Abstracts Archive - Page 1867 of 2425 - ACR Meeting Abstracts

Abstract Number: 2781 • 2014 ACR/ARHP Annual Meeting
Cost-Effectiveness of Adding Etanercept Vs. Sulfasalazine and Hydroxychloroquine to Methotrexate Therapy: A Randomized Noninferiority Trial
Nick Bansback¹, Ciaran Phibbs², Huiying Sun³, James R. O'Dell⁴, Mary Brophy⁵, Edward C. Keystone⁶, Sarah Leatherman⁷, Ted R. Mikuls⁴ and Aslam H. Anis³, ¹School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ²Health Economics Resource Center (152), Palo Alto VA Health Care System, Menlo Park, CA, ³St. Paul's Hospital, Centre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada, ⁴Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁵VA Boston Heathcare System, Boston, MA, ⁶Medicine, University of Toronto, Toronto, ON, Canada, ⁷VA Boston Heatlhcare System, Boston, MA
Background/Purpose: To estimate the incremental cost-effectiveness of etanercept plus methotrexate versus a triple regimen of disease-modifying anti rheumatic drugs (methotrexate, sulfasalazine, and hydroxychloroquine) over 24…
Abstract Number: 2782 • 2014 ACR/ARHP Annual Meeting
Autoantibodies from Single Circulating Plasmablasts React with Citrullinated Antigens and Porphyromonas Gingivalis in Rheumatoid Arthritis
Song Li¹, Yangsheng Yu¹, Yinshi Yue¹, Hongyan Liao¹, Wanqin Xie¹, Jessica Thai¹, Ted R. Mikuls², Geoffrey M. Thiele³, Michael J. Duryee⁴, Jeffrey Payne⁵, Lynell W. Klassen⁶, James R. O'Dell⁷, Zhixin Zhang⁸ and Kaihong Su¹, ¹Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, ⁶Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁸Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) and also believed to play a pathogenic role in RA. Porphyromonas gingivalis (P.…
Abstract Number: 2783 • 2014 ACR/ARHP Annual Meeting
Effect of Synovitis, Effusion and Bone Marrow Lesions on Development of Sensitization in Knee OA: The Multicenter Osteoarthritis Study
Tuhina Neogi¹, Michael C. Nevitt², Joachim Scholz³, Lars Arendt-Nielsen⁴, Clifford Woolf⁵, Laurence A. Bradley⁶, Emily K. Quinn⁷ and Laura Frey-Law⁸, ¹Boston University School of Medicine, Boston, MA, ²Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ³Columbia University, New York, NY, ⁴Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Center for Sensory-Motor Interaction, Aalborg, Denmark, ⁵F.M. Kirby Neurobiology Center, Children's Hospital Boston, Boston, MA, ⁶Div of Rheumatology, Univ of Alabama-Birmingham, Birmingham, AL, ⁷Clinical Epidemiology Unit, Boston University, Boston, MA, ⁸University of Iowa, Iowa City, IA
Background/Purpose: Alterations in the peripheral and central nervous systems including sensitization are thought to play an important role in the pain experience in knee OA.…
Abstract Number: 2784 • 2014 ACR/ARHP Annual Meeting
Contribution at the Spinal Level of Innate and Adaptive Immunity to the Development of Persistent Post-Inflammatory Mechanical Allodynia in Arthritic Mice
Sarah Woller¹, Cody Ocheltree², Tony Yaksh¹ and Marpiat Corr³, ¹Anesthesiology, UCSD, La Jolla, CA, ²Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA, ³University of California at San Diego, La Jolla, CA
Background/Purpose Individuals with arthritis frequently develop persistent pain despite adequate treatment of synovitis. There is a need to better understand the mechanisms underlying pain occurring…
Abstract Number: 2785 • 2014 ACR/ARHP Annual Meeting
Joint Specific Positional Differences in Coding and Noncoding Transcriptome of Synovial Fibroblasts As a Determinant of the Susceptibility of Synovial Joints to Rheumatoid Arthritis
Caroline Ospelt¹, Maria Armaka², Giancarlo Russo³, Anna Bratus³, Michelle Trenkmann⁴, Emmanuel Karouzakis¹, Christoph Kolling⁵, Renate E. Gay⁴, George Kollias⁶, Steffen Gay¹ and Mojca Frank Bertoncelj¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Institute of Immunology,, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, ³Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Schulthess Clinic, Zurich, Switzerland, ⁶Institute of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece
Background/Purpose The molecular mechanisms underlying the topographic differences in the susceptibility of synovial joints to develop rheumatoid arthritis (RA) are unknown. Positional embryonic expression of…
Abstract Number: 2786 • 2014 ACR/ARHP Annual Meeting
Aortitis: Outcomes from a Cohort of 196 Patients
Alison Clifford¹, Amr Arafat², Jahanzaib Idrees², Eric Roselli², Carmela D. Tan³, E. Rene Rodriguez³, Lars Svensson², Eugene Blackstone² and Gary S. Hoffman¹, ¹Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, ²Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, OH, ³Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Idiopathic aortitis is a rare diagnosis that may occur in the context of a primary systemic vasculitis, as part of a systemic autoimmune disease,…
Abstract Number: 2787 • 2014 ACR/ARHP Annual Meeting
Identification of Urinary Biomarkers for Lupus Nephritis
Carolina Landolt-Marticorena¹, Stephenie Prokopec², Heather Reich³, James Scholey⁴, Carmen Avila-Casado⁵, Paul R. Fortin⁶, Paul Boutros² and Joan Wither⁷, ¹Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ²Ontario Institute for Cancer Research, Toronto, ON, Canada, ³Nephrology, University Health Network, Toronto, ON, Canada, ⁴Department of Medicine, The Toronto Western Hospital, Toronto, ON, Canada, ⁵Pathology, University Health Network, Toronto, ON, Canada, ⁶Rheumatology, Laval University, Division of Rheumatology, Centre de Recherche du CHU de Québec and Department of Medicine, Quebec City, QC, Canada, ⁷Immunology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Lupus nephritis (LN) is a major determinant of morbidity and mortality in Systemic Lupus Erythematosus (SLE). Variability in clinical course, underlying renal injury, and…
Abstract Number: 2788 • 2014 ACR/ARHP Annual Meeting
Preliminary Population- Based Incidence and Prevalence Estimates of SLE: The California Lupus Surveillance Project
Maria Dall'era¹, Kurt Snipes², Miriam Cisternas³, C. Gordon⁴ and Charles G. Helmick⁵, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²California Department of Public Health, Sacramento, CA, ³MGC Data Services, San Diego, CA, ⁴Rheumatology (East Wing), Medical School, Birmingham, United Kingdom, ⁵National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Previous estimates of prevalence and incidence of systemic lupus erythematosus (SLE) in the United States have varied widely. The California Lupus Surveillance Project (CLSP)…
Abstract Number: 2789 • 2014 ACR/ARHP Annual Meeting
Medical Marijuana Related Outcomes in Patients with Systemic Lupus Erythematosis
Basmah Jalil¹, Wilmer Sibbitt Jr.², Romy Cabacangun³, Clifford Qualls⁴, Arthur Bankhurst⁵ and Roderick Fields⁶, ¹Internal Medicine/Rheumatology, University of New Mexico, Albuquerque, NM, ²Internal Medicine/Rheumatology, University of New Mexico HSC, Albuquerque, NM, ³Rheumatology, UNM, Albuquerque, NM, ⁴Biostatistics, UNM, Albuquerque, NM, ⁵Rheum/ MSC 105550, University of NM Med Ctr, Albuquerque, NM, ⁶Internal Medicine/ Rheumatology, University of New Mexico School of Medicine, Albuquerque, NM
Background/Purpose Medical cannabis is used extensively in the United States, usually in the form of smoked marijuana. There is growing research regarding the immunomodulatory effects…
Abstract Number: 2790 • 2014 ACR/ARHP Annual Meeting
CMR with Quantitative T2 Mapping in Patients with Active SLE
Stacy P. Ardoin¹, Wael N. Jarjour², Subha V. Raman², Amanda Kibler² and Tam Tran², ¹Pediatric & Adult Rheumatology, Ohio State University College of Medicine, Columbus, OH, ²Ohio State University, Columbus, OH
Background/Purpose: Cardiovascular (CV) disease is an important cause of morbidity in systemic lupus erythematosus (SLE) . Myocarditis is considered an uncommon complication of SLE…
Abstract Number: 2791 • 2014 ACR/ARHP Annual Meeting
Lung Cancer in SLE
Sasha Bernatsky¹, Rosalind Ramsey-Goldman², Michelle Petri³, Murray B. Urowitz⁴, Dafna D. Gladman⁴, Edward H. Yelin⁵, Christine Peschken⁶, John G. Hanly⁷, James E. Hansen⁸, Jean-Francois Boivin⁹, Lawrence Joseph¹⁰, Patrice Chrétien Raymer¹¹, Mruganka Kale¹², Ann E. Clarke¹³ and Systemic Lupus International Collaborating Clinics (SLICC)¹⁴, ¹Clinical Epidemiology - Rheumatology, McGill University, Montreal, QC, Canada, ²FSM-300, Northwestern University, Chicago, IL, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Arthritis Research Group, University of California, San Francisco, San Francisco, CA, ⁶Medicine & Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, ⁷Division of Rheumatology, Dalhousie University and Capital Health, Halifax, NS, Canada, ⁸Therapeutic Radiology, Yale University, New Haven, CT, ⁹Department of Epidemiology & Biostatistics, McGill University, Montreal, QC, Canada, ¹⁰McGill University, Montreal, QC, Canada, ¹¹Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ¹²Clinical Epidemiology Rheum, RI McGill Univ Health Ctr, Montreal, QC, Canada, ¹³Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ¹⁴Systemic Lupus International Collaborating Clinics (SLICC), ON, Canada
Background/Purpose: Lung cancer is 50% more common in SLE patients than their sex and age-matched counterparts. Our objective was to assess lung cancer risk in…
Abstract Number: 2792 • 2014 ACR/ARHP Annual Meeting
Methotrexate Prevents Inflammatory Osteolysis By Activation of the Adenosine a_2A Receptor (A2AR)
Aranzazu Mediero¹, Tuere Wilder² and Bruce N. Cronstein³, ¹Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ²Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ³NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Prior studies demonstrate that adenosine, acting at A2AR, mediates the anti-inflammatory effects of methotrexate (MTX) in models of both acute and chronic inflammation. We…
Abstract Number: 2793 • 2014 ACR/ARHP Annual Meeting
BMP2 Requires TGF-Beta to Induce Osteophytes during Experimental Osteoarthritis
Esmeralda Blaney Davidson¹, Arjen Blom², Arjan van Caam¹, Elly Vitters², Miranda Bennink¹, Wim van den Berg², Fons van de Loo³ and Peter van der Kraan⁴, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁴Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: Osteophytes are a major hallmark of osteoarthritis (OA). Both TGF-beta and BMP2 can induce osteophytes in murine knee joints. We demonstrated that TGF-beta could…
Abstract Number: 2754 • 2014 ACR/ARHP Annual Meeting
Predictors of Quality of Life in Behçet’s Syndrome
Selma Bozcan¹, Yesim Ozguler¹, Koray Tascilar¹, Caner Saygin¹, Didem Uzunaslan¹ and Gulen Hatemi², ¹University of Istanbul, Cerrahpasa Medical Faculty, Rheumatology, Istanbul, Turkey, ²Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey
Background/Purpose: Quality of life is commonly impaired in patients with chronic inflammatory diseases. The disease itself as well as the drugs used may be responsible…
Abstract Number: 2755 • 2014 ACR/ARHP Annual Meeting
Disease Activity and Quality of Life in BEHÇET’S Disease: The Role of Patients Reportedoutcomes
Elena Elefante¹, Rosaria Talarico², Chiara Stagnaro³, Anna d'Ascanio⁴, Antonio Tavoni⁵, Chiari Tani¹, Chiara Baldini¹, Marta Mosca⁶ and Stefano Bombardieri², ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Rheumatology Unit, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴Internal Medicine, University of Pisa, Pisa, Italy, ⁵University of Pisa, Immunoallergology Unit, Pisa, Italy, ⁶V. Roma 67, 56126 Pisa, S. Chiara, Pisa, Italy
Background/Purpose Behçet’s disease (BD) is a systemic vasculitis, typically characterised by recurrent oro-genital ulcers, ocular inflammation and skin manifestations; articular, vascular, gastro-enteric and neurological involvement…

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