ACR Meeting Abstracts

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  • Abstract Number: 3014 • 2014 ACR/ARHP Annual Meeting

    Does the Order or Amount of Risk-Benefit Information Presented Influence patients’ Perceived Value of a Proposed New Medication?

    Liana Fraenkel1, Richard Street2, Harjinder Chowdhary3, Sarah Swift3 and Ellen Peters4, 1Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Systems, New Haven, CT, 2Texas A&M University, College Station, TX, 3Yale University, New Haven, CT, 4Ohio State University, Columbus, OH

    Background/Purpose: The order and amount of information has been shown to influence risk perceptions related to hazards. In this study we sought to examine whether…
  • Abstract Number: 3015 • 2014 ACR/ARHP Annual Meeting

    Evaluation of the effuc Educational Needs Assessment Tool (ENAT) Focused Patient Education on Health Outcomes in Patients with Rheumatolid Arthritis – a Randomised Controlled Trial

    Adewale O. Adebajo1, Dawn Johnson2, Hardware Bernadette3, Claire Hale4 and Mwidimi Ndosi5, 1Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, United Kingdom, 2Research and Development, Barnsley Hospital NHS Foundation Trust, Barnsley, United Kingdom, 3Research and Development, Barnsley Hospital NHS Foundation Trust, Baarnsley, United Kingdom, 4School of Healthcare, University of Leeds, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom

    Background/Purpose The Educational Needs Assessment Tool (ENAT) is a quick and simple, self completed questionnaire that ensures that patient education is relevant, appropriate and timely for people…
  • Abstract Number: 3016 • 2014 ACR/ARHP Annual Meeting

    Measuring the Impact of an Early RA Support and Education Program Using a Program Evaluation with Patient Identified Outcomes

    Adena Batterman1, Kathryn Klingenstein1, Roberta Horton1, Linda Leff2, Theodore R. Fields3 and Vivian P. Bykerk4, 1Social Work Programs, Hospital for Special Surgery, New York, NY, 2Nursing, Hospital for Special Surgery, New York, NY, 3Rheumatology, Hospital for Special Surgery Weill Cornell Medical College, New York, NY, 4Rheumatology, Hospital for Special Surgery, New York, NY

    Background/Purpose The Early RA Support and Education Program addresses the unique psycho-educational needs of people recently diagnosed (
  • Abstract Number: 2976 • 2014 ACR/ARHP Annual Meeting

    Lung Ultrasound Screening for Interstitial Lung Disease in Rheumatoid Arthritis. Comparison with Usual Detection Algorithms in Clinical Practice

    Marco Antivalle, Michel Chevallard, Michele Battellino, MariaChiara Ditto, Valentina Varisco, Federica Rigamonti, Alessandra Mutti, Fabiola Atzeni, Alberto Batticciotto and Piercarlo Sarzi-Puttini, Rheumatology, L. Sacco University Hospital, Milano, Italy

    Background/Purpose: interstitial lung disease (RA-ILD) is one of the most serious extraarticular complications of rheumatoid arthritis (RA). Presently, it is not clear which is the…
  • Abstract Number: 2977 • 2014 ACR/ARHP Annual Meeting

    Distinct Serum Protein Signature and Novel Biomarkers of primary Sjogren’s Syndrome Revealed by comprehensive High-Throughput Proteomic Analysis

    Ayumi Nishikawa1, Katsuya Suzuki2, Yoshiaki Kassai3, Yuumi Gotou4, Takahiro Miyazaki3, Maiko Takiguchi5, Masaru Takeshita1, Atsuko Murota2, Rimpei Morita6, Akihiko Yoshimura6 and Tsutomu Takeuchi2, 1Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Inflammation Drug Discovery Unit, Takeda Pharmaceutical Company Limited, Kanagawa, Japan, 4Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, 5Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Japan, 6Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: The EULAR SS Disease Activity Index (ESSDAI) is currently used as an objective evaluation method of clinical disease activity in clinical research into primary…
  • Abstract Number: 2978 • 2014 ACR/ARHP Annual Meeting

    Characterization of the Sjögren’s Syndrome Intergenic Non-Coding RNA 1 (SSINCR1)

    John A. Ice1, He Li2,3, Indra Adrianto2, Mikhail G. Dozmorov4, Astrid Rasmussen5, Graham B. Wiley1, Jennifer A. Kelly1, Kimberly S. Hefner6, Donald U. Stone7, Raj Gopalakrishnan8, David M. Lewis9, Stephen Young9, Michael D. Rohrer8, Juan-Manuel Anaya10, Swamy Venuturupalli11, Barbara M. Segal12, Nelson L. Rhodus13, Lida Radfar14, Michael H. Weisman15, Judith A. James16,17, Courtney G. Montgomery18, R. Hal Scofield19,20,21, Patrick M. Gaffney1, Linda F. Thompson22, A. Darise Farris23, Susan Kovats1, Jonathan D. Wren1, Kathy L. Sivils24 and Christopher J. Lessard25, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Arthritis and Clincial Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Hefner Eye Care and Optical Center, Oklahoma City, OK, 7Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 8Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, 9College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 10Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, 11Cedars-Sinai Medical Center, West Hollywood, CA, 12Rheumatology, Hennepin County Medical Center, Minneapolis, MN, 13University of Minnesota, Minneapolis, MN, 14College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 15Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 16Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 17Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 18Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 19US Department of Veterans Affairs Medical Center, Oklahoma City, OK, 20College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 21Oklahoma Medical Research Foundation, Oklahoma City, OK, 22Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, OK, 23Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, 24Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 25825 N.E. 13th St., Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose Sjögren’s syndrome (SS) is a common autoimmune disorder characterized by immune-mediated exocrine gland destruction and systemic inflammatory responses that contribute to clinical heterogeneity. Widespread…
  • Abstract Number: 2979 • 2014 ACR/ARHP Annual Meeting

    Nucleic Acid Sensing Receptors TLR7, RIG-I and MDA5 Collaborate in Driving the Systemic IFN Signature and Amplify the Pathogenic Loop: Potential New Targets for Therapy in Primary Sjogrens Syndrome

    Naomi I Maria1, Cornelia G. van Helden-Meeuwsen1, Eline C. Steenwijk1, Arne S. IJpma2, Wouter Beumer1, Zana Brkic1, Virgil A. Dalm1, Paul L. van Daele1, P. Martin van Hagen1, Peter J. van der Spek2, Hemmo A. Drexhage1 and Marjan A. Versnel1, 1Erasmus Medical Center, Immunology, Rotterdam, Netherlands, 2Erasmus Medical Center, Bioinformatics, Rotterdam, Netherlands

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by autoantibodies targeting RNA-associated antigens, anti-SSA/SSB. The IFN-signature is present in over half of…
  • Abstract Number: 2980 • 2014 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Analysis of CD19+ B Cells in Primary Sjögren’s Syndrome

    Gunnel Nordmark1, Juliana Imgenberg-Kreuz2, Jonas Carlsson Almlöf2, Jessica Nordlund2, Roald Omdal3, Katrine B. Norheim3, Maija-Leena Eloranta4, Lars Rönnblom4 and Johanna K. Sandling2, 1Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 2Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 3Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, 4Department of Medical Sciences, SciLife Lab, Rheumatology, Uppsala University, Uppsala, Sweden, Uppsala, Sweden

    Background/Purpose Increasing evidence suggests an epigenetic contribution to the pathogenesis of autoimmune diseases, including primary Sjögren’s Syndrome (pSS) (1). A genome-wide DNA methylation study in…
  • Abstract Number: 2981 • 2014 ACR/ARHP Annual Meeting

    Prognostic Value of the Complex P2X7 Receptor-Inflammasome in Patients with Primary Sjögren’s Syndrome at Lymphoma Risk

    Chiara Baldini1, Eleonora Santini2, Chiara Rossi2, Francesca Sernissi1, Daniela Martini1, Alessia Gallo3, Valentina Donati2, Nicoletta Luciano1, Francesco Ferro1, Illias Alevizos4, Anna Solini2 and Stefano Bombardieri5, 1University of Pisa, Rheumatology Unit, Pisa, Italy, 2Department of Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, 3Sjogren's Clinic, NIDCR, Bethesda, MD, 4NIDCR, Bethesda, MD, 5Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: Pro-inflammatory P2X7-receptor has been recently implicated in the pathogenesis of primary Sjögren’s syndrome (pSS), suggesting that it may be involved in the initiation and…
  • Abstract Number: 2982 • 2014 ACR/ARHP Annual Meeting

    Identification of Whole Blood Gene Expression Signature in Primary Sjögren’s Syndrome Associated Lymphoma

    Shereen Al-Ali1,2, Simon Cockell3, Andrew Skelton4, Katherine James1, Jessica Tarn1, David Young5, Bridget Griffiths6, Simon Bowman7, James Locke1 and Wan-Fai Ng8, 1Newcastle University, Newcastle upon Tyne, United Kingdom, 2College of Science, University of Basrah, Basrah, Iraq, 3Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, United Kingdom, 4Bioinformatics support unit, Newcastle University, Newcastle Upon Tyne, United Kingdom, 5Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, 6Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom, 7Rheumatology Dept (Selly Oak), University Hospital Birmingham, Birmingham, United Kingdom, 8Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

    Background/Purpose: Primary Sjӧgren’s syndrome (pSS) is associated with a substantially increased risk of lymphoma development. The aim of our study is to identify a whole…
  • Abstract Number: 2983 • 2014 ACR/ARHP Annual Meeting

    Infliximab Added to Naproxen Does Not Increase Frequency of New Fatty Lesions on MRI of the Sacroiliac Joints and of the Spine As Compared to Naproxen Alone in Early Axial Spondyloarthritis

    Denis Poddubnyy and Joachim Sieper, Charité Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose:  Fatty lesions of the bone marrow in the axial skeleton (sacroiliac joints – SIJ, and spine) on magnetic resonance imaging (MRI) are considered nowadays…
  • Abstract Number: 2984 • 2014 ACR/ARHP Annual Meeting

    Degenerative Changes of the Spine on MRI in Patients with Inflammatory Back Pain from the DESIR Cohort

    F. de Bruin1, Marc Olivier Treyvaud2, Antoine Feydy2, Maxime Dougados3, Laure Gossec4, J.L Bloem1, Désirée van der Heijde5 and Monique Reijnierse5, 1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Paris Descartes University, Radiology B department, Cochin Hospital, Paris, France, 3Descartes University, Cochin Hospital, Paris, France, 4Rheumatology, UPMC Paris 06 University, GRC 08, Paris France and Pitié Salpétrière Hospital Paris France, Paris, France, 5Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose MRI is a sensitive method to detect early signs of axial spondyloarthritis (axSpA). A positive MRI of the sacroiliac joints is part of the…
  • Abstract Number: 2985 • 2014 ACR/ARHP Annual Meeting

    Autoantibodies to 14-3-3η Are Novel Biomarkers Associated with Inflammation and  Radiographic Progression in Ankylosing Spondylitis

    Walter P. Maksymowych1, Stephanie Wichuk1, RG Lambert2, Mairead Murphy3 and Anthony Marotta4, 1Medicine, University of Alberta, Edmonton, AB, Canada, 2Radiology, University of Alberta, Edmonton, AB, Canada, 3Augurex Life Sciences Corp., North Vancouver, BC, Canada, 41423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada

    Background/Purpose 14-3-3η is a ubiquitous intracellular chaperone protein that is expressed extracellularly in rheumatoid arthritis and mediates inflammatory cascades that result in expression of inflammatory…
  • Abstract Number: 2986 • 2014 ACR/ARHP Annual Meeting

    Fat Metaplasia on MRI of the Sacroiliac Joints Is a Lead Indicator of Radiographic Progression in the Spine of Patients with Ankylosing Spondylitis

    Walter P. Maksymowych1, S Wichuk2, P Chiowchanwisawakit3, RG Lambert4 and Sj Pedersen5, 1Medicine, University of Alberta, Edmonton, AB, Canada, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3Mahidol University, Bangkok, Thailand, 4Radiology, University of Alberta, Edmonton, AB, Canada, 5Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark

    Fat Metaplasia on MRI of the Sacroiliac joints is a Lead Indicator of Radiographic Progression in the Spine of Patients with Ankylosing SpondylitisMaksymowych WP, Wichuk…
  • Abstract Number: 2987 • 2014 ACR/ARHP Annual Meeting

    Value of Color Doppler Ultrasound Assessment of Sacroiliac Joints in Patients with    Inflammatory Chronic Low Back Pain

    Maximiliano Bravo1, Leandro Ferreyra Garrott1, David A. Navarta2, Emmanuel Bertiller1, Ricardo Garcia-Monaco3, Santiago Ruta1, Javier Rosa4 and Enrique Soriano1, 1Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 2Internal Medicine, Rheumatology Unit, Internal Medical Services, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, 3Radiology and Imagenology Department, Hospital italiano de Buenos Aires, Buenos Aires, Argentina, 4Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: The utility of ultrasound in the evaluation of sacroiliitishas not been extensively studied yet.  To evaluate the diagnostic value of color Doppler ultrasound (US) for…
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