Abstracts Archive - Page 1841 of 2607 - ACR Meeting Abstracts

Abstract Number: 2808 • 2015 ACR/ARHP Annual Meeting
Genetic Variants at Chromosome 5q15 Associated with Immune-Mediated Diseases Influence Gene Expression and Isoform Profile of the Endoplasmic Reticulum Aminopeptidase
Aimee Hanson¹, Katelin Haynes², Gethin Thomas², Thomas Cuddihy², Paul Leo² and Matthew A. Brown¹, ¹The University of Queensland Diamantina Institute, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Polymorphisms in the endoplasmic reticulum aminopeptidase genes ERAP1 and/or ERAP2 are strongly associated with the diseases AS, psoriasis, IBD and Behcet’s disease. Robust genetic…
Abstract Number: 2809 • 2015 ACR/ARHP Annual Meeting
Increased Frequencies of IL-23R Positive T Cells and IL-22 and IL-17 Producing MAIT Cells in the Peripheral Blood of Patients with Ankylosing Spondylitis: Preliminary Results.
Eric Toussirot¹, Caroline Laheurte², Béatrice Gaugler³ and Philippe Saas⁴, ¹Service de Rhumatologie, CHU J Minjoz, Besancon, France, ²Etablissement Français du Sang/ Université de Franche Comté / CBT506 / CHRU, INSERM UMR1098 / Plateforme Biomonitoring, Besançon, France, ³EFS Bourgogne Franche Comté, INSERM UMR1098 / Etablissement Français du Sang / Université de Franche Comté, Besançon, France, ⁴Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France
Background/Purpose: Ankylosing spondylitis (AS) is the prototypic and most common form of spondyloarthritis (SpA). It was recently suggested that IL-23 could play a pivotal role…
Abstract Number: 2810 • 2015 ACR/ARHP Annual Meeting
The Presence of HLA-B27 Increases Severity of Arthritis but Does Not Appear to Influence New Bone Formation in Different in Vitro and in Vivo Models
Barbara Neerinckx¹, Kerri Heritage², Jacqueline Shaw³, S. Kollnberger³, Paul Bowness³ and Rik Lories¹, ¹Rheumatology, UZ Leuven, Leuven, Belgium, ²Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven and University Hospitals Leuven., Leuven, Belgium, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: The strong genetic association between the HLA-B27 gene and ankylosing spondylitis (AS) has been known for over 40 years. Among AS patients, HLA-B27 positivity…
Abstract Number: 2811 • 2015 ACR/ARHP Annual Meeting
Higher Serum Level of Leptin Protects from Radiographic Spinal Progression in Patients with Ankylosing Spondylitis
Agnes Hartl¹, Kay-Geert Hermann¹, In-Ho Song^1,2, Joachim Listing³, Martin Rudwaleit^1,4, Joachim Sieper¹ and Denis Poddubnyy¹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Abbvie, Chicago, IL, ³German Rheumatism Research Centre, Berlin, Germany, ⁴Klinikum Bielefeld, Bielefeld, Germany
Background/Purpose: Fat tissue synthesizes and releases a series of biologically active substances (adipokines), which are involved in bone metabolism through effects on bone formation and…
Abstract Number: 2812 • 2015 ACR/ARHP Annual Meeting
Cytokine Secretion By Peripheral Blood Mononuclear Cells in Patients with Axial Spondyloarthritis and the Effect of Thymoquinone on Cytokine Profile
Erkan Kilic¹, Cagri Sakalar², Huriye Aksu³, Mustafa Cakir³, Gamze Kilic¹ and Salih Ozgocmen⁴, ¹Dept. PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey, ²Genome and Stem Cell Center (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ³Genome and Stem Cell Senter (GEN-KOK), Erciyes University, Faculty of Medicine, Medical Biology, Kayseri, Turkey, ⁴Dept.PRM, Erciyes University, Faculty of Medicine,Division of Rheumatology, Kayseri, Turkey
Background/Purpose: Axial spondyloarthritis (axSpA) defines a group of chronic inflammatory diseases which includes non-radiographic axSpA (nr-axSpA) who do not have definite sacroiliitis on pelvic X-rays.…
Abstract Number: 2813 • 2015 ACR/ARHP Annual Meeting
IL-17 Induces Skin Inflammation Independently of IL-23R+ T Cells and Is Protected By Conditional Deletion of Wdfy3 in Neutrophils
Erika Suzuki¹, Emanual Maverakis², Laura Bouchareychas¹, Vijay K. Kuchroo³, Frank Nestle⁴ and Iannis E. Adamopoulos¹, ¹Internal Medicine, University of California, Davis, Sacramento, CA, ²Dermatology, University of California, Davis, Sacramento, CA, ³Center of Neurological Disease, Harvard Medical School, Boston, MA, ⁴Mary Dunhill Chair of Cutaneous Medicine and Immunotherapy Division of Genetics and Molecular Medicine St Johns Institute of Dermatology, King's College London, London, England
Background/Purpose: IL-17 is elevated in both the lesional skin and arthritic joints of psoriatic arthritis (PsA) patients, however, the direct effect of IL-17 on myeloid…
Abstract Number: 2814 • 2015 ACR/ARHP Annual Meeting
IL-10 May Mitigate Cardiovascular Risk in Psoriatic Arthritis Via an Anti-Atherosclerotic Effect on Cellular Cholesterol Transport
Lucas McCaffrey¹, Iryna Voloshyna², Michael J. Littlefield², Eduard Zhurov³, Steven E. Carsons⁴, Elise Belilos⁵, Kristina Belostocki⁶, Lois Bonetti⁷, Gary Rosenblum⁶ and Allison B. Reiss², ¹Medicine, Division of Rheumatology, Winthrop-University Hospital, Mineola, NY, ²Medicine, Winthrop University Hospital, Mineola, NY, ³Winthrop-University Hospital, Mineola, NY, ⁴Rheumatology, Allergy and Immunology, Winthrop University Hospital, Mineola, NY, ⁵Winthrop University Hospital, Mineola, NY, ⁶Rheumatology, Winthrop University Hospital, Mineola, NY, ⁷Rheum & Immun, Winthrop University Hospital, Mineola, NY
Background/Purpose: The increased risk of major adverse cardiovascular events (MACE) in patients who suffer from systemic inflammatory conditions such as Rheumatoid Arthritis (RA), Systemic Lupus…
Abstract Number: 2815 • 2015 ACR/ARHP Annual Meeting
A Comparison of Th17 Gene Expression in Psoriatic Arthritis Synovial Fluid and Peripheral Blood
Fatima Abji¹, Remy Pollock², Kun Liang³, Vinod Chandran⁴ and Dafna Gladman⁴, ¹Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ²University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is a destructive inflammatory arthritis that develops in approximately 30% of patients with cutaneous psoriasis. Th17 cells infiltrate psoriatic skin and…
Abstract Number: 2816 • 2015 ACR/ARHP Annual Meeting
Is the Gender Difference in As Linked to IL-23?
Johannes Nossent¹ and Gunnstein Bakland^2,3, ¹Medicine, University of Western Australia, WA, Australia, ²Dept. of Rheumatology, University Hospital Northern Norway, Tromsø, Norway, ³University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Background/Purpose: Ankylosing Spondylitis (AS) has traditionally been portrayed as a disease where male patients outnumber female patients by a factor 3 to 4. It has…
Abstract Number: 2817 • 2015 ACR/ARHP Annual Meeting
The Microbiome of Reactive Arthritis in a Guatemalan Cohort
Alexis Ogdie-Beatty¹, Carles Ubeda², Helga Raquel Garcia Ferrer³, Joan Von Feldt⁴, A Garcia Kutzbach⁵ and Jose U. Scher⁶, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Institute for Research in Public Health, Valencia, Spain, ³Society for Worldwide Med Exchange, North Bay Village, FL, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Internal Medicine, Rheumatology Unit (AGAR), Francisco Marroquin University, School of Medicine, Guatemala City, Guatemala, ⁶Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Reactive arthritis (ReA) is an inflammatory arthritis that typically follows infection. Several agents microbial agents have been implicated, particularly Shigella, Salmonella, Campylobacter in the…
Abstract Number: 2818 • 2015 ACR/ARHP Annual Meeting
Associations of IL23R, BMP6 and PTGS1 Polymorphisms with Radiographic Severity of Ankylosing Spondylitis
Gulsen Ozen¹, Rabia Deniz², Fatih Eren³, Can Erzik³, Ali Ugur Unal¹, Sibel Z. Aydin⁴, Nevsun Inanc¹, Haner Direskeneli¹ and Pamir Atagunduz¹, ¹Department of Rheumatology, Marmara University Faculty of Medicine, Istanbul, Turkey, ²Marmara University Faculty of Medicine, Istanbul, Turkey, ³Department of Medical Biology, Marmara University Faculty of Medicine, Istanbul, Turkey, ⁴Department of Rheumatology, Koc University Faculty of Medicine, Istanbul, Turkey
Background/Purpose: Ankylosing spondylitis (AS) is an inflammatory disease affecting spine which may lead to new bone formation and disability. However, the radiographic severity of AS…
Abstract Number: 2819 • 2015 ACR/ARHP Annual Meeting
Rorc Antagonism Inhibits IL-23-Dependent Aberrant Bone Formation in Vivo
Mark Panzenbeck¹, Kathleen Hoyt¹, Donald Souza², Gregg Davis¹, Elizabeth Glynn¹, Thomas Wieckowski¹, Michael Turner¹, Robert Hughes¹, Dustin Smith¹, Christian Harcken¹, Gerald Nabozny³ and Mark Labadia⁴, ¹Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Immunology & Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ³Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT
Background/Purpose: RORγt is a nuclear hormone receptor expressed in Th17 cells and distinct subsets of lymphoid cells, including innate lymphoid cells (ILC), and γδ T-cells.…
Abstract Number: 2820 • 2015 ACR/ARHP Annual Meeting
Multi-Omics Studies of Gut Microbiota in Enthesitis-Related Arthritis Identify Diminished Microbial Diversity and Altered Typtophan Metabolism As Potential Factors in Disease Pathogenesis
Matthew L. Stoll¹, Landon S. Wilson², Stephen Barnes³, Ranjit Kumar⁴, Anna Genin⁵, Randy Q. Cron¹, Charles O. Elson⁶, Casey D Morrow⁷ and Elliot J. Lefkowitz⁸, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pharmicology / Toxicology, University of Alabama at Birmingham, Birmingham, AL, ³Pharmicology, University of Alabama at Birmingham, Birmingham, AL, ⁴Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ⁸Microbiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Children with enthesitis-related arthritis (ERA) and adults with spondyloarthritis are at risk for intestinal inflammation. We have previously shown altered microbiota in children with…
Abstract Number: 2821 • 2015 ACR/ARHP Annual Meeting
Increased CD4 T Cell GM-CSF Production in Spondyloarthritis
M Hussein Al-Mossawi¹, Jelle De Wit², Anna Ridley³ and Paul Bowness¹, ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ³Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, United Kingdom
Background/Purpose: Immunological, genetic and therapeutic studies have implicated the IL-17A/IL-23 inflammatory axis in SpA. GM-CSF is emerging as a cytokine that marks out a pathogenic…
Abstract Number: 2822 • 2015 ACR/ARHP Annual Meeting
Increased Peripheral Blood CCR6+/IL-23R+ Gamma Delta T Cells Are Associated with High Disease Activity in Patients with Axial Spondyloarthritis
Elizabeth Mainolfi¹, Susan M. Goodman², Shawn Anderson³, Jon Hill⁴, Thakker Paresh⁵, Meera Ramanujam⁶, Rivka Friedlander⁷, Elli Kim⁷, Dalit Ashany⁸, Ed Purdue⁹, Christine Averill⁹, Michael Nevid⁹, Allison Shaber⁹, Lisa Mandl¹⁰, Steven R. Goldring¹¹, Gerald Nabozny¹ and VP Bykerk², ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Immunology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁴Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁵Transl. Medicine & Clin. Pharmacology, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁶Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ⁷Department of Medicine, Rheumatology Division, Hospital for Special Surgery, New York, NY, ⁸Rheumatic Disease, Hospital for Special Surgery, New York, NY, ⁹Osteolysis Research Laboratory, Hospital for Special Surgery, New York, NY, ¹⁰Department of Rheumatology, Hospital for Special Surgery, New York, NY, ¹¹Hospital for Special Surgery, New York, NY
Background/Purpose: The IL-23 axis and Th17 type immunity has been implicated in the pathogenesis of Ankylosing Spondylitis (AS) and an enrichment of gamma delta (gd)…

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