Abstract Number: 3005 • 2015 ACR/ARHP Annual Meeting
Pulmonary Arterial Hypertension-Associated Single Nucleotide Polymorphisms of Hypoxia-Inducible Factor-3a Gene Cause Constitutive Activation of the Endothelin-1 Gene Promoter
Background/Purpose: Pulmonary arterial hypertension (PAH) is a progressive and fatal complication in the patients with connective tissue diseases (CTD). Elevation of endothelin-1 (ET-1) levels in…Abstract Number: 3006 • 2015 ACR/ARHP Annual Meeting
Cell-Free Circulating DNA in Systemic Sclerosis: Increased Levels and Global Cytosine Hypomethylation
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction, vascular injury, and activation of fibroblasts leading to organ fibrosis. The precise etiology…Abstract Number: 3007 • 2015 ACR/ARHP Annual Meeting
Cold Receptor Expression and Function in Human Dermal Fibroblast: Possible Role in the Pathogenesis of Scleroderma Fibrosis
Background/Purpose: Enhanced cold sensitivity is an early and consistent phenomenon in scleroderma (SSc). We previously demonstrated increased expression of the transient receptor potential melastatine 8…Abstract Number: 3008 • 2015 ACR/ARHP Annual Meeting
Role of PTP4A1 Tyrosine Phosphatase in Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a multi-system autoimmune connective tissue disorder that leads to fibrosis of the skin and internal organs, resulting in significant patient…Abstract Number: 3009 • 2015 ACR/ARHP Annual Meeting
Fli1 Deficiency Contributes to the Downregulation of Endothelial Protein C Receptor in Systemic Sclerosis: A Possible Role in Pro-Thrombotic Condition
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by fibrosis of the skin and certain internal organs due to the constitutive activation…Abstract Number: 3010 • 2015 ACR/ARHP Annual Meeting
Estrogens Inhibit the Profibrotic Effects of Transforming Growth Factor-Beta and Protect from the Development of Experimental Dermal Fibrosis
Background/Purpose: Systemic sclerosis (SSc) primarily affects postmenopausal women. This sex bias could partly be explained by the action of estrogens on the immune system and/or…Abstract Number: 3011 • 2015 ACR/ARHP Annual Meeting
The Homeoprotein Engrailed-1 Regulates Canonical TGF Beta Signaling in Experimental Systemic Sclerosis
Background/Purpose: Systemic sclerosis (SSc) is a chronic fibrotic connective disease of unknown etiology that affects the skin and internal organs. Transforming growth factor-β (TGFβ) has…Abstract Number: 3012 • 2015 ACR/ARHP Annual Meeting
Over-Expression of Ubiquitin-Specific Peptidases in Systemic Sclerosis Fibroblasts Increases Responses to TGF-Beta
Background/Purpose: Ubiquitination of proteins leads to their degradation by the proteasome, and is regulated by a small number of ubiquitin ligases, and a large number…Abstract Number: 3013 • 2015 ACR/ARHP Annual Meeting
Adipose Loss of Co-Repressor Ncor Attenuates Bleomycin-Induced Skin Fibrosis By Enhancing PPAR-Gamma Signaling
Background/Purpose: The adipogenesis master regulator PPAR-gamma (PPARg) is regulated by repressors such as NCoR. Systemic sclerosis (SSc) is associated with impaired PPARg expression and function…Abstract Number: 3014 • 2015 ACR/ARHP Annual Meeting
Endotrophin: A Novel Adipokine Linking Adipose Tissue and Skin Fibrosis in Systemic Sclerosis
Background/Purpose: Adipocytes and their progenitor cells are embedded in a network of extracellular matrix that plays a role in regulating its function. Type 6 collagen…Abstract Number: 3015 • 2015 ACR/ARHP Annual Meeting
Characterization of the Profibrotic/Antifibrotic Profile of microRNA Contained in Exosomes Isolated from Cultured Normal Human Dermal and Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition in Vitro
Background/Purpose: Systemic Sclerosis (SSc) is characterized by progressive fibrosis of skin and multiple internal organs, severe alterations in the microvasculature, and numerous immunological abnormalities. Recently…Abstract Number: 3016 • 2015 ACR/ARHP Annual Meeting
Bromodomain Inhibitor JQ1 Modulates Smooth Muscle Cell Switching and Ameliorates Chronic Hypoxia/SU5416-Induced Pulmonary Arterial Hypertension in Mice
Background/Purpose: Pulmonary arterial hypertension (PAH) represents a serious co-morbidity affecting up to 10% of systemic sclerosis (SSc) patients. Cardinal features of PAH include inflammation and…Abstract Number: 3017 • 2015 ACR/ARHP Annual Meeting
TYK2 and Systemic Sclerosis Susceptibility: a New Associated Locus in the IL-12 Pathway
Background/Purpose: Systemic sclerosis (SSc) is a complex autoimmune disease. The aetiology of the disease is largely unknown, although both environmental and a genetic factors are…Abstract Number: 3018 • 2015 ACR/ARHP Annual Meeting
Paracrine Effect of Proteins Secreted By Normal Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition on the Expression of Genes Associated with Tissue Fibrosis in Normal Human Lung Fibroblasts
Background/Purpose: Progressive tissue fibrosis and microvascular alterations are the hallmarks of Systemic Sclerosis (SSc). The mechanisms involved in SSc pathogenesis are complex and have not…Abstract Number: 3019 • 2015 ACR/ARHP Annual Meeting
The CD4+CD52low T Cell Contributes to Disease Activity and Autoantybody Production in Systemic Lupus Erythematosus
Background/Purpose: CD52 is a cell-surface glycoprotein that is widely expressed in lymphocytes, monocytes and eosinophils. The anti-CD52 antibody has been used to treat multiple autoimmune…
ACR Meeting Abstracts