Abstracts Archive - Page 1839 of 2607 - ACR Meeting Abstracts

Abstract Number: 2778 • 2015 ACR/ARHP Annual Meeting
Abatacept-Treated Rheumatoid Arthritis Patients Have Better Drug-Survival Rate When Abatacept Is the First or Second Line Biologic Agent with an Excellent Overall Safety Profile: A Single Center Experience
Irini Flouri¹, Argyro Repa², Antonis Fanouriakis², Nikolaos Kougkas², Ioannis Papalopoulos², Eleni Kampouraki², Dimitrios Boumpas³, Nestor Avgoustidis², George Bertsias² and Prodromos Sidiropoulos², ¹Rheumatology, Clinical Immunology, Allergy, University of Crete, Medical School, University Hospital, Heraklion, Greece, ²Rheumatology, Clinical Immunology, and Allergy, University of Crete, Medical School, University Hospital, Heraklion, Greece, ³Biomedical Research Foundation, Academy of Athens, Athens, Greece
Background/Purpose: Long-term prospective observational studies are complementary to controlled clinical trials in exploring the effectiveness and safety of biological therapies in rheumatoid arthritis (RA). We…
Abstract Number: 2779 • 2015 ACR/ARHP Annual Meeting
Better Drug Survival of Non-TNFi Compared to TNFi Biologics after Non-TNFi Failure in RA Patients: A Single Center Experience
Konstantinos Thomas, Christos Koutsianas, Argyro Lazarini, Christina Tsalapaki, Chrisoula Hatzara, Anna Kandili, Katerina Antonatou and Dimitrios Vassilopoulos, University of Athens Medical School, Clinical Immunology and Rheumatology Unit, 2nd Department of Medicine and Laboratory, Athens, Greece
Background/Purpose: There are sparse data in the literature regarding the drug survival of TNFi vs. non-TNFi biologics in rheumatoid arthritis (RA) patients who have already…
Abstract Number: 2780 • 2015 ACR/ARHP Annual Meeting
Relationship Between Immunogenicity, Hypersensitivity Reactions and Skin Tests Against Infliximab, Etanercept and Adalimumab in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Firas Doghanji¹, Sebnem Ataman², Ali Erhan Ozdemirel², Recep Bülent Seckin¹, Ayse Peyman Yalcin¹ and Sevim Bavbek³, ¹Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ²Rheumatology Department, Ankara University Faculty of Medicine, Ankara, Turkey, ³Immunology and Allergy, Ankara University Faculty of Medicine, Ankara, Turkey
Relationship between immunogenicity, hypersensitivity reactions and skin tests against Infliximab, Etanercept and Adalimumab in patients with rheumatoid arthritis and ankylosing spondylitis Background/Purpose: Anti-TNF drugs can…
Abstract Number: 2781 • 2015 ACR/ARHP Annual Meeting
Absence of Effects of Filgotinib on Erythrocytes, CD8+ and NK Cells in Rheumatoid Arthritis Patients Brings Further Evidence for the JAK1 Selectivity of Filgotinib
René Galien^1,2, Reginald Brys³, Annegret Van der Aa³, Pille Harrison³ and Chantal Tasset³, ¹Galapagos SASU, Romainville, France, ²102 Avenue Gaston Roussel, Galapagos SASU, Romainville, France, ³Galapagos NV, Mechelen, Belgium
Background/Purpose: The distinct role of JAK family members (JAK1, JAK2, JAK3 and TYK2) in signaling for cytokines and growth factors has established these kinases as…
Abstract Number: 2782 • 2015 ACR/ARHP Annual Meeting
Not Only 5 but Also 6 Weeks Intervals of Tocilizumab Infusion Induce Clinical Remission in Patients with Active Rheumatoid Arthritis
Hiroshi Uda¹, Koji Shigematsu², Yoshitaka Ishizaki² and Osamu Saiki^1,3, ¹Rheumatology, Higashiosaka City General Hospital, Higashiosaka, Japan, ²Orthopedics, Higashiosaka City General Hospital, Higashiosaka, Japan, ³Rheumatology, Shiraishi Hospital, Imabari, Japan
Background/Purpose: For active rheumatoid arthritis patients with inadequate response to synthetic disease modifying antirheumatic drugs (DMARDs), biologic agents are indicated. However, the cost of biologics,…
Abstract Number: 2783 • 2015 ACR/ARHP Annual Meeting
What Is the Rate of Primary and Secondary Failure of Anti-TNF in RA Patients? Data from a Rheumatoid Arthritis Cohort
Edward C. Keystone¹, Mohammad Movahedi^2,3, Angela Cesta², Xiuying Li², Sandra Couto², Emmanouil Rampakakis³, John S. Sampalis^3,4, Claire Bombardier^2,5,6 and OBRI Investigators, ¹The Rebecca MacDonald Centre For Arthritis, Mount Sinai Hospital, Toronto, ON, Canada, ²Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada, ³JSS Medical Research, St-Laurent, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵University of Toronto, Department of Medicine (DOM) and Institute of Health Policy Management, and Evaluation (IHPME), Toronto, ON, Canada, ⁶Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose: Although the majority of RA patients respond to treatment with anti-TNF agents, some patients present with refractory disease (1ry failure) while others show some…
Abstract Number: 2784 • 2015 ACR/ARHP Annual Meeting
Faecal Levels of Calprotectin Are Increased in Patients with Primary Sjögren’s Syndrome and Correlates with Disease Activity
Thomas Mandl¹, Bodil Ohlsson² and Kristofer Andreasson³, ¹Dept of Rheumatology, Skåne University Hospital Malmö, Lund University, Malmo, Sweden, ²Dept of Internal Medicine, Skane University Hospital Malmo, Lund University, Sweden, Malmo, Sweden, ³Dept of Rheumatology, Skane University Hospital Lund, Lund University, Sweden, Lund, Sweden
Background/Purpose: FC is a validated biomarker differentiating inflammatory bowel disease from irritable bowel syndrome. We have evaluated faecal levels of calprotectin (FC) in patients with…
Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting
Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome
Yoshiyuki Arinuma^1,2, Yuko Sakuma³, Eisuke Ogawa², Tatsuhiko Wada⁴, Tatsuo Nagai², Sumiaki Tanaka² and Shunsei Hirohata², ¹Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ³Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ⁴Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…
Abstract Number: 2786 • 2015 ACR/ARHP Annual Meeting
miR200b-5p: A Possible Predictor of Lymphoma Development in Sjögren’s Syndrome (SS)?
Efstathia K. Kapsogeorgou^1,2, Vasiliki C. Gourzi¹ and Athanasios G. Tzioufas¹, ¹Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ²Pathophysiology, School of Medicine, National University of Athens, Greece, Athens, Greece
Background/Purpose: miR200b miRNAs (miR200b-3p and miR200b-5p) are critical regulators of the expression of oncogenes and tumour suppressor genes. Herein, we sought to investigate whether their…
Abstract Number: 2787 • 2015 ACR/ARHP Annual Meeting
Expression of Interferons Lambda in Salivary Glands of Patients with Sjögren’s Syndrome
Eirini Apostolou¹, Efstathia K. Kapsogeorgou¹, Orsia D. Konsta¹, Maria Ioanna Saridaki², Evangelos Andreakos² and Athanasios G. Tzioufas¹, ¹Pathophysiology, Faculty of Medicine, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece, ²Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece
Background/Purpose: Type I and II interferons (IFNs) have been implicated in the pathophysiology of Sjögren’s Syndrome (SS). Recently a new family of IFNs, namely type…
Abstract Number: 2788 • 2015 ACR/ARHP Annual Meeting
DNA Microarray Analysis of Labial Salivary Glands in Patients with Sjögren’s Syndrome: Comparison with IgG4-Related Disease
Hiroyuki Takahashi¹, Hiroto Tsuboi¹, Mana Iizuka¹, Hiromitsu Asashima¹, Tomoya Hirota¹, Yuya Kondo¹, Isao Matsumoto¹, Takayuki Sumida¹, Seiji Nakamura², Sachiko Furukawa², Masafumi Moriyama³, Yuji Nakai⁴, Keiko Abe⁴ and Toshio Yoshihara⁵, ¹Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Faculty of Dental Science, Kyushu University, Fukuoka, Japan, ³Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan, ⁴Functional Food Science and Nutrigenomics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan, ⁵Department of Otolaryngology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: The previous reports showed that DNA microarray in Sjögren’s syndrome (SS) identified the genes associated with mononuclear infiltrates such as immunoglobulin, human leukocyte antigen,…
Abstract Number: 2789 • 2015 ACR/ARHP Annual Meeting
Blood and Salivary Gland BAFF-Driven B-Cell Hyperactivity in Rituximab Non-Responder Patients with Primary Sjögren’s Syndrome
Divi Cornec¹, Sebastian Costa², Valerie Devauchelle³, Sandrine Jousse-Joulin⁴, Pascale Marcorelles⁵, Jean-Marie Berthelot⁶, laurent chiche⁷, Eric Hachulla⁸, Pierre-Yves Hatron⁹, Vincent Goeb¹⁰, O Vittecoq¹¹, Alain Saraux¹² and Jacques-Olivier Pers¹³, ¹Department of rheumatology, Brest Occidentale University, Brest, France, ²anatomopathological department, Brest university hospital, Brest, France, ³Service de Rhumatologie, CHU Brest, Brest, France, ⁴Rheumatology, CHu La cavle Blanche, Brest, France, ⁵anatomopathological department, Brest university hospital, CHU Morvan, Brest, France, ⁶Rhumatologie, CHU Nantes, Nantes, France, ⁷internal medicine, Hopital Europeen, Marseille, France, ⁸Department of Internal Medicine, University Lille Nord-de-France, Lille, France, ⁹Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France, ¹⁰Rhumatologie, CHU Amiens, Amiens, France, ¹¹University Hospital, Rouen, France, ¹²Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ¹³EA2216/ERI29 UBO, Brest, France
Background/Purpose: To determine whether B-cell markers (blood and minor salivary gland (SG) B-cell depletion (BCD), autoantibodies, BAFF) are associated with clinical response to rituximab in…
Abstract Number: 2790 • 2015 ACR/ARHP Annual Meeting
Leflunomide/Hydroxychoroquine Combination Treatment Additively Inhibits T Cell Receptor/Toll-like Receptor 9-Triggered Th1 and Th17 Cytokine Secretion
E.H.M. van der Heijden^1,2, S.A.Y. Hartgring¹, S. Hiddingh¹, A.A. Kruize², T.R.D.J. Radstake^1,3 and J.A.G. van Roon¹, ¹Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is a systemic auto-immune disease, leading to an exocrinopathy of mainly salivary and lachrymal glands. T- and B-cell-driven immunity is…
Abstract Number: 2791 • 2015 ACR/ARHP Annual Meeting
TREX-1 Variants in Sjögren’s Syndrome Related Lymphomagenesis
Panagiota Makri¹, Adrianos Nezos², Michael Voulgarelis³, Haralampos M. Moutsopoulos⁴ and Clio Mavragani⁵, ¹Physiology, Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ³Pathophysiology, Department of Pathophysiology, Medical School of Athens, Athens, Greece, ⁴Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece, ⁵Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Three prime Repair Exonuclease 1 (TREX-1) is an exonuclease involved in DNA repair preventing genomic instability. TREX-1 variants have been previously associated with activation of type…
Abstract Number: 2792 • 2015 ACR/ARHP Annual Meeting
Not Only Sjögren’s Syndrome. EBV Infection Reactivation As a Risk Factor of the Dryness Symptome Development
Maria Maslinska¹ and Anna Zuk-Wasek², ¹Clinic of Early Arthritis, Institute of Rheumatology, Warsaw, Poland, ²2. National Institute of Public Health – National Institute of Hygiene (NIPH – NIH, Warsaw, Poland
Background/Purpose: The glandular cell apoptosis in Epstein-Barr virus (EBV) infection may play role in primary Sjögren’s Syndorme (pSS) development, possibly causing progressive gland damage and…

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