Abstract Number: 98 • 2015 ACR/ARHP Annual Meeting
The Mitochondrial DNA (mtDNA) Haplogroups Influence the Risk of Incidence Knee OA. Replication Study Including Data from Check and OAI Cohorts
Background/Purpose:Previous studies showed a significant influence of the mtDNA haplogroups on prevalence, radiographic progression and cartilage integrity of knee OA patients from different worldwide cohorts.…Abstract Number: 99 • 2015 ACR/ARHP Annual Meeting
Personalised Genetic Medicine: HLA-DRB1 Amino Acid Positions 11, 71 and 74 Predict Inflammation Level, Disease Activity and Disability in Rheumatoid Arthritis
Background/Purpose: Amino acid (AA) positions 11, 71 and 74 inside HLA-DRB1 confer susceptibility to rheumatoid arthritis (RA). AAs from these positions form 16 haplotypes, hierarchically…Abstract Number: 100 • 2015 ACR/ARHP Annual Meeting
Validation of a Distinct Psoriatic Arthritis Risk Variant at IL23R
Background/Purpose: Psoriatic Arthritis (PsA) is an inflammatory arthritis that is associated with psoriasis. In the UK, it is estimated to present in approximately 14% of…Abstract Number: 101 • 2015 ACR/ARHP Annual Meeting
New Technologies for Typing Self-Identifying Antigens Encoded By HLA Genes Provide Cost-Effective Alternatives to Identifying B27 Allele Status in Rheumatoid Arthritis Subjects
Background/Purpose: Human leukocyte antigen (HLA) genes code for proteins that allow the immune system to distinguish self from foreign cells. These genes have important indications…Abstract Number: 102 • 2015 ACR/ARHP Annual Meeting
Xanthine Oxidase Gene Variants and Their Association with Blood Pressure and Incident Hypertension: A Population Based Study
Background/Purpose: Uric acid (UA) has been associated with blood pressure (BP) and hypertension. During the final stage of purine metabolism, xanthine oxidoreductase (XOR) breaks down…Abstract Number: 103 • 2015 ACR/ARHP Annual Meeting
Axial Disease in Psoriatic Arthritis: Genetic Biomarkers of Psoriatic Spondyloarthritis
Background/Purpose: A lack of well-characterised clinical cohorts has impeded research of the genetics of axial disease in psoriatic arthritis (PsA). We sought to determine genetic…Abstract Number: 104 • 2015 ACR/ARHP Annual Meeting
A Genome-Wide Association Study Identifies SLC8A3 As a Susceptibility Locus for ACPA-Positive Rheumatoid Arthritis
Background/Purpose: Rheumatoid Arthritis (RA) patients with serum anti-citrullinated peptide antibodies (ACPA) have a strong and specific genetic background. We performed a genome-wide association study (GWAS)…Abstract Number: 105 • 2015 ACR/ARHP Annual Meeting
Analysis of the Association of PTGER4 Gene Variants with Radiological Joint Damage in Rheumatoid Arthritis
Background/Purpose: PTGER4(prostaglandin E receptor 4) is implicated in immune regulation and bone metabolism. The aim of this study was to analyze the role of single…Abstract Number: 106 • 2015 ACR/ARHP Annual Meeting
Does the Timing of Phenotype Assessment Influence Association Results in Pharmacogenetics Studies of Anti-TNF Response in Rheumatoid Arthritis?
Background/Purpose: Pharmacogenetics studies of anti-tumor necrosis factor (TNF) response among patients with rheumatoid arthritis (RA) have routinely used assessment of response at a single time-point,…Abstract Number: 107 • 2015 ACR/ARHP Annual Meeting
FCGR3A-158V/F Polymorphism Is Associated with a Lower Response Rate to Tumor Necrosis Factor α Blockers in Early Axial Spondyloarthritis: Data from the DESIR Cohort
Background/Purpose: The rs396991 polymorphism of FCGR3A alters the Fcγ Receptor Type IIIA function by enhancing or diminishing the affinity to the Fc of immunoglobulins (1)…Abstract Number: 108 • 2015 ACR/ARHP Annual Meeting
A New Susceptibility Locus for Systemic Lupus Erythematosus on Chromosome 12
Background/Purpose: Genome-wide association studies (GWASs) and large follow-up studies in European-descent or Asian subjects have identified a number of susceptibility loci for systemic lupus erythematosus…Abstract Number: 109 • 2015 ACR/ARHP Annual Meeting
Association of HLA-G and Leukocyte Immunoglobulin-like Receptor A3 Polymorphisms with the Susceptibility to Pulmonary Hyterpention in Systemic Sclerosis
Background/Purpose: Human leukocyte antigen-G (HLA-G) is a non-classical class I molecule expressed in the immune cells, the spleen, and the lungs, and plays a key…Abstract Number: 110 • 2015 ACR/ARHP Annual Meeting
Genome-Wide DNA Epigenetic Profiling of Monozygotic Twins[L1] Discordant for ACPA or ACPA-Positive Rheumatoid Arthritis Reveals Novel Associated Genes
Background/Purpose: Occurrence and progression of complex autoimmune diseases are orchestrated by interactions between genes and environment, in part mediated by epigenetic mechanisms. It is yet…Abstract Number: 111 • 2015 ACR/ARHP Annual Meeting
The Mitochondrial DNA (mtDNA) Haplogroups Influence the Risk of Radiographic OA Progression. a Meta-Analysis
Background/Purpose: In the last years the role played by the mtDNA haplogroups in the pathogenesis of OA attracted much attention. The aim of this study…Abstract Number: 112 • 2015 ACR/ARHP Annual Meeting
The Molecular Genetic Analysis of the Autoinflammatory Syndromes in Russian Patients with Manifestation of Systemic Juvenile Idiopathic Arthritis
Background/Purpose: Group of monogenic autoinflammatory syndromes is characterized by recurrent episodes of fever and inflammation. Methods: The study included 90 pts (37 boys, 63 girls)…
ACR Meeting Abstracts