Abstracts Archive - Page 1873 of 2425 - ACR Meeting Abstracts

Abstract Number: 2699 • 2014 ACR/ARHP Annual Meeting
Optimizing Scleroderma Centers of Excellence: Perspectives from Patients and Scleroderma (SSc) Experts
Veronika K. Jaeger¹, Andrew Aubin², Nancy Baldwin³, Kim Fligelstone⁴, Robyn Sims⁵, Joep Welling⁶, Ryan Burrill⁷, Kerri Connolly⁷, Tracy Frech⁸, Jessica K. Gordon⁹, Tanaka Ngcozana¹⁰, Monika Kowalczyk¹¹, Matthew R. Lammi¹², Ulrich A. Walker¹ and Lesley Ann Saketkoo¹³, ¹Department of Rheumatology, University Hospital Basel, Basel, Switzerland, Basel, Switzerland, ²Louisiana State University School of Medicine, New Orleans, LA, ³Scleroderma Foundation - Chicago Support Group, Chicago, IL, ⁴Royal Free Hospital, Scleroderma Unit and Scleroderma Society, London, United Kingdom, ⁵Scleroderma Australia, Victoria, Australia, ⁶The Dutch Patient Organization for Systemic Autoimmune Diseases, Utrecht, Netherlands, ⁷Scleroderma Foundation, Boston, MA, ⁸Div of Rheumatology, University of Utah, Salt Lake City, UT, ⁹Rheumatology, Hospital for Special Surgery, New York, NY, ¹⁰Rheumatology Department, Lower, Royal Free hospital, London, United Kingdom, ¹¹DIvision of Gastroenterology, Tulane University School of Medicine, New Orleans, LA, ¹²Louisiana State University Health Sciences Center, Pulmonary and Critical Medicine, New Orleans, LA, ¹³Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA
Background/Purpose: SSc is a complex, diffuse, devastating health condition of vascular injury, inflammation and fibrosis resulting in multiple organ-system derangements with high impact on…
Abstract Number: 2698 • 2014 ACR/ARHP Annual Meeting
Survival in Systemic Sclerosis-Pulmonary Arterial Hypertension By Serum Autoantibody Status
Monique Hinchcliff^1,2, Saira Khanna³, Jungwha Lee^4,5, Orit Almagor⁶, Rowland W. Chang^2,7, Virginia D. Steen⁸ and Lorinda Chung⁹, ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Preventive Medicine, Northwestern University Medical School, Chicago, IL, ⁶Northwestern University, Chicago, IL, ⁷Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ⁹Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA
Background/Purpose: Previous studies have shown that anticentromere (AC) and isolated nucleolar (NUC) antibodies are the most common autoantibodies in patients with systemic sclerosis (SSc) and…
Abstract Number: 2705 • 2014 ACR/ARHP Annual Meeting
Reduction of Cerebral and Corpus Callosum Volume in Systemic Sclerosis. a Volumetric Magnetic Resonance Imaging Study
Sergio Dertkigil¹, Tiago N. Amaral², Aline T. Lapa³, Fernando Peres¹, Renan Frittoli¹, Ana Paula del Rio¹, João Francisco Marques-Neto⁴ and Simone Appenzeller⁵, ¹State University of Campinas, Campinas, Brazil, ²Faculty of Medical Science, State University of Campinas, Campinas, Brazil, ³Medicine, State University of Campinas, Campinas, Brazil, ⁴University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose Systemic sclerosis (SSc) is a systemic disease characterized by cutaneous and visceral fibrosis, presence of autoantibodies and vasculopathy. The central nervous system has, however,…
Abstract Number: 2676 • 2014 ACR/ARHP Annual Meeting
The E3 Ligase Casitas B Lineage Lymphoma b (Cbl-b) Modulates Peripheral Regulatory T Cell Function Via p27^kip1in Patients with Systemic Lupus Erythematosus
Diana Gómez-Martín¹, Jorge Romo-Tena², Javier Merayo-Chalico³, Ana Barrera-Vargas¹ and Jorge Alcocer-Varela¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, ³Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The interplay between effector and regulatory T cells (Tregs) is a key element among peripheral tolerance mechanisms in Systemic Lupus Erythematosus (SLE). Resistance to…
Abstract Number: 2675 • 2014 ACR/ARHP Annual Meeting
The Selective Loss of SLAMF4⁺ CD8⁺ T Cells Contributes to the Decreased Cytotoxic Capacity Observed in Systemic Lupus Erythematosus
Katalin Kis-Toth¹, Denis Comte¹, Maria Karampetsou¹, Lakshmi Kannan² and George C. Tsokos¹, ¹Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, ²Rheumtology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose Signaling lymphocytic activation molecule family member 4 (SLAMF4) engagement by its ligand SLAMF2 can mediate the cytotoxicity of CD8+ T cells and natural killer…
Abstract Number: 2674 • 2014 ACR/ARHP Annual Meeting
The Effect and Mechanisms of Icaritin on Regulating Foxp3/IL17a Expression in CD4⁺ T Cells from SLE
Jieyue Liao¹, Yu Liu², Ming Zhao³, hai Jing Wu⁴ and Qianjin Lu⁵, ¹Department of Dermatology, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China, ²Department of Dermatology, Second Xiangya Hospital, Central South University, shangcha, China, ³Department of Dermatology, Second Xiangya Hospital, Central South University, changsha, China, ⁴Department of Dermatology, Second Xiangya Hospital, Central South University, sahngsha, China, ⁵Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose : Systemic lupus erythematosus (SLE) is a female predominant autoimmune disease characterized by overproduction of autoantibodies. The pathogenesis of SLE is complex. Several studies…
Abstract Number: 2693 • 2014 ACR/ARHP Annual Meeting
Hyporesponsiveness to TLR9 in Term of Cytokines Production By B Cells in SLE-Patients
Julia Sieber¹, Capucine Daridon¹, Sarah J. Fleischer¹, Vanessa Fleischer¹, Falk Hiepe¹, Tobias Alexander², Guido Heine³, Gerd Burmester⁴, Simon Fillatreau⁵ and Thomas Dörner¹, ¹Charité University Medicine, Dept. Medicine/Rheumatology and Clinical Immunology/German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Dept. Medicine/Rheumatology and Clinical Immunology, Charité University Medicine, Dept. Medicine/Rheumatology and Clinical Immunology/German Rheumatism Research Center (DRFZ), Berlin, Germany, ³Charité University Medicine, Dept. Dermatology, Venerology and Allergology, Berlin, Germany, ⁴Charité University Medicine, Dept. Medicine/Rheumatology and Clinical Immunology, Berlin, Germany, ⁵German Rheumatism Research Center (DRFZ), Berlin, Germany
Background/Purpose The role of B cells in immunity has been mainly related to the generation of antibodies and formation of immune complexes. However, B cells…
Abstract Number: 2692 • 2014 ACR/ARHP Annual Meeting
Up-Regulated Expression of CXCR4 on Circulating B Cells in Patients with Systemic Lupus Erythematosus
Hironari Hanaoka¹, Yuka Okazaki¹, Akinori Hashiguchi², Hidekata Yasuoka³, Tsutomu Takeuchi¹ and Masataka Kuwana¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²Department of Pathology, Keio University School of Medicine, Tokyo, Japan, ³Rheumatology, Keio University School of Medicine, Tokyo, Japan
Background/Purpose It is increasingly appreciated that circulating B cells are functionally altered and are involved in pathogenic process in patients with systemic lupus erythematosus (SLE).…
Abstract Number: 2690 • 2014 ACR/ARHP Annual Meeting
Autoregulatory Function of IL-10 Producing Pre-Naïve B Cells Is Defective in Systemic Lupus Erythematosus
Ji-Hyun Sim¹, Hang-Rae Kim¹, Soog-Hee Chang¹, In Je Kim², Peter E. Lipsky³ and Jisoo Lee^4,5, ¹Seoul National University, Seoul, South Korea, ²Rheumatology, Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea, ³AMPEL BioSolutions, Charlottesville, VA, ⁴Internal Medicine, Ewha Womans Univeristy School of Medicine, Seoul, South Korea, ⁵Ewha Womans University School of Medicine, Seoul, South Korea
Background/Purpose: Pre-naive B cells represent an intermediate stage in human B cell development with some functions of mature cells, but their involvement in immune responses…
Abstract Number: 2691 • 2014 ACR/ARHP Annual Meeting
A Novel CD123^–CD11c^– Dendritic Cell Subset Increased in Relation to Disease Activity in Patients with Systemic Lupus Erythematosus
Satoshi Kubo¹, Shingo Nakayamada¹, Naoki Yunoue¹, Maiko Yoshikawa¹, Kunihiro Yamaoka¹ and Yoshiya Tanaka², ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, ²University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
Background/Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by overproduction of autoantibodies by B cells and breaking self-tolerance of T cells and dendritic…
Abstract Number: 2689 • 2014 ACR/ARHP Annual Meeting
The CUL4^CRBN E3 Ubiquitin Ligase Modulator CC-220 Induces Degradation of the Transcription Factors Ikaros and Aiolos: Immunomodulation in Healthy Volunteers and Relevance to Systemic Lupus Erythematosus
Peter H. Schafer¹, Ying Ye², Lei Wu³, Jolanta Kosek⁴, Zhihong Yang⁵, Liangang Liu⁵, Michael Thomas⁵, Maria Palmisano⁵ and Rajesh Chopra⁵, ¹Celgene Corporation, Celgene Corporation, Summit, NJ, ²86 Morris Avenue, Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ, ⁴Translational Development, Celgene Corporation, Summit, NJ, ⁵Celgene Corporation, Summit, NJ
Background/Purpose: CC-220 is an immunomodulatory compound that binds to cereblon (CRBN), part of the CUL4CRBN E3 ubiquitin ligase complex, which has been shown to ubiquitinate…
Abstract Number: 2688 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive African-Americans Reveals Distinct Differences in T Cell and Progenitor Populations
Rufei Lu^1,2, Samantha Slight-Webb¹, Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge¹ and Judith A. James^5,6, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder which arises from both genetic and environmental factors that likely affect phenotypic and functional characteristics…
Abstract Number: 2687 • 2014 ACR/ARHP Annual Meeting
Estrogen-Mediated STAT1 Activation By Estrogen Receptor a Induces TLR8 Expression: A Novel Pathogenic Mechanism in Systemic Lupus Erythematosus
Nicholas Young¹, Giancarlo Valiente², Lai-Chu Wu³, Michael Bruss⁴, Stacy Ardoin², Craig Burd⁵ and Wael N. Jarjour⁶, ¹Ohio State University, Columbus, OH, ²Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Molecular & Cellular Biochemistry, The Ohio State University, Columbus, OH, ⁶Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Many autoimmune disorders, including Systemic Lupus Erythematosus (SLE) display female gender predominance. Previous studies have demonstrated significant hormonal contributions to SLE pathogenesis, including estrogen,…
Abstract Number: 2686 • 2014 ACR/ARHP Annual Meeting
Gene Array Analysis Reveals Unique Estrogen Signature in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus
Stephanie Amici¹, Nicholas A. Young², Lai-Chu Wu², Mireia Guerau¹ and Wael N. Jarjour³, ¹Health and Rehab Sciences, The Ohio State University, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder predominately affecting females in the reproductive age range. Estrogen is present at higher levels in this…
Abstract Number: 2685 • 2014 ACR/ARHP Annual Meeting
Ten-Eleven Translocation 2 Protein Down-Regulates DNA Methylation of Interleukin-17A Promoter and Induces Its Expression in CD4⁺t Cells of Patients with Systemic Lupus Erythematosus
Duo Li, Qian Tang, Lina Tan, Ming Zhao, Gongping Liang, Yang Yang and Qianjin Lu, Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Recent evidence indicates that IL-17A plays a key role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). SLE patients have…

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