Abstracts Archive - Page 1853 of 2607 - ACR Meeting Abstracts

Abstract Number: 2990 • 2015 ACR/ARHP Annual Meeting
Assessment of NT-Pro BNP As a Potential Marker for Pulmonary Hypertension in Systemic Sclerosis: Data from a Large, Prospective and Unselected Patient Cohort
Anna-Maria Hoffmann-Vold^1,2, Oyvind Midtvedt¹, Torhild Garen³, May Brit Lund⁴, Arne Andreassen⁵ and Øyvind Molberg⁶, ¹Rheumatology, Oslo University Hospital, Oslo, Norway, ²Institute of clinical medicine, University of Oslo, Oslo, Norway, ³Rheumatology, Department of Rheumatology, Oslo University Hospital, Oslo, Norway, ⁴Respiratory Diseases, Oslo University Hospital, Oslo, Norway, ⁵Cardiology, Oslo University Hospital, Oslo, Norway, ⁶Department of Rheumatology, Institute of Clinical Medicine, Oslo University Hospital, Oslo, Norway
Background/Purpose: In Systemic Sclerosis (SSc), pulmonary arterial hypertension (PAH) is often diagnosed at an advanced stage. Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are…
Abstract Number: 2991 • 2015 ACR/ARHP Annual Meeting
Evaluation of Serum Levels of Adipokines and Interleukines in Pericardial Effusion Related to Systemic Sclerosis
Angela Chialà¹, Cinzia Rotondo¹, Maria Grazia Anelli¹, Emanuela Praino¹, Luca Cantarini², Crescenzio Scioscia¹, Margherita Giannini¹, Giovanni Lapadula¹ and Florenzo Iannone¹, ¹DIM, Rheumatology Unit, Bari, Italy, ²Univ Siena, Siena, Italy
Background/Purpose: Pericardial involvement is common in rheumatic disease, as rheumatoid arthritis, lupus erythematosus, mixed connective disease and systemic sclerosis. Few data are available about pathogenesis…
Abstract Number: 2992 • 2015 ACR/ARHP Annual Meeting
Identification of a New Set of Activity Criteria for Systemic Sclerosis. Preliminary Report
Gabriele Valentini¹, Michele Iudici², Veronika K. Jaeger³, Christopher P. Denton⁴, Oliver Distler⁵, Otylia M. Kowal-Bielecka⁶, Ulf Müller-Ladner⁷, Gabriela Riemekasten⁸, Ulrich A. Walker³, Suzana Jordan⁵, Elise Siegert⁸, Serena Vettori² and Yannick Allanore⁹, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ³Department of Rheumatology, University Hospital Basel, Basel, Switzerland, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Department of Rheumatology and Internal Medicine, Medical University in Bialystok, Bialystok, Poland, ⁷Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁸Rheumatology and Clinical Immunology, Charité – University Hospital, Berlin, Berlin, Germany, ⁹Department of Rheumatology, University Paris Descartes and Cochin Hospital, Paris, France
Background/Purpose: The European Scleroderma Study Group (EScSG) Activity Index developed in 2001 has some limitations due to the procedure underlying its development and the inclusion…
Abstract Number: 2993 • 2015 ACR/ARHP Annual Meeting
Serum CXCL4 Increase in Patients with Undifferentiated Connective Tissue Disease at Risk for Systemic Sclerosis Is Associated with Anti-Scl70 Antibodies and ICAM-1, a Marker of Endothelial Activation
Serena Vettori¹, Rosaria Irace², Veronica Giacco², Antonella Riccardi², Lucia Vicedomini², Luciana Pellecchia² and Gabriele Valentini², ¹Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy
Background/Purpose: CXCL4 is a pleiotropic antiangiogenic and immunomodulatory chemokine, that has been shown to be increased in the sera of patients with systemic sclerosis (SSc)…
Abstract Number: 2994 • 2015 ACR/ARHP Annual Meeting
The Global Microrna Profile of Systemic Sclerosis Whole Skin/Dermal Fibroblasts and the Role of the Xq26.3 miRNA Cluster As a TGF-b Pathway Positive Feedback Mechanism
Gloria Salazar¹, John Hagan², Minghua Wu³, Xinjian Guo⁴, Xiaodong Zhou⁴, Julio Charles¹, Maureen D Mayes¹ and Shervin Assassi¹, ¹Rheumatology, University of Texas Medical School at Houston, Houston, TX, ²Neurosurgery, University of Texas at Houston, Houston, TX, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Internal Medicine, University of Texas Medical School at Houston, Houston, TX
Background/Purpose: MicroRNA (miRNA) are critical gene regulators that frequently play central roles in disease. Here, we report the miRNA expression signatures of systemic sclerosis (SSc)…
Abstract Number: 2995 • 2015 ACR/ARHP Annual Meeting
Genome Wide Analysis in Scleroderma Renal Crisis: Defining Genetic Risk in Patients with RNA Polymerase III Auto-Antibodies
Maria C Fonseca¹, Sandra Guerra¹, Edward Stern^1,2, Svetlana I. Nihtyanova¹, David Abraham³, Aine Burns², Mark Harber² and Christopher P. Denton⁴, ¹Rheumatology, UCL Division of Medicine, London, United Kingdom, ²Nephrology, Royal Free Hospital, London, United Kingdom, ³Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, ⁴Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom
Background/Purpose: Scleroderma renal crisis (SRC) is a severe complication of systemic sclerosis (SSc). Most SSc cases demonstrate a disease-specific antinuclear antibody including anti-RNA polymerase III…
Abstract Number: 2996 • 2015 ACR/ARHP Annual Meeting
Evaluation of Systemic Sclerosis Risk Genes in the Turkish Population
Javier Martín¹, Francisco David Carmona², Tamara Fernández-Aranguren¹, Alberto Serrano-Fernández³, Ahmet Mesut Onat⁴, Gema Robledo⁵, Enrique Raya⁶, Haner Direskeneli⁷, Amr H. Sawalha⁸ and Sule Yavuz⁹, ¹Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ²Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain, ³Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla, Spain, ⁴Ä°nternal Medicine Division of Rheumatology, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey, ⁵Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, ⁶Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ⁷Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁸Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁹Rheumatology, Istanbul Bilim University, Faculty of Medicine,Department of Rheumatology, Istanbul, Turkey
Background/Purpose: The use of high-throughput genotyping platforms has allowed a better understanding of the genetic background underlying systemic sclerosis (SSc). Sixteen non-HLA genes have been…
Abstract Number: 2997 • 2015 ACR/ARHP Annual Meeting
A Genome-Wide Association Study of a Hispanic Systemic Sclerosis Cohort
Lara Bossini-Castillo¹, Enrique Raya², John D. Reveille³, Shervin Assassi⁴, Olga Y Gorlova⁵, Dinesh Khanna⁶, Daniel E. Furst⁷, Suzanne Kafaja⁸, Robert W. Simms⁹, Robert Lafyatis⁹, Tracy M. Frech¹⁰, Virginia D. Steen¹¹, Barri J. Fessler¹², Jerry A. Molitor¹³, Marta Alarcón-Riquelme^14,15, Javier Martín¹⁶ and Maureen D Mayes⁴, ¹Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain, ²Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ³Internal Medicine/Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁵Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁶Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁷Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁸Rheumatology, University of California Los Angeles, Los Angeles, CA, ⁹Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁰Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Department of Rheumatology, Georgetown University Medical Center, Washington, DC, ¹²Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹³Rheumatology, University of Minnesota, Minneapolis, MN, ¹⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, ¹⁵Centre for Genomics and Oncological Research (GENYO), Pfizer–University of Granada–Junta de Andalucia, Parque Tecnológico de la Salud (PTS), Granada, Spain, ¹⁶Instituto de Parasitología y Biomedicina López- Neyra, IPBLN-CSIC, PTS-Granada, Granada, Spain
Background/Purpose: Genome-wide association studies (GWASs) have resulted in the identification of several genetic loci involved in systemic sclerosis (SSc) susceptibility. However, GWASs are normally focused…
Abstract Number: 2998 • 2015 ACR/ARHP Annual Meeting
Microchimerism Is Present in Systemic Sclerosis Lung and Includes CD31-Positive Cells
Coline GENTIL¹, Julie Randolph-Habecker², David. K. Madtes^3,4, Min FANG⁵, Hilary S. Gammill⁶, Corinne L. Fligner⁷, McGarry, A. Houghton^3,8 and J. Lee Nelson^9,10, ¹Clinical Division, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ²Histopathology, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ³Clinical Research, Fred Hutchinson Cancer Research Center, SEATTLE, WA, ⁴University of Washington, SEATTLE, WA, ⁵Cytogenetics, Seattle Cancer Care Alliance, SEATTLE, WA, ⁶Obstetrics and Gynecology, University of Washington, Seattle, WA, ⁷Pathology, University of Washington, SEATTLE, WA, ⁸Pulmonary medicine, University of Washington, SEATTLE, WA, ⁹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, ¹⁰University of Washington, Seattle, WA
Background/Purpose: Microchimerism (Mc), harboring a small number of cells (or DNA) that originated in a different individual, occurs commonly due to bi-directional maternal-fetal exchange during…
Abstract Number: 2999 • 2015 ACR/ARHP Annual Meeting
Maternal Microchimerism Is Increased in Multiple Cellular Subsets of Patients with Systemic Sclerosis Compared to Healthy Controls
Sami B. Kanaan¹, Whitney Harrington^2,3, Laurence S. Loubiere⁴, Tessa M. Aydelotte¹ and J. Lee Nelson^1,5, ¹Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, ²Seattle Children's Hospital, Seattle, WA, ³Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, ⁴University of Birmingham, Birmingham, United Kingdom, ⁵University of Washington, Seattle, WA
Background/Purpose: Microchimerism (Mc) is naturally acquired through bi-directional exchange of small amounts of cells or DNA between mother and fetus during pregnancy. Higher amounts of…
Abstract Number: 3000 • 2015 ACR/ARHP Annual Meeting
Intrinsic Gene Expression Subset Predicts Improvement in Systemic Sclerosis Patients during Dasatinib (SprycelTM) Therapy
Viktor Martyanov¹, Jonathan Goldin², Kim Hyun³, Oumar Sy⁴, Wendy Hayes⁴, Shuyan Du⁴, Michael Whitfield¹ and John Varga⁵, ¹Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, NH, ²David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, ³Radiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, ⁴Bristol-Myers Squibb, Princeton, NJ, ⁵Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL
Background/Purpose: Intrinsic gene expression subsets are molecular pathway-driven subtypes of systemic sclerosis (SSc) that have been reproduced across multiple cohorts of SSc patients. The goal…
Abstract Number: 3001 • 2015 ACR/ARHP Annual Meeting
Exome Sequencing for Identification of Potential Causal Variants for Diffuse Cutaneous Systemic Sclerosis
Angel CY Mak¹, Paul LF Tang², Clare Cleveland^3,4, M Kari Connolly⁵, Tamiko Katsumoto^3,4, Paul Wolters⁶, Pui-Yan Kwok^2,5 and Lindsey A. Criswell⁷, ¹Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, ²Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, ³Rosalind Russell Medical Research Center for Arthritis, University of California, San Francisco, San Francisco, CA, ⁴Department of Medicine, University of California, San Francisco, San Francisco, CA, ⁵Department of Dermatology, University of California, San Francisco, San Francisco, CA, ⁶Pulmonary Division, Department of Medicine, University of California, San Francisco, San Francisco, CA, ⁷Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA
Background/Purpose: Scleroderma is a genetically complex autoimmune disease with substantial phenotypic heterogeneity. Previous genome-wide association studies (GWAS) have identified a large number of gene regions…
Abstract Number: 3002 • 2015 ACR/ARHP Annual Meeting
The Regulatory Role of Gammadelta T Cells in Bleomycin-Induced Pulmonary Fibrosis
Seiji Segawa¹, Daisuke Goto², Akira Iizuka³, Masahiro Yokosawa³, Shunta Kaneko³, Yuya Kondo³, Isao Matsumoto³ and Takayuki Sumida³, ¹Division of Clinical Immunology, Doctoral Program in Clinical Sciences,, University of Tsukuba, Tsukuba, Japan, ²Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan, ³Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose: Interstitial pneumonia (IP) is a chronic progressive interstitial lung disease associated with high mortality and poor prognosis. However, the exact mechanism of IP remains…
Abstract Number: 3003 • 2015 ACR/ARHP Annual Meeting
Increased Heparanase Expression in Keratinocytes Promotes Dermal Fibrosis in Scleroderma
In-Woon Baek¹, Wan-Uk Kim², Chul-Soo Cho¹ and Ki-Jo Kim³, ¹Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea, ²Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea, ³Internal Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, South Korea
Background/Purpose: Interactions between keratinocyte and dermal fibroblast via paracrine loop play an important role in wound repair and keloid formation. In this study, we investigated…
Abstract Number: 3004 • 2015 ACR/ARHP Annual Meeting
Scleroderma Keratinocytes Promote Fibroblast Activation Independent of TGF-ß
Sara S McCoy¹, Tamra J Reed¹, Pei-Suen Tsou², Dinesh Khanna³, J. Michelle Kahlenberg⁴ and Celine C. Berthier⁵, ¹Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁵Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is a devastating fibrosing disease that primarily involves the skin, but may have life-threatening effects on the heart, lungs, gastrointestinal tract,…

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