Abstracts Archive - Page 1873 of 2607 - ACR Meeting Abstracts

Abstract Number: 21 • 2015 ACR/ARHP Annual Meeting
Pseudostarvation Using the AMPK Activator Metformin Downregulates Inflammation in Rheumatoid Arthritis Synovial Tissue
Lorna Gallagher¹, Ursula Fearon², Douglas J. Veale³, David Kane⁴, Luke A. O'Neill⁵ and Ronan Mullan⁴, ¹Clinical Medicine, School of Medicine, Trinity College Dublin, Dublin, Ireland, ²St. Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ³St Vincent's University Hospital, Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, Dublin 4, Ireland, ⁴Department of Rheumatology, Tallaght Hospital, TCD, Dublin 24, Ireland, ⁵Inflammation Research, School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
Background/Purpose: AMP-activated protein kinase (AMPK) is a highly conserved, regulator of cellular energy status. In inflammation, AMPK inactivation is associated with increased glucose consumption through…
Abstract Number: 22 • 2015 ACR/ARHP Annual Meeting
Expression of High Mobility Group Box 1 Protein and the Receptor for Advanced Glycation End Products in Primary Gouty Arthritis
Yu-Feng Qing¹, Quan-Bo Zhang², Shu-Yue Pan³ and Jingguo Zhou⁴, ¹Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nanchong, China, ²Department of geriatrics of the Affiliated Hospital of North Sichuan Medical College, Sichuan 637007, China, Nachong, China, ³Department of Rheumatology and Immunology of the Affiliated Hospital of North Sichuan Medical College, Sichuan 637000, China, Nachong, China, ⁴Department of Rheumatology and Immunology, Affliated hospital of North Sichuan Medical College, Nanchong, China
Background/Purpose: To investigate the role of high mobility group box 1 protein (HMGB1) and the receptor for advanced glycation end products (RAGE) in the pathogenesis…
Abstract Number: 23 • 2015 ACR/ARHP Annual Meeting
Microvesicle-Associated Hsa-Mir-223-3p Is Elevated in Rheumatoid Synovial Fluid Compared with Osteoarthritis Synovial Fluid
Nancy D. Kim¹, Robert B. Lochhead¹, Pauline Schmit², Minna J. Kohler³ and Andrew D. Luster⁴, ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Charlestown, MA, ³Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Microvesicles (MVs) (100-1000 nm diameter) are subcellular particles that are enriched in nucleic acid, including microRNA (miR), which may be transferred from cell to…
Abstract Number: 24 • 2015 ACR/ARHP Annual Meeting
Investigating the Role of Vitamin D in the Transition to Systemic Lupus Erythematosus in Individuals at Risk for the Disease
Kendra A. Young¹, Melissa E. Munroe², Joel M. Guthridge², Diane L. Kamen³, Timothy B. Niewold⁴, Gary S. Gilkeson⁵, Michael H. Weisman⁶, Mariko L. Ishimori⁶, Daniel J Wallace⁷, David R. Karp⁸, John B. Harley⁹, Judith A. James¹⁰ and Jill M. Norris¹¹, ¹Epidemiology, University of Colorado Denver, Aurora, CO, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Medicine, Medical University of South Carolina, Charleston, SC, ⁴Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁵Department of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Internal Medicine - Rheumatic Diseases, University of Texas Southwestern Medical Center, Dallas, TX, ⁹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹¹University of Colorado Denver, Aurora, CO
Background/Purpose: Lower vitamin D levels are associated with increased disease activity in systemic lupus erythematosus (SLE) and individuals with SLE have increased prevalence of vitamin…
Abstract Number: 25 • 2015 ACR/ARHP Annual Meeting
Attrition and Participant Characteristics in a Rheumatoid Arthritis Cohort
Angela Cesta¹, Xiuying Li¹, Mark Tatangelo^2,3 and Claire Bombardier^1,4,5, ¹Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ²Clinical Decision Making and Health Care, Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Division of Rheumatology and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada, ⁵Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose: The generalizability and validity of in longitudinal observational studies is contingent on participant characteristics. If attrition is not random, it is important to identify…
Abstract Number: 26 • 2015 ACR/ARHP Annual Meeting
Higher Scores of Women Compared to Men for Most Clinical Measures of Rheumatoid Arthritis (RA) Status: Greater Differences for Patient Self-Report Scores Than for Rheumatologist Estimates: A Cross-Sectional 3 Center Study from Routine Care
Isabel Castrejón¹, Martin Bergman², Yusuf Yazici³, Annie Huang¹, Joel A. Block¹ and Theodore Pincus¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Division of Rheumatology, Taylor Hospital, Ridley Park, PA, ³NYU Hospital for Joint Diseases, New York, NY
Background/Purpose: Higher scores for women compared to men have been reported for all 7 rheumatoid arthritis (RA) Core Data Set measures (1, 2). Most of…
Abstract Number: 27 • 2015 ACR/ARHP Annual Meeting
Self-Reported Sedentary Behavior in Patients with Rheumatoid Arthritis
Abigail Gilbert¹, Julia (Jungwha) Lee², Madeleine Ma¹, Pamela Semanik³, Dorothy D. Dunlop⁴ and Rowland W. Chang⁵, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ³College of Nursing, Rush University, Chicago, IL, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Abstract Background/Purpose: Sedentary behavior is associated with increased risk of functional decline and disability. Individuals with rheumatoid arthritis (RA) spend more time in sedentary activity…
Abstract Number: 28 • 2015 ACR/ARHP Annual Meeting
The Decrease over Time of Orthopaedic Surgery in Patients with Rheumatoid Arthritis Is Mainly Due to Reduced Rates Among Those with Rheumatoid Factor Positive Disease – Results from a Well Defined Area
Korosh Hekmat^1,2, Lennart T.H. Jacobsson³, Jan-Åke Nilsson¹, Minna Willim¹, Martin Englund^4,5, Ingemar F Petersson⁴ and Carl Turesson⁶, ¹Department of Rheumatology. Malmö University Hospital, Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Karolinska University Hospital, Department of Medicine, Unit of Rheumatology, Stockholm, Stockholm, Sweden, ³Department of Rheumatology Malmö University Hospital, Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ⁴Department of Orthopedics, Clinical Sciences Lund, Lund University, Lund, Sweden, ⁵Clinical Epidemiology Unit, Orthopedics, Dept of Clinical Sciences Lund, Lund University, Lund, Sweden, ⁶Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden
Background/Purpose : Seropositive and seronegative rheumatoid arthritis (RA) differ in course and prognostic feature. The overall incidence of orthopaedic surgery in patients with RA has…
Abstract Number: 29 • 2015 ACR/ARHP Annual Meeting
Development of Multimorbidity in Patients with Newly Diagnosed Rheumatoid Arthritis – a Population-Based Study
Helga Radner^1,2, Rishi Desai³, Theodore Tsacogianis⁴, Daniel H. Solomon⁵ and Seoyoung C. Kim⁶, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Department of Internal Medicine III; Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³PharmacoEpidemiology & PharmacoEconomics, Brigham and Women's Hospital, Boston, MA, ⁴Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁶Medicine/Rheumatology, University of Pennsylvenia, Philadelphia, PA
Background/Purpose: Limited information exists whether RA patients are likely to develop more morbid conditions after RA diagnosis compared to those without RA and the…
Abstract Number: 30 • 2015 ACR/ARHP Annual Meeting
Complications of Inflammatory Arthritis in First Nations and Non-First Nations Populations of Alberta, Canada
Cheryl Barnabe¹, Gilaad Kaplan², J Antonio Avina-Zubieta³, Diane Lacaille⁴, Brenda Hemmelgarn⁵ and JM Esdaile⁶, ¹Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ²Division of Gastroenterology, University of Calgary, Calgary, AB, Canada, ³Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada, ⁵Division of Nephrology, University of Calgary, Calgary, AB, Canada, ⁶Rheumatology, Arthritis Research Canada, Richmond, BC, Canada
Background/Purpose: With markedly improved control of the acute effects of inflammatory arthritis, the major causes of morbidity and premature death now arise from the complications…
Abstract Number: 31 • 2015 ACR/ARHP Annual Meeting
Risk of Chronic Obstructive Pulmonary Disease in Rheumatoid Arthritis: A Population Based Cohort Study
Katherine McGuire¹, J Antonio Avina-Zubieta², Eric C. Sayre¹, JM Esdaile³ and Diane Lacaille⁴, ¹Arthritis Research Canada, Richmond, BC, Canada, ²Arthritis Research Canada / University of British Columbia, Vancouver, BC, Canada, ³Rheumatology, Arthritis Research Canada, Richmond, BC, Canada, ⁴Arthritis Research Centre, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: A link between chronic obstructive pulmonary disease (COPD) and inflammation has been established in a number of studies. This raises the question of whether…
Abstract Number: 32 • 2015 ACR/ARHP Annual Meeting
Risk for Lung Cancer in RA and Different RA Phenotypes: Results from a Population-Based Case-Control Study
Katerina Chatzidionysiou¹, Gudrun Reynisdottir², Vijay Joshua², Thomas Frisell³, Johan Askling³ and Anca I Catrina², ¹Department of Medicine, Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: It has been shown that patients with Rheumatoid Arthritis (RA) are at increased risk for certain malignancies, among them lung cancer. We aimed to…
Abstract Number: 33 • 2015 ACR/ARHP Annual Meeting
Analysis of Incidence Rates of Pulmonary Embolism in the Rheumatoid Arthritis Population Compared with the Non-Rheumatoid Arthritis Population
Richa Rajwanshi¹, Khaled Sarsour², Laura Governale², Brandon Arnieri², David Oliveri² and Erhan Berber², ¹1 Dna Way, Ms 361a, Genentech, South San Francisco, CA, ²Genentech, South San Francisco, CA
Background/Purpose: This study was conducted in a large health care claims database to determine whether there is a difference in the incidence rate (IR) of…
Abstract Number: 34 • 2015 ACR/ARHP Annual Meeting
The Impact of Cardiovascular and Lung Disorder Morbidities on Physical Activity in People with Inflammatory Arthritis Compared to the General Population in the UK
Michael Cook¹, Eftychia Bellou², Jamie C Sergeant³, John Bowes², Anne Barton⁴, Terence W. O'Neill¹ and Suzanne M.M. Verstappen¹, ¹Arthritis Research UK Centre for Epidemiology, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ²Arthritis Research UK Centre for Genetics and Genomics, The University of Manchester, Centre for Musculoskeletal Research, Manchester, United Kingdom, ³NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁴NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester Academic Health Science Centre, Manchester, United Kingdom
Background/Purpose: Cardiovascular and lung disorder morbidities are more common in people with inflammatory arthritis (IA) than in the general population. However, little is known about…
Abstract Number: 35 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis As a Risk Factor for Cardiovascular Events Following Hospitalized Pneumonia; A Population-Based Cohort Study
Mette Holland-Fischer¹, Ulrik Tarp², Reimar W. Thomsen³ and Mette Nørgaard³, ¹Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, ²Department of Rheumatology, Aarhus University Hospital, AArhus, Denmark, ³Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark
Background/Purpose: Cardiovascular disease is a major cause of morbidity and mortality in patients with Rheumatoid Arthritis (RA). Patients with RA do also have an increased…

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