ACR Meeting Abstracts

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  • Abstract Number: 2238 • 2014 ACR/ARHP Annual Meeting

    Exploratory Six Month Phase IIa Study of a Potential Disease Modifying Drug in Patients with OA of the Knee

    Ketan Desai, Voltarra Pharma, Easton, PA

    Background/Purpose: No disease modifying drugs exists to treat osteoarthritis.  Recently, a phase II study from Tasmania showed that Zoledronic Acid, a bisphosphonate, has an effect…
  • Abstract Number: 2239 • 2014 ACR/ARHP Annual Meeting

    Efficacy of Ketoprofen Lysine Salt in Reducing Inflammation and Pain in Primary Osteoarthritis of the Hand: Preliminary Results of a Retrospective and Prospective Clinical Trial

    Maurizio Muratore1, Laura Quarta1, Antonella Grimaldi1, Daniela Costanza1, Luigi Lanata2, Michela Bagnasco2, Alessandra Monguzzi2 and Eugenio Quarta1, 1Department of Rheumatology, Hospital Galateo, San Cesario di Lecce, Italy, 2Medical Department, Dompé SpA, Milan, Italy

    Background/Purpose: Osteoarthritis (OA) is a common progressive joint disease and a leading cause of musculoskeletal pain and functional disability worldwide. Despite various interventional treatment approaches…
  • Abstract Number: 2240 • 2014 ACR/ARHP Annual Meeting

    An Exploratory 4-Week Study of a P2X3 Antagonist AF-219 in the Treatment of Patients with Osteoarthritis (OA) of the Knee

    Vibeke Strand1, Michael Kitt2, Alan Kivitz3, Anthony Ford2, Peter Butera2 and Bruce McCarthy2, 1Stanford University, Portola Valley, CA, 2Afferent Pharmaceuticals, Inc., San Mateo, CA, 3Altoona Center for Clinical Research, Duncansville, PA

    Background/Purpose Targeting P2X3 receptors that mediate the sensitizing effects of ATP released from inflamed and damaged tissues on the primary afferent neurons (PAN) of musculoskeletal…
  • Abstract Number: 2241 • 2014 ACR/ARHP Annual Meeting

    Intermittent Analgesic Use and Risk of Pain Exacerbation in Knee Osteoarthritis: A Web Based Case-Crossover Study

    Tahereh Erfani1, Yuqing Zhang2, Joanna Makovey1, Ben Metcalf3, Lyn March1, Kim Bennell3 and David J. Hunter1, 1Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, 2Boston University School of Medicine, Boston, MA, 3University of Melbourne, Melbourne, Australia

    Background/Purpose: The pain experienced by osteoarthritis (OA) patients is neither constant nor stable and most patients experience episodes of pain exacerbations or flares. A number…
  • Abstract Number: 2242 • 2014 ACR/ARHP Annual Meeting

    Effects of Intraarticular (IA) Corticosteroid Injections on Bone Markers and Endogenous Cortisol in Patients with Knee Osteoarthritis (OA): A Randomized, Double-Blind, Placebo Controlled Trial

    Muhammad Imran1, Aruna Baratham2, Jo Wick3, Barbara Lukert4 and Herbert Lindsley5, 1Rheumatology, University of Kansas Medical Center, Kansas City, KS, 2Rheumatology, Allergy and Immunology, Private Community Practice, Kansas city, KS, 3Biostatistics, Kansas University Med Ctr, Kansas City, KS, 4Internal Medicine, Kansas University Medical Center, kansas city, KS, 5Rheumatology, Kansas University Med Ctr, Kansas City, KS

    Background/Purpose: IA steroids are used to treat knee OA. Little is known about the systemic effect of intraarticular steroid injections on bone or the hypothalamic-pituitary-…
  • Abstract Number: 2243 • 2014 ACR/ARHP Annual Meeting

    Comparison Between Two Diclofenac Diethylamine Gel Formulations, 1.16% Vs 2.32%: Is It Only Increasing the Strength of the Active Ingredient Enough?

    Giuseppa Quartarone1 and Nathalie Hasler-Nguyen2, 1Medical Affairs, Novartis CH R&D OU Italy Greece, Milan, Italy, 2Pre-Cinical Development, Novartis CH Global R&D, Nyon, Switzerland

    Background/Purpose Topically applied non-steroidal anti-inflammatory drugs (NSAIDs) can produce clinically effective drug concentrations at a peripheral site, but with low systemic concentrations and thus a…
  • Abstract Number: 2244 • 2014 ACR/ARHP Annual Meeting

    Multimedia Patient Education Tool for Patients with Osteoarthritis

    Aparna Ingleshwar1, Maria A. Lopez-Olivo2, Robert Volk1, Andrea Barbo3, Maria Jibaja-Weiss4, Heather Lin5 and Maria E. Suarez-Almazor6, 1General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 2Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, 3Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 4Office of Outreach and Health Disparities, Baylor College of Medicine, Houston, TX, 5Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, 6The Department of General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX

    Background/Purpose:  The use of video modelling in patient education can result in positive patient outcomes including informed decision-making and improved self-management. The purpose of our…
  • Abstract Number: 2245 • 2014 ACR/ARHP Annual Meeting

    Characteristics of Conventional Footwear and Their Association with Reductions in Knee Loading with a Flexible Footwear Intervention

    Najia Shakoor1, Roy H. Lidtke2, Chris Ferrigno3, Anjali Nair2, Markus A. Wimmer4, Laura E. Thorp5, K. Douglas Gross6 and Joel A. Block2, 1Rheumatology, Rush University Medical Center, Chicago, IL, 2Section of Rheumatology, Rush University Medical Center, Chicago, IL, 3Anatomy, Rush University, Chicago, IL, 4Orthopedic Surgery, Rush University Medical Center, Chicago, IL, 5Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, 6Clinical Epidem Rsrch, Boston Univ School Medicine, Boston, MA

    Background/Purpose: The peak external knee adduction moment (KAM) as measured through gait analyses has been associated with severity, progression and pain in medial knee osteoarthritis (OA);…
  • Abstract Number: 2246 • 2014 ACR/ARHP Annual Meeting

    Reduction of Knee Osteoarthritis Symptoms in a Cohort of Bariatric Surgery Patients

    Andrea Leyton-Mange1, Janice Lin1, Ryan Flanagan1, Evan Wilder1, Jay Bhatia1, Farah Taufiq1, Lauren Browne1, Mukundan Attur1, Renata La Rocca Vieira2, Manish Parikh3, Christine Ren-Fielding3, Steven B. Abramson4 and Jonathan Samuels1, 1Rheumatology, NYU Langone Medical Center, New York, NY, 2Department of Radiology, NYU Langone Medical Center, New York, NY, 3Department of Surgery, NYU Langone Medical Center, New York, NY, 4Dept of Rheumatology/Medicine, NYU Langone Medical Center, New York, NY

    Background/Purpose: Obesity is a modifiable risk factor of knee osteoarthritis (KOA). While medical treatments can have limited beneficial effects, an alternative strategy would target weight…
  • Abstract Number: 2247 • 2014 ACR/ARHP Annual Meeting

    Bariatric Surgery Improves Quality of Life in Patients with Osteoarthritis and Obesity Compared to Non-Surgical Weight Loss

    Christopher Chong1, Sangeeta Kashyap2, Philip Schauer2, Colin O'Rourke3 and M. Elaine Husni4, 1Rheumatology, Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH, 3Quantitative Health Sciences, JJN3-01, Cleveland Clinic, Cleveland, OH, 4Rheumatology Dept A50, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose: Numerous studies support obesity as a strong risk factor for development and progression of knee osteoarthritis (OA).  The potential benefits of massive weight loss,…
  • Abstract Number: 2248 • 2014 ACR/ARHP Annual Meeting

    Clinical Outcomes, Neuropathic Pain and Patient Satisfaction over a 15 Year Period Following Primary Tka: A Repeat-Cross-Sectional Analysis

    Anne Lübbeke1, Matthieu Zingg2, Daniel Fritschy1, Pierre Hoffmeyer1 and Hermes Miozzari2, 1Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland, 2Orthopaedics, Geneva University Hospitals, Geneva, Switzerland

    Background/Purpose Studies evaluating patient-reported long term outcomes (>10 years) after primary TKA are lacking. Moreover, variability in patient satisfaction after TKA has been reported for…
  • Abstract Number: 2249 • 2014 ACR/ARHP Annual Meeting

    Criteria for Clinically Important Worsening in Knee and Hip Osteoarthritis

    Elien A.M. Mahler1, Alfons A. den Broeder2, Vincent J.J.F. Busch3, Johannes W.J. Bijlsma4 and Els van den Ende1, 1Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 2Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 3Orthopedics, Sint Maartenskliniek, Nijmegen, Netherlands, 4Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose Clinically important worsening in OA has not been well defined. Validated worsening criteria are important for research but also clinical practice to make informed…
  • Abstract Number: 2250 • 2014 ACR/ARHP Annual Meeting

    The Effects of Treatment on Disease Symptoms and Progression of Structural Changes in Knee Osteoarthritis Participants from the Osteoarthritis Initiative Progression Cohort

    Jean-Pierre Pelletier1, Camille Roubille1, François Abram2, Marc Dorais3, Philippe Delorme1, Jean-Pierre Raynauld1 and Johanne Martel-Pelletier1, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 2Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, 3StatSciences Inc., Notre-Dame de l’Île-Perrot, QC, Canada

    Background/Purpose: In the perspective of personalized management of osteoarthritis (OA), a clinically relevant concern is the impact of meniscal extrusion on response to treatment. This study evaluated the role…
  • Abstract Number: 2211 • 2014 ACR/ARHP Annual Meeting

    Epidemiologic and Clinical Features of Patients with Adult and Juvenile Dermatomyositis, Polymyositis and Inclusion Body Myositis from Myovision, a National Myositis Patient Registry

    Abdullah Faiq1, Payam Noroozi Farhadi1, Nastaran Bayat1, Mikaela Chase1, Anna Jansen1, Karen Malley2, Jesse Wilkerson3, Kathryn Rose4, Caroll Co4, Lukasz Itert5, Anne Johnson6, Richard Morris4, Christine Parks7, Edward H. Giannini8, Hermine I. Brunner8, Frederick W. Miller1, Bob Goldberg9 and Lisa G. Rider1, 1Environmental Autoimmunity Group, NIEHS, NIH, Bethesda, MD, 2Malley Research Programming, Inc, Bethesda, MD, 3Social and Scientific Systems, Inc., Research Triangle Park, NC, 4Social and Scientific Systems, Inc., Durham, NC, 5Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Epidemiology Branch, NIEHS, NIH, Research Triangle Park, NC, 8Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9The Myositis Association, Alexandria, VA

    Background/Purpose: The myositis syndromes are rare systemic autoimmune diseases, little is known about their epidemiology.  We describe the demographics and comorbidities of patients in a…
  • Abstract Number: 2212 • 2014 ACR/ARHP Annual Meeting

    Serum Adipokines in Dermatomyositis: Correlation with Risk Factors Associated to Cardiovascular Diseases and Metabolic Syndrome

    Marilda Guimarães Silva, Suzana Beatriz Veríssimo de Mello and Samuel Katsuyuki Shinjo, Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Adipokines are a group of cytokines produced by adipose tissue, which include adiponectin, resistin and leptin. The adiponectin has anti-diabetic, anti-inflammatory and anti-atherogenic effects,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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