ACR Meeting Abstracts

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  • Abstract Number: 2963 • 2014 ACR/ARHP Annual Meeting

    The URAT1 Uric Acid Transporter Is Important in Uric Acid Homeostasis and Its Activity May be Altered in Gout Patients and in Drug-Induced Hyperuricemia

    Philip K. Tan, Sha Liu and Jeffrey N. Miner, Ardea Biosciences, Inc., San Diego, CA

    Background/Purpose: Gout results from chronic hyperuricemia. Most gout patients exhibit an increased renal reabsorption of uric acid which leads to elevated levels of serum uric…
  • Abstract Number: 2964 • 2014 ACR/ARHP Annual Meeting

    Association Analysis of Apolipoprotein B and Very Low-Density Lipoprotein with Hyperuricemia and Gout

    Humaira Rasheed1, Angela Hsu1, Nicola Dalbeth2, Lisa K. Stamp3, Sally McCormick1 and Tony R. Merriman1, 1Department of Biochemistry, University of Otago, Dunedin, New Zealand, 2Department of Medicine, University of Auckland, Auckland, New Zealand, 3University of Otago, Christchurch, New Zealand

    Background/Purpose: Gout results from an innate immune response to monosodium urate (MSU) crystals deposited in joints. Increased very low-density lipoprotein (VLDL) has been associated with…
  • Abstract Number: 2965 • 2014 ACR/ARHP Annual Meeting

    Effects of Anti-NGF Strategies in Two Animal Models of Osteoarthritis (OA)

    Lilian Ngozi Nwosu1, Paul Mapp1, Karyn Bouhana2, Steven Andrews2, Victoria Chapman3 and David Walsh4, 1Academic Rheumatology, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, 2Array BioPharma, Boulder, CO, 3Life Sciences, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom, 4Academic Rheum/Clin Sci Bldg, Arthritis Research UK Pain Centre, University of Nottingham, Nottingham, United Kingdom

    Background/Purpose Levels of endogenous nerve growth factor (NGF) are increased in osteoarthritic (OA) joints in patients and animal models and may be an important cause…
  • Abstract Number: 2966 • 2014 ACR/ARHP Annual Meeting

    Genome-Wide Association Analysis of Pain Reduction in Rheumatoid Arthritis Patients Treated with TNF Inhibitors

    Marieke J.H. Coenen1, Maša Umicevic-Mirkov1, Sophine B. Krintel2, Julia Johansen3, Corinne Miceli-Richard4, Henrik Kallberg5, Hans Scheffer1, Wietske Kievit1, Mart A. van de Laar6, Piet L.C.M. van Riel1, X. Mariette7, Saedis Saevarsdottir8, Merete Lund Hetland9, Sita Vermeulen1 and Cornelis A. Albers1, 1Radboud university medical center, Nijmegen, Netherlands, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Glostrup, Denmark, 3Department of Medicine, Herlev, University of Copenhagen, Frederiksberg, Denmark, 4Rheumatology Department, Université Paris-Sud 11, Bicêtre Hospital,, Kremlin Bicêtre, France, 5Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, 6University Twente & Medisch Spectrum Twente, Enschede, Netherlands, 7Paris-Sud University, Paris, France, 8Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 9DANBIO, Center for Rheumatology and Spine Diseases, Glostrup Univ Hospital, Glostrup, Denmark

    Background/Purpose: Pain is the dominant and prevailing symptom of rheumatoid arthritis (RA). Tumor necrosis factor inihibitors (TNFi) have proven very successful in pain reduction. Interestingly,…
  • Abstract Number: 2967 • 2014 ACR/ARHP Annual Meeting

    Patient Reported Pain By the Paindetect Questionnaire Reveals Multimodal Elements to Pain Perception in Rheumatoid Arthritis

    Saqa Ahmed1, Tejal Magan1, Mario Vargas1, Abiola Harrison1 and Nidhi Sofat2, 1Rheumatology, Mailpoint J1A, St George's, University of London, London, United Kingdom, 2Rheumatology, St. George's University of London, London, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory autoimmune condition typified by systemic inflammation targeted towards synovial joints. Inhibition of pro-inflammatory networks by disease-modifying anti-rheumatic drugs…
  • Abstract Number: 2968 • 2014 ACR/ARHP Annual Meeting

    Improvement Following Total Knee Replacement (TKR) Surgery:  Exploring Preoperative Symptoms and Change in Preoperative Symptoms

    Ernest R. Vina1, Michael J. Hannon2 and C. Kent Kwoh3, 1Division of Rheumatology and Clinical Immunology, University of Pittsburgh and VA Healthcare System, Pittsburgh, PA, 2Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 3Division of Rheumatology and Clinical Immunology, University of Arizona, Tucson, AZ

    Background/Purpose Few have examined the trajectories of preoperative health-related quality of life (HRQL) measures in osteoarthritis (OA) patients who undergo TKR.  Yet, the type and…
  • Abstract Number: 2969 • 2014 ACR/ARHP Annual Meeting

    Mortality after Knee Replacement Surgery for Osteoarthritis in a Population-Based Propensity-Score Matched Cohort

    Devyani Misra1, Tuhina Neogi2, Na Lu3, David T. Felson3, Thomas Einhorn4, Hyon K. Choi5, Jessica Maxwell6 and Yuqing Zhang3, 1Rheumatology, Boston University School of Medicine, Boston, MA, 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Boston, MA, 4Orthopedics, Boston University School of Medicine, Boston, MA, 5Division of Rheumatology, Allergy, and Immunology Massachusetts General Hospital, Harvard Medical School, Boston, MA, 6Physical Therapy & Athletic Training, Boston University, Boston, MA

    Background/Purpose : Knee replacement (KR) surgery for osteoarthritis (OA) provides improvement in symptoms and function. Whether these improvements translate into survival benefit has been unclear,…
  • Abstract Number: 2970 • 2014 ACR/ARHP Annual Meeting

    Psoriatic Arthritis is Associated with Heterotopic Ossification after Total Hip Arthroplasty

    Mario Cedillo1, Arielle Fein2, Susan M. Goodman3, Rebecca Zhu4, Mark P. Figgie5, Michael Alexiades6, Jayme C. Burket7 and Lisa A. Mandl3, 1Weill Cornell Medical College, New York, NY, 2Hospital for Special Surgery, New York, NY, 3Rheumatology, Hospital for Special Surgery, New York, NY, 4Clinical Research, Hospital for Special Surgery, New York, NY, 5Orthopedics, Hospital for Special Surgery, New York, NY, 6Orthopaedics, Hospital for Special Surgery, New York, NY, 7Healthcare Research Institute, Hospital for Special Surgery, New York, NY

    Background/Purpose:  Heterotopic ossification (HO), the pathologic deposition of ectopic bone in soft tissues, is a feared complication of total hip arthroplasty (THA). HO is strongly…
  • Abstract Number: 2971 • 2014 ACR/ARHP Annual Meeting

    Patient’s Self-Monitoring Via Smartphone: The Compass Study Correlation Between Patient Self-Assessment of Rheumatoid Arthritis Disease Activity Via Smartphone Technology and Physicians’ Validated Scores

    Ruediger Mueller1, Ulrich Walker2, Diego Kyburz3, Robert Theiler4, Adrian Forster5, Fabiana Ganz6 and Patrick Dufner7, 1Rheumatology, Kantonspital St. Gallen, St. Gallen, Switzerland, 2Department of Rheumatology, Basel University, basel, Switzerland, 3Rheumatology, University Hospital, Basel, Switzerland, 4Rheumatology, Triemli spital, Zurich, Switzerland, 5Spital Thurgau AG, Diessenhofen, Switzerland, 6Medical Immunology, Abbvie AG, Baar, Switzerland, 7Immunology, Abbvie AG, Baar, Switzerland

    Background/Purpose In clinical practice, patients with RA are usually seen every 3 to 6 months1. Although desirable, monthly visits with assessments of disease activity are…
  • Abstract Number: 2972 • 2014 ACR/ARHP Annual Meeting

    Elevations of Certain Memory-Effector T Cell and Inflammatory Monocyte Subpopulations in Rheumatoid Arthritis Are Associated with the Presence of Subclinical Coronary Artery Atherosclerosis

    Robert Winchester1, Jon T. Giles2, Simona Nativ3, Hui-Zhu Zhang2, Kendall Downer2 and Joan Bathon2, 1Department of Medicine, Columbia University, New York, NY, 2Medicine, Columbia University, New York, NY, 3Morristown Medical Center, Morristown, NJ

      Background/Purpose: Factors that identify cardiovascular disease (CVD) fully in RA are lacking.  Peripheral blood mononuclear cell (PBMC) subsets in RA patients differ markedly, on average,…
  • Abstract Number: 2973 • 2014 ACR/ARHP Annual Meeting

    The Multi-Biomarker Disease Activity Score As a Predictor of Radiographic Progression in a Registry of Patients with Rheumatoid Arthritis

    Eric H. Sasso1, George Wu2, CC Hwang2, Michael E. Weinblatt3, Nancy A. Shadick4, Claire Alexander5 and Oscar Segurado1, 1Crescendo Bioscience Inc., South San Francisco, CA, 2Biostatistics, Crescendo Bioscience Inc., South San Francisco, CA, 3Division of Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA, 4Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA, 5Clinical Operations, Crescendo Bioscience Inc., South San Francisco, CA

    Background/Purpose This study evaluated the association between baseline disease activity, as assessed with the multi-biomarker disease activity (MBDA) blood test, CRP or clinical measures, and…
  • Abstract Number: 2974 • 2014 ACR/ARHP Annual Meeting

    Multi-Biomarker Disease Activity Score Is Associated with Power Doppler Ultrasound in Patients with Rheumatoid Arthritis in Low Disease Activity State

    Margaret H. Ma1, Toby Garrood2, Wanying Li3, Nadine A. Defranoux3, Gabrielle H. Kingsley4, Andrew P. Cope5 and David L. Scott6, 1King's College Hospital, London, United Kingdom, 2Rheumatology, Guy's and St. Thomas' Foundation Hospital NHS Trust, London, United Kingdom, 3Crescendo Bioscience Inc., South San Francisco, CA, 4Academic Rheumatology, Kings College London, London, United Kingdom, 5Academic Dept Rheumatology, King's College London, London, United Kingdom, 6King's College London, Department of Rheumatology, London, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) patients increasingly achieve clinical remission with intensive treatment regimens. However, ultrasound (US) subclinical synovitis has been reported in remission states. The…
  • Abstract Number: 2975 • 2014 ACR/ARHP Annual Meeting

    Residual Large Joint Synovitis By Power Doppler Ultrasonography Is Associated with Higher Disease Activity and Significant Impact of Disease in Multi-Ethnic Asian Patients with Established Rheumatoid Arthritis

    Yu Xiao Guo1, Manjari Lahiri2,3 and Peter Cheung2,3, 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 2Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, 3Division of Rheumatology, National University Hospital, Singapore, Singapore

    Background/Purpose Regular monitoring of disease activity with appropriate modification of disease-modifying anti-rheumatic drug (DMARD) therapy results in improved radiographic and functional outcomes in patients with…
  • Abstract Number: 2936 • 2014 ACR/ARHP Annual Meeting

    Is Ankylosing Spondylitis a Risk Factor for Cardiovascular Diseases, and How Does These Risks Compare to Those in Rheumatoid Arthritis?

    Johan Askling1, Lennart Jacobsson2 and Jonas Eriksson1, 1Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 2sahlrenska academy, gothenburg, Sweden

     Background/Purpose Patients with RA are at increased risk of cardiovascular (CV) diseases, including acute coronary syndromes (ACS), deep venous thromboembolism (DVT) and pulmonary embolism (PE),…
  • Abstract Number: 2937 • 2014 ACR/ARHP Annual Meeting

    Evaluation of Referral Models for Axial Spondyloarthritis in Primary Care in the Spondyloarthritis Caught Early Cohort

    Ozair Abawi1, Rosaline van den Berg1, Désirée van der Heijde2 and Floris van Gaalen1, 1Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose  Several models have been proposed to refer patients (pts) with possible axial spondyloarthritis (axSpA) from primary care to the rheumatologist. Aim of the study…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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