ACR Meeting Abstracts

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  • Abstract Number: 2552 • 2014 ACR/ARHP Annual Meeting

    Effectiveness and Safety of Low-Dose Cyclosporine a in Patients with Primary Sjögren’s Syndrome (pSS) with Articular Involvement – Results of a Pilot Study

    Claudia Kedor1, Jan Zernicke1, Anja Hagemann2, Kathrin Mattat1, Gerd Burmester1 and Eugen Feist1, 1Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 2Department of Rheumatology and Immunology, Charité University Medicine, Berlin, Germany

    Background/Purpose Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease, where musculoskeletal manifestations are usually treated by symptomatic measures and different conventional DMARDs by off-label…
  • Abstract Number: 2551 • 2014 ACR/ARHP Annual Meeting

    Presence of Germinal Centers at Baseline Is Associated with Clinical Response of Glandular Essdai Domain after Abatacept Treatment in Primary Sjogren’s Syndrome

    Erlin A. Haacke1, Frans G.M. Kroese2, Petra M. Meiners3, Bert van der Vegt1, Arjan Vissink4, Fred K.L. Spijkervet3 and Hendrika Bootsma2, 1Pathology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 3Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 4Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

    Background/Purpose: Abatacept inhibits the costimulatory interaction of T-lymphocytes and antigen-presenting cells. Treatment of early and active primary Sjögren's Syndrome (pSS) with abatacept decreases disease activity.…
  • Abstract Number: 2550 • 2014 ACR/ARHP Annual Meeting

    Impaired Speckle Tracking As a Marker of Subclinical Left Ventricular Dysfunction in Patients Affected By Primary Sjögren’s Syndrome

    Fabiola Atzeni1, Stefano Galaverna2, Chiara Colombo2, Luigi Gianturco2, Laura Boccassini1, Piercarlo Sarzi-Puttini1 and Maurizio Turiel2, 1Rheumatology Unit, L. Sacco University Hospital, Milan, Italy, 2Cardiology Unit, IRCCS-Galeazzi Orthopedic Institute,, Milan, Italy

    Background/Purpose Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease that particularly affects the salivary and lachrymal glands, and leads to dry eyes and…
  • Abstract Number: 2549 • 2014 ACR/ARHP Annual Meeting

    Renal Involvement in Primary Sjögren’s Syndrome: A Multicenter French Study of 95 Biopsy Proven Cases

    Benjamin Terrier1, Magali Jasiek2, Hélène Francois3, Rafik Mesbah4, Laurent Chiche5, Anne-Laure Fauchais6, Guillaume Moulis7, Guillaume Le Guenno8, Estibaliz Lazaro9, Nathalie Costedoat-Chalumeau10, Raphaèle Seror11, Luc Mouthon1, Loïc Guillevin1, Xavier Mariette12, Eric Thervet13, Alexandre Karras14 and Véronique Le Guern15, 1National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 2Nephrology, Bicêtre Hospital, University Paris Sud, France, Paris, France, 31Nephrology, Bicêtre Hospital, University Paris Sud, France, PARIS, France, 4Nephrology, Hôpital Boulogne sur Mer, France, Boulogne Sur Mer, France, 5147 Boulevard Baille, CHU Marseille, Marseille, France, 6Department of Internal Medicine A, Dupuytren Hospital, Limoges University Hospital, Limoges, France, 7Internal Medicine department, Toulouse, Toulouse, France, 8Internal Medicine department, Clermont-Ferrand, France, 9Hôpital Haut-Lévêque, Pessac, France, 10Internal medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 11Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 12rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, France, 13Nephrology, Hopital Européen Georges Pompidou, APHP, PARIS, France, 14Nephrology, Hôpital Européen Georges Pompidou, APHP, Paris, France, 15Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France

    Background/Purpose Renal involvement is reported in 5 to 25% of patients with primary Sjögren's syndrome (pSS). However, data on pSS-related nephropathy with renal biopsy (RB)…
  • Abstract Number: 2548 • 2014 ACR/ARHP Annual Meeting

    Primary Sjögren’s Syndrome Is Associated with Significant Cognitive Dysfunction

    Mehmet Engin Tezcan1, Seminur Haznedaroglu2, Emine Belgin Kocer3, Cemile Sonmez4, Ridvan Mercan5, Aysegul Atak Yucel6, Hale Zeynep Batur3, Berivan Bitik7 and Berna Goker8, 1Rheumatology, Lutfi Kirdar Kartal EA Hospital,, Istanbul, Turkey, 2Department of Internal Medicine, Division of Rheumatology,, Gazi University School of Medicine,, Ankara, Turkey, 3Department of Neurology, Gazi University School of Medicine,, Ankara, Turkey, 4Public Health Institution of Turkey,, Ankara, Turkey, 5Department of Internal Medicine Division of Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 6Department of Basic Immunology, Gazi University School of Medicine,, Ankara, Turkey, 7Internal Medicine-Rheumatology, Gazi University School of Medicine, Ankara, Turkey, 8Department of Internal Medicine- Rheumatology, Gazi University School of Medicine, Ankara, Turkey

    Background/Purpose Primary Sjögren’s syndrome (PSS) is an autoimmune exocrinopathy with multiple clinical manifestations.  We aimed to evaluate the frequency and type of cognitive dysfunction and…
  • Abstract Number: 2547 • 2014 ACR/ARHP Annual Meeting

    The Impact of Primary Sjögren’s Syndrome on Female Sexual Function

    Jolien F. van Nimwegen1, Suzanne Arends1, Greetje S. van Zuiden1, Arjan Vissink2, Frans G.M. Kroese1 and Hendrika Bootsma1, 1Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, 2Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands

    Background/Purpose . Primary Sjögren's syndrome (pSS) is a chronic and disabling disease, characterized by sicca symptoms of the eyes and mouth as well as fatigue.…
  • Abstract Number: 2546 • 2014 ACR/ARHP Annual Meeting

    Metabolic Disorders Causing Fatigue in Sjogren’s Syndrome

    Lakshmanan Suresh1, Julian Ambrus2, Long Shen3 and Sahana Vishwanath4, 160 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, 2100 High St., University Of Buffalo, Buffalo, NY, 3Department of Medicine, SUNY at Buffalo, Buffalo, NY, 4Medicine, SUNY- Buffalo, buffalo, NY

    Background/Purpose Sjogren’s syndrome (SS) is a complex disorder involving both the innate and immune system. Fatigue is a common feature of the disease. Mitochondrial dysfunction…
  • Abstract Number: 2545 • 2014 ACR/ARHP Annual Meeting

    Risk of Cervical Root and Incisal Caries in Patients with Sjogren’s Syndrome

    Nicola Berman1, Jonathan S. Dunham2, Joshua Baker3 and Frederick B. Vivino4, 1Medicine, Pennsylvania Hospital, Philadelphia, PA, 2Rheumatology, Univ of Pennsylvania, Philadelphia, PA, 3Medicine/Rheumatology, Philadelphia VA Medical Center, Philadelphia, PA, 4Medicine, Penn Presbyt Med Ctr, Philadelphia, PA

    Risk of Cervical Root and Incisal Caries in Patients with Sjogren's SyndromeBackground/Purpose Pathologic (cervical root and incisal caries) cause significant morbidity in patients with Sjogren's…
  • Abstract Number: 2544 • 2014 ACR/ARHP Annual Meeting

    How Does a Younger Age at the Onset of Sjögren’s Syndrome (pSS) Influence the Clinical Presentation and the Clinical Course of the Disease?

    Chiara Baldini1, Luca Quartuccio2, Elena Bartoloni-Bocci3, Roberta Priori4, Francesco Carubbi5, Alessia Alunno3, Roberto Gerli3, Guido Valesini4, Salvatore De Vita2 and Stefano Bombardieri6, 1University of Pisa, Rheumatology Unit, Pisa, Italy, 2Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, 3Clinical and Experimental Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 4Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy, 5Rheumatology Clinic, University of L'Aquila, L'Aquila, Italy, 6Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: (1) To analyze the clinical presentation and the clinical course of Sjögren’s Syndrome (pSS) in Caucasian patients with an “early-onset” pSS and (2) to compare…
  • Abstract Number: 2543 • 2014 ACR/ARHP Annual Meeting

    Anti-Ro/SSA Positive Incomplete Sjögren’s Syndrome

    R. Hal Scofield1, Anne Igoe2, Donald U Stone3, Lida Radfar4, Kimberly S. Hefner5, David M. Lewis6, Stephen Young6, Judy Harris7, Kiely Grundahl7, Biji T. Kurien8, Jacen Maier-Moore9, Kristi A. Koelsch10, James Chodosh11, Nelson L. Rhodus12, Raj Gopalakrishnan13, Barbara M. Segal14, A. Darise Farris15, Courtney G. Montgomery16, Christopher J. Lessard17, Kathy L. Sivils18 and Astrid Rasmussen7, 1US Department of Veterans Affairs Medical Center, Oklahoma City, OK, 2Metro Health, Cleveland, OH, 3Dean McGee Eye Institute, Oklahoma City, OK, 4College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Hefner Eye Care and Optical Center, Oklahoma City, OK, 6College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 7Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 8U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 9Dept. of Clinical Laboratory Science, University of Texas at El Paso, El Paso, TX, 10Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, 11Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, 12University of Minnesota, Minneapolis, MN, 13Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 14Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 15Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 16Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 17825 N.E. 13th St., Oklahoma Medical Research Foundation, Oklahoma City, OK, 18Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren’s syndrome (SS) is a systemic disease characterized by dry eyes and mouth resulting from immune mediated damage and dysfunction of the lacrimal and…
  • Abstract Number: 2542 • 2014 ACR/ARHP Annual Meeting

    La Positive, Ro60 Negative Subset of Primary Sjögren’s Syndrome Is a Reality

    Debashish Danda1, Dat Truong2, Marshall Shaw3, Celia Quang3, Kristi A. Koelsch4, Biji T. Kurien5, Harini Bagavant2, Umesh Deshmukh2 and R. Hal Scofield6, 1Clincial Immunology and Rheumatology, Christian Medical College, Vellore, India, Vellore, India, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, 5U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 6US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose Twenty-nine sera from 348 primary Sjögren’s syndrome patients were identified as anti-Ro60 (anti-SSA) negative and anti-La (anti-SSB) positive by immunodiffusion, line immunoassays and multiplex…
  • Abstract Number: 2541 • 2014 ACR/ARHP Annual Meeting

    Autoantibodies in Pediatric Sjogren’s Patients

    Lakshmanan Suresh1, Minako Tomiita2, Akira Hoshioka3, Long Shen4, Kishore Malyavantham5 and Julian Ambrus6, 160 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, 2Department of Allergy and Rheumatology, Chiba Children’s Hospital, Chiba, Japan, 3Department of Allergy and Rheumatology,, Chiba Children’s Hospital,, Chiba, Japan, 4Department of Medicine, SUNY at Buffalo, Buffalo, NY, 5Research and Development, IMMCO Diagnostics Inc ., Amherst, NY, 6100 High St., University Of Buffalo, Buffalo, NY

    Background/Purpose Sjogren’s syndrome (SS) is a common autoimmune disease involving the salivary and lacrimal glands along with various other organs. It is generally seen in…
  • Abstract Number: 2540 • 2014 ACR/ARHP Annual Meeting

    Sjö™, an Advanced Diagnostic Panel for Detection of Sjögren’s Syndrome Autoantibodies

    Mark Jasek1, Kishore Malyavantham2, Lakshmanan Suresh3, Julian Ambrus4 and Dennis Pardo5, 1Medical and Scientific Affairs, Nicox Inc, Fort Worth, TX, 2Office of Science & Technology, IMMCO Diagnostics Inc., Amherst, NY, 360 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, 4Division of Allergy, Immunology and Rheumatology, Department of Medicine, State University of New York at Buffalo, Buffalo, NY, 5Professional Affairs, Nicox Inc, Fort Worth, TX

    Background/Purpose Sjögren’s syndrome (SS) is a complex autoimmune disease involving the salivary and lacrimal glands along with various systemic manifestations. It is a difficult disease to…
  • Abstract Number: 2523 • 2014 ACR/ARHP Annual Meeting

    Are Biologic Agents Effective on the Treatment of Secondary Amyloidosis: A Multicenter Report on Turkish Rheumatoid Arthritis and Ankylosing Spondylitis Patients

    Omer Nuri Pamuk1, Umut Kalyoncu2, Kenan Aksu3, Salim Donmez4, Yavuz Pehlivan5, Yonca Cagatay6, Ahmet Omma7, Orhan Küçükşahin8, Gozde Yildirim Cetin9, Özün Bayındır10, Fatih Yildiz11, Ayse Balkarli12, Levent Kilic13, Necati Cakir14, Bunyamin Kisacik15, Ahmet Mesut Onat15, Mustafa Ferhat Özgür16, Veli Cobankara12 and Mehmet Sayarlioglu17, 1Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, 2Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey, 3Rheumatology, Ege University School of Medicine, Izmir, Turkey, 4Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey, 5Rheumatology, Uludag University, School of Medicine, Bursa, Turkey, 6Department of Rheumatology, Bilim University Faculty of Medicine, Istanbul, Turkey, 7ROMATOLOJI SERVISI, IST. UNV. TIP FAK. HASTANESI, ISTANBUL, Turkey, 8Trakya University Medical Faculty, İstanbul, Turkey, 9Ismet Pasa Mah, None, Kahramanmaras, Turkey, 10Ege University Medical Faculty, Izmir, Turkey, 11Rheumatology, Cukurova University, School of Medicine, Adana, Turkey, 12Department of Rheumatology, Pamukkale University School of Medicine, Denizli, Turkey, 13Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 14Fatih Sultan Mehmet State Hospital, İstanbul, Turkey, 15Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, 16Uludag University Medical Faculty, Bursa, Turkey, 17Rheumatology, KahramanmarasSutçü ImamUniversity School of Medicine, Kahramanmaras, Turkey

    Background/Purpose Biologic drugs including anti-TNF agents have been used in the treatment of secondary amyloidosis, however, there is no controlled study concerning the efficacy of…
  • Abstract Number: 2522 • 2014 ACR/ARHP Annual Meeting

    Effect of Infliximab Dose Increase in Rheumatoid Arthritis at Different Trough Concentrations

    Alejandro Balsa1, Chamaida Plasencia-Rodriguez2, Maria Gema Bonilla3, Alejandro Villalba2, Diana Peiteado2, Sara Garcia-Carazo4, Laura Nuño5, Teresa Jurado6, Emilio Martín-Mola7 and Dora Pascual-Salcedo8, 1Rheumatology, Hospital La Paz-IdiPaz, Madrid, Spain, 2Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, 3Rheumatology Unit, La Paz University Hospital, Madrid, Spain, 4Rheumatology, Hospital La Paz-Idipaz, Madrid, Spain, 5Hospital La Paz-IdiPaz, Madrid, Spain, 6Immunology, La Paz University Hospital-Idipaz, Madrid, Spain, 7Rheumatology, Hospital Universitario La Paz, Madrid, Spain, 8Immunology, La Paz University Hospital, Madrid, Spain

    Background/Purpose To evaluate the effects of infliximab (Ifx) dose increase in active rheumatoid arthritis (RA) patients, presenting different serum infliximab concentrations.Methods Retrospective study including 42…
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