Abstracts Archive - Page 1822 of 2607 - ACR Meeting Abstracts

Abstract Number: 2523 • 2015 ACR/ARHP Annual Meeting
Characteristics and Outcomes of Prospectively-Reported Pregnancies Exposed to Certolizumab Pegol from a Safety Database
Megan E. B. Clowse¹, Douglas C. Wolf², Amanda Golembesky³, Laura Shaughnessy⁴, Dirk De Cuyper⁵ and Frauke Förger⁶, ¹Rheumatology & Immunology, Duke University, Durham, NC, ²Atlanta Gastroenterology Associates, Atlanta, GA, ³UCB Pharma, Raleigh, NC, ⁴8010 Arco Corporate Drive, Sui, UCB Pharma, Raleigh, NC, ⁵Safety Patient Solutions BioBrands, UCB Pharma, Brussels, Belgium, ⁶Rheumatology, Clinical Immunology and Allergology, Inselspital-University Hospital, Bern, Switzerland
Background/Purpose: Data on the impact of anti-TNF medications on pregnancy outcomes are limited. Certolizumab pegol (CZP) is a PEGylated Fc-free anti-TNF approved in more than…
Abstract Number: 2524 • 2015 ACR/ARHP Annual Meeting
Longterm Follow-up of Children Born to Mothers with Chronic Arthritides and Exposed to Anti-TNF Alfa Agents during Pregancy and Breastfeeding: A Case-Control Study
Rossella Reggia¹, Laura Andreoli¹, Chiara Bazzani¹, Maria Grazia Lazzaroni¹, Giovanna Mazza¹, Michele Agosti¹, Roberto Gorla², Marco Taglietti², Andrea Lojacono³, Mario Motta⁴ and Angela Tincani⁵, ¹Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ³Obstetrics and Gynecology, Spedali Civili and University of Brescia, Brescia, Italy, ⁴Neonatal Intensive Care Unit, University and Spedali Civili of Brescia, Brescia, Italy, ⁵Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Italy
Background/Purpose: Anti-TNFalfa agents have been used to control disease activity of patients with Chronic Arthritides (Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis) during the wash-out period…
Abstract Number: 2525 • 2015 ACR/ARHP Annual Meeting
Patterns and Secular Trends in Use of Immunosuppressive Agents during Pregnancy in Women with Rheumatologic Conditions
Rishi J. Desai¹, Krista Huybrechts², Brian Bateman², Sonia Hernandez-diaz³, Helen Mogun², Chandrasekar Gopalakrishnan⁴, Elisabetta Patorno⁴ and Seoyoung C. Kim⁵, ¹Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston, MA, ³Harvard School of Public Health, Boston, MA, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Div. of Pharmacoepidemiology and Pharmacoeconomics, Div. of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Systemic inflammatory conditions such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) affect many women during their…
Abstract Number: 2526 • 2015 ACR/ARHP Annual Meeting
Perinatal Patterns of Medication Use in Women with Rheumatoid Arthritis: A Population-Based Study
Mary A De Vera^1,2, Eric C. Sayre², Nicole Tsao^1,2 and J Antonio Avina-Zubieta^2,3, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Medicine, University of British Columbia, Department of Medicine, Division of Rheumatology, Vancouver, BC, Canada
Perinatal Patterns of Medication Use in Women with Rheumatoid Arthritis: A Population-based StudyBackground/Purpose: Although the incidence of RA peaks during the 4th and 5th decades…
Abstract Number: 2527 • 2015 ACR/ARHP Annual Meeting
Neonatal Outcome to Paternal Exposures with Anti-Rheumatic Therapy
Elisabeth Solau-Gervais¹ and Antoine Brigaud Jr.², ¹Rhumatologie, University Hospital, Poitiers, France, ²University hospital, Poitiers, France
Background/Purpose: There is a lack of studies about preconceptional paternal exposure to disease modified anti-rheumatic drugs (DMARDs) and the data of literature are controversial. The…
Abstract Number: 2528 • 2015 ACR/ARHP Annual Meeting
Utilization of Immune-Suppressive Medications during Pregnancy Among Women with Inflammatory Arthritis and Other Autoimmune Diseases
Jie Zhang^1,2, Jeffrey R. Curtis³, Fenglong Xie⁴, Melissa L. Mannion⁵, James D. Lewis^6,7, Megan E. B. Clowse⁸, Kenneth G. Saag³, Steven Bethard⁹, Jospeh Biggio⁹, Gerald McGwin⁹ and Timothy Beukelman¹⁰, ¹Epidemilogy, University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶University of Pennsylvania, Philadelphia, PA, ⁷Medicine, University of Pennsylvania, Philadelphia, PA, ⁸Clinical Rheumatologist, Duke University Medical Center, Durham, NC, ⁹UAB, Birmingham, AL, ¹⁰Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: To examine difference in the prevalence of immunosuppressive medication use during pregnancy by type of autoimmune disease and by insurance (Medicaid versus commercial) in…
Abstract Number: 2529 • 2015 ACR/ARHP Annual Meeting
Decreased Programmed Death Ligand-1 (PD-L1) in Systemic Lupus Erythematosus (SLE) Placenta
Gail Deutsch^1,2, Megan Yuasa³ and Anne M. Stevens^4,5, ¹Pathology, Seattle Children's Hospital, Seattle, WA, ²School of Medicine, University of Washington, Seattle, WA, ³Seattle Children's Res Institute, Seattle Children's Research Institute, Seattle, WA, ⁴Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ⁵Pediatrics, University of Washington, Seattle, WA
Background/Purpose: The increased rates of preeclampsia, preterm birth, and intrauterine growth restriction in SLE pregnancy are only partially explained by the vascular effects of anti-phospholipid…
Abstract Number: 2530 • 2015 ACR/ARHP Annual Meeting
A Multicenter Evaluation of Obstetric and Maternal Outcome in Prospectively Followed Pregnant Patients with Confirmed Positivity for Antiphospholipid Antibodies (aPL)
Micaela Fredi¹, Elena Aggogeri², Elisa Bettiga³, Laura Andreoli², Maria Grazia Lazzaroni², Véronique Le Guern⁴, Andrea Lojacono³, Fabrizio Lupoli², Nathalie Morel⁴, Jean Charles Piette⁵, Sonia Zatti³, Nathalie Costedoat-Chalumeau⁴ and Angela Tincani², ¹Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ²Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ³Obstetrics and Gynecology, Spedali Civili and University of Brescia, Brescia, Italy, ⁴Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ⁵Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France
Background/Purpose: Antiphospholipd antibodies (aPL) positivity is considered as a risk factors for a poor obstetric outcome. The aim of this work was to determine risk…
Abstract Number: 2531 • 2015 ACR/ARHP Annual Meeting
Hematologic Disorder during Pregnancy Associated with Adverse Pregnancy Outcomes Among Women with Systemic Lupus Erythematosus
Sara K. Tedeschi¹, Hongshu Guan², Alexander Fine², Bing Lu¹, Karen H. Costenbader¹ and Bonnie Bermas¹, ¹Rheumatology, Brigham & Women's Hospital, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies have found a relationship between overall systemic lupus erythematosus (SLE) activity and adverse pregnancy outcomes. We sought to investigate whether specific types…
Abstract Number: 2532 • 2015 ACR/ARHP Annual Meeting
Disease Activity in Women with Systemic Lupus Erythematosus during Pregnancy and the First Year Post Partum
Carina Gotestam Skorpen^1,2, Johan Skomsvoll³, Inge-Margrethe Gilboe⁴, Stian Lydersen⁵ and Marianne Wallenius³, ¹Dept of Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, ²Dept of Rheumatology, Trondheim University Hospital, Norwegian National Advisory Unit on Pregnancy and Rheumatic Diseases, Trondheim, Norway, ³Dept of Rheumatology, Trondheim University Hospital, National Advisory Unit on Pregnancy and Rheumatic Diseases, Trondheim, Norway, ⁴Revmatologisk avdeling seksjon, Oslo universitetssykehus HF, Rikshospitalet, Oslo, Norway, ⁵Regional Center for the health of children and adolescents, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Disease Activity in women with SLE during pregnancy and the first year post partumBackground/Purpose: Disease activity measured by validated methods has been sparsely examined during…
Abstract Number: 2533 • 2015 ACR/ARHP Annual Meeting
A Comparison of Pregnancy Outcomes before and after Lupus Diagnosis
Megan E. B. Clowse¹, Maria Dall'Era², Jennifer M. Grossman^3,4, Diane L. Kamen⁵, Jerry McGwin⁶, Robert Roubey⁷ and Jill P. Buyon⁸, ¹Rheumatology & Immunology, Duke University, Durham, NC, ²University of California San Francisco School of Medicine, San Francisco, CA, ³Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ⁴Rheumatology, UCLA, Los Angeles, CA, ⁵Medicine, Medical University of South Carolina, Charleston, SC, ⁶Deparment of Epidemiology, University Of Alabama at Birmingham, School of Public Health, Birmingham, AL, ⁷University of North Carolina, Chapel Hill, NC, ⁸Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: The frequency of pregnancy complications, including miscarriage, stillbirth, preeclampsia, and preterm birth varies between lupus cohorts. This analysis compares pregnancy outcomes that occurred before…
Abstract Number: 2534 • 2015 ACR/ARHP Annual Meeting
Increased Risk of Allergic Conditions in Children Born to Women with SLE
Julie Couture¹, Moshe Ben-Shoshan¹, Christian A. Pineau², Susan Scott³, Ann E. Clarke⁴, Sasha Bernatsky² and Evelyne Vinet², ¹McGill University Health Centre, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Division of Rheumatology, University of Calgary, Calgary, AB, Canada
Background/Purpose: Allergic conditions seem to be more prevalent in patients with SLE than in the general population. To date, a handful of small observational studies…
Abstract Number: 2535 • 2015 ACR/ARHP Annual Meeting
Increased Direct Healthcare Costs in SLE Pregnancies
Cristiano Moura¹, Sasha Bernatsky², Yvan St. Pierre³, Susan Scott³, Christian A. Pineau⁴, Ann E. Clarke⁵ and Evelyne Vinet⁴, ¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Division of Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ³Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁴Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Calgary, AB, Canada
Background/Purpose: Although adverse obstetrical complications are more frequent in SLE women, no one has evaluated healthcare costs during SLE pregnancies. Thus, we aimed to evaluate…
Abstract Number: 2536 • 2015 ACR/ARHP Annual Meeting
The Role of Race/Ethnicity and SES in Adverse Pregnancy Outcome in SLE and Apl
Sancia Ferguson¹, Elianna Kaplowitz², Laura Trupin³, Edward H. Yelin⁴, Patricia P. Katz^3,5 and Jane E. Salmon⁶, ¹Medicine/Rheumatology, University of California - San Francisco, San Francisco, CA, ²Hospital for Special Surgery, New York, NY, ³Medicine/Rheumatology, University of California San Francisco, San Francisco, CA, ⁴Medicine/Rheumatology, UC San Francisco, San Francisco, CA, ⁵Arthritis Research Group, University of California San Francisco, San Francisco, CA, ⁶Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Background/Purpose: Women with Systemic Lupus Erythematosus (SLE) and Anti-Phospholipid Antibodies (aPL) have pregnancies with higher rates of preterm labor, preeclampsia, and fetal loss than healthy…
Abstract Number: 2537 • 2015 ACR/ARHP Annual Meeting
Prescription Medication Use in Sweden Among Pregnant Women with Systemic Lupus Erythematosus and General Population Comparators
Kristin Palmsten¹, Julia F Simard^2,3, Christina D Chambers^1,4 and Elizabeth V Arkema⁵, ¹Department of Pediatrics, University of California, San Diego, La Jolla, CA, ²Division of Epidemiology, Health Research and Policy Department, and Division of Immunology & Rheumatology, Department of Medicine, Stanford School of Medicine, Stanford, CA, ³Clinical Epidemiology Unit, Dept of Medicine, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ⁵Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: There is limited information regarding medication use patterns among pregnant women with systemic lupus erythematosus (SLE). We aimed to characterize trends of medications used…

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