Abstracts Archive - Page 1875 of 2425 - ACR Meeting Abstracts

Abstract Number: 2668 • 2014 ACR/ARHP Annual Meeting
Maternal Clinical Characteristics of SLE and Pregnancy: Hopkins Lupus Pregnancy Cohort
Michelle Petri¹, Amanda Eudy², Marcy Powell², Greg Giguere², Qinggong Fu² and Deanna Hill², ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²GlaxoSmithKline, Research Triangle Park, NC
Background/Purpose Systemic lupus erythematosus (SLE) typically presents in women of childbearing age. As such, it is important to understand how the clinical characteristics of SLE…
Abstract Number: 2667 • 2014 ACR/ARHP Annual Meeting
First-Trimester Disease Activity Does Not Predict Pre-Eclampsia in SLE Pregnancy
Khaled Alderaan¹, Laurence S. Magder² and Michelle Petri³, ¹King Fahad Specilaist Hospital, Dammam, Saudi Arabia, ²Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Preeclampsia complicates up to 35% of lupus pregnancies compared to 8% of general population pregnancies. SLE has up to a 3-fold increased rate of…
Abstract Number: 2666 • 2014 ACR/ARHP Annual Meeting
Causes of Stillbirths in Women with SLE
Evelyne Vinet¹, Geneviève Genest², Susan Scott², Christian A. Pineau³, Ann E. Clarke⁴, Robert W. Platt⁵ and Sasha Bernatsky⁶, ¹McGill University Health Center, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose It is believed that pregnant women with SLE face an increased risk of stillbirths, although there are few precise or recent estimates of the…
Abstract Number: 2665 • 2014 ACR/ARHP Annual Meeting
Risk of Hydrocephalus and/or Macrocephaly in Children Born to Mothers with SLE
Catherine Huang¹, Sasha Bernatsky², Christian A. Pineau³, Susan Scott⁴, Ann E. Clarke⁵, Robert W. Platt¹ and Evelyne Vinet⁶, ¹McGill University, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁶McGill University Health Center, Montreal, QC, Canada
Background/Purpose Evidence suggests that both hydrocephalus and macrocephaly could be potential manifestations of neonatal lupus. In a recent study of 87 children born to mothers…
Abstract Number: 2664 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Hematological Malignancies in Children Born to Women with SLE
Evelyne Vinet¹, Ann E. Clarke², Christian A. Pineau³, Susan Scott⁴, Robert W. Platt⁵ and Sasha Bernatsky⁶, ¹McGill University Health Center, Montreal, QC, Canada, ²Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada
Background/Purpose Patients with SLE have an increased risk of hematological malignancies, particularly non-Hodgkin lymphoma, compared to the general population. Recently, in utero exposures, such as…
Abstract Number: 2663 • 2014 ACR/ARHP Annual Meeting
Sense of Smell, Anti-Ribosomal P Antibodies and Neuropsychiatric Manifestations in Systemic Lupus Erythematosus
Fernando Augusto Peres¹, Karina Oliveira Peliçari², Nailu A. Sinicato¹, Mariana Postal¹, Aline T. Lapa¹, Lilian Costallat³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, United Kingdom, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Neuropsychiatric manifestations occur in 12-95% of SLE patients. Recent studies have demonstrated the high specificity of antiribosomal P antibodies for SLE. Antiribosomal P antibodies…
Abstract Number: 2662 • 2014 ACR/ARHP Annual Meeting
Attribution Protocol and Clinical Significance of Neuropsychiatric Manifestations in Childhood-Onset Systemic Lupus Erythematosus
Renata Barbosa¹, Karina Oliveira Peliçari², Aline T. Lapa³, Nailu A. Sinicato³, Mariana Postal³, Roberto Marini⁴, Marcelo Govoni Sr.⁵ and Simone Appenzeller⁶, ¹Medicine, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Germany, ²State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Department of Clinical medicine and Experimental, University of Ferrara, Ferrara, Italy, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Systemic lupus erythematosus (SLE) is caused by an imbalance of the immune system and may lead to injury and dysfunction of various systems and…
Abstract Number: 2661 • 2014 ACR/ARHP Annual Meeting
Serum Neuronal Biomarkers and Brain Atrophy in Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Renata Barbosa², Fernando Cendes³, Roberto Marini⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Medicine, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Germany, ³Neurology, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose We aimedto investigate the association of serum biomarkers and regional and diffuse brain atrophy in cSLE. Methods We included consecutive cSLE patients (disease-onset before…
Abstract Number: 2659 • 2014 ACR/ARHP Annual Meeting
Neurofilament H Is Associated with White Matter Lesions in Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Lucas Ferreti Silveira², Fernando Cendes³, Roberto Marini⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Neurology, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Imaging findings in systemic lupus erythematosus (SLE) patients are diverse; and diffuse or regional atrophy and white matter hyperintensities (WMH) have been described in…
Abstract Number: 2660 • 2014 ACR/ARHP Annual Meeting
Metabolic Syndrome Features Can Influenciate Cognitive Functions and Brain Lesions in Childhood-Onset Systemic Lupus Erythematosus
Nailu A. Sinicato¹, Aline T. Lapa¹, Mariana Postal¹, Bruna Bellini¹, Paula T Fernandes², Roberto Marini³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Faculty of Physical Education, State University of Campinas, Campinas, Brazil, ³Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: The underlying factor for an association between the metabolic syndrome (MetS) and cognitive decline might be a subclinical inflammation. Inflammatory mechanisms are hypothesized to…
Abstract Number: 2658 • 2014 ACR/ARHP Annual Meeting
Cognitive Symptoms and Associated Disease and Non-Disease Related Factors in Patients with Systemic Lupus Erythematosus : A Longitudinal Study
Yang Gao, Yi Lo and Mo Yin Mok, Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE). Its associated disease and non-disease related factors have been inconsistently reported. Objective:…
Abstract Number: 2657 • 2014 ACR/ARHP Annual Meeting
Brain Gray and White Matter Volume Losses and Their Associations with Glucocorticoid Use in Patients with Newly Diagnosed Systemic Lupus Erythematosus (SLE) – a Prospective MR Study
Anselm Mak¹, Roger CM Ho², Hanying Tng³ and Juan Zhou³, ¹Medicine, National University of Singapore, Singapore, Singapore, ²Psychological Medicine, National University of Singapore, Singapore, Singapore, ³Center for Cognitive Neuroscience, Duke-NUS Graduate Medical School, Singapore, Singapore
Background/Purpose Data suggest that cerebral atrophy occurs in patients with SLE as early as within 9 months after disease onset. We aimed to address (1)…
Abstract Number: 2656 • 2014 ACR/ARHP Annual Meeting
The Burden of Neuropsychiatric Symptoms in Systemic Lupus Erythematosus: Physician’s and Patient’s Perspectives
Chiara Tani¹, Maria Francisca Moraes-Fontes², Ana Carolina Araújo², Linda Carli³, Manuel Pereira Gonçalves⁴, Francesca Querci⁵, Alexandra Mendes⁶, Viola Signorini⁷, Sabrina Vagnani⁵, Rosaria Talarico⁸, Céu Mateus⁹, Stefano Bombardieri¹⁰, Nuno Riso² and Marta Mosca¹¹, ¹Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ²Serviço de Medicina 2, Hospital de Curry Cabral, Centro Hospitalar Lisboa Central, Lisbon, Portugal, ³GenOMeC PhD, University of Siena, Siena, Italy, ⁴Mental Health Unit, Universidade Nova de Lisboa (UNL), Portugal, Lisboa, Portugal, ⁵Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ⁶Clinical Psychology Unit, CHLC, Portugal, Lisboa, Portugal, ⁷Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ⁸Rheumatology Unit, Pisa, Italy, ⁹Health Economy, National School of Public Health (UNL), Portugal, Lisboa, Portugal, ¹⁰Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ¹¹Rheumatology Unit, University of Pisa, Pisa, Italy
Background/Purpose: Neuropsychiatric symptoms (NPS) are observed in SLE with a variable prevalence depending on patient selection and assessment methods. In 2010, a 27-item questionnaire was…
Abstract Number: 2637 • 2014 ACR/ARHP Annual Meeting
Assessment of Plaque Thickness and Area in Patients with SLE As Measures of Atherosclerosis – Associations with Disease Activity
Sara Croca¹, Maura Griffin², David Isenberg³, Andrew Nicolaides⁴ and Anisur Rahman⁵, ¹5 University Street, University College London, London, United Kingdom, ²Vascular Screening and Diagnostic Centre, London, United Kingdom, ³Centre for Rheumatology Research, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, ⁴St Georges London/Nicosia Medical School, University of Nicosia, Cyprus, Nicosia, Cyprus, ⁵Centre for Rheumatology Research, University College London, London, United Kingdom
Background/Purpose SLE is an independent risk factor for cardiovascular disease (CVD). Traditional risk stratification tools underestimate CVD risk in patients with SLE. Previous vascular ultrasound…
Abstract Number: 2636 • 2014 ACR/ARHP Annual Meeting
Vitamin D Improves Endothelial Function in Patients with Clinically Stable Systemic Lupus Erythematosus (SLE)
John A. Reynolds¹, David W. Ray², Terence O'Neill³, Yvonne Alexander⁴ and Ian N. Bruce^5,6, ¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, United Kingdom, Manchester, United Kingdom, ²Institute of Human Development, Institute of Human Development, The University of Manchester, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, ⁴Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁶NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academy of Health Sciences, Manchester, United Kingdom
Background/Purpose SLE patients have an increased risk of cardiovascular disease (CVD). Vitamin D deficiency has been associated with both CVD risk factors and subclinical CVD…

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