Abstracts Archive - Page 1871 of 2425 - ACR Meeting Abstracts

Abstract Number: 2725 • 2014 ACR/ARHP Annual Meeting
Enhanced Expression of CCL25 to Facilitate Increased Numbers of CCR9-Expressing Tfh-like Cells in Salivary Glands of Primary Sjögren’s Syndrome Patients
S.L.M. Blokland^1,2, M.R. Hillen^1,2, A.a. Kruize², A. Kislat³, S. Meller³, B. Homey³, G.M. Smithson⁴, J. Zalevsky⁵, T.R.D.J. Radstake² and J.a.G. van Roon², ¹Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Dermatology, University of Düsseldorf, Medical Faculty, Düsseldorf, Germany, ⁴Takeda Pharmaceuticals International, Chicago, IL, ⁵Takeda California, San Diego, CA
Background/Purpose In primary Sjögren’s syndrome (pSS) B cell activation and autoantibody secretion are hallmark immunopathological features. Specific lymphoid organization (including germinal centers) is associated with…
Abstract Number: 2724 • 2014 ACR/ARHP Annual Meeting
Deficiency of Ro52/TRIM21 in Different Subsets of Peripheral Blood Mononuclear Cells from Patients with Inflammatory Myopathies
Angeles Shunashy Galindo-Feria¹, Diana Gómez-Martín², Ana Barrera-Vargas², Javier Merayo-Chalico¹ and Jorge Alcocer-Varela², ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: The detection of Ro52/TRIM21 autoantibodies has been considered an independent prognostic marker in different rheumatic conditions. However, the information about the expression of Ro52/TRIM21…
Abstract Number: 2723 • 2014 ACR/ARHP Annual Meeting
Programmed Death 1 Inhibits T-Cell Adhesion By Regulating Rap1
Inbar Alfaguter¹, Marianne Strazza¹ and Adam Mor², ¹NYU, New York, NY, ²Rheumatology and Pathology, NYU Langone Medical Center, New York, NY
Background/Purpose: Programmed Death-1 (PD-1) is an inhibitory co-receptor that is highly expressed in T lymphocytes. The binding of PD-1 to its ligands, PD-L1 or PD-L2,…
Abstract Number: 2722 • 2014 ACR/ARHP Annual Meeting
Rapamycin Corrects GATA-3 Deficiency in Lupus Treg
Hiroshi Kato¹ and Andras Perl², ¹Internal Medicine, Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ²Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: As demonstrated by the negative correlation between Treg frequency or suppressive function and SLE disease activity index score, it is tempting to speculate that…
Abstract Number: 2721 • 2014 ACR/ARHP Annual Meeting
Patients’ Perspective of Skin Involvement in Systemic Sclerosis
Ada Man¹, Amy Wu¹, Jessica Ziemek², Romy Christmann¹, Robert W. Simms¹, David T. Felson³ and Robert Lafyatis⁴, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology/Arthritis Center, Boston University School of Medicine, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Arthritis Center, Boston University, Boston, MA
Background/Purpose: Skin tightness and other abnormalities of the skin are the hallmark features of systemic sclerosis (SSc). While skin involvement may significantly impact a…
Abstract Number: 2720 • 2014 ACR/ARHP Annual Meeting
Prevalence and Features of Metabolic Syndrome in Systemic Sclerosis
Tiago N. Amaral¹, Karina Pereira², Nailu A. Sinicato³, Sandra Gasparini⁴, Fernando Augusto Peres³, Maria Carolina de Souza⁴, Ana Paula del Rio⁴, João Francisco Marques-Neto⁵ and Simone Appenzeller⁶, ¹Faculty of Medical Science, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Limeira, Brazil, ³Medicine, State University of Campinas, Campinas, Brazil, ⁴State University of Campinas, Campinas, Brazil, ⁵University of Campinas, Campinas, Brazil, ⁶Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by initial vascular injuries and resulted fibrosis of skin and internal organs. Vascular impairment in…
Abstract Number: 2719 • 2014 ACR/ARHP Annual Meeting
Performance of the New ACR Criteria in Systemic Sclerosis: A Multicenter Study
Necati Cakir¹, Omer Nuri Pamuk² and Mehmet Ali Balci², ¹Fatih Sultan Mehmet State Hospital, Istanbul, Turkey, ²Rheumatology, Trakya University Medical Faculty, Edirne, Turkey
Background/Purpose Reliable and validated classification criteria are needed to conduct high quality clinical research in systemic sclerosis (SSc). The most widely used classification criteria for…
Abstract Number: 2718 • 2014 ACR/ARHP Annual Meeting
The UCLA Gastrointestinal Tract Questionnaire (GIT)2.0 and GI Visual Analogue Scale(GI-VAS) Reflect Different Aspects of GI Involvement in Systemic Sclerosis
Yossra Suliman^1,2, Yasser Shaweesh³, Suzanne Kafaja^4,5,6, Lewei Duan⁷ and Daniel E. Furst⁸, ¹Division of Rheumatology, Department of Medicine., David Geffen School of Medicine, University of California Los Angeles,, Los Angeles, CA, ²Rheumatology and Rehabilitation department, Faculty of Medicine, Assiut university, Assiut, Egypt, ³Division of Rheumatology, Department of Medicine., David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, ⁴Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁵Medicine, University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁶David Geffen School of Medicine, UCLA, Los Angeles, CA, ⁷David Geffen School of Medicine, University of California School of Medicine, Los Angeles, CA, ⁸University of California at Los Angeles, Los Angeles, CA
Background/Purpose UCLA GIT2.0 is a validated measure for assessing the severity of gastrointestinal involvement in systemic sclerosis patients (SSc) patients; GI VAS is also a…
Abstract Number: 2717 • 2014 ACR/ARHP Annual Meeting
Comparison of PROMIS^® survey Between Scleroderma Patients in an Academic Center and Patient-Based Scleroderma Foundations
Vivek Nagaraja¹, Veronica Berrocal², Kerri Connolly³, Ann Kennedy⁴, Daniela Seelmann⁵ and Dinesh Khanna¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Biostatistics- School of Public Health, University of Michigan, Ann Arbor, MI, ³Scleroderma Foundation, Boston, MA, ⁴Federation of European Scleroderma Associations, Tournai, Belgium, ⁵Universidad de Los Andes, Santiago, Chile
Background/Purpose The National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS®) roadmap initiative is a cooperative research program designed to develop, evaluate, and standardize…
Abstract Number: 2716 • 2014 ACR/ARHP Annual Meeting
Development of a “Renal Crisis Prevention Card” As an Educational Tool Aimed at Improving Outcomes in High-Risk Patients with Systemic Sclerosis
Lee S. Shapiro^1,2,3, Lesley Ann Saketkoo⁴, Jessica F. Farrell^2,3,5 and Kim Fligelstone⁶, ¹Albany Medical College, Albany, NY, ²Steffens Scleroderma Center, Saratoga Springs, NY, ³The Center for Rheumatology, Albany, NY, ⁴Scleroderma and Sarcoidosis Patient Care and Research Center, Rheumatology and Pulmonary Medicine, Louisiana State University Health Sciences Center, New Orleans, LA, ⁵Pharmacy Practice, Albany College of Pharmacy & Health Sciences, Albany, NY, ⁶Royal Free Hospital, Scleroderma Unit and Scleroderma Society, London, United Kingdom
Background/Purpose: Scleroderma renal crisis (SRC) is a devastating complication of SSc. The introduction of effective treatment with ACE inhibition (ACE-I) in 1979 dramatically reduced…
Abstract Number: 2715 • 2014 ACR/ARHP Annual Meeting
Reliability and Validity of the Duruöz Hand Index in an Argentinian Population with Scleroderma
Vanesa Duarte¹, Gloria Crespo¹, Maritza Manzano¹, María Victoria Martire², Santiago Scarafia¹, Lucila Marino³, Felix Romanini¹, Marta Mamani¹ and Anastasia Secco¹, ¹Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ²Reumatología, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ³Rheumathology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina
Background/Purpose: The Duruöz Hand Index (DIH) is a reliable tool for the evaluation of hand´s function in patients with scleroderma. The aim of our study…
Abstract Number: 2714 • 2014 ACR/ARHP Annual Meeting
Application of the 2013 ACR/EULAR Classification Criteria for Systemic Sclerosis in Korean Patients with Raynaud Phenomenon
Jin Su Park¹, Hee-Jin Park¹, You Jung Ha², Yong-Beom Park³, Soo-Kon Lee¹ and Sang-Won Lee⁴, ¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ²Yonsei University College of Medicine, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, ⁴Department of Internal Medicine, Yonsei University College of Medicine, Seoul, NV, South Korea
Background/Purpose : The American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) suggested the 2013 ACR/EULAR classification criteria for systemic sclerosis (SSc),…
Abstract Number: 2733 • 2014 ACR/ARHP Annual Meeting
Decreased CXCR3+CCR4-CCR6+ CD4+ Effector Memory T Cells in Patients with Granulomatosis with Polyangiitis
Lucas L. Lintermans¹, Coen A. Stegeman², Abraham Rutgers¹, Peter Heeringa³ and Wayel H. Abdulahad¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Nephrology, University Medical Center Groningen, Groningen, Netherlands, ³Pathology and Medical Biology, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Persistent expansion of circulating CD4+ effector memory T cells (TEM) in patients with Granulomatosis with polyangiits (GPA) suggest their fundamental role in disease pathogenesis.…
Abstract Number: 2697 • 2014 ACR/ARHP Annual Meeting
Gender Disparities in Lung Transplantation in Patients with Systemic Sclerosis-Related Interstitial Lung Disease and Pulmonary Hypertension
Elizabeth Volkmann¹, Daniel E. Furst², Rajeev Saggar³, Philip J. Clements⁴, Bryant Torres⁵, Lynne Yoder¹ and Rajan Saggar¹, ¹Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²University of California, Los Angeles, CA, ³Cardiothoracic Surgery, University of Arizona College of Medicine, Phoenix, AZ, ⁴University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁵Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, GA
Background/Purpose: Lung transplantation is often the most viable option for patients with severe systemic sclerosis (SSc)-associated interstitial lung disease (ILD) that is unresponsive to pharmacologic…
Abstract Number: 2696 • 2014 ACR/ARHP Annual Meeting
Relationship Between Soluble sCD23 and B Cell Activation Factor in Patients with Systemic Lupus Erythematosus before and after Rituximab
Laura Heretiu^1,2, Maria J. Leandro³, Venkat Reddy⁴, David A. Isenberg⁵ and Geraldine Cambridge³, ¹Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Rheumatology and Internal Medicine, 'Sf. Maria' Clinical Hospital, Bucharest, Romania, ³Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ⁵Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom
Background/Purpose CD23 is the low-affinity receptor for IgE (FceRII). The soluble form, sCD23 is released into the circulation and in vitro this is consistent with…

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