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  • Abstract Number: 1980 • 2015 ACR/ARHP Annual Meeting

    Tocilizumab in Giant Cell Arteritis: A Multicentre Open-Label Study in France

    Alexis Regent1, Serge Redeker2, Alban Deroux3, Pierre Kieffer4, Kim Heang Ly5, Maxime Dougados6, Claire Larroche7, Loïc Guillevin1, Laurence Bouillet8, Olivier Espitia9, Nathalie Costedoat-Chalumeau10, Martin Soubrier11, Benoit Brihaye12, François Lifermann13, Guillaume Lefèvre14, Xavier Puéchal1, Luc Mouthon1, Eric Toussirot15 and GFEV and CRI, 1Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Paris, France, 243 rue de l'isle, Ch Abbeville, Abbeville, France, 3Internal Medicine, CHU Grenoble, Grenoble, France, 4Hopital Emile Muller, Mulhouse Cedex 1, France, 5CHU de Limoges, Service de médecine interne, Limoges, France, 6Medicine Faculty, Paris-Descartes University, Paris, UPRES-EA 4058, Cochin Hospital, Rheumatology B, Paris, France, 7Internal Medicine, Paris, France, 8CHU, Grenoble, France, 9Internal Medicine, Nantes University Hospital, Nantes, France, 10Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, 11Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 12Service de médecine interne et médecine polyvalente, Saint Quentin, France, 13CH Dax, Dax, France, 14Service de médecine interne, Centre National de Référence de la Sclérodermie Systémique, Hôpital Claude Huriez, CHRU Lille, Lille, France, 15Service de Rhumatologie, CHU J Minjoz, Besancon, France

    Background/Purpose: To report the French experience on the efficacy and safety of tocilizumab (TCZ) in patients with giant cell arteritis (GCA) and outcome after treatment…
  • Abstract Number: 1981 • 2015 ACR/ARHP Annual Meeting

    Increased Extracellular Water Measured By Bioimpedance Analysis in Polymyalgia Rheumatica Patients – Sign of Volume Overload

    Florian Günther1,2, Boris P. Ehrenstein2, Martin Fleck1 and Rainer Straub1, 1Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany, 2Department of Rheumatology/Clinical Immunology, Asklepios Medical Center, 93077 Bad Abbach, Germany

    Background/Purpose: Water retention is a typical feature of acute inflammatory episodes, chiefly implemented by the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This…
  • Abstract Number: 1982 • 2015 ACR/ARHP Annual Meeting

    Sonographic Scoring of the Synovial Components in the Shoulder Revealed That Shoulder Synovitis in PMR Patients Is Milder Than That in Elderly-Onset RA Patients with PMR-like Onset

    Takeshi Suzuki, Division of Allergy and Rheumatology, Japanese Red Cross Medical Center, Tokyo, Japan; Division of Rheumatology, Mitsui Memorial Hosipital, Tokyo, Japan

    Background/Purpose: Through the clinical experience, we noted that there seems to be differences not in the kind or the frequency but in the severity of…
  • Abstract Number: 1983 • 2015 ACR/ARHP Annual Meeting

    Interspinous Bursitis Evaluation By Ultrasound Is Very Useful for Diagnosis of Polymyalgia Rheumatica

    Kensuke Kume1, Kanzo Amano2, Susumu Yamada1, Toshikatsu Kanazawa3, Hiroshi Komori1, Kazuhiko Hatta4 and Noriko Kuwaba5, 1Rheumatology, Hiroshima Clinic, Hiroshima, Japan, 2rheumatology., hiroshima clinic, Hiroshima, Japan, 3rheumatology, hiroshima clinic, hiroshima, Japan, 4Rheumatology, Hatta Clinic, Kure, Japan, 5Medical Research, Sanki Clinical Link, Hiroshima, Japan

    Background/Purpose: Polymyalgia rheumatica (PMR) is a common inflammatory disease of the elderly, and 2012 provisional classification criteria were suggested, however it is provisional and not…
  • Abstract Number: 1984 • 2015 ACR/ARHP Annual Meeting

    Incidence and Intensity of 18fdg Uptake on Whole Body PET/CT in Patients with Polymyalgia Rheumatica

    Claire Owen1,2, Aurora Poon3,4, Sze Ting Lee2,3,4, Christine McMenamin1, Kunthi Pathmaraj3, Andrew Scott2,3,4 and Russell Buchanan1,2, 1Rheumatology, Austin Health, Heidelberg VIC, Australia, 2Medicine, University of Melbourne, Parkville VIC, Australia, 3Department of Molecular Imaging and Therapy, Austin Health, Heidelberg VIC, Australia, 4Olivia Newton-John Cancer Research Institute, Heidelberg VIC, Australia

    Incidence and Intensity of 18FDG Uptake on Whole Body PET/CT in Patients with Polymyalgia Rheumatica C.E. Owen1,2, A.M.T. Poon2,3, S.T. Lee2,3,4, K. Pathmakaj3, C. McMenamin1,…
  • Abstract Number: 1985 • 2015 ACR/ARHP Annual Meeting

    Abnormal B-Cell Distribution Is Improved By Tocilizumab Monotherapy in Patients with Polymyalgia Rheumatica

    Guillermo Carvajal Alegria1, Valerie Devauchelle2, Yves Renaudineau3, Alain Saraux4, Jacques-Olivier Pers5 and Divi Cornec6, 1Immunology, CHRU MORVAN, BREST, France, 2Service de Rhumatologie, CHU Brest, Brest, France, 3Immunology, Brest University Medical School Hospital, Brest, France, 4Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, 5EA2216/ERI29 UBO, Brest, France, 6Department of rheumatology, Brest Occidentale University, Brest, France

    Background/Purpose: Abnormalities in B-cell population distribution were recently reported in polymyalgia rheumatica (PMR) and giant cell arteritis, which improved with glucocorticoids. Our objective here was…
  • Abstract Number: 1986 • 2015 ACR/ARHP Annual Meeting

    Clinical Efficacy of Tocilizumab in Polymyalgia Rheumatica: An OPEN-Label Study.

    Eric Toussirot1, Antoine Martin2, Martin Soubrier3, serge redeker4, Alexis Régent5 and Le CRI6, 1Service de Rhumatologie, CHU J Minjoz, Besancon, France, 2Rheumatology, Centre Hospitalier, St Brieuc, France, 3Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, 443 rue de l'isle, Ch Abbeville, Abbeville, France, 5Paris Descartes University, UPRES-EA 4058, Paris, France, 6Rheumatology, CHU, Strasbourg, France

    Background/Purpose: polymyalgia rheumatic (PMR) is a chronic inflammatory disorder of unknown etiology that affects elderly people. Glucocorticoids (GC) are still the mainstay of therapy for…
  • Abstract Number: 1987 • 2015 ACR/ARHP Annual Meeting

    Dramatic Efficacy of Tocilizumab As First Line Therapy in Patients with Recent Polymyalgia Rheumatica (PMR): Results of the First Longitudinal Prospective Study

    Valerie Devauchelle1, Alain Saraux2, Jean-Marie Berthelot3, Divi Cornec4, Yves Renaudineau5, Sandrine Jousse-Joulin1, Thierry Marhadour6, Solene Querellou7, Florent Garrigues8, Michel De Bandt9 and Maelenn Gouillou10, 1Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, 2Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, 3Rheumatology, University Hospital, Nantes, France, 4Department of rheumatology, Brest Occidentale University, Brest, France, 5Immunology, Brest University Medical School Hospital, Brest, France, 6CHU La Cavale Blanche, Brest, France, 7Nuclear Medicine Department, Morvan University Hospital, Brest, France, 8Radiology department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, 9Rheumatology department, CHU Fort de France, Fort de France, France, 10Clinical Investigation Centre (CIC) 1412, CHU Cavale Blanche- Institut National de la Santé et de la Recherche Médicale (INSERM), Brest, France

    Background/Purpose: Glucocorticoids (GCs) are the cornerstone treatment of polymyalgia rheumatica (PMR) but induce several adverse events. Methods: Objectives: To evaluate efficacy and safety of tocilizumab…
  • Abstract Number: 1988 • 2015 ACR/ARHP Annual Meeting

    Efficacy and Safety of Mizoribine for Polymyalgia Rheumatica: Analysis of 47 Cases

    Ryo Rokutanda1, Chisun Min2, Yuko Kataoka1, Tokutaro Tsuda1, Shunya Kaneshita1, Ken-ichi Yamaguchi3, Koji Takasugi4, Masei Suda1, Akira Takeda3, Yukio Matsui1,3, Mitsumasa Kishimoto1 and Masato Okada1, 1Immuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan, 2Division of Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan, 3Allergy and Rheumatology, St. Luke's International Hospital, Tokyo, Japan, 4Imuno-Rheumatology Center, St. Luke's International Hospital, Tokyo, Japan

    Background/Purpose: Polymyalgia rheumatic (PMR) is an inflammatory rheumatic disease characterized by aching and morning stiffness of body, which is seen almost exclusively in adults over…
  • Abstract Number: 1989 • 2015 ACR/ARHP Annual Meeting

    Treatment of Refractory Non-Infectious Aortitis: Tocilizumab Compared to Antitnf Alfa Agents. Multicenter Study of 44 Patients

    Montserrat Santos-Gómez1, Javier Loricera1, Ricardo Blanco1, Jose L. Hernández2, Santos Castañeda3, Norberto Ortego-Centeno4, M. Enriqueta Peiró1, Paz Collado5, Sheila Melchor6, Antonio Mera7, Eva Pérez-Pampin8, Esteban Rubio Romero9, Jaime Calvo-Alen10, Elena Aurrecoechea11, Iñigo Rúa-Figueroa12, Mauricio Minguez13, Gabriel Herrero-Beaumont14, Beatriz Bravo15, José Rosas16, Javier Narváez17, Javier Calvo18, Rafael Ariza-Ariza19, Mercedes Freire20, Pablo Lluch Mesquida21, Cristina Mata22, Eva Galindez-Agirregoikoa23, Juan María Blanco Madrigal23, Amalia Sánchez24, José Salvatierra25, Vanesa Calvo-Río1, Carmen Gonzalez-Vela26, Natalia Palmou1, Leyre Riancho-Zarrabeitia1 and Miguel Angel Gonzalez-Gay1, 1Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 2Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, 3Rheumatology, Hospital Universitario de la Princesa, Madrid, Spain, 4Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, 5Rheumatology, Pediatric Rheumatology Unit, Hospital Universitario Severo Ochoa, Madrid, Spain, 6Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 7Hospital Universitario de Santiago de Compostela, La Coruña, Spain, 8Rheumatology, Hospital Universitario de Santiago de Compostela, La coruña, Spain, 9Rheumatology Department,, Hospital Universitario Virgen del Rocío, Sevilla, Spain, 10Rheumatology Division, Hospital de Sierrallana, Torrelavega, Spain, 11Rheumatology, Hospital de Sierrallana, Torrelavega, Spain, 12Rheumatology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canarias, Spain, 13Department of Rheumatology, Hospital Universitario San Juan, Alicante, Spain, 14Department of Osteoarticular Pathology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, 15Pediatric rheumatology, Hospital Virgen de las Nieves, Granada, Spain, 16Rheumatology, Hospital Marina Baixa, Villajoyosa, Spain, 17Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 18Rheumatology, Hospital General Consorcio de Valencia, Valencia, Spain, 19Rheumatology, Hospital Universitario Virgen de la Macarena, Sevilla, Spain, 20Rheumatology, Complejo Hospitalario Universitario de A Coruña, La Coruna, Spain, 21Hospital Mateu Orfila, Mahón (Menorca), Spain, 22Rheumatology, Hospital de Sierrallana, Laredo, Spain, 23Rheumatology, Hospital Universitario de Basurto, Bilbao, Spain, 24Hospital Lucus Augusti, Lugo, Spain, 25Hospital Universitario de San Cecilio, Granada, Spain, 26Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain

    Background/Purpose:    Aortitis is often refractory to conventional immunosuppressive (IS) therapy. The use of biological therapy, such as tocilizumab (TCZ) and anti-TNFα agents have been…
  • Abstract Number: 1990 • 2015 ACR/ARHP Annual Meeting

    Corticosteroid Use in Idiopathic Aortitis: A Systematic Review

    Nancy Maltez1 and Nataliya Milman2, 1Internal Medicine, University of Ottawa, Ottawa, ON, Canada, 2Division of Rheumatology, University of Ottawa, Ottawa, ON, Canada

    Background/Purpose: Idiopathic aortitis (IA) is a poorly defined entity with no specific pathological or clinical criteria for its classification or diagnosis, except for the presence…
  • Abstract Number: 1991 • 2015 ACR/ARHP Annual Meeting

    Large Vessel Involvement By IgG4-Related Disease

    Cory Perugino1, Zachary Wallace1 and John H. Stone2, 1Rheumatology, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA

    Background/Purpose: IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory condition of uncertain etiology. Reports have described inflammatory aortitis and peri-aortitis in the setting of retroperitoneal fibrosis…
  • Abstract Number: 1992 • 2015 ACR/ARHP Annual Meeting

    Plasma Endothelin-1 Parallels the Vasoconstriction Phase in Reversible Cerebral Vasoconstriction Syndrome

    Seby John1, Leonard H. Calabrese2, Juan J. Maya3, Alex Massiello4, Ken Uchino1, Serpil Erzurum5, Allison Janocha5 and Rula A Hajj-Ali6, 1Cerebrovascular Center, Cleveland Clinic Foundation, Cleveland, OH, 2Rheumatic & Immunologic Dis, Cleveland Clinic Foundation, Cleveland, OH, 3Internal Medicine, Cleveland Clinic, Cleveland, OH, 4Rheumatology, Cleveland Clinic, Cleveland, OH, 5Cleveland Clinic, Cleveland, OH, 6Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

    Plasma Endothelin-1 parallels the vasoconstriction phase in Reversible Cerebral Vasoconstriction SyndromeBackground/Purpose: Cerebral vasoconstriction is thought to be the underlying pathogenetic mechanism of Reversible Cerebral Vasoconstriction…
  • Abstract Number: 1993 • 2015 ACR/ARHP Annual Meeting

    Imaging Findings of Cerebral Amyloid Angiopathy, Abeta-Related Angiitis (ABRA) and Cerebral Amyloid Angiopathy-Related Inflammation: A Single Institution 25 Year Experience

    Carlo Salvarani1, Jonathan M Morris2, Caterina Giannini2, Teresa J. H. Christianson3, Robert D. Brown Jr.4 and Gene G. Hunder5, 1Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy, 2Mayo Clinic, Rochester, MN, 3Division of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN, 4Department of Neurology, Mayo Clinic, Rochester, MN, 5Dept Internal Med/Rheum, Mayo Clinic, Rochester, MN

    Background/Purpose: To investigate the role of imaging in differentiating cerebral amyloid angiopathy (CAA) with and without inflammation.                                                    Methods: We studied 54 patients seen over 25…
  • Abstract Number: 1994 • 2015 ACR/ARHP Annual Meeting

    Electronic Patient Reported Outcome Measures in Systemic Lupus Erythematosus : A Potential Disease Modifying Impact on the Management of Disease Activity Flares and Damage Accrual

    Yasser M. El Miedany1, Sami Bahlas2, Maha El Gaafary3, Sally Youssef4 and Ihab Ahmed5, 1Rheumatology, Darent Valley Hospital, Dartford, United Kingdom, 2Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, 3Community, Environmental and Occupational Medicine, Ain Shams University, Abbassia, Egypt, 4Rheumatology and Rehabilitation Departmennt, Ain Shams University, Cairo, Egypt, 5Medicine, Cairo University, Cairo, Egypt

    Background/Purpose: Patient reported outcomes measures (PROMs) are changing the landscape in rheumatology care. Electronic PROMs (ePROMs) is a new patient-centric model of collaboration that fully…
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