Abstracts Archive - Page 1823 of 2607 - ACR Meeting Abstracts

Abstract Number: 2538 • 2015 ACR/ARHP Annual Meeting
A Population-Based Assessment of Induced Abortions in Women with Systemic Lupus Erythematosus
Evelyne Vinet¹, Emily McDonald², Susan Scott³, Christian A. Pineau¹ and Sasha Bernatsky⁴, ¹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: SLE women with unplanned pregnancies might be at increased risk of both disease and pregnancy complications. Until now, there has been no population-based estimate…
Abstract Number: 2539 • 2015 ACR/ARHP Annual Meeting
The Validity and Reliability of Turkish Version of the Jenkins Sleep Scale in Rheumatoid Arthritis
M Tuncay Duruoz¹, Cagri Ünal², Firat Ulutatar³, Canan Sanal Top² and Osman Hakan Gunduz⁴, ¹Dept of PM&R, Rheumatology Clinic, Marmara University Medical School, Istanbul, Turkey, ²PM&R, Marmara University Medical School, Istanbul, Turkey, ³Physical Medicine and Rehabilitation Department, Marmara University Medical School, Istanbul, Turkey, ⁴Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey
Background/Purpose: The Jenkins Sleep Scale has 4 questions to assess the estimation of sleep problems in clinical research. It was developed in USA (1). Aim: To…
Abstract Number: 2540 • 2015 ACR/ARHP Annual Meeting
Construct Validity of the Promis-29 in Systemic Sclerosis: Results from the Scleroderma Patient-Centered Intervention Network (SPIN) Cohort
Linda Kwakkenbos¹, Brett D. Thombs¹, Susan J. Bartlett², Marie-Eve Carrier³, Marie Hudson¹, Luc Mouthon⁴, Vanessa L. Malcarne⁵, Maureen Sauvé⁶, Dinesh Khanna⁷ and SPIN investigators, ¹McGill University, Montreal, QC, Canada, ²Medicine, McGill University, Montreal, QC, Canada, ³Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada, ⁴Paris Descartes University, UPRES-EA 4058, Department of Internal Medicine, Cochin Hospital, Paris, France, ⁵SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, ⁶Scleroderma Societies of Canada and Ontario, Hamilton, QC, Canada, ⁷Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Patient-Reported Outcomes Measurement Information System (PROMIS¨) initiative is a cooperative research program designed to develop, evaluate, and standardize item banks to measure patient-reported…
Abstract Number: 2541 • 2015 ACR/ARHP Annual Meeting
Improving Adherence with Treat to Target in Rheumatoid Arthritis through a Learning Collaborative: Rationale and Design of the Traction Trial
Daniel H. Solomon¹, Sara Lee², Agnes Zak², Jen Agosti³, Asaf Bitton⁴, Liana Fraenkel⁵, Leslie Harrold⁶, Elena Losina⁷, Bing Lu⁸, Theodore Pincus⁹, Josef S. Smolen¹⁰ and Jeffrey N. Katz¹¹, ¹Rheumatology, Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³JRA Consulting, Andover, MA, ⁴Medicine, Brigham and Women's Hospital, Boston, MA, ⁵Medicine, Yale University School of Medicine, New Haven, CT, ⁶Dept of Medicine, UMass Medical School, Worcester, MA, ⁷Orthopedics, Brigham and Women's Hospital, BU School of Public Health and Harvard Medical School, Boston, MA, ⁸Rheumatology Immunology & Allergy, Brigham & Women's Hospital, Boston, MA, ⁹Medicine-Rheumatology, NYU Hospital for Joint Diseases, New York, NY, ¹⁰Medical University of Vienna, Vienna, Austria, ¹¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Treat to target (TTT) is a recommended paradigm in the management of rheumatoid arthritis (RA). However, various data sources suggest that TTT is…
Abstract Number: 2542 • 2015 ACR/ARHP Annual Meeting
The Multidimensional Assessment of Fatigue Scale: A 25-Year Review and Evaluation
Basia Belza¹, Christina Miyawaki^2,3, Minhui Liu¹, Xi Zhang⁴ and Melissa Fessel¹, ¹University of Washington School of Nursing, Seattle, WA, ²University of Houston Graduate College of Social Work, Houston, TX, ³Group Health Research Institute, Seattle, WA, ⁴Henan Provincial People's Hospital, Zhengzhou, China
Background/Purpose: The Multidimensional Assessment of Fatigue (MAF) scale was originally developed in 1990 for adults with rheumatoid arthritis. Since then, the MAF has been translated…
Abstract Number: 2543 • 2015 ACR/ARHP Annual Meeting
Content Validity of the Improved Health Assessment Questionnaire in Knee Osteoarthritis Patients
Mei Chung¹, Shanshan Liu², Zhuxuan Fu², Lori Lyn Price³, John B. Wong⁴ and Chenchen Wang⁵, ¹Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, ²Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, ³Clinical Care Research, Tufts Medical Center, Boston, MA, ⁴Medicine/Clinical Decision Making, Tufts Medical Center, Boston, MA, ⁵Rheumatology, Tufts Medical Center, Bosotn, MA
Background/Purpose: Developed in general population, rheumatoid arthritis and osteoarthritis patients, the Improved Health Assessment Questionnaire (iHAQ, formerly PROMIS HAQ) assesses physical function. The objective of…
Abstract Number: 2544 • 2015 ACR/ARHP Annual Meeting
Representing the Variability in Patients’ Preferences
Raluca Cozmuta¹, Sonal Bhalla² and Liana Fraenkel³, ¹Rheumatology, Yale University School of Medicine, New Haven, CT, ²Yale University School of Medicine, New Haven, CT, ³Medicine, Yale University School of Medicine, New Haven, CT
Background/Purpose: Data describing patients' priorities, concerns, and preferences are essential to inform important decisions in health care, including treatment planning and the development of programs…
Abstract Number: 2545 • 2015 ACR/ARHP Annual Meeting
Psychometric Testing of the Valued Life Activities Questionnaire in People with Rheumatoid Arthritis in the UK: Rasch Analysis
Yeliz Prior¹, Alan Tennant² and Alison Hammond³, ¹Centre for Health Sciences, University of Salford, Greater Manchester, United Kingdom, ²Human Functioning Sciences, ICF Unit, Swiss Paraplegic Research, Nottwil, Switzerland, ³Centre for Health Sport & Rehabilitation Research, University of Salford, Salford, United Kingdom
Background/Purpose: Developed in the USA, the Valued Life Activities Scale (VLAs) measures participation in daily activities. We have linguistically and culturally adopted the VLAs 33…
Abstract Number: 2546 • 2015 ACR/ARHP Annual Meeting
Targeting Synovial Fibroblasts By the Intra-Articular Delivery of microRNA-140-3p and -5p Ameliorates Experimental Autoimmune Arthritis
Chrong-Reen Wang¹, Jia-Shiou Peng², Shih-Yao Chen³, Chao-Liang Wu⁴ and Ai-Li Shiau⁵, ¹Rheum/Immun Sec/Int Med Dept, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ²Institute of Basic Medical Sciences, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ³Internal Medicine, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan, ⁵Microbiology and Immunology, College of Medicine, National Cheng Kung University, Medical Coll/Nat'l Cheng Kung, Tainan, Taiwan
Background/Purpose: Synovial fibroblasts (SF) with aberrant expression of microRNAs (miRNA) are critical pathogenic regulators of rheumatoid joint, and studies examining the effect of overexpressing or…
Abstract Number: 2547 • 2015 ACR/ARHP Annual Meeting
NIP-565, a Novel JAK1-Selective Inhibitor, for the Treatment of Rheumatoid Arthritis
Yuuki Hidaka¹, Takanori Nakamura², Tadashi Igarashi², Takeshi Nanya², Shuhei Hagiwara², Kazuya Takeuchi², Tomonori Yaguchi³, Yutaka Kawakami³ and Takeshi Naito², ¹Pharmaceutical Research Department, Nissan Chemical Industries,LTD., Saitama, Japan, ²Nissan Chemical Industries,LTD., Saitama, Japan, ³Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Non-selective Janus kinase (JAK) inhibitors have shown long-term efficacy in treating rheumatoid arthritis (RA). However, clinical efficacy is limited due to concerns of dose-limiting…
Abstract Number: 2548 • 2015 ACR/ARHP Annual Meeting
M-CSF-R Is a Critical Determinant for the Differentiation of Classical to Non-Classical Monocytes
Philip J. Homan¹, Alexander Misharin¹, Carla Cuda², Salina Dominguez², Rana Saber², Fu-Nien Tsai³ and Harris R. Perlman⁴, ¹Medicine-Rheumatology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Medicine, Rhuematology, Northwestern University, Chicago, IL, ⁴Feinberg School of Medicine, Northwestern University, Chicago, IL
Background/Purpose: Colony-stimulating factors (CSF) are simply defined as haemotopoitec growth factors. However, CSFs have been implicated to have additional functions in various autoimmune diseases. Specifically…
Abstract Number: 2549 • 2015 ACR/ARHP Annual Meeting
Characterizing the RPTPσ Mediated Proteoglycan Switch As a Target for Rheumatoid Arthritis Therapy
Karen M. Doody¹, Stephanie M. Stanford¹, Mattias N. D. Svensson¹, Cristiano Sacchetti¹, Gary S. Firestein², A. Radu Aricescu³ and Nunzio Bottini^1,4, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA, ³Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, ⁴Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA
Background/Purpose: RPTPσ (gene PTPRS) is a protein tyrosine phosphatase that binds heparan sulfate- and chondroitin sulfate-containing proteoglycans with its extracellular immunoglobulin domains 1 and…
Abstract Number: 2550 • 2015 ACR/ARHP Annual Meeting
Metabolomic Profiling of Joints in Murine Models of Inflammatory Arthritis
Ilya gertsman¹, Jesus Rivera-Nieves², Maripat Corr², Bruce Barshop¹ and Monica Guma³, ¹pediatrics, University of California, San Diego, La Jolla, CA, ²Medicine, University of California, San Diego, La Jolla, CA, ³Pharmacology, University of California, San Diego, La Jolla, CA
Background/Purpose: Given the complexity and heterogeneous nature of rheumatoid arthritis (RA), it is unlikely that a single biomarker may provide sufficient discrimination; therefore biomarker signatures…
Abstract Number: 2551 • 2015 ACR/ARHP Annual Meeting
Antibodies to Malondialdehyde-Acetaldhyde Adducts Are Increased in the Serum of Mice Following Infection with P. Gingivalis and/or Injection of Citrullinated Mouse Type II Collagen: a Model of Human Disease Response
Geoffrey M. Thiele⁴, Einstein Juma¹, Roxanne Haslam¹, Michael J. Duryee², Anand Dusad³, Carlos D. Hunter², James R. O'Dell⁴, Lynell W. Klassen⁴, Ted R. Mikuls⁴ and Geoffrey M. Thiele⁴, ¹University of Nebraska Medical Center, Omaha, NE, ²Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ³Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁴Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Patients with RA complicated by periodontal disease (PD) have been shown to have higher anti-citrullinated protein antibody (ACPA) levels, which have also become predictive…
Abstract Number: 2552 • 2015 ACR/ARHP Annual Meeting
Alterations in the Colonic Microbiome Precede the Development of Murine Inflammatory Arthritis
Jason Hendrickson¹, Gaurav Mehta², NIRMAL BANDA¹ and Kristine A. Kuhn¹, ¹University of Colorado School of Medicine, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Alterations in resident bacteria, termed dysbiosis, is present in patients in early stages of rheumatoid arthritis, psoriatic arthritis, and spondyloarthritis. However, it remains unclear…

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