Abstracts Archive - Page 1863 of 2607 - ACR Meeting Abstracts

Abstract Number: 3140 • 2015 ACR/ARHP Annual Meeting
A Meta-Immunochip Analysis Suggests IL12B As a Common Susceptibility Factor for Large-Vessel Vasculitides
Francisco David Carmona¹, Patrick Coit², Güher Saruhan-Direskeneli³, Maria C. Cid⁴, Roser Solans⁵, Santos Castañeda⁶, Augusto Vaglio (on behalf of the Italian GCA Study Group)⁷, Haner Direskeneli (on behalf of the Turkish Takayasu Study Group)⁸, Peter A. Merkel⁹, Carlo Salvarani¹⁰, Miguel A. Gonzalez-Gay¹¹, Javier Martín¹², Amr H. Sawalha² and Spanish GCA consortium, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Physiology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, ⁴Autoimmune and Systemic Diseases, Hospital Clínic. IDIBAPS. University of Barcelona, Barcelona, Spain, ⁵Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, ⁶Rheumatology, H.U. La Princesa, Madrid, Spain, ⁷Medicina Clinica e Nefrologia, Università di Parma, Parma, Italy, ⁸Department of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey, ⁹Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ¹⁰Azienda Ospedaliera ASMN, Istituto di Ricovero e Cura a Carattere Scientifico, Reggio Emilia, Italy, ¹¹Reumatologia, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain, ¹²Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain
Background/Purpose: Large-vessel vasculitides (LVV) comprise giant cell arteritis (GCA) and Takayasu arteritis (TAK). They are characterized by self-sustaining inflammatory damage of the wall of large-sized…
Abstract Number: 3141 • 2015 ACR/ARHP Annual Meeting
Endothelial Cells Regulate Proinflammatory T Cell Responses in Large Vessel Vasculitis Via NOTCH-NOTCH Ligand Interactions
Zhenke Wen¹, Hui Zhang¹, Joyce Liao², Gerald Berry³, Lindsy J. Forbess⁴, Michael Weissman⁵, Jorg Goronzy¹ and Cornelia M. Weyand⁶, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ³Pathology, Stanford University School of Medicine, Stanford, CA, ⁴Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: In large vessel vasculitis (LVV), inflammatory infiltrates typically accumulate within the mural layers of the aorta and its major branches and are composed of…
Abstract Number: 3142 • 2015 ACR/ARHP Annual Meeting
Tocilizumab Enhances Regulatory T-Cell Activation and Proliferation in Giant Cell Arteritis
Chie Miyabe¹, Klemen Strle², Yoshishige Miyabe¹, John H. Stone^1,3, Andrew D. Luster^1,4 and Sebastian Unizony^1,5, ¹Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital, Charlestown, MA, ⁵Rheumatology, Massachusetts General Hospital, Boston, MA
Background/Purpose : CD4+ T helper (Th) 17 cells, Th1 cells, and regulatory T-cells (Treg) contribute to the pathogenesis of giant cell arteritis (GCA). Interleukin (IL)-6,…
Abstract Number: 3143 • 2015 ACR/ARHP Annual Meeting
Mapping the Back-Door Routes into the Vascular Wall: 3D Microscopic Reconstruction of Microvasculature in the Normal Temporal Artery and in Giant Cell Arteritis
Daniel Drayton¹, Aruna Chakrabarty², Ann Morgan³, Darren Treanor⁴ and Sarah Mackie⁵, ¹School of Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Cellular Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR-Leeds Musculoskeletal Biomedical Research Unit, University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Cancer and Pathology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, University of Leeds, Leeds, United Kingdom
Background/Purpose: The arterial wall is nourished by microvessels (vasa vasorum), which are a potential route of entry for inflammatory cells in vasculitis. Little is known…
Abstract Number: 3144 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety of Tocilizumab for Polymyalgia Rheumatica
Lindsay Lally¹, Lindsy J. Forbess², Chris Hatzis¹ and Robert F. Spiera³, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Rheumatology, HSS, New York, NY
Background/Purpose: IL-6 is a pivotal cytokine in PMR pathogenesis, yet the efficacy of IL-6 blockade with tocilizumab (TCZ) for treatment of PMR is unknown. The…
Abstract Number: 3145 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety of Modified-Release Prednisone in Patients with Polymyalgia Rheumatica: Results of a Multicenter, Randomized, Active-Controlled Phase 3 Study
Maurizio Cutolo¹, Michael Hopp², Stefan Liebscher², Bhaskar Dasgupta³ and Frank Buttgereit⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²Medical Science, Mundipharma Research GmbH & Co. KG, Limburg, Germany, ³Rheumatology, Southend University Hospital, Essex, United Kingdom, ⁴Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Polymyalgia rheumatica (PMR) is characterized by persisting proximal pain and morning stiffness of the neck, shoulder and hip girdles of 2 weeks' duration, an…
Abstract Number: 3146 • 2015 ACR/ARHP Annual Meeting
Health Related Quality of Life in Adults with JIA – a 30 Year Longitudinal Study
Anita Tollisen^1,2,3, Anne Marit Selvaag¹, Hanne A. Aulie¹, Anners Lerdal^4,5 and Berit Flato^1,2, ¹Department of Rheumatology, Oslo University Hospital, Rikshospitalet, Oslo, Norway, ²Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway, ³Department of Medicine, Lovisenberg Diakonale Hospital, Oslo, Oslo, Norway, ⁴Faculty of Medicine, Institute of Health and Society, University of Oslo, Oslo, Norway, ⁵Lovisenberg Diakonale Hospital, Oslo, Oslo, Norway
Background/Purpose: Improvement of health-related quality of life (HRQOL) is a central aim in treatment of patients with JIA. The primary aim of the study is…
Abstract Number: 3147 • 2015 ACR/ARHP Annual Meeting
Inter-Provider Reliability in Scoring the Physician Global Assessment of Disease Activity Among Patients with Juvenile Idiopathic Arthritis Patients Who Met the ACR Provisional Criteria for Clinical Inactive Disease
Janalee Taylor¹, Edward H. Giannini¹, Daniel Lovell² and Esi M. Morgan DeWitt¹, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: With the advent and implementation of advanced drug therapy clinical inactive disease (CID) has become an attainable target in the treatment of juvenile idiopathic…
Abstract Number: 3148 • 2015 ACR/ARHP Annual Meeting
Physical Activity in Children and Adolescents with Juvenile Idiopathic Arthritis and Associated Factors
Sabrina Cavallo¹, Marie-Ève Mathieu², Annette Majnemer³, Désirée B. Maltais⁴, Ciarán M. Duffy⁵, Mélanie Henderson⁶ and Debbie Ehrmann Feldman⁷, ¹École de Santé Publique, Université de Montréal, Montreal, QC, Canada, ²Département de Kinésiologie, Université de Montréal, Montréal, QC, Canada, ³School of Physical and Occupational therapy, McGill University, Montreal, QC, Canada, ⁴Département de Réadaptation, Université de Laval, Québec, QC, Canada, ⁵Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, ON, Canada, ⁶Centre de recherche du Centre Hospitalier Universitaire Sainte-Justine, Montréal, QC, Canada, ⁷School of Rehabilitation, Université de Montréal, Montreal, QC, Canada
Background/Purpose: Physical activity has health benefits for all children and adolescents, including those with juvenile idiopathic arthritis (JIA). Our study aimed 1) to determine whether…
Abstract Number: 3149 • 2015 ACR/ARHP Annual Meeting
Predictors of Longitudinal Quality of Life Impact in Pediatric Localized Scleroderma
Kaveh Ardalan, Christina Kelsey and Kathryn S. Torok, Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Background/Purpose: Localized scleroderma (LS) is an autoimmune disease characterized by inflammation and fibrosis of the skin and a wide range of extracutaneous manifestations (ECMs). The…
Abstract Number: 3150 • 2015 ACR/ARHP Annual Meeting
Virtual Peer-to-Peer Mentoring Support for Adolescents with Juvenile Idiopathic Arthritis: The Virtual Peer-to-Peer Program
Jennifer N. Stinson¹, Sara Ahola Kohut^2,3, Khush Amaria², Mary J. Bell⁴, Paula Forgeron⁵, Miriam Kaufman⁶, Nadia Luca⁷ and Lynn R. Spiegel⁸, ¹Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ²Hospital for Sick Children, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada, ⁴Rheum Div/Univ of Toronto, University of Toronto, Toronto, ON, Canada, ⁵University of Ottawa, Ottawa, ON, Canada, ⁶Adolescent Medicine, The Hospital for Sick Children, Toronto, ON, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁸Rheumatology/Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is a common chronic disease that results in physical and emotional symptoms as well as difficulties in social and role…
Abstract Number: 3151 • 2015 ACR/ARHP Annual Meeting
Validation of Patient-Reported Outcomes Measurement Information System (PROMIS®) Modules for Use in Childhood-Onset Lupus
Jordan T. Jones¹, Janet Wootton², Jun Ying³, Brianna Liberio⁴, Jiha Lee⁵, Adam Carle⁶, Laura Schanberg² and Hermine I. Brunner⁶, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Pediatrics, Duke Medical Center, Durham, NC, ³University of Cincinnati, Cincinnati, OH, ⁴University of Cincinnati College of Medicine, Cincinnati, OH, ⁵Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Childhood-onset lupus (cSLE) has a substantial negative impact on health-related quality of life (HRQoL). Patient-reported outcomes (PROs) that accurately assess HRQoL and are responsive…
Abstract Number: 3152 • 2015 ACR/ARHP Annual Meeting
The IL-21 Signaling Pathway Is Enhanced in RA B Cells and Has the Potential to Alter Development and Cytokine Production in RA B Cells
Jane H. Buckner¹ and Elizabeth Samuelson², ¹Benaroya Research Institute at Virginia Mason, Seattle, WA, ²Translational Research, Benaroya Research Institute at Virginia Mason, Seattle, WA
Background/Purpose: B cells have been implicated in the development of rheumatoid arthritis (RA) based on their production of autoantibodies and cytokines as well as the…
Abstract Number: 3153 • 2015 ACR/ARHP Annual Meeting
Microrna-155/PU.1 Axis As an Epigenetic Regulator of B-Cells in Rheumatoid Arthritis
Stefano Alivernini¹, Barbara Tolusso¹, Mariola Kurowska-Stolarska², Roberta Benvenuto³, Antonella Mangoni³, Silvia Canestri¹, Luca Petricca¹, Anna Laura Fedele¹, Maria Rita Gigante¹, Clara Di Mario¹, Elisa Gremese¹, Iain B. McInnes² and Gianfranco Ferraccioli¹, ¹Division of Rheumatology, Institute of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, ²Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ³Division of Pathology - Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: MicroRNA-155(miR-155) has been shown to be a key regulator of B cell biology by PU.1 regulation. However, the role of miR-155 in the activation…
Abstract Number: 3154 • 2015 ACR/ARHP Annual Meeting
The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies
Elisa Corsiero¹, Emanuela Carlotti², Costantino Pitzalis³ and Michele Bombardieri⁴, ¹WHRI - EMR, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ³Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, ⁴Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom
Background/Purpose: We previously showed that anti-citrullinated peptide/protein antibodies (ACPA) targeting citrullinated antigens contained in neutrophils extracellular traps (NETs) can be manufactured within ectopic germinal center-like…

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