Abstracts Archive - Page 1814 of 2607 - ACR Meeting Abstracts

Abstract Number: 3230 • 2016 ACR/ARHP Annual Meeting
Genome-Wide Association Study Identifies Novel Sjögren’s Syndrome Risk Loci in the Regions of NAB1, TYK2, and PTTG1-mir146a
Christopher J. Lessard¹, Indra Adrianto¹, John Ice¹, Astrid Rasmussen², Kiely Grundahl³, Jennifer A. Kelly⁴, R. Hal Scofield¹, Simon Bowman⁵, Susan Lester⁶, Per Eriksson⁷, Maija-Leena Eloranta⁸, Johan G. Brun⁹, Lasse G. Goransson¹⁰, Erna Harboe¹⁰, Marika Kvarnström¹¹, Michael T. Brennan¹², James Chodosh¹³, Raj Gopalakrishnan¹⁴, Andrew J.W. Huang¹⁵, Pamela Hughes¹⁶, David M. Lewis¹⁷, Michael D. Rohrer¹⁸, Donald U. Stone¹⁹, Nelson L. Rhodus²⁰, Barbara M. Segal²¹, Lida Radfar²², A. Darise Farris²³, Joel M. Guthridge²⁴, Patrick M. Gaffney¹, Judith A. James¹, John B. Harley²⁵, Lars Rönnblom⁸, Juan-Manuel Anaya²⁶, Deborah S. Cunninghame-Graham²⁷, Timothy J. Vyse²⁸, Ilias Alevizos²⁹, Xavier Mariette³⁰, Roald Omdal¹⁰, Marie Wahren-Herlenius³¹, Torsten Witte³², Roland Jonsson³³, Maureen Rischmueller³⁴, Lindsey A. Criswell³⁵, Courtney G. Montgomery¹, Wan-Fai Ng³⁶, Gunnel Nordmark³⁷ and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ³Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁶Queen Elizabeth Hospital, University of Adelaide, Adelaide, Australia, ⁷University Hospital, Rheumatology clinic, Linköping, Sweden, ⁸Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ⁹Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ¹⁰Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹¹Karolinska Institutet, Stockholm, Sweden, ¹²Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, ¹³Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁴Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁵Washington University,, St Louis, MO, ¹⁶Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁷Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ¹⁸Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁹Dean McGee Eye Institute, Oklahoma City, OK, ²⁰Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ²¹Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ²²Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ²³Arthritis & Immunology Program, Oklahoma Medical Research Foun, Oklahoma City, OK, ²⁴Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁵Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ²⁶Center for Autoimmune Diseases Research (CREA). School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, Colombia., Bogotá, Colombia, ²⁷Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ²⁸Division of Immunology, Infection and Inflammatory Disease, King’s College London, London, United Kingdom, ²⁹Sjögren's Syndrome Clinic, National Institute of Dental and Craniofacial Research, Bethesda, MD, ³⁰Institut National de la Santé et de la Recherche Médicale, Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ³¹Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ³²Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ³³Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ³⁴Rheumatology, University of Adelaide, Adelaide, Australia, ³⁵Division of Rheumatology, UCSF, San Francisco, CA, ³⁶Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³⁷Rheumatology, Department of Medical Sciences, Uppsala University, Sweden, Uppsala, Sweden
Background/Purpose: Sjögren’s syndrome (SS) is a complex autoimmune disease with both environmental and genetic factors contributing to pathophysiology. The goal of this genome-wide association study…
Abstract Number: 3231 • 2016 ACR/ARHP Annual Meeting
miR200b-5p Expression in Minor Salivary Glands (MSG): A Possible Predictor of Lymphoma Development in Sjögren’s Syndrome (SS)?
Efstathia K. Kapsogeorgou¹, Aristea Papageorgiou¹, Michael Voulgarelis² and Athanasios G. Tzioufas³, ¹Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ²Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ³School of Medicine, Pathophysiology Department, National and Kapodistrian University of Athens, Athens, Greece
Background/Purpose: The miRNAs of the miR-200 family are critical regulators of oncogene and tumor suppressor genes. A preliminary study of several miRNAs in the MSGs…
Abstract Number: 3232 • 2016 ACR/ARHP Annual Meeting
Decreased Expression of Micro-RNA 130a and Micro-RNA 708 in Type-1 Classical Dendritic Cells of Patients with Primary SS Indicates Their Dysregulation
Maarten R. Hillen^1,2, Sofie L.M. Blokland^1,2, Elena Chouri^1,2, Ana Lopes^1,2, Aike A. Kruize², Marzia Rossato^1,2, Timothy R.D.J. Radstake^1,2 and Joel A.G. van Roon^1,2, ¹Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands
Background/Purpose: cDespite the fact that especially cDC1s are candidate key players in the activation of local T and B-cells in pSS, they have rarely been…
Abstract Number: 3233 • 2016 ACR/ARHP Annual Meeting
Determinants of Pain, Fatigue, Physical Function and Social Participation in SLE Patients, Measured with Patient Reported Outcomes Measurement Information System (PROMIS®) Computerized Adaptive Tests
Shanthini Kasturi¹, Jayme C. Burket², Jessica Berman¹, Kyriakos A. Kirou¹, Alana B. Levine¹, Lisa R. Sammaritano¹ and Lisa Mandl¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Healthcare Research Institute, Hospital for Special Surgery, New York, NY
Background/Purpose: Poor SLE outcomes have been associated with certain clinical and socio-demographic characteristics, but the determinants of patient reported outcomes (PROs) in SLE are unknown.…
Abstract Number: 3234 • 2016 ACR/ARHP Annual Meeting
Prevalence and Metric of Depression and Anxiety in Lupus: A Systematic Review and Meta-Analys
Ahmed Moustafa¹, Mohamed Hassanein², Lihi Eder³, Joan E. Wither⁴, William Fung⁵, Panayiotis Lambiris⁶ and Zahi Touma⁴, ¹Medicine, Western University, London, ON, Canada, ²Michigan State University, East Lansing, MI, ³Medicine, University of Toronto, Women's College Hospital, Toronto, ON, Canada, ⁴Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁵Medicine, University of Toronto, Toronto, ON, Canada, ⁶University Health Network, Toronto, ON, Canada
Background/Purpose: To systematically review the literature on the: 1) prevalence of depression and anxiety in SLE patients and 2) metrics of depression and anxiety. …
Abstract Number: 3235 • 2016 ACR/ARHP Annual Meeting
Long-Term Impact of Belimumab on Health-Related Quality of Life and Fatigue in Patients with Systemic Lupus Erythematosus: Up to 7 Years of Treatment Exposure
Vibeke Strand¹, Pam Berry², Sulabha Ramachandran² and James Fettiplace³, ¹Stanford University School of Medicine, Palo Alto, CA, ²GSK, Philadelphia, PA, ³GSK, Uxbridge, Middlesex, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that causes long-term organ damage over time and impairment in health-related quality of life (HRQoL).…
Abstract Number: 3236 • 2016 ACR/ARHP Annual Meeting
Socio-Demographic and Clinical Factors Influencing Generic and Disease-Specific Quality of Life in Patients with Systemic Lupus Erythematosus: Results of a Prospective Multicenter Study
Hervé Devilliers¹, Jean-François Besancenot¹, Sylvain Audia², Bernard Bonnotte³, Francois Maurier⁴, Christiane Broussolle⁵, Nadine Magy-Bertrand⁶, Denis Wahl⁷, Jean-Loup Pennaforte⁸, Thierry Martin⁹, Olivier Aumaître¹⁰, Gilles Blaison¹¹, Geraldine Muller¹, Alexis Mathian¹², Christine Binquet¹³ and Zahir Amoura¹⁴, ¹Department of Internal Medicine and Systemic Diseases, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ²Department of Internal Medicine and Clinical Immunology, Hôpital François Mitterrand, CHU de Dijon; INSERM, UMR1098, University of Bourgogne Franche-Comté, FHU INCREASE, Dijon, France, ³Department of Internal Medicine and Clinical Immunology, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ⁴Department of Internal Medicine, HP Metz Belle Isle Hospital, Metz, France, ⁵Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, ⁶CHU Jean-Minjoz, Service de médecine interne et immunologie clinique, Besançon, France, ⁷CHU de Nancy, Vascular Medicine Division and Regional Competence Centre For Rare Vascular And Systemic Autoimmune Diseases; and UMR_S U1116 Research Unit, Nancy, France, ⁸Internal Medicine, Internal medicine departement, CHU de Reims, Reims, France, ⁹Internal medicine and clinical immunology departement, Strasbourg University Hospital, Strasbourg, France, ¹⁰CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ¹¹Internal medicine departement, Colmar Hospital, Colmar, France, ¹²Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ¹³INSERM, CIC 1432, Clinical Epidemiology Unit, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ¹⁴Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France
Background/Purpose: To describe demographic, socio-economic and lupus-related factors associated with health-related quality of life (HRQOL) in systemic lupus erythematosus (SLE), as measured by 2 generic…
Abstract Number: 3237 • 2016 ACR/ARHP Annual Meeting
Responsiveness and Its Magnitude in the 36-Item Short Form Health Survey and the Lupus Quality of Life Questionnaire in Patients with Active Disease
Stephanie Nantes¹, Jiandong Su² and Zahi Touma³, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: SF-36 and LupusQoL are Health-Related Quality-of-Life (HRQoL) questionnaires used in SLE. We determined: (1) concurrent construct validity of SF-36 and LupusQoL against disease activity…
Abstract Number: 3238 • 2016 ACR/ARHP Annual Meeting
Depression Symptoms throughout the Lifespan in a Low-Income, Minority Cohort of Lupus Patients: Who Is at Risk?
Tamar Rubinstein¹, Noa Schwartz², Nicole Jordan³, Rebecca Lois⁴, Dawn Wahezi^5,6, Ruth E K Stein^7,8 and Chaim Putterman², ¹Division of Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, ²Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ³Montefiore Medical Center, New York, NY, ⁴Psychiatry and Pediatrics, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, ⁵Pediatric Rheumatology, Albert Einstein College of Medicine, Bronx, NY, ⁶Pediatric Rheumatology, The Children's Hospital at Montefiore, Bronx, NY, ⁷Pediatrics, Children's Hospital at Montefiore, Bronx, NY, ⁸Pediatrics, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Depression is commonly seen in lupus, but widely varying prevalence rates have been reported. This may be due to different demographics and characteristics…
Abstract Number: 3239 • 2016 ACR/ARHP Annual Meeting
Expression of IFN-Regulated Genes in Autoantibody Exposed Babies in Utero
Malin Hedlund¹, Gudny-Ella Thorlacius¹, Margarita Ivanchenko¹, Vijole Ottosson¹, Amina Ossoinak¹, Linda Lagnefeldt¹, Joanna Tingstrom¹, Alexander Espinosa¹, Lars Rönnblom², Maija-Leena Eloranta², Sven-Erik Sonesson¹ and Marie Wahren-Herlenius³, ¹Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Stockholm, Sweden, ²Uppsala University, Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala, Sweden, ³Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: Ro/SSA autoantibodies and an IFN signature are commonly present in women with Sjögren’s syndrome and SLE. During pregnancy, the autoantibodies are transported across the…
Abstract Number: 3240 • 2016 ACR/ARHP Annual Meeting
Interferon Kappa Is a Novel Type I IFN That Drives Cutaneous Inflammation in Systemic Lupus
Jasmine Stannard¹, Tamra J. Reed², Emily Myers³, Lori Lowe⁴, Mrinal Sarkar⁴, Xianying Xing⁵, Celine C. Berthier⁶, Johann Gudjonsson⁴ and J. Michelle Kahlenberg⁷, ¹Int. Medicine/Rheumatology, University of Michigan, Ann Arbor, MI, ²Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Rheumatology, Georgetown University, Washington, DC, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Dermatology, University of Michigan, University of Michigan, Ann Arbor, MI, ⁶Nephrology, Division of Nephrology, University of Michigan Medical Center, Ann Arbor, MI, ⁷Internal Medicine, Division of Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Cutaneous lupus erythematosus (CLE) lesions are disfiguring, scarring, difficult to treat, and affect up to 70% of patients with systemic lupus erythematosus (SLE). Type…
Abstract Number: 3241 • 2016 ACR/ARHP Annual Meeting
Genetic Variation and Tobacco Smoke Exposure in Systemic Lupus Erythematosus: A Case Control Study Among African Americans
Bethany Wolf¹, Paula S. Ramos², Paul Nietert³, J. Madison Hyer¹, Viswanathan Ramakrishnan¹, Gary S. Gilkeson⁴, Gerard Hardiman² and Diane L. Kamen⁵, ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects African Americans, and the development of SLE is believed to be triggered by exposure to one or more…
Abstract Number: 3242 • 2016 ACR/ARHP Annual Meeting
Identification and Functional Characterization of TNIP1 Causal Variants Associated with Systemic Lupus Erythematosus
Satish Pasula¹, Mandi Wiley¹, Ying-yu Wu¹, Ajay Nair¹, Jaanam Gopalakrishnan² and Patrick M. Gaffney¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by autoantibody production and dysregulated interferon responses. Genome-wide association studies (GWAS) have identified more…
Abstract Number: 3243 • 2016 ACR/ARHP Annual Meeting
Intestinal Microbial Dysbiosis in SLE Is Linked to Elevated IgA and Induction of Autoimmunity
Doua F. Azzouz¹, Lelise Getu², Celine Anquetil¹, Jill P. Buyon³ and Gregg J. Silverman³, ¹Medicine, NYU School of Medicine, New York, NY, ²Department of Medicine, New York University School of Medicine, New York, NY, ³Medicine, New York University School of Medicine, New York, NY
Background/Purpose: SLE is a complex multifactorial systemic autoimmune disease, which has been attributed to poorly understood interactions between genetic and environmental factors. Recent reports have…
Abstract Number: 3244 • 2016 ACR/ARHP Annual Meeting
Observations of Early and Late B Cell Alterations during Belimumab Treatment in Patients with Systemic Lupus Erythematosus Using Mass Cytometry (CyTOF)
Ioannis Parodis¹, Daniel Ramsköld¹, Petter Brodin², Agneta Zickert¹, Lakshmikanth Tadepally², Yang Chen², Jaromir Mikes², Adnane Achour², Iva Gunnarsson¹ and Vivianne Malmström¹, ¹Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ²Science for Life Laboratory, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Belimumab is a recombinant monoclonal antibody that inhibits soluble B lymphocyte stimulator (BLyS), also known as BAFF or TNFSF13B, and is approved for treating…

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