tumor Necrosis Factor Therapy in a Large US Registry Cohort

    Dennis Parenti1, Shelly Kafka1, George W. Reed2, Jeffrey D. Greenberg2,3 and Raphael DeHoratius1,4, 1Janssen Scientific Affairs, LLC, Horsham, PA, 2Corrona, LLC, Southborough, MA, 3NYU School of Medicine, New York, NY, 4Kimmel School of Medicine, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: The objective of this analysis was to examine persistence with intravenous (IV) and subcutaneous (SC) anti-TNF therapies among rheumatoid arthritis (RA) patients (pts) within…
  • Abstract Number: 487 • 2015 ACR/ARHP Annual Meeting

    Early Rheumatoid Arthritis Patients in the Worse Disease Trajectory Group Fail to Achieve Improvement in Physical Function

    Cheryl Barnabe1, Ye Sun2, Susan J. Bartlett3,4, Gilles Boire5, Carol Hitchon6, Edward C. Keystone7, Boulos Haraoui8, J Carter Thorne2, Diane Tin9, Janet E. Pope10, VP Bykerk11 and CATCH Investigators, 1Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 2University of Toronto, Toronto, ON, Canada, 3Division of Rheumatology, Johns Hopkins School of Medicine, Baltimore, MD, 4Medicine , Divisions of Clinical Epidemiology, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, 5Department of Medicine/Division of Rheumatology, Université de Sherbrooke, Sherbrooke, QC, Canada, 6Department of Rheumatology, University of Manitoba, Winnipeg, MB, Canada, 7Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 8Institut de Rhumatologie, Montreal, QC, Canada, 9The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, 10University of Western Ontario, London, ON, Canada, 11Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Disease trajectories in early rheumatoid arthritis (ERA) are characterized by differences in absolute levels of disease activity and rates of improvement, with patients in…
  • Abstract Number: 488 • 2015 ACR/ARHP Annual Meeting

    Six-Year Retention Rates with Abatacept Vs TNF Inhibitors in the Treatment of Rheumatoid Arthritis: Experience from the Real-World Rhumadata Clinical Database and Registry 

    Denis Choquette1, Louis Bessette2, Boulos Haraoui3, Jean-Pierre Raynauld1, Diane Sauvageau1, Angèle Turcotte4, Édith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de recherche en rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, 3Université de Montréal, Montreal, QC, Canada, 4Rheumatology, Centre d’ostéoporose et de rhumatologie de Québec (CORQ), Québec, QC, Canada

    Background/Purpose: The sustainability of any regimen is an important factor to consider when selecting therapy for chronic conditions, such as rheumatoid arthritis (RA). Recent reports…
  • Abstract Number: 489 • 2015 ACR/ARHP Annual Meeting

    Drug Survival and Toxicity of Methotrexate Monotherapy in Daily Clinical Practice.  Results from an Early Arthritis Clinic

    Christian A. Waimann1,2, Margarita Landi3, Fernando Dal Pra3, Gustavo Citera4, Maria Celeste Orozco4, Osvaldo Luis Cerda3, Federico Ceccatto5, Sergio Paira5, Francisco Colombres6, Alberto Berman7, Horacio Berman7, Anastasia Secco8, Marta Mamani8, Maritza Manzano8, Maria Victoria Martire8, Francisco Caeiro9, Maria Haye Salinas10, Alejandro J. Alvarellos10, Ana C. Alvarez10, Javier Rosa11, Valeria Scaglioni12, Enrique R. Soriano11, Josefina Marcos13, Mercedes Argentina García14, AC Costi15, Alejandro Martinez16, Oscar Luis Rillo16, Edson Veloso17, Ricardo V. Juárez18, Maria Elena Crespo19, Ana Quinteros20, Doralia Vasquez20, C Ledesma21, Gabriela Salvatierra21, R Quintana22, Monica Sacnun23 and Marcelo Abdala24, 1Rheumatology, Hospital Dr. Hector Cura, Olavarria, Argentina, 2Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 5Hospital Jose Maria Cullen, Santa Fe, Argentina, 6Tucuman, Centro Médico Privado de Reumatología, Tucumán, Argentina, 7Centro Médico Privado de Reumatología, Tucumán, Argentina, 8Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, 9Reumatología, Hospital Privado de Córdoba, Córdoba, Argentina, 10Rheumatology, Hospital Privado de Córdoba, Córdoba, Argentina, 11Hospital Italiano, Buenos Aires, Argentina, 12Rheumatology, Hospital Italiano, Buenos Aires, Argentina, 13HIGA San Martín, La Plata, Argentina, 14Rheumatology Unit, HIGA San Martín, La Plata, Argentina, 15Rheumatology, HIGA San Martín, La Plata, Argentina, 16Rheumatology, Hospital General de Agudos “Dr. Ignacio Pirovano”, Buenos Aires, Argentina, 17Sanatorio y Universidad Adventista Del Plata, Entre Rios, Argentina, 18Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, 19Hospital Señor del Milagro, Salta, Argentina, 20Centro Integral De Reumatologia, Tucumán, Argentina, 21Instituto Provincial De Rehabilitación Integral, Santiago del Estero, Argentina, 22Rheumatology, Hosp. Provincial, Rosario, Argentina, 23Hosp. Provincial, Rosario, Argentina, 24Hospital Provincial del Centenario, Santa Fe, Argentina

    Background/Purpose: Several trials had reported the efficacy and toxicity of methotrexate monotherapy in patients with early rheumatoid arthritis. However, patients outside clinical trials could be…
  • Abstract Number: 490 • 2015 ACR/ARHP Annual Meeting

    Personalizing the Treat to Target Approach in Rheumatoid Arthritis

    Eric M. Ruderman1, Jennifer Beaumont2, Azra Muftic2, Arthur M. Mandelin II1, Amy Eisenstein2, George J. Greene2 and David Cella2, 1Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: The treat to target (T2T) approach has become part of the standard of care in RA management. Implicit in this approach is patient involvement…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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