Abstracts Archive - Page 1877 of 2607 - ACR Meeting Abstracts

Abstract Number: 83 • 2015 ACR/ARHP Annual Meeting
Immediate Benefits of a Multidisciplinary Educational Program for Fibromyalgia on Patients’ Pain Related Self-Efficacy and Health Locus of Control
Amrita Kaur Bath¹, Carmen E. Gota², Anabelle Morales Cavolo³ and Sara Davin⁴, ¹Internal medicine, Fairview Hospital- Cleveland Cinic, Cleveland, OH, ²Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ³former Cleveland Clinic fellow, Cleveland, OH, ⁴Neurologic Institute, Cleveland Clinic, Cleveland, OH
Background/Purpose: To evaluate the effect of an intensive, brief, multidisciplinary educational intervention on self –efficacy and locus of control specific self-management constructs, in patients who…
Abstract Number: 84 • 2015 ACR/ARHP Annual Meeting
Sexual Dimorphism in the Association Between Multi-Site Pain and Other Fibromyalgia Features: an Analysis of Data from Three UK Population-Based Studies
Linda E. Dean¹, Lesley Arnold², Robert Bennett³, Leslie J. Crofford⁴, Don Goldenberg⁵, Elisa Flüß¹, Daniel J. Clauw⁶, Mary-Ann Fitzcharles⁷, Eduardo Paiva⁸, Roland Staud⁹ and Gary J. Macfarlane¹, ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²University of Cincinnati, Cincinnati, OH, ³SN-Office of Research & Development, Oregon Health & Science Univ, Portland, OR, ⁴Medicine, Vanderbilt University, Nashville, TN, ⁵Newton-Wellesley Hospital, Newton, MA, ⁶Anesthesiology, University of Michigan, Ann Arbor, MI, ⁷MGH, Montreal, QC, Canada, ⁸Rheumatology, Universidade Federal do Parana, Curitiba Parana, Brazil, ⁹University of Florida, Gainesville, FL
Background/Purpose: The 2011 modification of the preliminary 2010 American College of Rheumatology criteria for fibromyalgia require the self-report of multi-site pain in addition to a…
Abstract Number: 85 • 2015 ACR/ARHP Annual Meeting
Low Socioeconomic Status, High Disability Rates, and Increased Use of Health Care Resources in Fibromyalgia Patients Taking Narcotics
Carmen E. Gota¹, Sahar Kaouk² and William Wilke³, ¹Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ²Undergraduate, John Caroll University, University Heights, OH, ³retired Cleveland Clinic staff, Cleveland, OH
Background/Purpose: To determine the prevalence and characteristics of fibromyalgia patients who are prescribed opiod drugs.Methods: Consecutive patients who met the ACR 1990 criteria for fibromyalgia,…
Abstract Number: 86 • 2015 ACR/ARHP Annual Meeting
Auxilin Is a Novel Susceptibility Gene for Congenital Heart Block Modulating Cardiac Function
Sabrina Meisgen¹, Malin Hedlund¹, Aurélie Ambrosi¹, Lasse Folkersen², Vijole Dzikaite-Ottosson³, Bo Ding¹, Linn Strandberg⁴, Luca Biavati⁴, Daniel Ramsköld⁵, David Forsberg¹, Lisa Bergin¹, Sabrina Ruhrmann¹, The Swedish Congenital Heart Block Study Group¹, Robert M. Hamilton⁶, Anders Franco-Cereceda¹, Anders Hamsten¹, Tomas Olsson⁷, Lois Greene⁸, Per Eriksson¹, Kristina Gemzell-Danielsson¹, Stina Salomonsson¹, Vijay K. Kuchroo⁹, Eric Herlenius¹, Ingrid Kockum⁷, Sven-Erik Sonesson¹ and Marie Wahren-Herlenius¹⁰, ¹Karolinska Institutet, Stockholm, Sweden, ²Technical University of Denmark, Copenhagen, Denmark, ³Department of Medicine, Rheumatology Unit, Centre for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden, ⁴Hospital for Sick Children Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ⁶Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ⁷Neuroimmunology, Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden, ⁸National Heart, Lung and Blood Institute, Bethesda, MD, ⁹Center of Neurological Disease, Harvard Medical School, Boston, MA, ¹⁰Department of medicine, Rheumatology unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Congenital heart block (CHB) may affect children of women with anti-Ro/SSA and anti-La/SSB autoantibodies. The most recognized manifestation of CHB is an atrioventricular (AV)…
Abstract Number: 87 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA) Risk Gene CCR6 Polymorphism: Drug-Induced “Reversal” of ER Binding and the Expression of Inflammatory Mediators -Potential Molecular Mechanism Links Between Estrogen and RA
Ming-Fen Ho¹, Richard M. Weinshilboum², Liewei Wang², James N. Ingle³ and Tim Bongartz⁴, ¹Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Rochester, Rochester, MN, ²Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, ³Department of Medical Oncology, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: The rheumatoid arthritis (RA) risk locus CCR6 SNP rs3093024, is in tight linkage disequilibrium with rs3093023 which has been associated with RA risk. RA…
Abstract Number: 88 • 2015 ACR/ARHP Annual Meeting
Integrating Evidence for Genetic Association and Natural Selection Helps Detect New Systemic Lupus Erythematosus Risk Loci in African-Americans
Paula S. Ramos¹, Satria Sajuthi², Jasmin Divers³, Kenneth M. Kaufman⁴, Uma Nayak⁵, Wei-Min Chen⁵, Kelly J. Hunt⁶, Diane L. Kamen⁷, Gary S. Gilkeson⁸, Jyotika K. Fernandes⁷, Ida J. Spruill⁹, Robert P. Kimberly¹⁰, John B. Harley¹¹, W. Timothy Garvey¹², Michèle M. Sale¹³ and Carl D. Langefeld², ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Public Health Sciences, University of Virginia, Charlottesville, VA, ⁶Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁷Medicine, Medical University of South Carolina, Charleston, SC, ⁸Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁹Nursing, Medical University of South Carolina, Charleston, SC, ¹⁰Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹²Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ¹³Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA
Background/Purpose: In many rheumatologic and autoimmune diseases African Americans (AA) have a higher prevalence and greater disease severity than other ethnicities. We posit that population-specific…
Abstract Number: 89 • 2015 ACR/ARHP Annual Meeting
A Longitudinal Genome-Wide Association Study of Anti-Tumor Necrosis Factor Response Among Japanese Patients with Rheumatoid Arthritis
Kyoko Honne¹, Ingileif Hallgrimsdottir², Chunsen Wu³, Ronnie Sebro⁴, Nicholas Jewell², Takeo Sakurai⁵, Masahiro Iwamoto⁶, Seiji Minota⁶ and Damini Jawaheer⁷, ¹Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ²UC Berkeley, Berkeley, CA, ³University of Southern Denmark, Odense, Denmark, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Inoue Hospital, Takasaki, Japan, ⁶Department of Internal Medicine, Division of Rheumatology/Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, ⁷Children's Hospital Oakland Research Institute, Oakland, CA
Background/Purpose: Studies of patients with rheumatoid arthritis (RA) to identify genetic biomarkers of anti-tumor necrosis factor (TNF) response have been conducted mostly in Caucasian populations.…
Abstract Number: 90 • 2015 ACR/ARHP Annual Meeting
Influence of Susceptible HLA-DRB1 Alleles on Clinical Subphenotypes of Systemic Lupus Erythematosus in Koreans
So-Young Bang¹, Ji-Young Choi¹, Songree Park¹, Seung Lee², Jeongim Choi¹, Seung-Jae Hong³, Hye-Soon Lee¹, Chan-Bum Choi¹ and Sang-Cheol Bae¹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Kyung Hee University Hospital, seoul, South Korea
Background/Purpose: We investigated the association between human leukocyte antigen (HLA)-DRB1 alleles and systemic lupus erythematosus (SLE) susceptibility and whether each allele has a significant effect…
Abstract Number: 91 • 2015 ACR/ARHP Annual Meeting
Coevolution of a Uric Acid Transporter and Uricase: Implications for Gout
Philip K. Tan¹, Eric A. Gaucher² and Jeffrey N. Miner³, ¹Ardea Biosciences, San Diego, CA, ²Georgia Institute of Technology, Atlanta, GA, ³Discovery Biology, Ardea Biosciences, San Diego, CA
Background/Purpose: Gout is caused by chronic hyperuricemia, leading to uric acid deposition. Humans and apes have relatively high serum uric acid (sUA) levels due to…
Abstract Number: 92 • 2015 ACR/ARHP Annual Meeting
Variation at Interleukin-6 Receptor Gene Is Associated to Joint Damage in Rheumatoid Arthritis
María López-Lasanta¹, Antonio Julià¹, Joan Maymo², Benjamin Fernandez Gutierrez³, Inmaculada Ureña⁴, Francisco J. Blanco⁵, Juan D. Cañete⁶, Mercedes Alperi-López⁷, Alejandro Olivé⁸, Hector Corominas⁹, Jesús Tornero¹⁰, Alba Erra¹¹, Miriam Almirall¹², Nuria Palau¹³, Ana M. Ortiz Garcia¹⁴, Gabriela Avila¹³, Luis Rodriguez-Rodriguez¹⁵, Arnald Alonso¹, Raül Tortosa¹, Isidoro González-Alvaro¹⁶ and Sara Marsal¹, ¹Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ²Rheumatology, Hospital del Mar, Barcelona, Spain, ³Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, ⁴Rheumatology service, Hospital Regional Universitario Carlos Haya, Malaga, Spain, ⁵Osteoarticular and Aging Research Lab, INIBIC–Complejo Hospitalario Universitario A Coruña, A Coruña, Spain, ⁶Arthritis Unit. Rheumatology, Arthritis Unit. Rheumatology Department. Hospital Clínic, Barcelona, Spain, ⁷Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ⁸Rheumatology, Hospital Germans Trias i Pujol, Badalona, Spain, ⁹Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, ¹⁰Rheumatology Department, Hospital Universitario Guadalajara, Guadalajara, Spain, ¹¹Rheumatology, Rheumatology Hospital San Rafael, Barcelona, Spain, ¹²Rheumatology Department, Hospital del Mar, Barcelona, Spain, ¹³Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ¹⁴Rheumatology, H.U. La Princesa, Madrid, Spain, ¹⁵Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, ¹⁶Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain
Background/Purpose: Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint…
Abstract Number: 93 • 2015 ACR/ARHP Annual Meeting
An HLA-C Amino Acid Variant in Addition to HLA-B*27 Confers Risk for Ankylosing Spondylitis in the Korean Population
Kwangwoo Kim¹, So-Young Bang², Seunghun Lee³, Hye-Soon Lee², Seung-Cheol Shim⁴, Young Mo Kang⁵, Chang-Hee Suh⁶, Celi Sun⁷, Swapan Nath⁷, Sang-Cheol Bae² and Tae-Hwan Kim², ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Department of Radiology, Hanyang University College of Medicine, Seoul Hospital, Seoul, South Korea, ⁴Division of Rheumatology, Daejeon Rheumatoid and Degenerative Arthritis Center, Chungnam National University, Daejeon, South Korea, ⁵Dept of Internal Medicine, Kyungpook National University School of Medicine, Daegu, South Korea, ⁶Allergy-Rheumatology, Ajou University School of Medicine, Suwon, South Korea, ⁷Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Ankylosing spondylitis (AS) is a highly heritable rheumatic disease causing chronic inflammation of axial spine, joints and various organs. The presence of HLA-B*27 is…
Abstract Number: 94 • 2015 ACR/ARHP Annual Meeting
NGS Panel for the Detection of Monogenic SLE in Children: Initial Results
Alexandre Belot¹, Gillian Rice², Anne-Laure Mathieu¹, Brigitte Bader-Meunier³, Thierry Walzer¹, Tracy A. Briggs², James O'Sullivan⁴, Simon Wiliams⁵, Michael W. Beresford⁶, Yanick Crow^2,7 and GENIAL Investigators, UK JSLE Study Group, ¹INSERM U1111, Lyon, France, ²Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ³Pediatric Rheumatology & Immunology, Necker hospital, Imagine Institution, Paris, France, ⁴University of Manchester, Manchester, United Kingdom, ⁵University of Manchester, Manchester, France, ⁶Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom, ⁷Neuroinflammation, Institut Imagine, Paris, France
Background/Purpose: Next generation sequencing (NGS) represents a revolution in the field of molecular medicine, and offers a new approach to deciphering the pathogenesis of complex…
Abstract Number: 95 • 2015 ACR/ARHP Annual Meeting
Validation of Differential Methylation in Paternally Versus Maternally Transmitted Psoriatic Disease
Remy Pollock¹, Darren O'Reilly², Amanda Dohey², Dianne Codner², Vinod Chandran³, Dafna Gladman³ and Proton Rahman⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Memorial University of Newfoundland, St. John's, NF, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Computer Sciences, Memorial University of Newfoundland, St. John's, NF, Canada
Background/Purpose: Several studies have demonstrated excessive paternal transmission of psoriasis and psoriatic arthritis (PsA). This phenomenon is thought to be mediated by genomic imprinting. We…
Abstract Number: 96 • 2015 ACR/ARHP Annual Meeting
The ABCG2 polymorphism Is Associated with Hyperuricemia in a Community-Based Korean Cohort
Jae-Bum Jun¹, Hye-Jin Jeong², Chang-Nam Son³, Ji-Min Kim³, Sang-Hyon Kim³, So-Young Bang⁴ and Sang-Cheol Bae¹, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea, ⁴Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea
Background/Purpose: Hyperuricemia is known as a risk factor of diverse diseases such as gout, hypertension, metabolic syndrome, diabetes mellitus, and cardiovascular diseases. Recent genome-wide association…
Abstract Number: 97 • 2015 ACR/ARHP Annual Meeting
Genomic Sequencing of Uric Acid Metabolizing and Clearing Genes in Relationship to Xanthine Oxidase Inhibitor Dose
Matthew Carroll¹, Kristen Cook² and Thomas Shaak³, ¹Rheumatology, Keesler Medical Center, Keesler AFB, MS, ²Internal Medicine, Keesler Medical Center, Keesler AFB, MS, ³Clinical Research Laboratory, Keesler Medical Center, USAF, Keesler AFB, MS
Background/Purpose: Effective long term uric acid lowering therapy with the xanthine oxidase inhibitors (XOI) allopurinol and febuxostat exists. When compliant with therapy, it is unclear…

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