Abstracts Archive - Page 1836 of 2425 - ACR Meeting Abstracts

Abstract Number: 2205 • 2015 ACR/ARHP Annual Meeting
Inhibition of Dickkopf1 Dampens Anti Osteogenic Effect of Fibroblast-like Synoviocytes
Eiji Sugiyama, Yusuke Yoshida and Satoshi Yamasaki, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Fibroblast-Like Synoviocytes (FLS) play important roles in RA progression. Previous studies have revealed importance of FLS in osteoclast activation, however, the roles of…
Abstract Number: 2206 • 2015 ACR/ARHP Annual Meeting
Dopamine Pathway and Bone Metabolism in Arthritis
Silvia Capellino¹, Klaus W. Frommer¹, Markus Rickert², Jürgen Steinmeyer³, Stefan Rehart⁴, Ulf Müller-Ladner¹ and Elena Neumann¹, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Dept of Orthopedics and Orthopedic Surgery, University Hospital of Giessen and Marburg, Gießen, Germany, ³Dept Orthopedics and Experimental Orthopedics, University Hospital of Giessen and Marburg, Giessen, Germany, ⁴Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany
Background/Purpose: A body of studies demonstrates the influence of the nervous system on the immune response. We recently described that dopamine, a neurotransmitter of the…
Abstract Number: 2207 • 2015 ACR/ARHP Annual Meeting
Interleukin-32Î³ Exhibited Protective Effects on Osteoporosis
Seokchan Hong¹, Eun-Jin Lee², Sang-Min Kim³, Eun-Ju Chang², Doo-Ho Lim⁴, Byeongzu Ghang⁵, Wookjang Seo⁶, Yong-Gil Kim⁴, Chang-Keun Lee¹ and Bin Yoo⁴, ¹Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ²Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Univerisy of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ⁶Internal Medicine, Seoul Veterans Hospital, Seoul, South Korea
Background/Purpose: Interleukin-32 (IL-32) has been known to be implicated in the pathogenesis of various inflammatory diseases. Osteoporosis, characterized by low bone density and increases the…
Abstract Number: 2208 • 2015 ACR/ARHP Annual Meeting
Macrophage Migration Inhibitory Factor: A Novel Biomarker in Ankylosing Spondylitis That Can Drive Spinal Fusion
Vidya Ranganathan¹, Ismail Sari², Janogini Muralitharan³, Ammepa Anton⁴ and Nigil Haroon², ¹University Health Network, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Rheumatology, University Health Network, Toronto, ON, Canada
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis that predominantly affects the axial skeleton. Disease progression in AS is marked by new bone formation…
Abstract Number: 2209 • 2015 ACR/ARHP Annual Meeting
Stimulation of the Adenosine A2A Receptor (A2AR) Regulates the Expression of Netrin-1 (Ntn1) and Its Receptors (Unc5b, DCC) and Inhibits Wear Particle-Induced Inflammatory Osteolysis in a Model of Joint Prosthesis Loosening
Aranzazu Mediero¹, Bhama Ramkhelawon², Miguel Perez-Aso³, Kathryn Moore² and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Leon H. Charney Division of Cardiology, Department of Medicine,, NYU School of Medicine, New York, NY, ³Provital S.A., Barberà del Vallès, Spain, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Ntn1 is a member of the family of axonal guidance proteins that plays a role in leukocyte function and inflammation and is critical for…
Abstract Number: 2210 • 2015 ACR/ARHP Annual Meeting
Immunological Dysregulation and Inadequate Hypoxia Adaptation – HIF-Stabilization As Possible Prevention of Fracture Healing Disorders in RA or Immune-Suppressed Patients
Annemarie Lang^1,2,3, Sarah Fuegener², Paula Hoff^1,2, Katharina Schmidt-Bleek⁴, Timo Gaber^1,2 and Frank Buttgereit², ¹German Rheumatism Research Center (DRFZ), Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, ³Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, ⁴Julius Wolff Institut, Charité University Medicine, Berlin, Germany
Background/Purpose: Patients suffering from rheumatoid arthritis (RA) are often affected by fracture-healing complications such as increased fracture healing time or non-unions. There is not much…
Abstract Number: 2211 • 2015 ACR/ARHP Annual Meeting
Extracellular Vesicles from Cow Milk Accelerate Osteoblast Differentiation into Osteocytes, However, Type I Collagen Synthesis Is Reduced and Bone Matrix Organization Is Impaired
Marina C. Oliveira¹, Onno J. Arntz¹, Esmeralda Blaney Davidson¹, Wim van den Berg¹, Adaliene V.M. Ferreira² and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Nutrition, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Milk consumption during childhood stimulates bone growth but the claimed beneficial effect of milk on bone at adulthood is a matter of debate. Recently…
Abstract Number: 2212 • 2015 ACR/ARHP Annual Meeting
Identification of a Novel Chemokine-Dependent Molecular Mechanism Underlying Rheumatoid Arthritis-Associated Autoantibody-Mediated Bone Destruction
Akilan Krishnamurthy¹, Vijay Joshua², Aase Haj Hensvold³, Tao Jin⁴, Meng Sun³, Marianne Engström³, Khaled Amara¹, Malin MAgnusson⁴, Camilla Svensson⁵, Vivianne Malmström³, L. Klareskog¹, Heidi Wähämaa³ and Anca I Catrina³, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, Gothenberg, Sweden, ⁵Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rheumatoid arthritis (RA)-specific anti-citrullinated protein/peptide antibodies (ACPAs) appear before disease onset and are associated with bone destruction. We aimed to dissect the role of…
Abstract Number: 2213 • 2015 ACR/ARHP Annual Meeting
RA-Associated Autoantibodies Promote Synovial Fibroblasts Migration and Adhesion through a Peptidylarginine Deiminases (PAD) Dependent Pathway
Meng Sun¹, Vijay Joshua², Aase Haj Hensvold^1,3, Khaled Amara⁴, Vivianne Malmström¹, Heidi Wähämaa¹ and Anca I Catrina¹, ¹Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Solna, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: The presence of anti-citrullinated proteins antibodies (ACPAs) in RA is associated with a more aggressive disease phenotype and bone destruction. Synovial fibroblasts (SFs) are…
Abstract Number: 2214 • 2015 ACR/ARHP Annual Meeting
Activation Feature of RANKL/RANK Signaling Pathway in Ankylosing Spondylitis Patients Compared with Healthy People
Benyong Liu¹, Hongxiao Liu¹, Nan Jiang², Yingyan Zhou³, Xinghua Feng¹, Xiaoyan Feng⁴, Heqiu Zhang⁴, Quan Jiang¹, Xiaodan Wang⁴, Junyao Song¹ and Ziqi Xu¹, ¹Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China, ²Department of Rheumatology and Nephrology, The Second Affiliated Hospital of Tianjin University of Chinese Medicine, Tianjin, China, ³Department of Rheumatology, Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou, China, ⁴Institute of Basic Medical Sciences, Academy of Military Medical Sciences, Beijing, China
Background/Purpose: Bone destruction is one of the main pathological features in ankylosing spondylitis (AS). This research aims to explore the role of nuclear factor kappa-B…
Abstract Number: 2215 • 2015 ACR/ARHP Annual Meeting
Ticagrelor Regulates Osteoblast and Osteoclast Function and Promotes Bone Formation in Vivo By Increasing Adenosine Levels
Aranzazu Mediero¹, Tuere Wilder², Carl Whatling³ and Bruce Cronstein⁴, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³CVMD Innovative Medicine Unit, Translational Sciences, AstraZeneca R&D, Mölndal, Sweden, ⁴Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: The antiplatelet drugs Ticagrelor and clopidogrel are P2Y12 antagonists but ticagrelor also inhibits cellular adenosine uptake via ENT1 and thereby increases extracellular adenosine levels.…
Abstract Number: 2216 • 2015 ACR/ARHP Annual Meeting
Quality Assessment of Websites Providing Educational Content about Rheumatoid Arthritis
Maria A. Lopez-Olivo¹, Ana Ojeda-Prias², Eric Heung³, Amye L. Leong⁴, Irmgard Willcockson⁵ and Maria E. Suarez-Almazor¹, ¹General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²The University of Houston, Houston, TX, ³Lake Erie College of Osteopathic Medicine, Erie, PA, ⁴Spokesperson; Strategic Relations, BONE AND JOINT DECADE, Santa Barbara, CA, ⁵School of Biomedical Informatics, The University of Texas, Houston Science Center, Houston, TX
Background/Purpose: The Internet can support remote and immediate access to health information. It is the second most consulted information source next to physicians. Google is…
Abstract Number: 2217 • 2015 ACR/ARHP Annual Meeting
#Rheumjc: Development, Implementation and Analysis of an International Twitter-Based Rheumatology Journal Club
Christopher Collins¹, Paul Sufka², Jonathan S. Hausmann³, Arundathi Jayatilleke⁴, Jose Campos⁵ and Suleman Bhana⁶, ¹Rheumatology, Washington Hospital Center, Washington, DC, ²Rheumatology, HealthPartners, Saint Paul, MN, ³Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, ⁴Medicine, Division of Rheumatology, Drexel University College of Medicine, Philadelphia, PA, ⁵Rheumatology, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain, ⁶Crystal Run Healthcare, Middletown, NY
Background/Purpose: Twitter is an increasingly popular platform for discussion and engagement amongst healthcare professionals. Here we describe the development, implementation and analysis of a rheumatology…
Abstract Number: 2218 • 2015 ACR/ARHP Annual Meeting
A Randomized Controlled Trial to Evaluate a Multimedia Patient Education Tool in Patients with Knee Osteoarthritis. Six-Month Results
Maria A. Lopez-Olivo¹, Andrea Barbo², Tara Rizvi³, Robert Volk⁴, Heather Lin⁵ and Maria E. Suarez-Almazor¹, ¹General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Rheumatology, Baylor College of Medicine, Houston, TX, ⁴General Internal Medicine, UT MD Anderson Cancer Center, Houston, TX, ⁵Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: Video modelling is often used in patient education to improve patient outcomes. We conducted a multi-centered, open-label, parallel, randomized controlled trial that evaluated the…
Abstract Number: 2219 • 2015 ACR/ARHP Annual Meeting
Improving Outcomes with a Multimedia Patient Education Tool in Patients with Osteoporosis after 6 Months. a Randomized Controlled Trial
Maria A. Lopez-Olivo¹, Andrea Barbo², Tara Rizvi³, Robert Volk⁴, Heather Lin⁵ and Maria E. Suarez-Almazor¹, ¹General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ²Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, ³Rheumatology, Baylor College of Medicine, Houston, TX, ⁴General Internal Medicine, UT MD Anderson Cancer Center, Houston, TX, ⁵Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX
Background/Purpose: We conducted a 6-month multi-centered, open-label, parallel, randomized control trial to compare a multimedia-patient education tool (MM-PtET) including storylines and narratives with a written…

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