Abstracts Archive - Page 1867 of 2607 - ACR Meeting Abstracts

Abstract Number: 3200 • 2015 ACR/ARHP Annual Meeting
Characterization of Early and Progressive Autoimmunity in Sjogrens Syndrome: The Incomplete Sjogrens Syndrome Model
Astrid Rasmussen¹, Christopher J Lessard², Indra Adrianto¹, Graham B. Wiley¹, Donald U Stone^3,4, C. Erick Kaufman⁵, Lida Radfar⁶, David M. Lewis⁷, Stephen K Young⁸, Michael H. Weisman⁹, Daniel J Wallace¹⁰, Swamy Venuturupalli¹¹, Barbara M. Segal¹², John A. Ice¹, Juan-Manuel Anaya¹³, Michael D. Rohrer¹⁴, Raj Gopalakrishnan¹⁵, Glen D Houston¹⁶, James Chodosh¹⁷, Pamela J Hughes¹⁸, Nelson L. Rhodus¹⁹, Jennifer A. Kelly²⁰, Kiely Grundahl²¹, Kimberly Hefner²², R. Hal Scofield^1,23,24 and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁴Department of Ophthalmology, Johns Hopkins University, Riyadh, Saudi Arabia, ⁵College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, ⁷College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁰Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹¹Cedars-Sinai Medical Center, West Hollywood, CA, ¹²Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹³Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ¹⁴Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ¹⁵Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota, Minneapolis, MN, ¹⁶Heartland Pathology, Oklahoma City, OK, ¹⁷Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹⁸Division of Oral and Maxillofacial Surgery, University of Minnesota, Minneapolis, MN, ¹⁹Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁰Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ²²Hefner Eye Care and Optical Center, Oklahoma City, OK, ²³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁴US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Autoimmune diseases are often preceded by subclinical serologic and functional abnormalities that predate diagnosis by several years. The insidious and progressive nature of these…
Abstract Number: 3201 • 2015 ACR/ARHP Annual Meeting
IL-7 Drives Cytokine Secretion of IL-7Rabright CCR9-Expressing T-Follicular Helper-like Cells: Potential New Axis in Lymphoid Neogenesis in Salivary Glands of Primary Sjogren s Syndrome Patients
S.L.M. Blokland^1,2, M.R. Hillen^1,2, A.A. Kruize¹, A. Kislat³, S. Meller³, B. Homey³, G.M. Smithson⁴, J. Zalevsky⁵, T.R.D.J. Radstake^1,2 and J.A.G. van Roon^1,6, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Dermatology, University of Düsseldorf, Medical Faculty, Düsseldorf, Germany, ⁴Takeda Pharmaceuticals International, Chicago, IL, ⁵Takeda California, San Diego, CA, ⁶Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: In primary Sjögren’s syndrome (pSS) B cell hyperactivity including autoantibody secretion and lymphoma development are hallmark immunopathological features. Specific lymphoid organization (including germinal centers)…
Abstract Number: 3202 • 2015 ACR/ARHP Annual Meeting
Functional Anti-Muscarinic Receptor-3 Monoclonal Antibodies Derived from Salivary Gland in Patients of Sjögren’s Syndrome
Syed M.S. Quadri^1,2, Kristi A. Koelsch³, Valerie Harris⁴, Biji T Kurien⁵ and R. Hal Scofield⁶, ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁴University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Sjögren's syndrome (SS) is a chronic autoimmune inflammatory disease characterized by bilateral hypofunction of lacrimal and salivary glands leading to keratoconjuctivitis and xerostomia. The…
Abstract Number: 3203 • 2015 ACR/ARHP Annual Meeting
The Clinical Efficacy and Safety of Baminercept, a Lymphotoxin-Beta Receptor Fusion Protein, in Primary Sjögren’s Syndrome: Results from a Randomized, Double-Blind, Placebo-Controlled Phase II Trial
E. William St.Clair¹, Alan N. Baer², Ghaith Noaiseh³, Anne Parke⁴, Andreea Coca⁵, Tammy Utset⁶, Mark C. Genovese⁷, Daniel J Wallace⁸, James McNamara⁹, Karen Boyle¹⁰, Lynette Keyes-Elstein¹⁰, Nathalie Franchimont¹¹, Judith A James¹² and for the Autoimmunity Centers of Excellence supported by a grant from NIAID 5U19-AI056363, ¹Medicine, Duke University, Durham, NC, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴University of Connecticut, Farmington, CT, ⁵University of Rochester Medical Center, Rochester, NY, ⁶University of Chicago, Chicago, IL, ⁷Division of Rheumatology, Stanford University Medical Center, Palo Alto, CA, ⁸Cedars-Sinai Medical Center, West Hollywood, CA, ⁹NIAID/NIH, Bethesda, MD, ¹⁰Rho Federal Systems, Inc., Chapel Hill, NC, ¹¹Biogen, Cambridge, MA, ¹²OMRF, OU, Oklahoma City, OK
Background/Purpose: Primary Sjögren’s syndrome (pSjS) is characterized by chronic inflammation of the lacrimal and salivary glands, as well as frequent extraglandular involvement and increased risk…
Abstract Number: 3204 • 2015 ACR/ARHP Annual Meeting
Hypoechoic Lesions on Parotid Gland Ultrasound Are a Surrogate Marker of Focal Lymphocytic Sialadenitis on Minor Salivary Gland Biopsy in Sjögren’s Syndrome
Thomas Grader-Beck¹, Joel Fradin², Jean Kim³, Esen Akpek⁴, Brendan Antiochos⁵, Julius Birnbaum⁶ and Alan N. Baer⁷, ¹Medicine Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ³Otolaryngology, Head & Neck Surgery, Johns Hopkins University, Baltimore, MD, ⁴Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Medicine-Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁶Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: To determine whether hypoechoic lesions on parotid gland ultrasound can serve as a surrogate marker for a focus score ≥1 on minor salivary gland…
Abstract Number: 3205 • 2015 ACR/ARHP Annual Meeting
Treatment with Abatacept or Rituximab Targets T Follicular Helper Cells in Patients with Primary Sjogren s Syndrome
Gwenny M. Verstappen¹, Petra M. Meiners², Odilia B.J. Corneth³, Rudi W. Hendriks³, Arjan Vissink⁴, Frans G.M. Kroese⁵ and Hendrika Bootsma⁵, ¹Rheumatology & Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Pulmonary Medicine, Erasmus MC, Rotterdam, Netherlands, ⁴Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: T cell-dependent B cell hyperactivity is a characteristic pathogenetic feature of primary Sjögren’s syndrome (pSS). This is illustrated by the finding that treatment of…
Abstract Number: 3206 • 2015 ACR/ARHP Annual Meeting
Inflammation on MRI in Sacroiliac-Joints and Spine Is Longitudinally Related to Disease Activity in Male but Not in Female Patients with Axial Spondyloarthritis: 2-Year Data from the DESIR Cohort
Victoria Navarro-Compán¹, Sofia Ramiro², Robert B. M. Landewé³, Maxime Dougados⁴, Corinne Miceli-Richard⁵, Pascal Richette⁶ and Désirée van der Heijde⁷, ¹Rheumatology, University Hospital La Paz, Madrid, Spain, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Amsterdam Rheumatology & Immunology Center, Academic Medical Center, Amsterdam, Netherlands, ⁴Université Paris René Descartes and Hôpital Cochin, Paris, France, ⁵Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ⁶Université Paris Diderot, UFR médicale, Paris, France; APHP Hôpital Lariboisière, Fédération de Rhumatologie and Inserm U1132, Hôpital Lariboisière, Paris, France, ⁷Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: In patients with axial spondyloarthritis (axSpA), clinical disease activity measures (DA) have been longitudinally related to radiographic progression. Interestingly, a gender disparity has been…
Abstract Number: 3207 • 2015 ACR/ARHP Annual Meeting
Axial Disease in Psoriatic Arthritis: A Clinical and Radiographic Comparison with Ankylosing Spondylitis
Deepak R. Jadon¹, Raj Sengupta¹, Alison L Nightingale², Mark Lindsay³, Eleanor Korendowych¹, Graham Robinson⁴, Amelia Jobling⁵, Gavin Shaddick⁶, Anne Barton⁷ and Neil J. McHugh⁸, ¹Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ³Pharmacy & Pharmacology, University of Bath, Bath, United Kingdom, ⁴Royal United Hospital, Bath, United Kingdom, ⁵Mathematical Sciences, University of Bath, Bath, United Kingdom, ⁶Department of Mathematics, University of Bath, Bath, United Kingdom, ⁷Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University Of Manchester, Manchester, United Kingdom, ⁸Rheumatology, Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, United Kingdom
Background/Purpose: Little is known of the characteristics of psoriatic spondyloarthritis (PsSpA). A study was conducted to determine the: (i) prevalence of PsSpA in a psoriatic…
Abstract Number: 3208 • 2015 ACR/ARHP Annual Meeting
Spinal Radiographic Progression in Early Axial Spondyloarthritis: Data from the DESIR Cohort
Sofia Ramiro¹, Désirée van der Heijde¹, Rosaline van den Berg², Victoria Navarro-Compán³, Antoine Feydy⁴, Maria-Antonietta d'Agostino⁵, Damien Loeuille⁶, Maxime Dougados⁷, Monique Reijnierse⁸ and Pascal Claudepierre⁹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology, University Hospital La Paz, Madrid, Spain, ⁴Paris Descartes University, Radiology B department, Cochin Hospital, Paris, France, ⁵Rheumatology, Versailles-Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁶Rheumatology, Nancy University Hospital, Nancy, France, ⁷Rheumatology Department, Cochin hospital, Paris-Descartes University, Paris, France, ⁸Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁹Rheumatology, Université Paris Est Créteil, Créteil, France
Background/Purpose: The development of radiographic damage over time has been investigated in patients with AS, but not yet in early axial spondyloarthritis (axSpA). We have…
Abstract Number: 3209 • 2015 ACR/ARHP Annual Meeting
Utility of Power Doppler Ultrasound-Detected Synovitis for the Prediction of Short Term Flare in Psoriatic Arthritis Patients in Clinical Remission
Josefina Marin^1,2, M Laura Acosta-Felquer², Leandro Ferreyra-Garrot³, Erika Catay⁴, Javier Rosa⁵, Santiago Ruta², Mirtha Sabelli², Ricardo Garcia-Monaco Sr.⁶ and Enrique R. Soriano⁷, ¹Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ²Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ³Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Instituto Universitario Hospital Italiano de Buenos Aires, and Fundacion PM Catoggio, Internal Medicine, Argentina, Buenos Aires, Argentina, ⁴Salguero 569 7 35, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁵Rheumatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁶Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁷Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Ultrasound has been shown to detect subclinical synovitis in in rheumatoid arthritis and psoriatic arthritis (PsA in clinical remission.). The value of power Doppler…
Abstract Number: 3210 • 2015 ACR/ARHP Annual Meeting
Evaluation of Sacroiliac Joint Radiographs in Patients with Chronic Low Back Pain: Is Erosion the Main Driver of Interreader Disagreement?
Alice Ashouri Christiansen^1,2, Oliver Hendricks^1,2, Dorota Kuettel¹, Kim Hørslev-Petersen^1,2, Anne Grethe Jurik^2,3,4, Steen Nielsen¹, Kaspar Rufibach⁵, Anne Gitte Loft^6,7, Susanne Juhl Pedersen^8,9, Louise Thuesen Hermansen^1,2, Mikkel Østergaard^8,10, Bodil Arnbak^2,4, Claus Manniche^2,4 and Ulrich Weber^1,2, ¹Department of Research, King Christian 10th Hospital for Rheumatic Diseases, Graasten, Denmark, ²Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, ³Department of Radiology, Aarhus University Hospital, Aarhus, Denmark, ⁴Hospital Lillebaelt, Spine Centre of Southern Denmark, Middelfart, Denmark, ⁵rePROstat, Basel, Switzerland, ⁶Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁷Department of Rheumatology, Vejle Hospital, Vejle, Denmark, ⁸Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, ⁹Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen, Denmark, ¹⁰Rigshospitalet-Glostrup, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet - Glostrup, Glostrup, Denmark
Background/Purpose: Evaluation of sacroiliac joints (SIJ) on pelvic radiographs according to the modified New York criteria (mNYc) is considered the gold standard for classification of…
Abstract Number: 3211 • 2015 ACR/ARHP Annual Meeting
Current Smoking, Its Intensity and Duration, Is Associated with Fat Metaplasia on MRI in Patients with Spondyloarthritis
Walter Maksymowych¹, Stephanie Wichuk¹, Praveena Chiowchanwisawakit², Zheng Zhao³, Donald Spady¹, Barbara Conner-Spady¹, Robert G Lambert⁴ and Susanne Juhl Pedersen⁵, ¹Medicine, Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Rheumatology, Chinese PLA General Hospital, Beijing, China, ⁴Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Copenhagen Center for Arthritis Research, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: Smoking has been associated with radiographic severity and progression in SpA although there is little understanding of the mechanism. Prospective MRI data indicates…
Abstract Number: 3212 • 2015 ACR/ARHP Annual Meeting
Characterizing the Effects of the G-CSF-R Coding rs13377964 SNP Located within Murine Lupus Susceptibility Locus Sle2c2
Ramya Sivakumar¹ and Laurence Morel², ¹Pathology, University of Florida, Gainesville, FL, ²Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL
Background/Purpose: The genetic analysis of the lupus prone NZM2410 mouse has identified a suppressor locus, Sle2c2, which confers resistance to both spontaneous and chronic graft-vs.-host…
Abstract Number: 3214 • 2015 ACR/ARHP Annual Meeting
Impaired Phagocytosis of Apoptotic Cells in Pristane-Induced Lupus Simulates the Clearance Defect in Human SLE
Shuhong Han¹, Haoyang Zuang¹, Ravil Khaybullin², Stepan Shumyak³, Anan Afaneh⁴, Xin Qi⁵, Lijun yang⁶ and Westley H. Reeves⁷, ¹Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL, ²medicinal chemistry, University of Flordia, gainesville, FL, ³division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁴Division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁵medicinal chemistry, University of Florida, gainesville, FL, ⁶Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, ⁷Medicine, University of Florida, Gainesville, FL
Background/Purpose: Defective phagocytosis of dead cells is seen in SLE patients’ monocytes. Pristane-induced lupus causes accumulation of dead cells in tissues resembling that in SLE…
Abstract Number: 3215 • 2015 ACR/ARHP Annual Meeting
Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses
Fu-Nien Tsai¹ and Harris R. Perlman², ¹Medicine, Rhuematology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…

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