Abstracts Archive - Page 1824 of 2607 - ACR Meeting Abstracts

Abstract Number: 2553 • 2015 ACR/ARHP Annual Meeting
Involvement of M2 Macrophages in the Pathogenesis of Arthritis in a Mouse Model
Shinjiro Kaieda¹, Naomi Yoshida², Yukiko Kunitake³, Daisuke Wakasugi⁴, Yukio Fujiwara⁵, Yoshihiro Komahara⁶, Hiroaki Ida⁷ and Tomoaki Hoshino², ¹Department of Medicine, *Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, kurume, Japan, ²Department of Medicine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ³Kurume University School of Medicine, Kurume, Japan, ⁴Medecine, Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan, ⁵Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan, ⁶Cell Pathology, Graduate School of Medical Sciences, Kurume University, Kumamoto, Japan, ⁷Respiorogy, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan
Background/Purpose: Synovial lining macrophages play an important role in initiating and maintaining joint inflammation in arthritis. Classically activated pro-inflammatory macrophages and alternatively activated anti-inflammatory macrophages…
Abstract Number: 2554 • 2015 ACR/ARHP Annual Meeting
Inhibition of IL6 Receptor Improves Arthritis and Atherosclerosis in a Mouse Model of Rheumatoid Arthritis
Amy Archer¹, Carla Cuda², Alexander Shaffer², Emily Alex Waters³, Chad Haney⁴, Rana Saber², George Kenneth Haines III⁵, Jason Low⁶ and Harris R. Perlman⁷, ¹Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, ⁴Center for Advanced Molecular Imaging, Northwestern University, Evanston, IL, ⁵Mount Sinai, New York, NY, ⁶Genentech, San Francisco, CA, ⁷Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Rheumatoid arthritis is a chronic, systemic, autoimmune disease associated with an increased risk of cardiovascular disease. However, it is unclear what role patients’ dyslipidemia…
Abstract Number: 2555 • 2015 ACR/ARHP Annual Meeting
14-3-3η As a Novel RA Drug Target: Anti-14-3-3η Monoclonal Antibody Delays the Onset and Mitigates the Severity of Arthritis in CIA Mice
Abedelnasser Abulrob¹, Mario Mercier¹, Slavisa Corluka¹, Roger MacKenzie¹, Shalini Raphael¹, Sara Michienzi², Jane Savill², Yuan Gui², Walter Maksymowych³ and Anthony Marotta², ¹National Research Council of Canada, Ottawa, ON, Canada, ²Augurex Life Sciences Corp., Vancouver, BC, Canada, ³Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: As an extracellular ligand, 14-3-3η potently and concentration-dependently upregulates the expression of multiple factors including TNFα, IL-6, and RANKL and its clinical detection is…
Abstract Number: 2556 • 2015 ACR/ARHP Annual Meeting
Functional Genetics of PTPN2 in Rheumatoid Arthritis: Haploinsufficiency of PTPN2 Promotes Severity of CD4+ T-Cell Mediated Autoimmune Arthritis
Mattias N.D Svensson¹, Karen M. Doody¹, Cristiano Sacchetti¹, Dennis J. Wu¹, Gisen Kim², Annelie Hellvard³, Brith Bergum³, Piotr Mydel³, Mitchell Kronenberg², Michel L. Tremblay⁴ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Clinical Science, Broegelmann Research Laboratory, Bergen, Norway, ⁴Goodman Cancer Centre, McGill University, Montréal, QC, Canada
Background/Purpose: Several genome-wide associations studies have in recent years linked polymorphisms in the PTPN2 locus to rheumatoid arthritis (RA) and other autoimmune diseases. PTPN2 encodes…
Abstract Number: 2557 • 2015 ACR/ARHP Annual Meeting
Comparable Therapeutic Potential of Umbilical Cord Mesenchymal Stem Cells in Collagen Induced Arthritis with Anti-Tumor Necrosis Factor or Anti-CD20
Yue Sun, Wei Kong, Weiwei Chen, Genhong Yao, Xuebing Feng and Lingyun Sun, Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Tremendous progress has been made in the development of non-conventional therapies for rheumatoid arthritis (RA). Mesenchymal stem cells (MSC) present multiple immunosuppressive capacities and…
Abstract Number: 2558 • 2015 ACR/ARHP Annual Meeting
The Role of Leukocyte Associated Immunoglobulin-like Receptor-1 (LAIR-1) in Collagen-Induced Arthritis
Seunghyun Kim¹, John E. Coligan², Jeoung-Eun Park³, John M. Stuart⁴, Andrew Kang⁵ and Linda Myers⁵, ¹Rheumatology, University of Tennessee Health Science Center, Memphis, TN, ²NIH, Bethesda, MD, ³University of Tennessee, Memphis, TN, ⁴University of Tennessee/Veterans Affairs, Memphis, TN, ⁵University of Tennessee Health Science Center, Memphis, TN
Background/Purpose: Several observations implicate a critical role for T cell dysregulation as a central problem in RA. We present a method for suppressing T cell…
Abstract Number: 2559 • 2015 ACR/ARHP Annual Meeting
PRO-Resolving Mediators Issued from Apoptotic CELL Efferocytosis (SUPERMAPO) Modulate Antigen Presenting CELL Properties Toward a Tolerogenic Profile: Efficacy in the Treatment of Collagen- Induced Arthritis
Francis Bonnefoy¹, Romain Vallion², Mélanie Couturier³, Anna Daoui³, Eric Toussirot⁴ and Sylvain Perruche¹, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²INSERM UMR 1098, EFS Bourgogne Franche Comté, Besançon, France, ³INSERM UMR1098, EFS Bourgogne Franche Comté, Besançon, France, ⁴Service de Rhumatologie, CHU J Minjoz, Besancon, France
Background/Purpose: Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and…
Abstract Number: 2560 • 2015 ACR/ARHP Annual Meeting
The Mer Tyrosine Kinase Receptor Plays a Protective Role in Joint Inflammation By Mediating Efferocytosis
Claire E.J. Waterborg¹, Silke Beermann¹, Miranda B. Bennink¹, Carla V. Rothlin², Greg Lemke³ and Fons A.J. van de Loo¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Department of Immunobiology, Yale University School of Medicine, New Haven, CT, ³Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a hyper-inflammatory response in synovial joints. In joints of patients with active RA, few…
Abstract Number: 2561 • 2015 ACR/ARHP Annual Meeting
TAS5315, a Novel Bruton’s Tyrosine Kinase (BTK) Inhibitor, Demonstrates Potent Efficacy in an Animal Model of Rheumatoid Arthritis
Fumihito Hosoi, Youhei Yoshiga, Satoru Iguchi, Ryuusuke Kaneko, Yoshinori Nakachi, Daichi Akasaka, Kazuhiko Yonekura, Teruhiro Utsugi, Eiji Sasaki and Yoshikazu Iwasawa, TAIHO PHARMACEUTICAL CO., LTD., TSUKUBA, Japan
Background/Purpose: Bruton’s tyrosine kinase (BTK) is a member of the Tec family kinases, and is expressed in B cells, monocytes/macrophages, mast cells, basophils and osteoclast1,2.…
Abstract Number: 2562 • 2015 ACR/ARHP Annual Meeting
The Inhibition of Wnt/Beta-Catenin Signaling Pathway Via Paricalcitol and Pyrvinium Ameliorates Experimental Arthritis
Suleyman Serdar Koca¹, Servet Yolbas², Ahmet Yildirim², Ahmet Tektemur³, Zulfinaz Betul Celik³, Ebru Etem Onalan³, Ibrahim Hanifi Ozercan⁴ and Mustafa Akin⁴, ¹İnternal Medicine Division of Rheumatology, Firat University, Faculty of Medicine, Elazig, Turkey, ²Rheumatology, Department of Rheumatology, Firat University, Elazig, Turkey, ³Department of Medical Biology Faculty of Medicine, Firat University, Elazig, Turkey, ⁴Department of Pathology, Faculty of Medicine, Firat University, Elazig, Turkey
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progression of which leads to the destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) display…
Abstract Number: 2563 • 2015 ACR/ARHP Annual Meeting
Immune Regulation By Migrating Mesenchymal Stem Cells Ameliorate Inflammatory Arthritis in Mice
Seung Min Jung, Yoojun Nam and Ji Hyeon Ju, Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea
Background/Purpose: Mesenchymal stem cells (MSCs) function as immune regulators in inflammatory conditions. However, it is unclear how to control local inflammation by systemically administered MSCs. We…
Abstract Number: 2564 • 2015 ACR/ARHP Annual Meeting
Nuclear Receptor 4A2 Is Selectively Upregulated in the Human TNF-Alpha Transgenic Model of Rheumatoid Arthritis
Jackeline Araujo, Cullen Lilley and Kimberlee Mix, Biological Sciences, Loyola University New Orleans, New Orleans, LA
Background/Purpose: The orphan nuclear receptor 4A2 (NR4A2 / NURR1) is emerging as a critical transcription factor in chronic inflammatory joint diseases. We have demonstrated elevated…
Abstract Number: 2565 • 2015 ACR/ARHP Annual Meeting
ACPA Specific IVIG Attenuate Collagen Induced Arthritis in Mice
Shaye Kivity¹, Nina Svetliscky¹, Qusim Odeh¹, Smadar Gertel¹, Howard Amital¹, Omer Gendelman¹, Iris Barshack², Alexander Volkov², Eran Bar-Meir³, Miri Blank¹ and Yehuda Shoenfeld⁴, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ³Plastic surgeon Poria Medical Center affiliated to Faculty of medicine in the Galilee Bar-Ilan university, Poria, Israel, ⁴Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Administration of intravenous-immunoglobulin (IVIg) is a recognized safe and efficient immunomodulatore therapy for many autoimmune diseases. Anti-idiotypic antibody binding to pathogenic autoantibodies was proposed…
Abstract Number: 2566 • 2015 ACR/ARHP Annual Meeting
Novel Therapeutic Compound Tuftsin-Phosphorylcholine Attenuate Collagen Induced Arthritis
Tomer Bashi¹, Miri Blank¹, Jasna Omersel², Alexander Volkov³, Iris Barshack³ and Yehuda Shoenfeld¹, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²Faculty of pharmacy, University of Ljublijana, Ljublijana, Slovenia, ³Sheba Medical Center, Institute of Pathology, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Treatment with helminthes and ova from helminthes, improved clinical findings of several autoimmune diseases in patients and in animal models. We aimed to decipher…
Abstract Number: 2567 • 2015 ACR/ARHP Annual Meeting
SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis
Ryoji Fujii¹, Iwao Seki², Rie Komatsu¹, Tomomi Kohara², Miwa Takai², Tomoo Sato³, Koji Konomi², Hiroyuki Aono², Kazuo Yudoh¹, Kusuki Nishioka⁴ and Toshihiro Nakajima⁵, ¹Institute of Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ²Santen Pharmaceutical Co. Ltd., Nara, Japan, ³Molecular Medical Science, St. Marianna University School of Medicine, Kanagawa, Japan, ⁴Institute of Medical Science, Tokyo Medical University, Tokyo, Japan, ⁵Department of Locomotor Science/Future Medical Science, Institute of Medical Science, integrated Gene Editing Section (iGES), Tokyo Medical University, Tokyo, Japan
Background/Purpose: SPACIA1/SAAL1 is a gene associated with abnormal synovial proliferation. We previously showed that SPACIA1/SAAL1 small interfering RNA inhibited the proliferation of rheumatoid arthritis synovial…

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