Abstracts Archive - Page 1828 of 2425 - ACR Meeting Abstracts

Abstract Number: 2085 • 2015 ACR/ARHP Annual Meeting
DC-STAMP Regulates Osteoclastogenesis through the Ca2+ /NFATc1 Axis
Yahui Grace Chiu¹, Dongge Li², Yue-Xin Xu³, Tzong-Ren Sheu⁴, Minsoo Kim⁵ and Christopher T. Ritchlin⁶, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ³Microbiology & Immunology, University of Rochester, Rochester, NY, ⁴Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ⁵Microbiology and Immunology, University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Osteoclasts (OC) are the only cell type known to erode bone. Many bone diseases including osteoporosis and arthritis are caused by excessive OC activity.…
Abstract Number: 2086 • 2015 ACR/ARHP Annual Meeting
Inhibition of Macrophage Inflammatory Protein 1-Alpha (CCL3) Significantly Reduced Bone Resorption in Vitro and the Development of Erosive Joint Pathology in Collagen-Induced Arthritis
Lauren A. Jordan¹, Ruth Davies¹, Alastair J. D. Robertson², Ann K. Harvey¹, Ernest H. Choy¹, Malin Erlandsson³, Maria I. Bokarewa⁴, Rachel J. Errington¹ and Anwen S. Williams¹, ¹Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, ²William Harvey Hospital, Willesborough, Ashford, United Kingdom, ³University of Goteborg, Goteborg, Sweden, ⁴Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose: The destruction of bone is a common feature of diseases like rheumatoid arthritis (RA) and multiple myeloma (MM). CCL3 is significantly elevated in the…
Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting
Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass
Julia F. Charles¹ and Joerg Ermann², ¹Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…
Abstract Number: 2088 • 2015 ACR/ARHP Annual Meeting
Immature Dendritic Are Potent OC Precursors in RA and Are Targeted By RA-Specific Antibodies
Akilan Krishnamurthy¹, Vijay Joshua², Heidi Wähämaa³, Vivianne Malmström³, Khaled Amara¹, Jimmy Ytterberg⁴ and Anca I Catrina³, ¹Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Unit of Rheumatology, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Immature dendritic cells (iDC) have been shown to act as OC precursors and are important cell players in the pathogenesis of RA. We aimed…
Abstract Number: 2089 • 2015 ACR/ARHP Annual Meeting
Netrin-1 and Its Receptors Unc5b and DCC May be Useful Targets for Preventing Multiple Myeloma Bone Lesions
Aranzazu Mediero¹, Tuere Wilder² and Bruce Cronstein³, ¹Medicine, Divison of Translational Medicine, NYU School of Medicine, New York City, NY, ²Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ³Medicine, Division of Rheumatology, NYU School of Medicine, NEW YORK, NY
Background/Purpose: Multiple Myeloma is characterized by the uncontrolled proliferation of plasma cells. This type of malignancy is particularly trophic to bone where it induces osteoclastic…
Abstract Number: 2090 • 2015 ACR/ARHP Annual Meeting
Gender-Specific Pathways Linking Arthritis, Activity Limitation and Incident Heart Disease: A Causal Mediation Analysis of the Canadian Longitudinal National Population Health Survey
Orit Schieir¹, Sheilah. Hogg-Johnson^1,2, Richard H Glazier^3,4,5,6 and Elizabeth M. Badley^1,7, ¹Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ²Institute for Work and Health, Toronto, ON, Canada, ³Family and Community Medicine, St. Michael's Hospital, Toronto, ON, Canada, ⁴Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, ON, Canada, ⁵Family and Community Medicine, University of Toronto, Toronto, ON, Canada, ⁶Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁷Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Arthritis and activity limitation are risk factors for cardiovascular (CVD) morbidity and mortality. As arthritis is a major cause of activity limitation, the objective…
Abstract Number: 2091 • 2015 ACR/ARHP Annual Meeting
Influence of Increasing Physical Activity on Longitudinal Changes in Disability Status Among Inactive Older Adults
Jing Song¹, Abigail Gilbert², Rowland W. Chang³, Christine Pellegrini⁴, Linda S. Ehrlich-Jones⁵, Julia (Jungwha) Lee⁶, Daniel Pinto⁷, Pamela Semanik⁸, Leena Sharma⁹, C. Kent Kwoh¹⁰, Rebecca D. Jackson¹¹ and Dorothy D. Dunlop¹², ¹Institute for Healthcare Studies, Northwestern University, Chicago, IL, ²Northwestern University Feinberg School of Medicine, Chicago, IL, ³Dept Preventive Med, Northwestern Univ, Chicago, IL, ⁴Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Research CROR, Rehabilitation Institute Chicago, Chicago, IL, ⁶Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Department of Physical Therapy & Human Movement Sciences, Northwestern University, Chicago, IL, ⁸College of Nursing, Rush University, Chicago, IL, ⁹Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁰Rheumatology, University of Arizona, Tucson, AZ, ¹¹Ohio State University, Columbus, OH, ¹²Inst Hlthcare Studies, Northwestern Univ, Chicago, IL
Background/Purpose: An estimated 21% of disability attributed to arthritis is related to inactivity. This study analyzed data from the Osteoarthritis Initiative (OAI) to evaluate the…
Abstract Number: 2092 • 2015 ACR/ARHP Annual Meeting
Knee Pain Burden Is Associated with Decreased Moderate to Vigorous Physical Activity: Data from the Osteoarthritis Initiative
Javad Razjouyan¹, Bijan Najafi², Erin Ashbeck³, Dorothy D. Dunlop⁴, Julia (Jungwha) Lee⁵, Lynn Hamilton³ and C. Kent Kwoh⁶, ¹Consortium on Advanced Motion Performance (iCAMP), Department of Surgery, University of Arizona, Tucson, AZ, ²Department of Surgery and Department of Biomedical Engineering, University of Arizona, Tucson, AZ, ³Arthritis Center, University of Arizona, Tucson, AZ, ⁴Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Rheumatology, University of Arizona, Tucson, AZ
Knee Pain Burden is Associated with Decreased Motor Performance: Data from the Osteoarthritis InitiativeBackground/Purpose: The influence of knee pain perception on daily life motor performance…
Abstract Number: 2093 • 2015 ACR/ARHP Annual Meeting
Are General and Central Adiposity Associated with MRI-Assessed Structural Changes in the Knees of Older Adults?
Tomoko Fujii¹, Iva Miljkovic¹, Robert M. Boudreau², Ali Guermazi³, Sara R. Piva⁴, Elsa S. Strotmeyer², Laura Carbone⁵, Tamara B. Harris⁶, Elisa A. Marques⁶, M Kyla Shea⁷, Michael C. Nevitt⁸, Anne B. Newman² and C Kent Kwoh⁹, ¹University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, Pittsburgh, PA, ³Department of Radiology, Boston University School of Medicine, Boston, MA, ⁴Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ⁵Rheumatology, Georgia Regents University, Augusta, GA, ⁶National Institute on Aging, Bethesda, MD, ⁷Tuffs University, Boston, MA, ⁸Epidemiology and Biostatistics, UCSF, San Francisco, CA, ⁹University of Arizona, Tucson, AZ
Background/Purpose: Obesity is one of the few modifiable risk factors of knee osteoarthritis (OA). However, it is not established whether a mechanical or metabolic mechanism…
Abstract Number: 2094 • 2015 ACR/ARHP Annual Meeting
Identification of Gout Flare Using an Administrative Claims Based Algorithm
Lindsey MacFarlane¹, Daniel H. Solomon¹ and Seoyoung C. Kim², ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology; Division of Pharmacoepidemiology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Gout is a common inflammatory arthritis characterized by repeated acute flares. The ability to accurately identify gout flares is critical for comparative effectiveness studies…
Abstract Number: 2095 • 2015 ACR/ARHP Annual Meeting
Dietary Patterns (DASH, Prudent, Western Diets) and the Risk of Gout in US Women – the Nurses Health Study
Jeewoong Choi¹, Na Lu², Yuqing Zhang³, Sharan K. Rai⁴, Gary C. Curhan⁵ and Hyon K. Choi², ¹Massachusetts College of Pharmacy and Health Sciences, Boston, MA, ²Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³BUSM, Boston, MA, ⁴Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, ⁵Renal Division, Brigham and Women's Hospital, Boston, MA
Background/Purpose: There is a remarkable, rising disease burden of gout and associated cardiovascular-metabolic comorbidities (e.g., hypertension in 74% and obesity in 53% of cases in…
Abstract Number: 2096 • 2015 ACR/ARHP Annual Meeting
Immune Dysregulation in Patients with TRNT1 Deficiency
Angeliki Giannelou¹, Qing Zhou², Hong-Wei Sun³, Dan Yang⁴, Susan Moir⁵, Jehad H. Edwan³, Wanxia L. Tsai³, Elisavet Serti⁶, Monique Stoffels², Deborah L. Stone⁷, Amanda K. Ombrello⁷, Karyl Barron⁵, Helen C. Su⁵, Abdullah Al Sonbul⁸, Sarita Joshi⁹, Kimberly Risma¹⁰, Lucie Sramkova¹¹, Martha M. Quezado¹², Katherine Calvo¹³, Abu-Asab Mones¹⁴, Gustavo Gutierrez-Cruz³, Massimo G. Gadina³, Markus Hafner³, Ivona Aksentijevich^2,15 and Daniel Kastner², ¹National Human Genome Research Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²NIH/NHGRI, Metabolic, Cardiovascular, and Inflammatory Disease Genomics Branch, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, ⁵National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ⁶Immunology Section, Liver Diseases Branch, NIDDK, NIH, Bethesda, MD, ⁷National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ⁸King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia, ⁹Nationwide Children's Hospital, Columbus, OH, ¹⁰Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹¹Charles University 2nd Faculty of Medicine and UH Motol, Prague, Czech Republic, ¹²Laboratory of Pathology/National Cancer Institute, National Institutes of Health, Bethesda, MD, ¹³Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, ¹⁴National Eye Institute, National Institutes of Health, Bethesda, MD, ¹⁵Inflammatory Disease Section, National Human Genome Research Institute, Bethesda, MD
Background/Purpose: Next generation sequencing has led to the discovery of new diseases and molecules regulating immune function. Hypomorphic mutations in the TRNT1 gene cause a…
Abstract Number: 2097 • 2015 ACR/ARHP Annual Meeting
HLA-B27 Expression Profoundly Shapes the Host-Microbiota Metabolome
Mark Asquith¹, Patrick Stauffer², Sean Davin³, Stephen R. Planck⁴, Phoebe Lin⁵ and James T. Rosenbaum⁶, ¹OHSU, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Oregon Health and Science University, Portland, OR, ⁴Casey Eye Institute, Oregon Health & Science University, Portland, OR, ⁵Casey Eye Institute, Oregon Health and Science University, Portland, OR, ⁶Devers Eye Institute, Legacy Hospital system, Portland, OR
Background/Purpose: The intestinal microbiota plays a pivotal role in both host fitness and disease. Increasing evidence implicates microbial metabolites in the modulation of host immunity…
Abstract Number: 2098 • 2015 ACR/ARHP Annual Meeting
Prioritizing Likely Causative Genes in Genome-Wide Association Studies (GWAS) Identified Risk Loci for Immune-Mediated Inflammatory Disorders Using Cell-Type Specific Expression Quantitative Loci (eQTL) Information
Elisa Docampo¹, Ming Fang¹, Julia Dmitrieva¹, Emilie Théâtre¹, Mahmoud Elansary¹, Rob Mariman¹, Ann-Stephan Gori¹, Myriam Mni¹, François Crins², Wouter Coppieters², Edouard Louis³ and Michel Georges¹, ¹Unit of Animal Genomics, GIGA-R Université de Liège, Liège, Belgium, ²GenoTranscriptomics platform, GIGA-R Université de Liège, Liège, Belgium, ³Department of Gastroenterology, University Hospital CHU of Liège, Liège, Belgium
<h1> Background/Purpose: </h1> Immune-mediated inflammatory disorders (IMIDs) share many genetic risk factors. Pleiotropy may exist at different levels and most of the underlying mechanisms are…
Abstract Number: 2099 • 2015 ACR/ARHP Annual Meeting
Genome-Wide Association Study of Clinically-Defined Gout Identifies Multiple Risk Loci: A Clue for Future Companion Diagnostics of Gout
Hirotaka Matsuo¹, Ken Yamamoto², Hirofumi Nakaoka³, Akiyoshi Nakayama¹, Masayuki Sakiyama¹, Atsushi Takahashi^4,5, Takahiro Nakamura⁶, Yusuke Kawamura¹, Nobuyuki Hamajima⁷, Ituro Inoue⁸, Michiaki Kubo⁴, Kimiyoshi Ichida⁹, Hiroshi Ooyama¹⁰, Toru Shimizu¹¹ and Nariyoshi Shinomiya¹, ¹Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan, ²Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Japan, ³Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan, ⁴Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, ⁵Research Center, National Cerebral and Cardiovascular Center, Suita, Japan, ⁶National Defense Medical College, Laboratory for Mathematics, Tokorozawa, Japan, ⁷Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan, ⁸Department of Integrated Genetics, National Institute of Genetics, Mishima, Japan, ⁹Department of Pathophysiology, Tokyo University of Pharmacy and Life Sciences, Hachioji, Japan, ¹⁰Ryougoku East Gate Clinic, Tokyo, Japan, ¹¹Midorigaoka Hospital, Takatsuki, Japan
Background/Purpose: Gout, caused by hyperuricaemia, is a multifactorial disease. Recently, genome-wide association studies (GWASs) of gout have been reported; however, they included self-reported gout cases.…

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