Abstracts Archive - Page 1889 of 2425 - ACR Meeting Abstracts

Abstract Number: 2464 • 2014 ACR/ARHP Annual Meeting
Anti-Arthritic Effect of Tubastatin A, a Novel Histone Deacetylases-6 Inhibitor, Is Mediated By Stabilization of IkB Via Suppression of Ubiquitin-Proteasome Pathway
Eun Chung Hong¹, Hemin Jeong², Jiwon Hwang², Eun-Kyung Bae¹, Hyungjin Kim², Joong Kyong Ahn³, Hoon-Suk Cha², Eun-mi Koh⁴ and Jaejoon Lee⁴, ¹Samsung Biomedical Research Institute, Seoul, South Korea, ²Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ³Sungkyunkwan univ. school of medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
Background/Purpose: Histone deacetylase-6 (HDAC-6) functions as a non-epigenetic deacetylase for non-histone substrates and regulates microtubule-mediates processes such as cell migration, cell cycle arrest, and angiogenesis.…
Abstract Number: 2465 • 2014 ACR/ARHP Annual Meeting
Cyclic Phosphatidic Acid (cPA) Suppresses MMP-3, a Disintegrin and Metalloproteinase with Thrombospondin Motifs(ADAMTS)-4, -5 and Stimulates HAS2 Expression in Inflammatory Rheumatoid Synovial Fibroblasts Induced with IL-1β and/or TNF-α
Ikuko Masuda^1,2, Kodo Okada³, Hisashi Yamanaka⁴ and Shigeki Momohara⁴, ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Rheumatology, Jyujyo Takeda Rehabilitation Hospital, Kyoto, Japan, ³SANSHO, Co. Ltd., Tokyo, Japan, ⁴Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose Cyclic phosphatidic acid (cPA) is one of bioactive lipid, has been implicated as an mediator of various biological effects including i) antiproliferative effect on…
Abstract Number: 2466 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Rheumatoid Arthritis (RA) Among Shared Epitope-Negative (SE-) Mothers with Shared Epitope-Positive (SE+) Children
Giovanna Cruz¹, Lindsey A. Criswell², Xiaorong Shao³, Hong L. Quach¹, Janelle Noble⁴, Nikolaos Patsopoulos⁵, Michael Busch⁶ and Lisa F. Barcellos¹, ¹Epidemiology, University of California, Berkeley, Berkeley, CA, ²Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Genetic Epidemiology and Genomics Lab, Division of Epidemiology, University of California, Berkeley, Berkeley, CA, ⁴Children's Hospital Oakland Research Institute (CHORI), Oakland, CA, ⁵Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ⁶Blood Systems Research Institute, San Francisco, CA
Background/Purpose RA (RA [MIM 180300]) disproportionately affects women of reproductive age, implicating pregnancy-related factors. Fetal microchimerism (FMC), or the persistence of a small population of…
Abstract Number: 2433 • 2014 ACR/ARHP Annual Meeting
Efficacy of Ketoprofen Vs Ibuprofen and Diclofenac for Treating Pain in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
Fabiola Atzeni^1,2, Alessandra Monguzzi³, Elisabetta Grillo³, Luigi Lanata³ and Piercarlo Sarzi-Puttini², ¹V Giovanni Battista Grassi 74, Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ²Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, ³Medical Department, Dompé SpA, Milan, Italy
Background/Purpose: Patients with rheumatic diseases, including rheumatoid arthritis (RA), describe symptoms such as pain and stiffness as important factors affecting their quality of life. The…
Abstract Number: 2434 • 2014 ACR/ARHP Annual Meeting
Gait Instability in the Elderly: A New Dedicated out-Patients Consultation
Vincent Goeb¹, Bernard Auvinet² and Claude Touzard³, ¹Rhumatology Department, University Hospital, AMIENS, France, ²Rheumatology Unit, Polyclinic, LAVAL, France, ³Gerontology Unit, Hospital of Laval, LAVAL, France
Background/Purpose Gait instability which represents a common but non-specific complaint, mainly in the elderly, is of major interest in PubMed (6038 references). Gait Instability can…
Abstract Number: 2435 • 2014 ACR/ARHP Annual Meeting
‘It’s like the Worst Toothache You’ve Ever Had’ – How Persons with Rheumatoid Arthritis Describe and Manage Pain in Daily Life
Maria Bergström¹, Inger Ahlstrand², Ingrid Thyberg³, Torbjörn Falkmer⁴, Björn Börsbo⁵ and Mathilda Björk⁶, ¹School of Health Sciences, Jönköping University, Jönköping, Sweden, ²School of Health Sciences Jönköping University, Jönköping, Sweden, ³Rheumatology, Linköping University Hospital, Linkoping, Sweden, ⁴School of Occupational Therapy and Social Work, CHIRI, Curtin University, Perth, WA, Australia, Perth, Australia, ⁵Rehabilitation Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden, ⁶Rehabilitation Center and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Background/Purpose: Although it is reported that biological treatment has a positive effect on Rheumatoid arthritis (RA), pain intensity is still moderate to high in the…
Abstract Number: 2436 • 2014 ACR/ARHP Annual Meeting
Analytical and Clinical Evaluation of an Immunoassay for Estimating Immunogenicity of Infliximab and Etanercept in Indian Population
Canna Ghia¹, Shashank Akerkar², Shailaja Sabnis³, Rao RK Uppuluri⁴ and Gautam Rambhad⁵, ¹Medical, Medical Advisor, Pfizer Limited, India, Mumbai, India, ²Rheumatology, Mumbai Arthritis Clinic and Research Centre, Mumbai, India, ³Rheumatology, Sneh Nursing Home,, mumbai, India, ⁴Rheumatology, Sri Deepti Rheumatology Centre, Hyderabad, India, ⁵Medical, Associate Director Medical Services, Pfizer Limited, India, Mumbai, India
Background/Purpose Biologic anti-TNFs in India have improved the patient management. Significant proportions of patients lose response over time or do not respond. Possible explanations are…
Abstract Number: 2437 • 2014 ACR/ARHP Annual Meeting
Why Doesn’t Participation in Activity Increase Following Hip or Knee Replacement?
Aileen Davis¹, Viji Venkataramanan¹, Jessica Bytautas², Rose Wong¹, Lisa Carlesso¹, Anthony Perruccio³ and Fiona Webster², ¹Division of Health Care & Outcomes Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Department of Family and Community Medicine, University of Toronto, Toronto, ON, Canada, ³Toronto Western Hospital, University Health Network, Toronto, ON, Canada
Background/Purpose Activity is critical for healthy aging. Our prior work demonstrated that despite improved pain and function, people did not increase their participation in activity…
Abstract Number: 2438 • 2014 ACR/ARHP Annual Meeting
A Multi-Centre Survey of Tolerability Problems for Patients on Regular Methotrexate
David Walker¹, Emmanuel George², Sarah Gibson³, Una Martin⁴, Hilary Wrightson⁵, Peta S. Heslop⁶, Peter Prowse⁷, Matthew Kalinowski⁷, Adewale O. Adebajo⁸, David Marshall⁹, Michael Reed¹⁰ and Sandra M. Robinson⁶, ¹Dept of Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom, ²Rheumatology, Wirral University Teaching Hospital NHS Foundation Trust, The Wirral, United Kingdom, ³Rheumatology, WIRRAL UNIVERSITY TEACHING HOSPITAL NHS FOUNDATION TRUST, The Wirral, United Kingdom, ⁴Rheumatology, Waterford Regional Hospital, Waterford, United Kingdom, ⁵Rheumatology, Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom, ⁶R&D, North Tyneside General Hospital, North Shields, United Kingdom, ⁷Rheumatology, Hampshire Hospitals NHS Foundation Trust, Basingstoke, United Kingdom, ⁸Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom, ⁹Department of Rheumatology, Inverclyde Royal Hospital, Greenock, United Kingdom, ¹⁰Rheumatology, Inverclyde Royal Hospital, Greenock, United Kingdom
Background/Purpose Methotrexate has become the core DMARD for the treatment of Rheumatoid Arthritis. It has also found utility in treating other forms of inflammatory arthritis…
Abstract Number: 2439 • 2014 ACR/ARHP Annual Meeting
Knee Joint Pathology in Patients with Rheumatoid Arthritis and Osteoarthritis Using a Validated Ultrasound Scoring System: A Cross Sectional Study
Karen Ellegaard¹, Marius Henriksen², Birgit Falk Riecke³, Søren Just⁴, Jakob Espesen⁵, Mohammed Yusuf Naderi⁶ and Henning Bliddal³, ¹Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark, Frederiksberg, Denmark, ²Department of Rheumatology, The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen F, Denmark, ³The Parker Institute, Copenhagen, Denmark, ⁴Department of Rheumatology, Svenborg Sygehus, Svendbotg, Denmark, ⁵Odense Universitetshospital, Odense, Denmark, ⁶Department of Rheumatology, Esbjerg Sygehus, Esbjerg, Denmark
Background/Purpose Ultrasound (US) signs of inflammation in joints are synovial hypertrophy, effusion, and Doppler activity (increased perfusion), which have been demonstrated in both osteoarthritis (OA)…
Abstract Number: 2440 • 2014 ACR/ARHP Annual Meeting
Factors Influencing Health Related Quality of Life (HR-QOL) for Korean Patients with Rheumatoid Arthritis
SeungIn Paek¹, Kyeong Yae Sohng² and Sung-Hwan Park³, ¹Center for Rheumatic disease, ST Mary's Hospital, Seoul, South Korea, ²College of Nursing, The Catholic Univ of Korea, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose The purpose of this study was to identify factors influencing the Health-related quality of life (HR-QOL) for Korean patients with rheumatoid arthritis and factors…
Abstract Number: 2441 • 2014 ACR/ARHP Annual Meeting
Prevalence and Determinants of Treatment Adherence Among Patients with Rheumatoid Arthritis
Maria Celeste Orozco¹, Maria Florencia Marengo², Christian A. Waimann², Ana Inés Marcos³, Amelia Granel³, Sofia Velez⁴, Federico Zazzetti⁵, Juan C. Barreira⁶, Paula Kohan⁷, Oscar L. Rillo⁸, María Victoria Collado⁹, Graciela Gómez¹⁰, Ricardo V. Juárez¹¹, Veronica Lencina¹², Andrea D'Orazio¹³, Gustavo Rodriguez Gil¹³, Mariana Salcedo¹⁴ and Gustavo Citera¹⁵, ¹Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ²Rheumatology section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ³Rheumatology, Hospital San Roque de Gonnet, La Plata, La Plata, Argentina, ⁴Rheumatology, Hospital Britanico, Buenos Aires, Argentina, ⁵Hospital Britanico, Buenos Aires, Argentina, ⁶Rheumatology, British Hospital, Buenos Aires, Argentina, ⁷rheumatology, Hospital Gral. de agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁸Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, Buenos Aires, Argentina, ⁹Instituto de Investigaciones Medicas Alfredo Lanari, Buenos Aires, Argentina, ¹⁰Diaz Colodrero 2537 8° A, Insituto de Investigaciones Medicas de la UBA, Capital Federal, Argentina, ¹¹Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, ¹²Rheumatology section, Hospital Señor del Milagro, Salta, Argentina, ¹³rheumatology, Hospital Municipal de agudos Dr. Leonidas Lucero, Bahía Blanca, Argentina, ¹⁴Consultorio Privado, San Nicolás, Argentina, ¹⁵Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina
Background/Purpose : Treatment adherence is a crucial part of successfully managing rheumatic diseases such as Rheumatoid Arthritis (RA). Low adherence to treatment has been related…
Abstract Number: 2442 • 2014 ACR/ARHP Annual Meeting
Aligning Ethics with Digital Health Technologies and Shared Decision-Making: Interview Accounts of Patients and Clinicians
Anne F. Townsend^1,2,3,4, Paul Adam⁵, Jenny Leese⁶, Linda C. Li^6,7, Michael McDonald², Sheila Kerr⁸, Gordon Whitehead⁸ and Catherine Backman^6,9, ¹Qualitative Research, Arthritis Research Centre of Canada, Richmond, BC, Canada, ²Maurice Young Centre for Applied Ethics, School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ³Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Mary Pack Arthritis Centre, Vancouver, BC, Canada, ⁶Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁷Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ⁸Arthritis Patient Advisory Board, Richmond, BC, Canada, ⁹Department of Occupational Science & Occupational Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose Medical ethics evolves as health care develops. Digital health technologies are transforming health care delivery and patient and clinician relationships. Ethical approaches are shifting…
Abstract Number: 2443 • 2014 ACR/ARHP Annual Meeting
A New Meta-Analysis on Safety of Ketoprofen Vs Ibuprofen and Diclofenac: Risk and Benefit of Nsaids Beyond Efficacy Meta-Analysis
P. Sarzi-Puttini¹, F. Atzeni¹, Luigi Lanata², Alessandra Monguzzi² and Michela Bagnasco², ¹Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy, ²Medical Department, Dompé SpA, Milan, Italy
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for management of mild-to-moderate pain, chronic inflammatory and degenerative joint diseases. Among NSAIDs, ketoprofen, ibuprofen and diclofenac…
Abstract Number: 2444 • 2014 ACR/ARHP Annual Meeting
Pharmacist-Developed Letters May Enhance Success in Obtaining Insurer Approval for Off-Label Use of Biologics
Jessica F. Farrell^1,2,3, Lee S. Shapiro^1,2,4, Joel M. Kremer⁵ and Aixa Toledo-Garcia⁶, ¹Steffens Scleroderma Center, Saratoga Springs, NY, ²The Center for Rheumatology, Albany, NY, ³Pharmacy Practice, Albany College of Pharmacy & Health Sciences, Albany, NY, ⁴Albany Medical College, Albany, NY, ⁵Medicine, Albany Medical College and the Center for Rheumatology, Albany, NY, ⁶Rheumatology, The Center for Rheumatology, Albany, NY
Background/Purpose A growing number of publications suggest that biological DMARDs, predominantly approved for RA, can be efficacious treatment options for several rare rheumatic diseases. These potentially…

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