ACR Meeting Abstracts

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  • Abstract Number: 2892 • 2014 ACR/ARHP Annual Meeting

    The Relative Risk of Incident NON-Ischemic Heart Failure  in Prevalent Rheumatoid Arthritis

    Ängla Mantel1, Marie Holmqvist2, Johan Askling3, Lars Lund4 and Daniel Andersson5, 1Dept of Medicine, Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Solna, Sweden, 2Karolinska Institutet, Unit of Clinical Epidemiology, Department of medicine, Stockholm, Sweden, 3Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 4Karolinska Institutet, Unit of Cardiology section for Heart Failure. Department of Medicine, Stockholm, Sweden, 5Karolinska Institutet, Unit of Cardiology section for heart failure. Department of Medicine, Stockholm, Sweden

    Background/Purpose: Patients with rheumatoid arthritis (RA) may be at increased risk of developing heart failure (HF). Inflammatory activity has been linked to the pathogenesis of…
  • Abstract Number: 2893 • 2014 ACR/ARHP Annual Meeting

    Genome-Wide Association Study of Osteoarthritis Progression: Results from the Osteoarthritis Initiative

    Michelle S. Yau1, Laura M. Yerges-Armstrong1, Youfang Liu2, David J. Duggan3, Joanne M. Jordan2, Braxton D. Mitchell1, Rebecca D. Jackson4 and Marc C. Hochberg5, 1Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, 2Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, 3Translational Genomics Research Institute, Phoenix, AZ, 4Division of Endocrinology, Diabetes, & Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH, 5Division of Rheumatology & Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD

    Background/Purpose: Most genome-wide association (GWA) studies have focused on OA prevalence, but few have focused on OA progression. GWA studies of OA progression may help…
  • Abstract Number: 2894 • 2014 ACR/ARHP Annual Meeting

    Relationship of Dermal Advanced Glycation End Products and Hand OA

    Charles Eaton1, Jeffrey Driban2, Bing Lu3, Mary Roberts4 and Timothy E. McAlindon5, 1Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, 2Rheumatology, Tufts Medical Center, Boston, MA, 3Rheumatology, Brigham and Women's Hospital, Foxboro, MA, 4Center for Primary Care and Prevention, Pawtucket, RI, 5Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: Hand Osteoarthritis (HOA) is characterized by the progressive destruction of articular cartilage and bony changes and is strongly and positively associated with age but…
  • Abstract Number: 2855 • 2014 ACR/ARHP Annual Meeting

    Efficacy and Safety of Rituximab Retreatment Regimen at Clinical Relapse in Severe Cryoglobulinemic Vasculitis

    Luca Quartuccio1, Francesca Zuliani2, Patrizia Scaini3, Marco Lenzi4, Antonio Tavoni5, Marco Sebastiani6, Teresa Urraro7, Francesco Saccardo8, Costanza Sbreglia9, Pietro Pioltelli10, Paolo Fraticelli11, Davide Filippini12, Salvatore Scarpato13, Oreste Perrella9, Armando Gabrielli14, Dario Roccatello15, Anna Linda Zignego16, Clodoveo Ferri17, Stefano Bombardieri18, Maurizio Pietrogrande19, Massimo Galli20, Giuseppe Monti8 and Salvatore De Vita1, 1Rheumatology, DSMB, University Hospital Santa Maria della Misericordia, Udine, Italy, 2Rheumatology Clinic, University Hospital of Udine, Udine, Italy, 3Nephrology, Spedali Civili di Brescia, Brescia, Italy, 4University of Bologna, Bologna, Italy, 5Rheumatology Clinic, University of Pisa, Pisa, Italy, 6Rheumatology Clinic, University of Modena and Reggio Emilia, Modena, Italy, 7Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 8Internal Medicine Unit, Saronno Hospital, Azienda Ospedaliera di Busto Arsizio, Saronno (VA), Italy, 9Rheumatology Unit, AO Cotugno, Naples, Italy, 10Hematology, S.Gerardo Hospital, Monza, Italy, 11Istituto di Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, 12Rheumatology Unit, Ospedale Niguarda Ca’ Granda, Milan, Italy, 13Rheumatology Unit, M. Scarlato Hospital, Scafati, Salerno, Italy, 14Scienze Cliniche e Molecolari, Università Politecnica delle Marche, Ancona, Italy, 15CORSO RAFFAELLO 30, UNIVERSITY OF TURIN (ITALY), TURIN, Italy, 16University of Florence, Center for Systemic Manifestations of Hepatitis Viruses (MASVE), Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 17Internal Med/Rheumatology, Univ Modena Reggio Emilia, Modena, Italy, 18Rheumatology Unit, University of Pisa, Pisa, Italy, 19Internal Medicine Unit, Policlinico San Marco, Bergamo, Italy, 20Istituto di Malattie Infettive e Tropicali, Università di Milano c/o Ospedale L. Sacco, Milano, Italy

    Background/Purpose: Two independent controlled randomized trials recently reported the efficacy and safety of rituximab (RTX) monotherapy in severe cryoglobulinemic vasculitis (CV) (1, 2), with one…
  • Abstract Number: 2856 • 2014 ACR/ARHP Annual Meeting

    Update on Long-Term Outcomes after Reversible Cerebral Vasoconstriction Syndrome (RCVS)

    Seby John1, Aneesh Singhal2, Leonard H. Calabrese3, Ken Uchino4, Tariq Hammad3, Stewart Tepper3, Mark Stillman3 and Rula A Hajj-Ali5, 19500 Euclid Avenue S10-C, Cleveland Clinic Foundation, Cleveland, OH, 2Neurology, Massachusetts General Hospital, Boston, MA, 3Cleveland Clinic Foundation, Cleveland, OH, 4Neurology, Cleveland Clinic Foundation, Cleveland, OH, 5Rheumatology, Cleveland Clinic Foundation, Cleveland, OH

    Background/Purpose RCVS is characterized by acute onset of severe headaches, with or without neurologic deficit with evidence of reversible cerebral vasoconstriction. We have previously reported…
  • Abstract Number: 2857 • 2014 ACR/ARHP Annual Meeting

    Restricting Back Pain Is Strongly Associated with Disability in Community-Living Older Persons over the Course of 13 Years

    Una Makris1,2, Liana Fraenkel3, Ling Han4, Linda Leo-Summers4 and Thomas M. Gill5, 1Rheumatology, UT Southwestern Medical Center, Dallas, UT, 2Rheumatology, Dallas VA Medical Ctr, Dallas, TX, 3Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Systems, New Haven, CT, 4Internal Medicine, Department of Medicine, New Haven, CT, 5Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT

    Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain severe enough to restrict activity [hereafter referred…
  • Abstract Number: 2858 • 2014 ACR/ARHP Annual Meeting

    Education Effects on Outcome Expectations for Exercise in Adults with Knee Osteoarthritis

    Tressa Gamache1, Lori Lyn Price2, Jeffrey B. Driban1, William F. Harvey1 and Chenchen Wang1, 1Rheumatology, Tufts Medical Center, Boston, MA, 2Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA

    Background/Purpose Outside of a clinical trial setting, higher outcome expectations for exercise, more education, and greater physical activity are inter-related, and outcome expectations may partly…
  • Abstract Number: 2859 • 2014 ACR/ARHP Annual Meeting

    Randomized Controlled Trial of Postoperative Care Navigation in Total Knee Arthroplasty Patients: Does One Size Fit All?

    Elena Losina1, Jamie E. Collins1, John Wright2, Meghan E. Daigle1, Laurel Donnell-Fink3, Doris Strnad2, Vladislav Lerner1, Stanley Abrams4 and Jeffrey N. Katz5, 1Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, 2Orthopaedics, Brigham and Women's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Orthopedics and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, 5Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: A number of TKA recipients have suboptimal improvements after surgery. Our objective was to establish the efficacy of a motivational-interviewing (MI)-based telephone intervention aimed…
  • Abstract Number: 2860 • 2014 ACR/ARHP Annual Meeting

    Randomised Comparison of the Effectiveness of a Non-Pharmacological Multidisciplinary Face-to-Face Group-Based Treatment Program Vs. a Telephone-Delivered Treatment Program on Daily Function in Patients with Generalized Osteoarthritis

    Nienke Cuperus1, Thomas Hoogeboom2, Clarinda Kersten3, Leonie Rietveld4, Alfons den Broeder4, Thea Vliet Vlieland5 and Cornelia H.M. van den Ende4, 1Rheumatology Department, Sint Maartenskliniek, Nijmegen, Netherlands, 2Department of Epidemiology, CAPHRI school for public health and primary care, CCTR centre for Care Technology Research, Maastricht University, Maastricht, Netherlands, 3Department of Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 4Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, 5Dept of Orthopaedics, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Generalized osteoarthritis (GOA) is a widely accepted and prevalent OA phenotype characterized by the involvement of multiple joints. However, current research and clinical practice…
  • Abstract Number: 2861 • 2014 ACR/ARHP Annual Meeting

    Changes in Knee Kinematics from a 6-Week Hip and Trunk Strengthening Program for Persons with Patellofemoral Osteoarthritis

    Lisa Hoglund1, Laura Pontiggia2, John Kelly IV3, Mark Arnott4, Olumide Babalola4, Andrew Gushen4 and James Carey3, 1Department of Physical Therapy, University of the Sciences, Philadelphia, PA, 2Mathematics, Physics, and Statistics, University of the Sciences, Philadelphia, PA, 3Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, 4Physical Therapy, University of the Sciences, Philadelphia, PA

    Background/Purpose: Patellofemoral (PF) osteoarthritis (OA) is prevalent in middle-aged adults. Aberrant lower extremity (LE) biomechanics is one etiology of knee OA. Reduced peak knee flexion…
  • Abstract Number: 2862 • 2014 ACR/ARHP Annual Meeting

    Satisfaction Following Total Knee Replacement: Journey or Destination?

    Jeffrey N. Katz1, Yan Dong2, Jamie E. Collins2, John Wright3, David Dalury4, Kirk Kindsfater5 and Elena Losina2, 1Rheumatology and Orthopedics, Brigham and Women's Hospital, Boston, MA, 2Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, 3Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, 4Townson Orthopedics, Maryland, Baltimore, MD, 5Orthopedic Center for the Rockies, Ft. Collins, CO

    Background/Purpose: Total knee replacement (TKR) outcome is often assessed with measures of pain and function (fxn), but there is no consensus on whether surgery should…
  • Abstract Number: 2863 • 2014 ACR/ARHP Annual Meeting

    IgG Antiphospholipid Antibodies Enhance Stroke Damage: An in Vivo Ischemia/Reperfusion Study

    Charis Pericleous1, Valerie Taylor2, Lauren Bourke3, Daniel Stuckey2, Jed Wingrove4, Mark Lythgoe5, Silvia S. Pierangeli6, Anisur Rahman3, Ian Giles1 and Yiannis Ioannou7, 1Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 2Centre for Advanced Biomedical Imaging (CABI), University College London, London, United Kingdom, 3Centre for Rheumatology Research, University College London, London, United Kingdom, 4Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 5Centre for Advanced Biomedical Imaging, Centre for Advanced Biomedical Imaging (CABI), University College London, London, United Kingdom, 6Rheumatology/Dept Int Med, University of Texas Medical Branch, Galveston, TX, 7Centre for Rheumatology Research, University College Hospital London, London, United Kingdom

    Background/Purpose Circulating pathogenic antiphospholipid antibodies (aPL) are the hallmark of antiphospholipid syndrome (APS) and a major risk factor for ischemic stroke, with up to one…
  • Abstract Number: 2864 • 2014 ACR/ARHP Annual Meeting

    Markers of Thrombotic Events in Autoimmune Diseases:Comparison of Antiphospholipid Score (aPL-S) and Global Anti-Phospholipid Syndrome Score (GAPSS)

    Kenji Oku, Olga Amengual, Ryo Hisada, Kazumasa Oomura, Ikuma Nakagawa, Toshiyuki Watanabe, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda and Tatsuya Atsumi, Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Background/Purpose Recently, new scoring systems to quantify the probability for the diagnosis of antiphospholipid syndrome (APS) have been proposed in sequence: the Antiphospholipid Score(aPL-S) and…
  • Abstract Number: 2865 • 2014 ACR/ARHP Annual Meeting

    The Cellular Effects of ANTI-Factor Xa Antibodies Isolated from Patients with Antiphospholipid Syndrome ARE Inhibited By Factorxa Inhibitors, Hydroxychloroquine and Fluvastatin

    Bahar Artim-Esen1, Natalia Smoktunowicz2, Vera M. Ripoll3, Charis Pericleous4, Rachel Chambers2, Ian Mackie5, David Isenberg6, Anisur Rahman7, Yiannis Ioannou6 and Ian Giles4, 1Department of Internal Medicine, Division of Rheumatology, Rheumatology Division, Department of Internal Medicine, Istanbul Faculty of Medicine,Istanbul University, Istanbul, Turkey, 2Rayne Institute, 1st floor, Respiratory Research Unit, University College London, London, United Kingdom, 3Centre for Rheumatology, Rayne Institute, 4th floor, Centre for Rheumatology, University College London, London, United Kingdom, 4Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 5Haemostasis Research Unit, 1st Floor, 51 Chenies Mews, Haemostasis Research Unit, University College London, London, United Kingdom, 6Centre for Rheumatology Research, University College Hospital London, London, United Kingdom, 7Centre for Rheumatology Research, University College London, London, United Kingdom

    Background/Purpose Recently we showed that FXa reactive IgG in patients with the antiphospholipid syndrome (APS) displayed higher avidity binding to FXa and had greater functional…
  • Abstract Number: 2866 • 2014 ACR/ARHP Annual Meeting

    External Validation of the Global Anti-Phospholipid Syndrome Score in Comparison to IgG Antibodies Directed Against Domain I of ß2-Glycoprotein I. a Prospective Multicentre Cohort Study

    Stephane Zuily1, Bas De Laat2, Veronique Regnault3, Pierre Kaminsky4, Hilde Kelchtermans5, Zakera Shums6, Roger Albesa7, Gary L Norman6, Philip de Groot8, Anne-Christine Rat9, Jacques Ninet10, Nadine Magy-Bertrand11, Jean-Louis Pasquali12, Marc Lambert13, Bernard Lorcerie14, Thomas Lecompte15, Francis Guillemin16 and Denis Wahl17, 1CHU de Nancy, Vascular Medicine Division and Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Nancy, F-54000, France; Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France, Nancy, France, 2Biochemistry, CARIM, Maastricht University, Maastricht, Netherlands, 3Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Contrat d’interface, Nancy, F-54000, France, Nancy, France, 4Internal Medicine, CHU Nancy, Vandoeuvre, France, 5Biochemistry, CARIM, Maastricht University, The Netherlands; Synapse BV, Maastricht, The Netherlands, Maastricht, Netherlands, 6INOVA Diagnostics, San Diego, CA, 7Research, INOVA Diagnostics, San Diego, CA, 8Clinical Chemistry and Hematology, UMC Utrecht, The Netherlands, Utrecht, Netherlands, 9University Paris Descartes, EA 4360 APEMAC, University of Lorraine, Nancy, France, 10Department of Nephrology and Internal Medicine, Hôpital Edouard Herriot, Lyon, France, Lyon, France, 11Bensançon University Hospital, Besançon, France, 12Service de Medecine Interne, Nouvel Hospital Civil, Strasbourg Cedex, France, 13Lille University Hospital, Lille, France, 14Hopital Du Bocage, Service de Médecine Interne et Immunologie Clinique, Dijon, France, 15Inserm, UMR_S 1116, Nancy, F-54000, France; Université de Lorraine, Nancy, F-54000, France; CHU de Nancy, Haematology Laboratory, Nancy, F-54000, France; Division of Haematology, HUG, Geneva, Switzerland (current address), Geneva, Switzerland, 16INSERM, Centre d'Investigation Clinique - Epidémiologie Clinique (CIC-EC) CIE6, Nancy, France, 17Regional Competence Center For Rare Vascular And Systemic Autoimmune Diseases, Nancy University Hospital and INSERM U961, Vandoeuvre-Les-Nancy, France

    Background/Purpose: Our objectives were 1- to perform an external validation of the Global Anti-Phospholipid Syndrome Score (GAPSS) and 2- to compare prognostic significances of GAPPS…
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