Abstracts Archive - Page 1856 of 2425 - ACR Meeting Abstracts

Abstract Number: 2938 • 2014 ACR/ARHP Annual Meeting
A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of Subcutaneous Golimumab in Patients with Active Nonradiographic Axial Spondyloarthritis
J Sieper¹, D van der Heijde², M Dougados³, Walter P. Maksymowych⁴, J Boice⁵, G Bergman⁵, S Curtis⁵, A Tzontcheva⁵, S Huyck⁵ and HH Weng⁵, ¹University Clinic Benjamin Franklin, Berlin, Germany, ²Leiden University Medical Center, Leiden, Netherlands, ³Paris-Descartes University, Paris, France, ⁴Department of Medicine, University of Alberta, Alberta, AK, ⁵Merck & Co., Inc., Whitehouse Station, NJ
Background/Purpose Axial spondyloarthritis (axSpA), including ankylosing spondylitis and nonradiographic axial SpA (nr-axSpA), is a chronic inflammatory disease marked by back pain and progressive spinal stiffness.…
Abstract Number: 2939 • 2014 ACR/ARHP Annual Meeting
Increased Diagnosis of Spondyloarthritis in Female Patients Started in the Early Biologic Era
Nisha Nigil Haroon¹, Ping Li², Michael Paterson² and Nigil Haroon³, ¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Institute of Clinical Evaluative Sciences, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose The health and economic impact of spondyloarthritis is considerable and growing. Over the past decade or more, there have been two major changes in…
Abstract Number: 2940 • 2014 ACR/ARHP Annual Meeting
Do Patients with Non-Radiographic Axial Spondyloarthritis and Ankylosing Spondylitis Respond Similarly Well to Nsaids? – a Prospective Study Including Magnetic Resonance Imaging
Xenofon Baraliakos¹, Uta Kiltz¹, Frank Heldmann¹, Heiner Appel², Friedrich Dybowski³, Manfred Igelmann⁴, Ludwig Kalthoff⁵, Dietmar Krause⁶, Hans-Jürgen Menne⁷, Ertan Saracbasi⁸, Elmar Schmitz-Bortz⁹ and Jürgen Braun¹, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumatology and Nephrology Practice, Hamm, Germany, ³Rheumatology Practice, Herne, Germany, ⁴Rheumatology Practice, Bochum, Germany, ⁵Rheumatology practice, Herne, Germany, ⁶Rheumatology practice, Gladbeck, Germany, ⁷Rheumatology practice, Dortmund, Germany, ⁸Rheumatology practice, Oberhausen, Germany, ⁹Rheumatology practice, Hattingen, Germany
Background/Purpose: Patients classified as axial spondyloarthritis (axSpA) may have ankylosing spondylitis (AS) or non-radiographic axSpA (nr-axSpA). Treatment recommendations for AS consider non-steroidal anti-inflammatory drugs (NSAIDs)…
Abstract Number: 2941 • 2014 ACR/ARHP Annual Meeting
Physical Function Is Independently Associated with Mortality Among Individuals with Knee and/or Hip OA: The Johnston County Osteoarthritis Project
Rebecca J. Cleveland¹, Todd Schwartz¹, Jordan B. Renner², Joanne M. Jordan³ and Leigh F. Callahan⁴, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina Department of Radiology, Chapel Hill, NC, ³University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ⁴Thurston Arthritis Res Ctr, University of North Carolina, Chapel Hill, NC
Background/Purpose Declining physical function (PF) is a common consequence of osteoarthritis (OA), and poor PF is associated with death. It is possible that the resulting…
Abstract Number: 2942 • 2014 ACR/ARHP Annual Meeting
A Longitudinal Population-Based Study 1994-2010 of Age, Period, and Cohort Effects in the Prevalence of Arthritis: The Effect of Improving Socioeconomic Status and Increasing Obesity over Time
Elizabeth M. Badley^1,2, Mayilee Canizares^3,4, Anthony V. Perruccio^5,6, Sheilah. Hogg-Johnson^6,7 and Monique A.M. Gignac^6,7, ¹Division Health Care and Outcomes Research,, Toronto Western Research Institute, Toronto, ON, Canada, ²Dalla Lana School of Public Health,, University of Toronto, Toronto, ON, Canada, ³Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, ON, Canada, ⁴Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada, ⁵Arthritis Program, Toronto Western Hospital, Toronto, ON, Canada, ⁶Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁷Institute for Work and Health, Toronto, ON, Canada
Background/Purpose: To examine birth cohort and period effects in the age-trajectories of reported arthritis from 1994 to 2010 in a representative sample of Canadians; and…
Abstract Number: 2943 • 2014 ACR/ARHP Annual Meeting
Severity of Foot Pain Is Linked to the Prevalence of Depressive Symptoms: The Framingham Foot Study
Arunima Awale¹, Alyssa B. Dufour², Patricia P. Katz³, Virginia A. Casey¹ and Marian T. Hannan⁴, ¹Institute for Aging Research, Hebrew SeniorLife, Boston, MA, ²Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School & Beth Israel Deaconess Medical Center, Boston, MA, ³Medicine, University of California, San Francisco, CA, ⁴Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: While a number of risk factors for foot pain are established, the relation between depression and foot pain has not been well studied. The…
Abstract Number: 2944 • 2014 ACR/ARHP Annual Meeting
Sedentary Time Is an Independent Risk Factor for Disability Onset Among Adults at Elevated Risk: Prospective Cohort Study
Jungwha Lee¹, Jing Song², Barbara Ainsworth³, Rowland W. Chang⁴, Linda S. Ehrlich-Jones⁵, Christine Pellegrini⁶, Pamela Semanik⁷, Dorothy D. Dunlop² and Leena Sharma⁸, ¹Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Arizona State University, Pheonix, AZ, ⁴Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Rehabilitation Institute of Chicago, Chicago, IL, ⁶Center for Behavioral Health, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Rush University, Chicago, IL, ⁸Northwestern University, Chicago, IL
Background/Purpose: Disability threatens personal independence and is a major driver of health care costs. Physical activity has been shown to prevent disability. Sedentary behavior, already…
Abstract Number: 2945 • 2014 ACR/ARHP Annual Meeting
Foot Structure and Function Show Associations with Lower Extremity Physical Function
Yvonne M. Golightly¹, Marian T. Hannan², Patricia P. Katz³, Howard J. Hillstrom⁴, Alyssa B. Dufour⁵ and Joanne M. Jordan⁶, ¹Gillings School of Global Public Health, Dept of Epidemiology, Thurston Arthritis Research Center, Injury Prevention Research Center, University of North Carolina Dept of Epidemiology, Chapel Hill, NC, ²Institute for Aging Research, Hebrew SeniorLife, Dept. of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Rehabilitation, Hospital Special Surgery (HSS), New York, NY, ⁵Institute for Aging Research, Hebrew SeniorLife & Boston Univ, Boston, MA, ⁶University of North Carolina Dept of Epidemiology, Chapel Hill, NC
Background/Purpose . Foot pain is associated with poorer physical function in older adults, but few studies have examined how foot structure (high / low arches) and…
Abstract Number: 2946 • 2014 ACR/ARHP Annual Meeting
The Association Between Accelerometer Monitored Sedentary Behavior and Observed Physical Function Loss
Pamela Semanik¹, Rowland W. Chang², Jing Song³, Jungwha Lee⁴ and Dorothy D. Dunlop³, ¹Nursing, Rush University College of Nursing, Chicago, IL, ²Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Preservation of function in older adults is critical to maintaining independence. Physical activity interventions often focus on increasing activity while giving limited attention to…
Abstract Number: 2947 • 2014 ACR/ARHP Annual Meeting
Adenosine a_2A Receptor As a Potential New Therapeutic Target for the Prevention/Treatment of Osteoarthritis
Carmen Corciulo¹, Aranzazu Mediero², Tuere Wilder³ and Bruce N. Cronstein⁴, ¹Division of Translational Medicine, Department of Medicine, NYU School of Medicine, New York, NY, ²Medicine, Division of Translational Medicine, NYU School of Medicine, New York, NY, ³Medicine, division of Translational Medicine, NYU School of Medicine, New York, NY, ⁴NYU School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose Osteoarthritis results from trauma, mechanical factors or metabolic changes in bone and cartilage. Adenosine, acting via the A2AR, inhibits inflammation and plays a critical…
Abstract Number: 2948 • 2014 ACR/ARHP Annual Meeting
S100 Proteins Induce Canonical Wnt Signaling, Which Causes Increased Expression of MMPs in the Synovium
Martijn H. van den Bosch¹, Arjen B. Blom², R. Pelle Hoek², Rik F. Schelbergen³, Sylvia W. Suen², Anke E. van Erp², Wim B. van den Berg¹, Peter M. van der Kraan¹ and Peter L. van Lent⁴, ¹Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ³Radboud university medical center, Nijmegen, Netherlands, ⁴Experimental Rheumatology, Experimental Rheumatology, Radboud University, Nijmegen, Netherlands
Background/Purpose: Many osteoarthritis (OA) patients show synovial activation, which is thought to be involved in joint destruction. Previously, we found that the alarmins S100A8 and A9,…
Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting
Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice
Ru Bryan¹, Xianling Zhao², Yun Wang³, Han Sol Lee², Hyunje Kim⁴, Alifah Akasdi² and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²VAMC, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ⁴Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…
Abstract Number: 2950 • 2014 ACR/ARHP Annual Meeting
Synovial Macrophages Promote TGF-β Activation after Intra-Articular Injections of Oxidized LDL in Naïve Murine Knee Joints, Preventing Production of Pro-Inflammatory Factors S100A8/9, Chemokines and Aggrecanase-Induced Neo-Epitopes
Wouter de Munter, Peter M. van der Kraan, Wim B. van den Berg and Peter L. van Lent, Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: In previous studies we found that synovial macrophages regulate joint pathology during experimental osteoarthritis (OA). Recently, we found that high systemic levels of LDL…
Abstract Number: 2951 • 2014 ACR/ARHP Annual Meeting
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway
Charlotte Kimberley Clarke¹, Annelena Held¹, Richard Stange², Uwe Hansen³, Lars Godmann⁴, Jessica Bertrand⁵, Thomas Pap⁶, Giovanna Nalesso⁷, Frank Echtermeyer⁸, Francesco Dell'Accio⁹ and Joanna Sherwood⁷, ¹University Hospital Muenster, Institute of Experimental Musculoskeletal Medicine (IEMM), Muenster, 48149, Germany, ²Dept. of Trauma, Hand and Reconstructive Surgery, University Hospital Münster, Münster, Germany, ³Institute for Physiological Chemistry & Pathobiochemistry, University Hospital Münster, Münster, Germany, ⁴Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany, ⁵Institute of Experimental Musculoskeletal Medicine, University Hospital Münster, Münster, Germany, ⁶Institute of Experimental Musculoskeletal Medicine, University Hospital Muenster, Muenster, Germany, ⁷Centre for Experimental Medicine and Rheumatology, Queen Mary University London, London, United Kingdom, ⁸Dept. of Anaesthesiology and Intensive Care Medicine, University Hospital Hannover, Hanover, Germany, ⁹William Harvey Research Institute, Barts and the London Queen Mary's School of Medicine and Dentistry, Centre for Experimental Medicine and Rheumatology, London, United Kingdom
Background/Purpose Syndecan-4 (Sdc4), family member of type I transmembrane heparan sulfate proteoglycans (HSPGs), is a regulator of various cartilage-related processes including osteoarthritis (OA). Blockade of…
Abstract Number: 2952 • 2014 ACR/ARHP Annual Meeting
S100A9 Inhibitor Paquinimod (ABR-215757) reduces Joint Destruction in Experimental Osteoarthritis and Blocks Activating Effects of S100A9 in OA Synovium
Peter L. van Lent¹, Rik Schelbergen², Arjen B. Blom¹, Tomas Leanderson³, Helena Eriksson⁴ and Wim B. van den Berg⁵, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Radboud university medical center, Nijmegen, Netherlands, ³Immunology Group, Lund University, Lund, Sweden, ⁴BioScience, Active Biotech AB, Lund, Sweden, ⁵Experimental Rheumatology (272), Radboud university medical center, Nijmegen, Netherlands
Background/Purpose Synovial activation is present in more than 50% of osteoarthritis (OA) patients and it is thought to be involved in the development of OA…

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