Abstracts Archive - Page 1813 of 2425 - ACR Meeting Abstracts

Abstract Number: 1860 • 2015 ACR/ARHP Annual Meeting
Autoantibodies Utilizing the Immunoglobulin Heavy Chain Variable Region Gene 4-34 (VH4-34) Exhibit Autoreactivity Towards, and Potential Competition with Galectins within Systemic Lupus Erythematosus (SLE)
Kevin Cashman¹, Asiya Chida² and Ignacio Sanz², ¹Department of Medicine- Division of Rheumatology, Emory University, Atlanta, GA, ²Medicine, Emory University, Atlanta, GA
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the propagation of autoreactive B cell populations leading to the production of pathogenic antibodies…
Abstract Number: 1861 • 2015 ACR/ARHP Annual Meeting
Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis and the Prothrombotic and Proinflammatory Activities of Monocytes
Carlos Perez-Sanchez¹, M.Ángeles Aguirre Zamorano¹, María Galindo², Patricia Ruiz-Limon¹, Nuria Barbarroja¹, Yolanda Jiménez Gómez¹, Pedro Segui³, Eduardo Collantes-Estevez¹, Mª Jose Cuadrado⁴ and Chary Lopez-Pedrera¹, ¹IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, ²Department of Rheumatology. Hospital Universitario 12 de Octubre, Madrid, Spain, ³IMIBIC-Reina Sofia University Hospital, Radiology Unit, Cordoba, Spain, ⁴Lupus Research Unit, St Thomas Hospital, London, United Kingdom
Background/Purpose: Atherothrombosis in systemic lupus erythematosus (SLE) has been related to the combined effects of autoimmune elements and cells of the immune system, where monocytes…
Abstract Number: 1862 • 2015 ACR/ARHP Annual Meeting
Identification of Homogeneous Systemic Lupus Erythematosus (SLE) Patient Groups Using Clustered Autoantibody Reactivities
Petra Budde¹, Hans-Dieter Zucht¹, Daniel Chamrad¹, Anna Telaar¹, Johannes Schulte-Pelkum¹, Stefan Vordenbäumen², Peter Schulz-Knappe¹ and Matthias Schneider³, ¹Protagen AG, Dortmund, Germany, ²Department of Rheumatology, Univ. Duesseldorf, Düsseldorf, Germany, ³Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: In SLE, early diagnosis, differentiation to other autoimmune diseases and prognostic stratification are still great challenges. Hence, SLE represents an enormous challenge for the…
Abstract Number: 1863 • 2015 ACR/ARHP Annual Meeting
Epigenetic Changes in SLE Implicate Enhancers As a Force in Pathologic Cell Behavior
Lihua Shi¹, Li Song¹, Zhe Zhang², Michelle Petri³ and Kathleen E. Sullivan⁴, ¹Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Bioinformatics, Children's Hospital of Philadelphia, Bioinformatics, Philadelphia, PA, ³Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁴Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: We previously identified novel non-coding RNAs that were markedly overexpressed in SLE patient monocytes. Among all classes of RNAs, these non-coding RNAs were by…
Abstract Number: 1864 • 2015 ACR/ARHP Annual Meeting
H3K4me3 Peak Shape Dictates Transcription and Regulates Differential Expression in SLE
Kathleen E. Sullivan¹, Lihua Shi², Li Song³, Michelle Petri⁴ and Zhe Zhang⁵, ¹Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ⁵Bioinformatics, Children's Hospital of Philadelphia, Bioinformatics, Philadelphia, PA
Background/Purpose: H3K4me3 is a post-translational modification of histone H3 associated typically with gene activation. We had previously characterized changes in H3K4me3 associated with SLE in…
Abstract Number: 1865 • 2015 ACR/ARHP Annual Meeting
Association Between Changes in Expression of Gene Signatures and Disease Activity Among Patients with Systemic Lupus Erythematosus
Michelle Petri¹, Wei Fu², Ann Ranger³, Norm Allaire⁴, Patrick Cullen⁴ and Laurence S Magder⁵, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Biogen Inc., Cambridge, MA, ⁴Biogen Idec Inc., Cambridge, MA, ⁵University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: In recent work, we showed that a single measurement of several gene signatures in whole blood was associated with levels of disease activity at…
Abstract Number: 1866 • 2015 ACR/ARHP Annual Meeting
Fall in Dicer1 Gene Expression Flags Abnormal Lymphocyte Activation in Lupus
Olga Sanchez-Pernaute¹, Fredeswinda Romero², Maria Perez-Ferro¹, Cristina Serrano³, María J Martinez-Becerra⁴, F Javier de la Hera⁵ and Rosario Haro⁶, ¹Section for Autoimmune Diseases, Rheumatology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ²Section for Autoimmune Diseases. Rheumatology., Jiménez Díaz Foundation University Hospital, Madrid, Spain, ³Section for Autoimmune Diseases. Immunology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ⁴Immunology, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ⁵Section for Autoimmune Diseases, Internal Medicine, Jiménez Díaz Foundation University Hospital, Madrid, Spain, ⁶Section for Autoimmune Diseases. Dermatology, Jiménez Díaz Foundation University Hospital, Madrid, Spain
Background/Purpose: The integrity of the microRNA machinery is required for the normal reactivity of the immune system both during differentiation and upon antigen engagement. Dicer1…
Abstract Number: 1867 • 2015 ACR/ARHP Annual Meeting
Functional Androgen Receptor Variants Associated with Greater Damage in Systemic Lupus Erythematosus
Yun Deng¹, Jennifer M. Grossman^1,2, Qiong Fu¹, William J. Martin¹, Judith A. James³, Joan T. Merrill⁴, Diane L. Kamen⁵, Gary S. Gilkeson⁵, Susan A. Boackle⁶, Chaim Putterman⁷, Jane E. Salmon⁸, Vasileios C. Kyttaris⁹, George C. Tsokos⁹, Matthew Quirk¹⁰, Seema Kamble¹, Melissa Barcelona¹, Erika Magdangal¹⁰, Lori Sahakian¹¹, Seung Yoon Lee¹, Tracy Y. Lin¹, Weiling Chen¹, Jennifer M.P. Woo¹², Ornella J. Rullo¹², Deborah K. McCurdy¹², Bevra H. Hahn^13,14, Maureen A. McMahon¹¹, Sang-Cheol Bae¹⁵ and Betty P. Tsao¹, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ²Rheumatology, UCLA, Los Angeles, CA, ³Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁶Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁷Division of Rheumatology, Albert Einstein College of Medicine, New York, NY, ⁸Division of Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, ⁹Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ¹⁰Division of Rheumatology, Department of Medicine,, David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, ¹¹Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ¹²Pediatric Rheumatology, Mattel Children's Hospital, University of California Los Angeles, Los Angeles, CA, ¹³Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ¹⁴Rheumatology, Professor Emeritus, Department of Medicine/Rheumatology, David Geffen School of Medicine UCLA, Los Angeles, CA, ¹⁵Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Background/Purpose :Organ damage predicts physical disability and mortality of SLE. Given that men with SLE tend to develop accelerated damage, we selected an X-linked androgen…
Abstract Number: 1868 • 2015 ACR/ARHP Annual Meeting
BLK Pathway-Associated rs13277113 GA Genotype Is More Frequent in Systemic Lupus Erythematosus Patients and Associated with Low Gene Expression and Increased Flares
Omer Nuri Pamuk¹, Hakan Gurkan², Mehmet Ali Balci¹, Hilmi Tozkir³, Julide Duymaz², Gülce Sari², Metin Yazar² and Gulsum Pamuk⁴, ¹Department of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ²Trakya University Medical Faculty, EDIRNE, Turkey, ³Genetics, Trakya University Medical Faculty, EDIRNE, Turkey, ⁴Hematology, Trakya University Medical Faculty, Edirne, Turkey
Background/Purpose: It was reported that genetic variations in B cell signal transduction were associated with susceptibility to SLE. However, these studies were limited in number…
Abstract Number: 1869 • 2015 ACR/ARHP Annual Meeting
Association of CLEC16A with SLE in a Large Multi-Ancestry Cohort and Implication in B-Cell Receptor Signaling
Isaac TW Harley^1,2,3, Samuel Vaughn⁴, Adrienne H. Williams⁵, Julie T. Ziegler⁶, Mary Comeau⁷, Miranda Marion⁸, Stuart Glenn⁹, Adam Adler¹⁰, Kenneth M. Kaufman¹¹, Sang-Cheol Bae¹², Carl D. Langefeld¹³, Jennifer Kelly¹⁴, Patrick M. Gaffney¹⁵, R. Hal Scofield¹⁶, Michelle Petri¹⁷, Jeffrey C. Edberg¹⁸, Joel M. Guthridge¹⁵, Susan A. Boackle¹⁹, Barry Freedman²⁰, Diane L. Kamen²¹, Elizabeth E. Brown on behalf of PROFILE²², Gary S. Gilkeson²³, John D. Reveille²⁴, Joan T. Merrill²⁵, Marta E. Alarcón-Riquelme²⁶, Timothy Vyse²⁷, Lindsey A. Criswell²⁸, Rosalind Ramsey-Goldman²⁹, Juan-Manuel Anaya³⁰, Betty P. Tsao³¹, Judith A. James³², Graciela S. Alarcón³³, Anne M. Stevens³⁴, Kathy Moser Sivils¹⁵, Robert P. Kimberly³⁵, Luis M. Vilá³⁶, Chaim O. Jacob³⁷, Bahram Namjou³⁸, Leah C. Kottyan³⁹, Timothy B. Niewold⁴⁰ and John B. Harley^11,41, ¹Division of Internal Medicine, University of Colorado, Aurora, CO, ²Immunobiology Graduate Program and Medical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH, ³Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Rheumatology and The Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Dept of Med, Div of Rheum, NYU School of Medicine, New York, NY, ⁶Biostatistical Sciences and Center for Public Health Genomics, Wake Forest University Health Sciences, Winston-Salem, NC, ⁷Wake Forest University Health Sciences, Winston-Salem, NC, ⁸Department of Biostatistical Sciences, Wake Forest University Health Sciences, Wake Forest, NC, ⁹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City,, OK, ¹¹US Department of Veterans Affairs Medical Center, Cincinnati, OH, ¹²Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ¹³Wake Forest University, Wake Forest, NC, ¹⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁵Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁷Rheumatology, Johns Hopkins University Hospital, Baltimore, MD, ¹⁸Medicine/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹⁹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ²⁰Department of Internal Medicine, Wake Forest University Health Sciences, Wake Forest, NC, ²¹Medicine, Medical University of South Carolina, Charleston, SC, ²²University of Alabama at Birmingham, Birmingham, AL, ²³Department of Rheumatology, Medical University of South Carolina, Charleston, SC, ²⁴Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²⁵Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²⁶Oklahoma Medical Research Foundation and Centro de Genómica e Investigación Oncológica Pfizer-Universidad de Granada-Junta de Andalucía (GENYO), Granada, Spain, Oklahoma City, OK, ²⁷Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ²⁸Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, ²⁹Northwestern University Feinberg School of Medicine, Chicago, IL, ³⁰Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, ³¹Medicine/Rheumatology, Division of Rheumatology, UCLA, Los Angeles, CA, ³²Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK, ³³U of Alabama, Birmingham, AL, ³⁴Seattle Children's Res Inst, Seattle Children's Hospital, Seattle, WA, ³⁵Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³⁶Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, PR, ³⁷Medicine/Div of Rheumatology, USC School of Medicine, Los Angeles, CA, ³⁸Oklahoma Medical Research Foundation, Edmond, OK, ³⁹3333 Burnet Ave., Ml 15012, Cincinnati, OH, ⁴⁰Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁴¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Immune-mediated diseases appear to share a common genetic basis. Here we describe genetic association of single nucleotide polymorphisms (SNPs) within CLEC16A with SLE in…
Abstract Number: 1870 • 2015 ACR/ARHP Annual Meeting
A Lupus-Associated Variant in Purine Nucleoside Phosphorylase (PNP) Causes Cell Cycle Abnormalities
Yogita Ghodke-Puranik¹, Jessica M. Dorschner¹, Danielle Vsetecka¹, Shreyasee Amin², Ashima Makol³, Floranne C. Ernste², Thomas Osborn², Kevin Moder², Vaidehi Chowdhary⁴, Mark A. Jensen⁵ and Timothy B. Niewold¹, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Division of Rheumatology, Mayo Clinic, Rochester, MN, ³Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mayo Clinic, Rochester, MN, ⁵Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-system, autoimmune disease characterized by autoantibodies to nucleic acids and nucleosomal proteins. The type I interferon pathway is…
Abstract Number: 1871 • 2015 ACR/ARHP Annual Meeting
Familial Aggregation of Rheumatoid Arthritis, Sjögren’s Syndrome, and Systemic Sclerosis Were Detected in Systemic Lupus Erythematous Families
Rufei Lu¹, Hua Chen¹, Krista Bean¹, Teresa Aberle¹, Joel Guthridge¹ and Judith James^1,2, ¹Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Medicine & Pathology, Univ. of Oklahoma, Okla, OK
Background/Purpose: Many systemic autoimmune diseases share heritable and non-heritable risks, as well as some clinical manifestations. A recent meta-analysis based upon genome-wide genetic studies contrasting…
Abstract Number: 1872 • 2015 ACR/ARHP Annual Meeting
Symptomatic and Electrodiagnostic Features of Peripheral Neuropathy in Scleroderma
Julie J. Paik¹, Andrew Mammen², Fredrick M. Wigley³, Ami A. Shah⁴, Laura K. Hummers⁵ and Michael Polydefkis⁶, ¹Rheumatology, Johns Hopkins University, Baltimore, MD, ²Center Tower Ste 5300, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Neurology, Johns Hopkins University, Baltimore, MD
Title: Symptomatic and electrodiagnostic features of peripheral neuropathy in scleroderma Background/Purpose: Peripheral neuropathy in scleroderma has been poorly characterized and the prevalence is unknown. The…
Abstract Number: 1873 • 2015 ACR/ARHP Annual Meeting
Inter and Intrarater Reliability of the Modified Rodnan Skin Score in Early Diffuse Systemic Sclerosis
Jessica K. Gordon¹, Veronica J. Berrocal², Shervin Assassi³, Elana J. Bernstein⁴, Robyn T. Domsic⁵, Faye N. Hant⁶, Monique E. Hinchcliff⁷, Elena Schiopu⁸, Virginia D. Steen⁹, Tracy M. Frech¹⁰ and Dinesh Khanna¹¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Div of Rheumatology, University of Michigan, Ann Arbor, MI, ³Rheumatology, University of Texas Medical School at Houston, Houston, TX, ⁴Rheumatology, Columbia University College of Physicians & Surgeons, New York, NY, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁶Dept of Medicine, Medical University of South Carolina, Charleston, SC, ⁷Division of Rheumatology, Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸University of Michigan, Ann Arbor, MI, ⁹Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁰Div of Rheumatology, University of Utah, Salt Lake City, UT, ¹¹Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: The Modified Rodnan Skin Score (MRSS) is a semiquantitative assessment of skin thickness which is a commonly used outcome measure in Systemic Sclerosis (SSc)…
Abstract Number: 1874 • 2015 ACR/ARHP Annual Meeting
Impact of Socioeconomic Status on Survival in Connective Tissue Disease Associated and Idiopathic Pulmonary Arterial Hypertension
Helen Jin¹, John T. Granton², John Thenganatt³, Jakov Moric³, Ambika Gupta¹, Amie T. Kron¹, Cathy Chau¹ and Sindhu R. Johnson¹, ¹Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada, ²Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ³Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Poorer health outcomes for persons with chronic diseases have been reported in association with lower socioeconomic status (SES). No such evaluation exists for patients…

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