Abstracts Archive - Page 1870 of 2607 - ACR Meeting Abstracts

Abstract Number: 3246 • 2015 ACR/ARHP Annual Meeting
Does Loss of a Community Walking Speed Lead to More Symptoms of Depression in Knee OA? a Trajectory Analysis from the Osteoarthritis Initiative
Daniel White¹, Tuhina Neogi², Yuqing Zhang³, Jingbo Niu⁴ and Patricia P. Katz⁵, ¹Department of Physical Therapy, University of Delaware, Newark, DE, ²Clinical Epidemiology, BUSM, Boston, MA, ³BUSM, Boston, MA, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁵Rheumatology, UCSF, SF, CA
Background/Purpose: Knee osteoarthritis (OA) is a well-known risk factor for major depression. While major limitations, e.g., inability to walk, are thought to mediate this relationship,…
Abstract Number: 3247 • 2015 ACR/ARHP Annual Meeting
Dietary Intake of Omega-3 Fatty Acids and Vitamin C and D Associate with Decreased Pain, Independent of Inflammation, in MTX Treated Early RA Patients
Cecilia Lourdudoss¹, Alicja Wolk², Lars Alfredsson³, Lars Klareskog⁴, Ronald F. van Vollenhoven⁵ and Jon Lampa⁶, ¹Dept. of Medicine, ClinTRID, Karolinska institutet, Stockholm, Sweden, ²Institute of Environmental Medicine (IMM), Karolinska institutet, Stockholm, Sweden, ³The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Medicine, Karolinska University Hospital, Stockholm, Sweden, ⁵Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden, ⁶Dep of Medicine, Rheumatology unit, Karolinska Institute, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Chronic pain is common in RA and considered as the major disease burden from the patients’ perspective. Earlier data suggest that omega-3 fatty acids,…
Abstract Number: 3248 • 2015 ACR/ARHP Annual Meeting
Which Factors Explain Multi-Site Pain Caused By Obesity: A 5-Year Follow-up Study in Older Adults?
Feng Pan¹, Laura Laslett², Russell Thomson², Tania Winzenberg³, Flavia Cicuttini⁴, Changhai Ding⁵ and Graeme Jones⁵, ¹Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart,7000, Australia, ²Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ³Menzies Institute for Medical Research, University of Tasmania, Hobart,7000, Australia, ⁴Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ⁵Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Background/Purpose: Joint pain is common in older adults; typically multiple joints are involved. Obesity is an important risk factor in pathogenesis of multi-site joint pain…
Abstract Number: 3249 • 2015 ACR/ARHP Annual Meeting
Pooled Efficacy and Safety from Phase 3 Controlled Studies of Tanezumab in Patients with Osteoarthritis
Leslie Tive¹, David Radin², Alfonso Bello³, Ha Nguyen¹, Mark T. Brown⁴, Christine R. West⁴ and Kenneth M. Verburg⁴, ¹Pfizer, Inc, New York, NY, ²Stamford Therapeutics Consortium, Stamford, CT, ³Illinois Bone & Joint Inst, Glenview, IL, ⁴Pfizer Inc., Groton, CT
Background/Purpose: Tanezumab (TNZ) significantly reduces pain and improves physical function and Patient's Global Assessment (PGA) in patients with chronic pain. From June 2010 to August…
Abstract Number: 3250 • 2015 ACR/ARHP Annual Meeting
Systemic Inflammation and Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Laura Frey-Law², Devyani Misra¹, Michael C. Nevitt³, Lars Arendt-Nielsen⁴, Emily K. Quinn⁵ and Cora E. Lewis⁶, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²UIowa, Iowa City, IA, ³Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁴Aalborg University, Aalborg, Denmark, ⁵Data Coordinating Center, Boston University School of Public Health, Boston, MA, ⁶Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but its cause in humans is not well-understood. We recently demonstrated that local…
Abstract Number: 3251 • 2015 ACR/ARHP Annual Meeting
The Relation of Massive Weight Loss to Changes in Knee Pain and Sensitization
Joshua Stefanik^1,2, David T. Felson³, Jingbo Niu³, Anyu Hu⁴, Caroline Apovian⁵, Michael P. Lavalley⁶ and Tuhina Neogi⁷, ¹Northeastern University, Boston, MA, ²Clinical Epidemiology, Boston University, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Clinical Epidemiology Research Unit, Boston University School of Medicine, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶Biostatistics, Boston University School of Public Health, Boston, MA, ⁷Clinical Epidemiology, Boston University School of Medicine, Boston, MA
Background/Purpose: Individuals with chronic knee pain often develop central and/or peripheral sensitization (altered pain processing of the nervous system). Whether improvements in knee pain are…
Abstract Number: 3252 • 2015 ACR/ARHP Annual Meeting
Impact of Knee Pain Frequency on Physical Function in the Osteoarthritis Initiative
Jin Zhou¹, Erin Ashbeck², Lynn Hamilton² and C. Kent Kwoh³, ¹Epidemiology & Biostatistics, University of Arizona, Tucson, AZ, ²Arthritis Center, University of Arizona, Tucson, AZ, ³Rheumatology, University of Arizona, Tucson, AZ
Background/Purpose: Knee pain is a prominent symptom among patients with knee osteoarthritis (OA), but the impact of knee pain frequency on physical function has been…
Abstract Number: 3253 • 2015 ACR/ARHP Annual Meeting
The Predictive Value of Antibodies to Cyclic Citrullinated Peptide in Two Prospective Early Rheumatoid Arthritis Cohorts 10 Years Apart
Alf Kastbom¹, Michael Ziegelasch¹, Ingrid Thyberg¹, Birgir Arge², Klara Martinsson¹, Olle Svernell³, Åsa Häggström⁴, Per Salomonsson⁵, Britt-Marie Nyhäll-Wåhlin⁶, Sören Transö⁷, Claudia Jacobs⁸ and Thomas Skogh¹, ¹IKE/Rheumatology, Linköping University, Linköping, Sweden, ²Rheumatology clinic, Eskilstuna Hospital, Eskilstuna, Sweden, ³Rheumatology Dpt, Västervik Hospital, Västervik, Sweden, ⁴Rheumatology clinic, Kalmar Hospital, Kalmar, Sweden, ⁵Rheumatology Clinic, Örebro University Hospital, Örebro, Sweden, ⁶Department of Rheumatology, Falun Hospital, Falun, Sweden, ⁷Rheumatology Clinic, Ryhov Hospital, Jönköping, Sweden, ⁸Rheumatology Dept, Oskarshamn Hospital, Oskarshamn, Sweden
Background/Purpose: Antibodies to cyclic citrullinated peptides (anti-CCP) associate with a more severe rheumatoid arthritis (RA) disease course, and therefore have influence on therapeutic decisions. By…
Abstract Number: 3254 • 2015 ACR/ARHP Annual Meeting
A Clinical Risk Score to Predict Functional Disability at 1 Year in an Early Rheumatoid Arthritis Inception Cohort
Caroline Kronisch^1,2, David Mclernon³, James Dale⁴, Caron Paterson⁴, Stuart H. Ralston⁵, David M. Reid⁶, Ann Tierney⁴, John Harvie⁷, Neil McKay⁸, Hilary E. Wilson⁹, Robin Munro¹⁰, Sarah Saunders¹¹, Ruth Richmond¹², Derek Baxter¹³, Mike McMahon¹⁴, Vinod Kumar¹⁵, John McLaren¹⁶, Stefan Siebert⁴, Iain B. McInnes¹⁷, Duncan Porter⁴, Gary J. Macfarlane² and Neil Basu², ¹Department of Rheumatology, Cantonal Hospital Fribourg, Fribourg, Switzerland, ²Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ³Musculoskeletal Research Collaboration (Medical Statistics Team), University of Aberdeen, Aberdeen, United Kingdom, ⁴Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom, ⁵Centre for Genomic and Experimental Medicine, Western General Hospital, Edinburgh, United Kingdom, ⁶Musculoskeletal Research Collaboration (Medicine & Therapeutics), University of Aberdeen, Aberdeen, United Kingdom, ⁷Department of Rheumatology, Raigmore Hospital, Inverness, United Kingdom, ⁸Department of Rheumatology, Western General Hospital, Edinburgh, United Kingdom, ⁹Department of Rheumatology, Stobhill General Hospital, Glasgow, United Kingdom, ¹⁰Department of Rheumatology, Wishaw General Hospital, Lanarkshire, United Kingdom, ¹¹Centre of Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom, ¹²Department of Rheumatology, Borders General Hospital, Melrose, United Kingdom, ¹³Department of Rheumatology, University Hospital Ayr, Ayr, United Kingdom, ¹⁴Department of Rheumatology, Dumfries & Galloway Royal Infirmary, Dumfries, United Kingdom, ¹⁵Department of Rheumatology, Ninewells Hospital, Dundee, United Kingdom, ¹⁶Department of Rheumatology, Whyteman Brae Hospital, Fife, United Kingdom, ¹⁷Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: When diagnosed with rheumatoid arthritis (RA), patients are especially concerned by the prospect of disability. Predictors of future disability may inform early decision making.…
Abstract Number: 3255 • 2015 ACR/ARHP Annual Meeting
Brain White Matter Integrity: A Future Biomarker for Rheumatoid Arthritis Related Fatigue?
Neil Basu¹, Marayam Alsyedalhashem², Mariella D'Allesandro³, Alison D. Murray², Daniel J. Clauw⁴ and Gordon D. Waiter², ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom, ³Muscloskeletal Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ⁴Anesthesiology, University of Michigan, Ann Arbor, MI
Background/Purpose: Fatigue is a major burden among patients with rheumatoid arthritis (RA). The identification of reliable biomarkers would greatly enhance research in this challenging field. …
Abstract Number: 3256 • 2015 ACR/ARHP Annual Meeting
Epigenetic Chromosome Conformations Predict MTX Responsiveness in Early Rheumatoid Arthritis Patients
Claudio Carini¹, Aroul Ramadass², Philip Jordan², Ewan Hunter², Alexandre Akoulitchev², Iain. B. McInnes³, Carl. S. Goodyear³ and Scottish Early Rheumatoid Arthritis Inception Cohort Investigators, ¹35 Cambridgepark Drive, Pfizer, Cambridge, MA, ²Oxford Biodynamics, Oxford, United Kingdom, ³Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: In early rheumatoid arthritis (RA), it is not possible to predict response to first line DMARDs (e.g. methotrexate (MTX)) and as such treatment decisions…
Abstract Number: 3257 • 2015 ACR/ARHP Annual Meeting
The Link Between DAS28 and the Short-Term Risk of Acute Coronary Syndrome in RA, and Its Driving Factors
Lotta Ljung^1,2, Thomas Frisell³ and Johan Askling^3,4, ¹Department of Medicine, Solna, Clinical epidemiology unit, Karolinska Institutet, Stockholm, Sweden, ²Department for Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden, ³Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: The extent to which a short-term effect of the disease activity adds to the over-risk of coronary events in patients with Rheumatoid Arthritis (RA)…
Abstract Number: 3258 • 2015 ACR/ARHP Annual Meeting
Different Perception of Disease Activity in Multimorbid Rheumatoid Arthritis Patients
Helga Radner^1,2, Kazuki Yoshida^1,3, Sara K. Tedeschi⁴, M Frits⁵, C Iannaccone⁶, N Shadick⁷, Michael Weinblatt¹, Daniel Aletaha⁸, Josef S. Smolen⁹ and Daniel H. Solomon¹⁰, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Department of Internal Medicine III; Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Epidemiology, Harvard School of Public Health, Boston, MA, ⁴Rheumatology, Brigham & Women's Hospital, Boston, MA, ⁵Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Boston, MA, ⁷Division of Rheumatology, Immunology & Allergy, Brigham and Women's Hosp, Boston, MA, ⁸Rheumatology, Medical University Vienna, Vienna, Austria, ⁹Dept of Medicine 3, Division of Rheumatology, Medical Univ Vienna, Vienna, Austria, ¹⁰Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: The patient rating of global rheumatoid arthritis (RA) disease activity (PtGA) is a key variable in composite measures of disease activity as well as…
Abstract Number: 3259 • 2015 ACR/ARHP Annual Meeting
Immunoablation Followed By Autologous Stem Cell Transplantation in Systemic Sclerosis Patients Decreases Significantly the Interferon Signatrue
Shervin Assassi¹, Maureen D Mayes¹, Claudia Pedroza², Jeffrey T. Chang², Daniel E. Furst³, Leslie J. Crofford⁴, Richard Nash⁵, Peter McSweeney⁵, Mary Ellen Csuka⁶, Ellen Goldmuntz⁷, Lynette Keyes-Elstein⁸, Paul Wallace⁹ and Keith Sullivan¹⁰, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²University of Texas Medical School at Houston, Houston, TX, ³Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁴Medicine, Vanderbilt University, Nashville, TN, ⁵Colorado Blood Cancer Institute, Denver, CO, ⁶Rheum/Med Coll of Wisconsin, Med Coll of Wisconsin, Milwaukee, WI, ⁷NIAID, National Institutes of Health, Bethesda, MD, ⁸Rho Federal Systems, Inc., Chapel Hill, NC, ⁹Roswell Park, Buffalo, NY, ¹⁰Duke University, Durham, NC
Background/Purpose: Previous clinical trials have suggested that immunoablation followed by autologous hematopoietic cell transplantation (HCT) can lead to clinical improvements in systemic sclerosis (SSc). However,…
Abstract Number: 3260 • 2015 ACR/ARHP Annual Meeting
Increased Frequency of Malignancies Synchronous to the Onset of Systemic Sclerosis in Anti-RNA Polymerase III Antibodies Positive Patients: A Eustar Multicentre Study
Maria Grazia Lazzaroni¹, Enrico Colombo², Ilaria Cavazzana¹, Oliver Distler³, Rucsandra Dobrota³, Jasmin Eisenring³, Roger Hesselstrand⁴, Lazlo Czirjak⁵, Cecilia Varju⁵, Gabriella Nagy⁵, Vanessa Smith⁶, Paola Caramaschi⁷, Valeria Riccieri⁸, Eric Hachulla⁹, Katarzyna Romanowska-Próchnicka¹⁰, Alexandra Balbir-Gurman¹¹, Emmanuel Chatelus¹², Ana Carolina Araújo¹³, Yannick Allanore¹⁴, Paolo Airò¹⁵ and EUSTAR , ¹Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology Unit, University and Spedali Civili of Brescia, Brescia, Italy, ³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁵University of Pécs Medical Center, Pécs, Hungary, ⁶Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁷Rheumatology Unit, Azienda Ospedaliera Universitaria Integrata, Verona, Italy, ⁸Department of Internal Medicine and Medical Specialities, University Sapienza, Rome, Italy, ⁹Department of Internal Medicine, University Lille Nord-de-France, Lille, France, ¹⁰Department of Pathophysiology, Medical University of Warsaw and Department of Connective Tissue Diseases, Institute of Rheumatology, Warsaw, Poland, ¹¹B. Shine Rheumatology Unit, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion - Institute of Technology, Haifa, Israel, ¹²Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ¹³Serviço de Medicina 2, Hospital de Curry Cabral, Centro Hospitalar Lisboa Central, Lisbon, Portugal, ¹⁴Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France, ¹⁵Rheumatology and Clinical Immunology Unit, Spedali Civili of Brescia, Brescia, Italy
Increased Frequency of Malignancies Synchronous to the Onset of Systemic Sclerosis in Anti-RNA Polymerase III Antibodies Positive Patients: a EUSTAR Multicentre Study Background/Purpose: Several clinical issues…

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