Abstracts Archive - Page 1888 of 2607 - ACR Meeting Abstracts

Abstract Number: 250 • 2015 ACR/ARHP Annual Meeting
Postvaccination Antibody Titer Data in CAPS Patients Aged 28 Days to 4 Years Treated with Canakinumab: Results of an Open-Label Phase 3 Trial
Paul Brogan¹, Michaël Hofer², Jasmin B. Kuemmerle-Deschner³, Bernard R. Lauwerys⁴, Antonio Speziale⁵, Ken Abrams⁶, Karolynn Leon⁶, Xiaoling Wei⁷ and Ronald Laxer⁸, ¹Department of Paediatric Rheumatology, UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, ²Unité Romande de Rhumatologie Pédiatrique, Hospitalier Universitaire Vaudois, Lausanne, Switzerland, ³University Hospital Tuebingen, Tuebingen, Germany, ⁴Cliniques Universitaires Saint-Luc and Université Catholique de Louvain, Brussels, Belgium, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁷Novartis Pharma, Beijing, NU, China, ⁸University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Patients with autoinflammatory diseases treated with immunosuppressive agents reportedly experience an increased risk of serious infections.1 Therefore, these patients are likely candidates for vaccinations,…
Abstract Number: 251 • 2015 ACR/ARHP Annual Meeting
A New Genetic Mutation in TNF Receptor Associated Periodic Syndrome (TRAPS)
Mark Leith¹, Auleen Millar² and James Burns³, ¹Rheumatology, Antrim Area Hospital,, Antrim, Northern Ireland, ²Rhematology, Antrim area hospital, Antrim, Northern Ireland, ³Antrim area hospital, Antrim, Northern Ireland
Background/Purpose: ,We present the case of a family with a new diagnosis of TRAPs. The father, a 59 year old man with a history of…
Abstract Number: 252 • 2015 ACR/ARHP Annual Meeting
Pyrin (MEFV) Mutations in New York: Revisiting the Mount Sinai Experience with Periodic Fever and Serositis
Daniel Bunker and Mark Matza, Medicine, Mount Sinai Medical Center, New York, NY
Background/Purpose: In 1945, Dr. Sheppard Siegel, a Mount Sinai allergist, described 5 patients with “Benign Paroxysmal Peritonitis,” a disorder now recognized as Familial Mediterranean Fever…
Abstract Number: 253 • 2015 ACR/ARHP Annual Meeting
Multiple Serum Cytokine Profiling to Identify Specific Molecular Networks in Attacks of Familial Mediterranean Fever
Tomohiro Koga¹, Kiyoshi Migita², Shuntaro Sato³, Masataka Umeda⁴, Shoichi Fukui⁵, Ayako Nishino⁴, Shinya Kawashiri⁶, Naoki Iwamoto⁵, Kunihiro Ichinose⁵, Mami Tamai⁵, Hideki Nakamura⁵, Tomoki Origuchi⁷, Yukitaka Ueki⁸, Kazunaga Agematsu⁹, Katsumi Eguchi¹⁰ and Atsushi Kawakami⁴, ¹Departments of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Rheumatology and Clinical Research Center, Nagasaki Medical Center, Omura, Japan, ³Clinical Research Center, Nagasaki University Hospital, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁵Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁶Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁷Department of Rehabilitation Sciences, Nagasaki University, Nagasaki, Japan, ⁸Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Japan, ⁹Department of Infectious Immunology, Shinshu University, Graduate School of Medicine, Shinshu, Japan, ¹⁰Department of Rheumatology, Sasebo Chuo Hospital, Sasebo, Japan
Background/Purpose: Familial mediterranean fever (FMF) is caused by a number of mutations of the MEFV gene, coding for a protein named pyrin that acts as…
Abstract Number: 254 • 2015 ACR/ARHP Annual Meeting
The Interleukin-1 Inhibitor Canakinumab for Familial Mediterranean Fever: Long-Term Beneficial Effect in a Cohort of 13 Patients
KATERINA LASKARI¹, PANAGIOTA BOURA², GEORGE N DALEKOS³, ALEXANDROS GARYFALLOS⁴, DIMITRIOS KAROKIS⁵, DIMITRIOS PIKAZIS⁶, LOUKAS SETTAS⁷, GRIGORIS SKARANTAVOS⁸, ELENA TSITSAMI⁹ and PETROS P SFIKAKIS¹⁰, ¹Rheumatology Unit, 1st Dept. of Propaedeutic Internal Medicine, Athens University Medical School, Athens, Greece, ²Clinical Immunology Unit, 2nd Dept. of Internal Medicine, Aristotle University Medical School, Thessaloniki, Greece, ³Thessaly University Medical School, Larissa, Greece, ⁴4th Department of Internal Medicine, Aristotle University Medical School, Thessaloniki, Greece, ⁵Private rheumatologist, Patras, Greece, ⁶Pathophysiology, Athens University Medical School, Athens, Greece, ⁷First Dept. of Internal Medicine, Rheumatology Section, Aristotle University Medical School, Thessaloniki, Greece, ⁸Bone Metabolic Unit, 1st Dept. of Orthopedics, Athens University Medical School, Athens, Greece, ⁹First Department of Pediatrics, Athens University Medical School, Athens, Greece, ¹⁰1st Dept. of Propaedeutic Internal Medicine, Athens University Medical School, Athens, Greece
Background/Purpose: Interleukin-1 (IL-1) is a major mediator of the inflammatory cascade in Familial Mediterranean Fever (FMF) and an established therapeutic target (1). To retrospectively assess…
Abstract Number: 255 • 2015 ACR/ARHP Annual Meeting
What Acute Phase Reactants Accurately Identify Patients Who Will Develop Amyloidosis in Familial Mediterranean Fever? a Systematic Review
Burak Erer¹, Erkan Demirkaya², Seza Ozen^3,4, Tilmann Kallinich⁵ and Loreto Carmona⁶, ¹Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Gulhane Military Medical Faculty, Ankara, Turkey, ³Pediatric Nephrology and Rheumatology, Hacettepe University, Ankara, Turkey, Ankara, Turkey, ⁴Deptartment. of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey, ⁵Charite, University Medicine Berlin, Berlin, Germany, ⁶Instituto de Salud Musculoesqueletica, Madrid, Spain
Background/Purpose: Familial Mediterranean Fever (FMF) is a prototype of autoinflammatory diseases. Inflammation is expressed by attacks of fever and serositis and elevation of acute phase…
Abstract Number: 256 • 2015 ACR/ARHP Annual Meeting
The Predominant Attack Type and Associated Clinical-Laboratory Conditions in Patients with Familial Mediterranean Fever
Mustafa Cakar¹, Muharrem Akhan², Muhammet Cinar¹ and Sedat Yılmaz¹, ¹Rheumatology, Gulhane Medical Faculty, Ankara, Turkey, ²Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey
Background/Purpose: Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent attacks of fever and serositis. Abdominal pain is the most frequent symptom of…
Abstract Number: 257 • 2015 ACR/ARHP Annual Meeting
Investigation of the Arterial Stiffness and Associated Factors in Patients with Familial Mediterranean Fever
Mustafa Cakar¹, Muharrem Akhan², Tolga Doğan², Gurhan Taskin³, Kadir Ozturk⁴, Muhammet Cinar¹, Erol Arslan² and Sedat Yılmaz¹, ¹Rheumatology, Gulhane Medical Faculty, Ankara, Turkey, ²Internal Medicine, Gulhane Medical Faculty, Ankara, Turkey, ³Internal Medicine Intensive Care, Gulhane Medical Faculty, Ankara, Turkey, ⁴Gastroenterology, Gulhane Medical Faculty, Ankara, Turkey
Background/Purpose: Arterial stiffness represents the viscoelastic properties of the vessel wall. It occurs as a result of known atherosclerotic risk factors such as hypertension, diabetes…
Abstract Number: 258 • 2015 ACR/ARHP Annual Meeting
Quality of Life Changes with Canakinumab Therapy in Adults with Colchicine Resistant FMF
Ahmet Gul¹, Huri Ozdogan², Ozgur Kasapcopur³, Burak Erer⁴, Serdal Ugurlu⁵, S. Sevgi⁶ and Soner Turgay⁷, ¹Department of Internal Medicine, Rheumatology Division, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ³Istanbul University, Cerrahpasa Medical School, Department of Pediatric Rheumatology, Professor of Pediatric Rheumatology, Istanbul, Turkey, ⁴Istanbul Faculty of Medicine, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁵Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ⁶Novartis Pharma, Istanbul, Turkey, ⁷Medical, Novartis Pharma, İstanbul, Turkey
Background/Purpose: Introduction:Familial Mediterranean Fever (FMF), the most common form of the hereditary autoinflammatory disorders, is characterized by recurrent attacks of fever along with serosal or…
Abstract Number: 259 • 2015 ACR/ARHP Annual Meeting
How Safe IT Is to TREAT Pregnant FMF Patients with Anakinra ?
Huri Ozdogan¹, Serdal Ugurlu² and Bilgesu Ergezen¹, ¹Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: To assess the safety and efficacy of anakinra in pregnant FMF patients. Methods: Six FMF patients, treated with anakinra during pregnancy were monitored for…
Abstract Number: 260 • 2015 ACR/ARHP Annual Meeting
Tocilizumab Is Effective in the Treatment of AA Amyloidosis Secondary to Familial Mediterranean Fever
Huri Ozdogan¹, Serdal Ugurlu², Aysa Hacioglu², Yasaman Adibnia² and Vedat Hamuryudan², ¹Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ²Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: AA amyloidosis is the long-term complication of various chronic inflammatory diseases avoidable by the treatment of the underlying disease but with no established treatment…
Abstract Number: 261 • 2015 ACR/ARHP Annual Meeting
Anakinra Treatment in Patients with Familial Mediterranean Fever: A Single-Center Experience
Serdal Ugurlu¹, Bilgesu Ergezen² and Huri Ozdogan², ¹Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Turkey, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: To review the patients followed in our center with FMF who received anakinra, an anti IL-1 receptor antagonist, because of insufficient colchicine response. Methods: FMF…
Abstract Number: 262 • 2015 ACR/ARHP Annual Meeting
Canakinumab Therapy in Patients with Familial Mediterranean Fever
Serdal Ugurlu¹, Emire Seyahi², Gulen Hatemi², Aysa Hacioglu¹, Humeyra Ozcan¹, Fatma Nihan Akkoc¹ and Huri Ozdogan², ¹Rheumatology, Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: It has been reported that Canakinumab reduced the frequency of attacks in patients with Familial Mediterranean Fever (FMF) resistant to colchicine with no apparent…
Abstract Number: 263 • 2015 ACR/ARHP Annual Meeting
Use of Serum Ferritin and Heme Oxygenase 1 for the Diagnosis of Adult-Onset Still’s Disease: A Preliminary Report of Multicenter Study
Yohei Kirino¹, Yasushi Kawaguchi², Yoshifumi Tada³, Seiji Minota⁴, Toshiyuki Ota⁵, Kohei Nagasawa⁶, Hiroshi Tsukamoto⁷, Syuji Takei^8,9, Takahiko Horiuchi¹⁰, Hiroki Takahashi¹¹, Hisae Ichida², Masahiro Iwamoto⁴, Atsuhisa Ueda¹, Akihide Ohta¹², Yoshiaki Ishigatsubo^1,13 and Hypercytokinemia Study Group, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Department of Internal Medicine, Division of Rheumatology, Saga University, Saga, Japan, ⁴Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ⁵Department of Rheumatology, Iizuka Hospital, Iizuka, Japan, ⁶Rheumatic Disease Center, Sawara Hospital, Fukuoka, Japan, ⁷First Dept of Internal Med, Kyushu University, Fukuoka, Japan, ⁸School of Health Sciences, Faculty of Medicine,, Kagoshima University, Kagoshima City, Japan, ⁹School of Health Sciences, Faculty of Medicine, Kagoshima University, Kagoshima, Japan, ¹⁰Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ¹¹epartment of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan, ¹²Department of Adult and Gerontological Nursing, Saga University School of Medicine, Saga, Japan, ¹³Yokosuka Rheumatic Diseases Center, Yokosuka City Hospital, Yokosuka, Japan
Background/Purpose: Yamaguchi's criteria for classification of adult-onset Still's disease (AOSD) has been widely applied in clinic despite it was established decades ago. However, hyperferritinemia, which…
Abstract Number: 264 • 2015 ACR/ARHP Annual Meeting
Clinical Phenotype and Response to Treatment in Adult-Onset Still’s Disease with MEFV Variants
Fumiaki Nonaka¹, Toshimasa Shimizu², Katsumi Eguchi³, Masataka Umeda⁴, Yukitaka Ueki⁵, Keita Fujikawa⁶, Akinari Mizokami⁷, Munetoshi Nakashima⁸, Michio Yasunami⁹, Naoki Iwamoto⁴, Atsushi Kawakami², Yuka Jiuchi¹⁰ and Kiyoshi Migita¹⁰, ¹Department of Rheumatology and Metabloism, Sasebo City General Hospital, Sasebo, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Rheumatology, Sasebo Chuo Hospital, Sasebo, Japan, ⁴Department of Immunology and Rheumatology, Nagasaki University, Nagasaki, Japan, ⁵Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan, ⁶Arthritis and Connective Tissue Disease, Isahaya Health Insurance General Hospital, Isahaya, Japan, ⁷Department of Rheumatology, Isahaya Health Insurance General Hospital, Isahaya, Japan, ⁸Department of Rheumatology, Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan, ⁹Nagasaki University Institute of Tropical Medicine (NEKKEN), Nagasaki, Japan, ¹⁰Department of Rheumatology and Clinical Research Center, Nagasaki Medical Center, Omura, Japan
Background/Purpose: Adult-onset Still’s disease (AOSD) is a rare inflammatory disorder that has been recently classified as a polygenic autoinflammatory disorder. Patients with Familial Mediterranean Fever…

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