Abstracts Archive - Page 1860 of 2425 - ACR Meeting Abstracts

Abstract Number: 2877 • 2014 ACR/ARHP Annual Meeting
Novel Function of Tocilizumab As a Modulator of Interleukin-27-Mediated Anti-Inflammatory Responses
Misato Hashizume¹, Jun Kikuchi², Keiko Yoshimoto² and Tsutomu Takeuchi², ¹Product Research Department, Chugai Pharmaceutical Co., Ltd., Gotemba, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Background/Purpose The immunological roles of interleukin 27 (IL-27) have been reported in the function of regulatory T cells (Treg), monocytes and osteoclasts, and these cells…
Abstract Number: 2878 • 2014 ACR/ARHP Annual Meeting
G Protein Signaling Modulator 3 (GPSM3) Deficiency Is Protective in Inflammatory Arthritis Models and Altered GPSM3 Gene Products Correlate with Single Nucleotide Polymorphisms in Humans
Teresa K. Tarrant¹, D. Stephen Serafin², Elizabeth Sugg², Roman Timoshchenko², Matthew J. Billard², David P. Siderovski³ and Kristy Richards⁴, ¹Medicine/Rheumatology, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Physiology and Pharmacology, West Virginia University School of Medicine, Morgantown, WV, ⁴Medicine, Dept. of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose GPSM3, a newly described regulator of heterotrimeric G protein signaling, is selectively expressed in hematopoietic cells with high expression in monocytes. We have shown…
Abstract Number: 2879 • 2014 ACR/ARHP Annual Meeting
Epigallocatechin-3-Gallate (EGCG) Suppresses IL-1β-Induced IL-6 and IL-8 Synthesis By Selectively Inhibiting TAK1 Activation in Human Rheumatoid Arthritis Synovial Fibroblasts
Anil Singh¹, Sharayah Riegsecker², Sadiq Umar¹ and Salahuddin Ahmed¹, ¹Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, ²Department of Pharmacology, University of Toledo, Toledo, OH
Background/Purpose: In rheumatoid arthritis (RA), the role of interleukin-1β (IL-1β) signaling proteins (IRAK-1/TAK-1/TRAF-6) proximal to IL-1 receptor in mediating proinflammatory response is not completely understood.…
Abstract Number: 2880 • 2014 ACR/ARHP Annual Meeting
Elevated Levels of Soluble Inflammatory Mediators and Lupus-Specific Connective Tissue Disease Questionnaire Scores Discern Unaffected First Degree Relatives of Lupus Patients from Unaffected Individuals Not Related to Lupus Patients
Melissa E. Munroe¹, Kendra A. Young², Jennifer Fessler³, Dustin Fife³, Diane L. Kamen⁴, Joel M. Guthridge³, Timothy B. Niewold⁵, Michael H. Weisman⁶, Mariko L. Ishimori⁶, Daniel J. Wallace⁷, David R. Karp⁸, John B. Harley⁹, Gary S. Gilkeson⁴, Jill M. Norris² and Judith A. James^10,11, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁸Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ⁹Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Identifying populations at risk of SLE is essential to curtail inflammatory damage and select individuals for prevention trials. First-degree relatives (FDRs) of lupus patients…
Abstract Number: 2881 • 2014 ACR/ARHP Annual Meeting
The Center of Excellence in Musculoskeletal Care and Education: A Sustainable Interprofessional, Multidisciplinary Programmatic Innovation Developed with the Department of Veterans Affairs
Michael J. Battistone¹, Andrea M. Barker², Marissa Grotzke³, Peter Beck⁴, Jeffery Berdan⁵, Caroline Milne⁶, JoAnn Rolando⁷ and Grant W. Cannon¹, ¹Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ²General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, ³Division of Endocrinology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁴Orthopaedics, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁵Physical Medicine and Rehabilitation, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁶Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁷Salt Lake City VA and University of Utah, Salt Lake City, UT
Background/Purpose While musculoskeletal (MSK) problems are common in primary care, the current formal education in the evaluation and management of these conditions is inadequate. Through…
Abstract Number: 2882 • 2014 ACR/ARHP Annual Meeting
Using Decision-Based Learning to Highlight Rheumatic Disease for Third-Year Medical Students
Karen Law¹, J Richard Pittman² and Chad Miller³, ¹Emory University School of Medicine, Atlanta, GA, ²General Medicine and Geriatrics, Emory University School of Medicine, Atlanta, GA, ³Internal Medicine, Tulane University Health Sciences Center School of Medicine, New Orleans, LA
Background/Purpose: Opportunities for exposure to rheumatology are limited in medical school, especially during the clinical years. In addition, because the rheumatic diseases represent a small…
Abstract Number: 2883 • 2014 ACR/ARHP Annual Meeting
Rheumatology-Specific Milestones for a Musculoskeletal Radiology Curriculum
Michelle Newkirk¹, Liem Mansfield², Jay B. Higgs³ and Daniel Battafarano¹, ¹Rheumatology, San Antonio Military Medical Center, JBSA - Ft Sam Houston, TX, ²Musculoskeletal Radiology, San Antonio Military Medical Center, JBSA - Ft Sam Houston, TX, ³Rheumatology, San Antonio Military Medical Center, JBSA - Fort Sam Houston, TX
Background/Purpose In 2012, the Accreditation Council for Graduate Medical Education (ACGME) announced the required implementation of standardized milestones with entrustable professional activities (EPAs) for the…
Abstract Number: 2884 • 2014 ACR/ARHP Annual Meeting
Training the Rheumatologists of Tomorrow: The Canadian Experience
Alfred Cividino¹, Volodko Bakowsky², Susan Barr³, Louis Bessette⁴, Nader Khalidi⁵, Christian A. Pineau⁶, Janet E. Pope⁷, David Robinson⁸, Kam Shojania⁹, Elaine Yacyshyn¹⁰, Lynne Lohfeld¹¹ and Diane Crawshaw¹², ¹Medicine, McMaster University, Hamilton, ON, Canada, ²Medicine, Dalhousie University, Halifax, NS, Canada, ³University of Calgary, Heritage Medical Research Bldg, Calgary, AB, Canada, ⁴Rheumatology, Laval University, Québec, QC, Canada, ⁵Division of Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Rheumatology, McGill University Health Center, Montreal, QC, Canada, ⁷St Joseph Health Care, London, ON, Canada, ⁸Medicine, University of Manitoba, Winepeg, MB, Canada, ⁹Medicine, University of British Columbia, Vancouver, BC, Canada, ¹⁰562 Heritage Med Rsch Ctr, University of Alberta, Edmonton, AB, Canada, ¹¹Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, ON, Canada, ¹²Nursing, McMaster University, Hamilton, ON, Canada
Background/Purpose: Many countries face a shortage of rheumatologists. Based on an accepted benchmark of 1 specialist per 50,000 people as the number needed for effective…
Abstract Number: 2885 • 2014 ACR/ARHP Annual Meeting
Clinical Training Opportunities in Two Innovative Ambulatory Resources: The Primary Care Musculoskeletal Clinic and Center of Excellence Multidisciplinary Clinic
Michael J. Battistone¹, Andrea M. Barker², Marissa Grotzke³, Peter Beck⁴, Jeffery Berdan⁵, Phillip Lawrence⁶ and Grant W. Cannon¹, ¹Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ²General Internal Medicine, Salt Lake City VA and University of Utah, Salt Lake City, UT, ³Division of Endocrinology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁴Orthopaedics, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁵Physical Medicine and Rehabilitation, Salt Lake City VA and University of Utah, Salt Lake City, UT, ⁶Salt Lake City VA and University of Utah, Salt Lake City, UT
Background/Purpose While musculoskeletal (MSK) problems are common in primary care, current training models do not adequately prepare primary care providers (PCP) to deal with these…
Abstract Number: 2886 • 2014 ACR/ARHP Annual Meeting
Assessing Rheumatology Fellows’ Teaching Skills Using the Objective Structured Teaching Exercise (OSTE)
Eli M. Miloslavsky¹, Marcy B. Bolster¹, Kenneth S. O'Rourke² and Lisa G. Criscione-Schreiber³, ¹Rheumatology, Massachusetts General Hospital, Boston, MA, ²Section on Rheum & Immunology, Wake Forest School of Medicine, Winston-Salem, NC, ³Rheumatology, Duke University Health System, Durham, NC
Background/Purpose The interaction between rheumatology fellows and Internal Medicine residents in the setting of a consult offers an important opportunity for resident learning. However, teaching…
Abstract Number: 2887 • 2014 ACR/ARHP Annual Meeting
Post-Menopausal Factors and the Risk of Seropositive and Seronegative Rheumatoid Arthritis Phenotypes: Results from the Nurses’ Health Study
Camilla Bengtsson¹, Susan Malspeis², Jeffrey A. Sparks³, Karen H. Costenbader³ and Elizabeth W. Karlson³, ¹The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose Among women, the peak incidence of rheumatoid arthritis (RA) is reported to be 45-74 years of age. In addition, it has been suggested that…
Abstract Number: 2888 • 2014 ACR/ARHP Annual Meeting
Amount of Smoking, Duration of Smoking Cessation, and Their Interaction with Silica Exposure in the Risk of Rheumatoid Arthritis: Results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Xia Jiang¹, Camilla Bengtsson², Henrik Källberg³, Lars Klareskog⁴ and Lars Alfredsson², ¹Nobels vag13, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose Exposure to silica is a well-defined inhalation exposure, and is known to be associated with moderately increased rheumatoid arthritis (RA) risk, with the effect…
Abstract Number: 2889 • 2014 ACR/ARHP Annual Meeting
The Association Between Changes in Inflammation and High Density Lipoprotein Cholesterol Efflux Capacity in Rheumatoid Arthritis
K P Liao¹, Martin Playford², Michelle A. Frits³, Christine K. Iannaccone⁴, Jonathan S. Coblyn¹, Michael E. Weinblatt⁵, Nancy A. Shadick⁶ and Nehal N. Mehta⁷, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²National Heart, Blood, and Lung Institute, Bethesda, MD, ³Division of Rheumatology, Brigham and Women's Hospital, Boston, MA, ⁴Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁵Division of Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA, ⁶Brigham and Women's Hospital/Harvard University, Cambridge, MA, ⁷Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA
Background/Purpose: High density lipoprotein (HDL) cholesterol efflux capacity measures the functional ability of HDL to remove cholesterol from atherosclerotic plaque. Low HDL efflux capacity is…
Abstract Number: 2890 • 2014 ACR/ARHP Annual Meeting
Does a Family History of RA Influence the Clinical Presentation and Treatment Response in RA?
Thomas Frisell¹, Saedis Saevarsdottir^2,3 and Johan Askling^1,4, ¹Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Since family history of RA is among the strongest risk factors for developing the disease, individuals suspected to have RA are routinely asked about…
Abstract Number: 2891 • 2014 ACR/ARHP Annual Meeting
Inflammatory Genes Are Associated with Autoantibodies in Rheumatoid Arthritis-Free Individuals Who Are at-Risk for Future Disease
Ryan W. Gan¹, Kendra A. Young¹, M. Kristen Demoruelle², Michael H. Weisman³, Jane H. Buckner⁴, P. K. Gregersen⁵, Ted R. Mikuls⁶, James R. O'Dell⁶, Richard M. Keating⁷, Elizabeth W. Karlson⁸, Kevin D. Deane², V. Michael Holers⁹ and Jill M. Norris¹, ¹Epidemiology, Colorado School of Public Health, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁵Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, ⁶Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷Division of Rheumatology, Scripps Clinic, La Jolla, CA, ⁸Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁹Rheumatology Division, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: We previously found that presence of rheumatoid arthritis(RA)-related autoantibodies is associated with systemic inflammation, and that decreased consumption of anti-inflammatory omega-3 fatty acids (n-3…

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